CN108403544B - Oral care composition for children and preparation method thereof - Google Patents
Oral care composition for children and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a children oral care composition and a preparation method thereof. The children oral care composition comprises the following raw materials in percentage by weight: 2-10% of a humectant, 1-5% of a foaming agent, 0.05-2% of a sweetening agent, 0.1-7% of a metal salt, 0.01-5% of a cutin softener, 1-5% of sodium phytate, 1-5% of a licorice extract, 0.5-2% of an aloe barbadensis leaf extract, 1-3% of a panax japonicus extract, 3-8% of a white clove extract, 0.5-2% of a mint extract, 0.5-4% of a vitamin complex, 0.3-2% of a yeast polypeptide, 3-8% of a cationic surfactant, 0.5-3% of a preservative, 2-7% of poloxamer, 1-2% of an essence, and the balance of water. The children oral care composition provided by the invention contains plant extracts and sterilization gum-protecting functional ingredients, has natural and pure taste, has remarkable effects of sterilization, fire reduction, inflammation diminishing, pain relieving and bleeding stopping, is suitable for daily oral care, and can effectively clean oral cavity and firm teeth; has remarkable treatment effect on oral ulcer, gingival bleeding, periodontal disease and dental caries; the preparation method is simple and convenient, is suitable for large-scale production and has high economic benefit.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to a children oral care composition and a preparation method thereof.
Background
Common oral diseases include oral ulcer, periodontal disease, and dental caries. Clinically, oral ulcer, commonly known as aphtha, is a common ulcerative injury disease occurring in oral mucosa and is divided into catarrhal, aphthous, vesicular, cellulitis, pseudomembranous, ulcerative and papular types, and the incidence rate reaches 70-90%. The common clinical symptoms are manifested by salivation, loss of appetite or slow ingestion, oral malodor, flushing of the oral mucosa, warming, swelling, and pain. Periodontal disease refers primarily to gingivitis and periodontitis; gingivitis refers to acute and chronic inflammation occurring in gingival tissues, which is commonly manifested as gingival bleeding, redness and swelling, swelling and pain, and repeated outbreak of dental ulcer, the gingival bleeding, swelling and pain can affect each other to form a vicious circle, and if effective treatment is not carried out, periodontitis possibly developed to a deep layer can cause more serious problems of tooth loosening, tooth falling and the like. Periodontitis is a chronic inflammation that attacks the gingival and periodontal tissues, is a destructive disease, and is mostly a gingival inflammation and swelling caused by plaque, tartar, physical impaction, poor restoration, bite wound, etc., and meanwhile, the plaque is accumulated and aggravated and extends from the upper part of the gum to the lower part of the gum. Because of the characteristics of the subgingival micro-ecological environment, a large number of periodontal pathogenic bacteria with high toxicity, such as gingival bacteroides, intermediate bacteroides, spirochetes and the like, are bred in the subgingival bacterial plaque, so that the inflammation of gingiva is aggravated and expanded, alveolar bone formed by a periodontal pocket is absorbed, and periodontitis is caused, and the main inducement of periodontitis is also caused by the accumulation of the bacterial plaque.
At present, more Chinese herbal medicines can be used for treating oral ulcer and periodontal disease, and most of the raw materials used in the traditional Chinese medicine are plant or mineral components. Wherein, the plant is the extract of the root, stem and leaf, etc. after being practiced and screened for thousands of years, the plant is listed as the Chinese herbal medicine component in the Chinese pharmacopoeia, and can be called as the treasure of Chinese nation with the unique medicinal value and safety. With the continuous improvement of the technological level, nearly 3800 raw materials can be analyzed to determine the active ingredients of the raw materials, and qualitative or quantitative detection can be carried out at the same time. The efficacy of the active ingredient is also continually being demonstrated. The development and research of oral products such as Chinese herbal medicine toothpaste for treating oral ulcer and periodontal disease also become a new subject of recent research. The traditional Chinese herbal medicine toothpaste or other oral products are not available in the market, but the effect on treating oral ulcer and gingivitis is not ideal, most of the existing oral products only aim at cleaning oral cavity and transiently refreshing breath, do not substantially improve oral care, even damage enamel and tooth surface to make teeth fragile, stimulate and further damage oral mucosa, are not good for oral health, and are particularly not suitable for children.
Disclosure of Invention
The invention aims to provide a children oral care composition and a preparation method thereof. The children oral care composition disclosed by the invention is natural and pure in mouthfeel, has remarkable effects of sterilizing, reducing internal heat, diminishing inflammation, relieving pain and stopping bleeding, is suitable for daily oral care, can effectively clean oral cavity and firm teeth, and has remarkable treatment effects on oral ulcer, gingival bleeding, periodontal disease and decayed teeth; the preparation method is simple and convenient, is easy to operate, is suitable for large-scale production, and has high economic benefit.
In order to solve the technical problems, the technical scheme of the invention is as follows:
in a first aspect, the present invention provides a children oral care composition, which comprises the following raw materials by weight: 2-10% of a humectant, 1-5% of a foaming agent, 0.05-2% of a sweetening agent, 0.1-7% of a metal salt, 0.01-5% of a cutin softener, 1-5% of sodium phytate, 1-5% of a licorice extract, 0.5-2% of an aloe barbadensis leaf extract, 1-3% of a panax japonicus extract, 3-8% of a white clove extract, 0.5-2% of a mint extract, 0.5-4% of a vitamin complex, 0.3-2% of a yeast polypeptide, 3-8% of a cationic surfactant, 0.5-3% of a preservative, 2-7% of poloxamer, 1-2% of an essence, and the balance of water. Preferably, the licorice extract, the aloe barbadensis leaf extract, the panax japonicus extract, the lilac alba extract and the mint extract are powder, extract or extracting solution.
Preferably, the humectant is selected from one or more of propylene glycol, sorbitol and glycerin.
Preferably, the foaming agent is selected from one or more of disodium lauroyl glutamate, sodium lauroyl sarcosinate and sodium dodecyl sulfate.
Preferably, the sweetener is selected from one or more of xylitol, glycyrrhizin, aspartame, neotame, sodium cyclamate, aspartame and sucralose.
Preferably, the metal salt is selected from one or more of zinc salt, copper salt, stannous salt and potassium salt.
Preferably, the keratolytic agent is allantoin.
Preferably, the vitamin complex is selected from vitamin A, vitamin E, vitamin C, vitamin H, folic acid, cyanocobalamin and vitamin B3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1One ofOne or more of them.
Preferably, the cationic surfactant is selected from one or more of cetylpyridinium chloride, chlorhexidine, domiphen bromide.
Preferably, the preservative is selected from one or more of sodium benzoate, parabens and potassium sorbate.
In a second aspect, the present invention provides a method of making a children's oral care composition according to the first aspect, comprising the steps of:
(1) mixing sweetener, metal salt, cutin softener, sodium phytate, Glycyrrhrizae radix extract, folium Aloe Vera extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, compound vitamin, yeast polypeptide, and cationic surfactant, adding water, stirring and mixing to obtain mixture A;
(2) mixing poloxamer and essence, adding a humectant, and stirring and mixing to obtain a mixture B;
(3) adding the mixture A into the mixture B obtained in the step (2), and stirring and mixing to obtain a mixture C;
(4) adding a foaming agent into the mixture C obtained in the step (3), and stirring and mixing to obtain a mixture D;
(5) adding a preservative into the mixture D obtained in the step (4), and stirring and mixing to obtain the children oral care composition.
Compared with the prior art, the invention has the beneficial effects that:
the children oral care composition provided by the invention contains plant extracts and sterilization gum-protecting functional ingredients, has natural and pure taste, has remarkable effects of sterilization, fire reduction, inflammation diminishing, pain relieving and bleeding stopping, is suitable for daily oral care, and can effectively clean oral cavity and firm teeth; the raw materials adopted by the invention achieve mutual supplement and mutual synergy, and play a role in preventing and treating dental ulcer, periodontitis, tooth sensitivity, gingival red swelling and bleeding and decayed teeth; the preparation method is simple and convenient, is easy to operate, is suitable for large-scale production, and has high economic benefit.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
In a first aspect, the present invention provides a children oral care composition, which comprises the following raw materials by weight: 2-10% of a humectant, 1-5% of a foaming agent, 0.05-2% of a sweetening agent, 0.1-7% of a metal salt, 0.01-5% of a cutin softener, 1-5% of sodium phytate, 1-5% of a licorice extract, 0.5-2% of an aloe barbadensis leaf extract, 1-3% of a panax japonicus extract, 3-8% of a white clove extract, 0.5-2% of a mint extract, 0.5-4% of a vitamin complex, 0.3-2% of a yeast polypeptide, 3-8% of a cationic surfactant, 0.5-3% of a preservative, 2-7% of poloxamer, 1-2% of an essence, and the balance of water. In one embodiment of the present invention, the humectant is 3.5 to 7% by weight of the children's oral care composition.
In one embodiment of the present invention, the humectant is selected from one or more of propylene glycol, sorbitol, glycerin.
Further, in this embodiment, the humectant includes propylene glycol and sorbitol, wherein the weight percentage of the propylene glycol in the children's oral care composition is 3-5%, and the weight percentage of the sorbitol in the children's oral care composition is 0.5-2%.
In one embodiment of the invention, the foaming agent is selected from one or more of disodium lauroyl glutamate, sodium lauroyl sarcosinate and sodium dodecyl sulfate.
Further, in this embodiment, the foaming agent is disodium lauroyl glutamate.
In the invention, the disodium lauroyl glutamate can resist bacteria, stop caries, improve the content of calcium and phosphorus in tooth enamel, change the acid-base property of the tooth enamel surface, enhance the acid-resistant capability of the tooth enamel surface, effectively prolong the shelf life of the oral care agent and prevent the generation of precipitates in the oral care agent.
In one embodiment of the invention, the sweetener is selected from one or more of xylitol, glycyrrhizin, aspartame, neotame, sodium cyclamate, aspartame, sucralose.
Further, in this embodiment, the sweetener comprises xylitol and glycyrrhizin, wherein the xylitol is present in the children's oral care composition in an amount of 0.05 to 0.5% by weight, and the glycyrrhizin is present in the children's oral care composition in an amount of 0.1 to 1% by weight.
In the invention, the xylitol and the glycyrrhizin are all pure natural sweeteners, have high sweetness, low heat energy, safety, no toxicity and stronger medical care efficacy, can avoid the defects that the sweeteners such as sucralose and the like induce diseases such as hypertension, diabetes and the like, and have the effects of resisting inflammation, resisting allergy, protecting the film structure and the like.
In one embodiment of the present invention, the metal salt is present in the children's oral care composition in an amount of 1.5 to 4% by weight.
In one embodiment of the present invention, the metal salt is selected from one or more of zinc salt, copper salt, stannous salt and potassium salt.
Further, in this embodiment, the metal salt includes a copper salt and a zinc salt, wherein the copper salt is 1-2% by weight of the children oral care composition; the weight percentage of the zinc salt in the children oral care composition is 0.5-2%.
Further, in this embodiment, the copper salt is selected from one or more of copper chlorophyll, copper fluoride, copper chloride, copper iodide, copper chlorofluoride, copper acetate, copper hexafluorozirconate, copper sulfate, copper lactate, and copper citrate.
Still further, in this embodiment, the copper salt is copper chlorophyll.
Further, in this embodiment, the zinc salt is selected from one or more of zinc glycinate, zinc fluoride, zinc chloride, zinc iodide, zinc chlorofluoride, zinc acetate, zinc hexafluorozirconate, zinc sulfate, zinc lactate, zinc tartrate, zinc gluconate, zinc citrate, and zinc malate.
Still further, in this embodiment, the zinc salt is zinc glycinate.
In one embodiment of the present invention, the keratolytic agent is allantoin.
Further, in this embodiment, the allantoin is present in the children's oral care composition in an amount ranging from 0.1% to 2% by weight.
In the invention, the allantoin is applied to the surface of the oral skin, so that the skin cutin is softened, the tissue healing is promoted, the sterilization effect of the antibacterial agent can be enhanced, and a certain itching relieving effect is achieved.
In the invention, the sodium phytate is an important pure natural green additive, and has the most remarkable characteristics of strong chelating action with metal ions, strong oxidation resistance and color protection; but also has good effect of dissolving complexing agent for color spots on the tooth surface or alkaline bacterial plaques deposited on the tooth surface, helps to remove the dental stains, and can achieve certain effect of cleaning the dental plaques without mechanical friction of a toothbrush in the using process of the care solution.
In an embodiment of the present invention, the licorice extract, aloe barbadensis leaf extract, panax japonicus extract, lilac alba extract, and mint extract are powders, extracts, or extracts.
The liquorice extract, the aloe barbadensis leaf extract, the panax japonicus extract, the white clove extract and the mint extract adopted by the invention are safe, efficient, purely natural and traditional Chinese medicine components without incompatibility; the invention creatively combines the four traditional Chinese medicine extracts together to realize synergistic effect, wherein the licorice extract contains glycyrrhizin, glycyrrhetinic acid and a plurality of flavonoid compounds, and has the effects of clearing away heat and toxic materials, relieving spasm and pain and harmonizing the drugs; the panax japonicus extract mainly contains saponin, rich amino acids, polysaccharide, a small amount of volatile oil and other components, and can activate oral mucosa protective factors, remove oral mucosa oxygen free radicals and lipid peroxides, and has effects of relieving swelling and pain and resisting ulcer; the Syringa oblata extract is rich in volatile oil, mainly contains eugenol and caryophyllene, and has anti-inflammatory, antibacterial and analgesic effects; the aloe leaf extract is rich in aloin A, wound hormone, polypeptide mannan (Ke-2) and the like, has the functions of diminishing inflammation, sterilizing, clearing heat, reducing swelling, softening skin and keeping cell activity, and has wound healing activity by combining curdlan and callus acid; the herba Menthae extract contains menthol, menthone, menthyl acetate, etc., and has effects of dispelling pathogenic wind, clearing heat, clearing throat, relieving inflammation, relieving pain, killing bacteria and relieving itching.
In one embodiment of the present invention, the vitamin complex is selected from vitamin A, vitamin E, vitamin C, vitamin H, folic acid, cyanocobalamin, vitamin B3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1One or more of (a).
In the present invention, the multivitamins have the effects of promoting collagen synthesis and preventing gingival bleeding.
In the invention, the yeast polypeptide is easy to disperse and dissolve in water, has strong thermal stability, can change the oral care composition and quality and flavor of children, and can also enhance functionality; the organic peptide in the yeast polypeptide mainly exists in a form of small molecular active polypeptide, so that the anaphylaxis of macromolecular protein is avoided, 8 amino acids necessary for a human body are contained, and the variety of the amino acids is complete; further contains folic acid and vitamin B3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1Mineral, nucleotide and other physiologically active matter, and the fat content is far lower than 1%.
In one embodiment of the invention, the cationic surfactant is selected from one or more of cetylpyridinium chloride, chlorhexidine, domiphen bromide.
Further, in this embodiment, the cationic surfactant comprises cetylpyridinium chloride, chlorhexidine, domiphen bromide, wherein the weight percentage of cetylpyridinium chloride in the children's oral care composition is 1-2%, the weight percentage of chlorhexidine in the children's oral care composition is 0.5-1.5%, and the weight percentage of domiphen bromide in the children's oral care composition is 1.5-4.5%.
In the present invention, the cetylpyridinium chloride acts as a bactericide, mainly against anaerobic bacteria.
In the invention, the chlorhexidine is named chlorhexidine, has a chemical name of chlorhexidine, has quite strong broad-spectrum antibacterial and bactericidal effects, and is a better bactericidal and disinfectant medicine; the oral cavity gargling liquid is positively charged, is adsorbed on plaque with negative charge and the surface of oral mucosa when the oral cavity gargling liquid is used for gargling, then adsorbed medicines are dispersed from the parts and gradually separated out to generate a continuous effect, the concentration of the medicine in saliva is reduced after 24 hours, the oral cavity gargling liquid is adsorbed on a permeation barrier of a bacterial cell serosa, so that cell contents leak out, and the oral cavity gargling liquid has a bacteriostatic effect at low concentration and a bactericidal effect at high concentration. Even in the presence of serum, blood, etc., is effective; but are not effective against spores, acid-fast bacilli, fungi, and viruses.
In the present invention, domiphen bromide is also known as domiphen bromide, chlorfenapyr; white or yellowish crystal, no odor or slight peculiar odor, slightly bitter taste and soap taste, has broad-spectrum bactericidal action, and its action is enhanced in alkalinity.
In one embodiment of the invention, the preservative is selected from one or more of sodium benzoate, parabens, and potassium sorbate.
Further, in this embodiment, the preservative is potassium sorbate.
In one embodiment of the invention, the poloxamer is selected from poloxamer 188, poloxamer 237, poloxamer 401 and poloxamer 407.
Poloxamers of the present invention are nonionic triblock copolymers comprised of a central hydrophobic chain of polyoxypropylene (poly (propylene oxide)) and two hydrophilic chains of polyoxyethylene (poly (ethylene oxide)) pendant thereto.
Further, in this embodiment, the poloxamer is poloxamer 407 (supplied by BASF as pluronic F127 or Croda as synperonic PE/F127), poloxamer 407 having increased water solubility and increased emulsifiability over other poloxamers.
In a second aspect, the present invention provides a method of making a children's oral care composition according to the first aspect, comprising the steps of:
(1) mixing sweetener, metal salt, cutin softener, sodium phytate, Glycyrrhrizae radix extract, folium Aloe Vera extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, compound vitamin, yeast polypeptide, and cationic surfactant, adding water, stirring and mixing to obtain mixture A;
(2) mixing poloxamer and essence, adding a humectant, and stirring and mixing to obtain a mixture B;
(3) adding the mixture A into the mixture B obtained in the step (2), and stirring and mixing to obtain a mixture C;
(4) adding a foaming agent into the mixture C obtained in the step (3), and stirring and mixing to obtain a mixture D;
(5) adding a preservative into the mixture D obtained in the step (4), and stirring and mixing to obtain the children oral care composition.
In the following examples and comparative examples, the licorice extract, aloe barbadensis leaf extract, panax japonicus extract, lilac alba extract, and peppermint extract were all extracts.
Example 1
The preparation method of the children oral care composition provided by the embodiment of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 3% of propylene glycol, 0.5% of sorbitol, 1% of disodium lauroyl glutamate, 0.5% of xylitol, 1% of glycyrrhizin, 2% of copper chlorophyll, 0.5% of zinc glycinate, 5% of allantoin, 5% of sodium phytate, 1% of licorice extract, 0.5% of aloe barbadensis leaf extract, 1% of panax japonicus extract, 3% of excrementum passeris extract, 0.5% of mint extract and 0.9% of vitamin complex (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.1 percent), the yeast polypeptide is 0.3 percent, the domiphen bromide is 1.5 percent, and the chlorhexidine is 1.5 percentPercentage, cetylpyridinium chloride 2%, disodium lauroyl glutamate 3%, poloxamer 4077%, essence 2% and water in balance;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407407 and essence, and stirring propylene glycol and sorbitol to obtain mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Example 2
The preparation method of the children oral care composition provided by the embodiment of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 5% of propylene glycol, 2% of sorbitol, 5% of disodium lauroyl glutamate, 0.05% of xylitol, 1% of glycyrrhizin, 1% of copper chlorophyll, 2% of zinc glycinate, 0.01% of allantoin, 1% of sodium phytate, 5% of licorice extract, 2% of aloe barbadensis leaf extract, 3% of panax japonicus extract, 8% of white clove extract, 2% of mint extract and 3.6% of compound vitamin (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.4 percent), the yeast polypeptide is 2 percent, the domiphen bromide is 4 percent, the chlorhexidine is 0.5 percent, the cetylpyridinium chloride is 1 percent, the disodium lauroyl glutamate is 0.5 percent, the poloxamer 4072 percent, the essence is 1 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407407 and essence, and stirring propylene glycol and sorbitol to obtain mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Example 3
The preparation method of the children oral care composition provided by the embodiment of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4% of propylene glycol, 1% of sorbitol, 3% of disodium lauroyl glutamate, 0.2% of xylitol, 0.8% of glycyrrhizin, 1.4% of copper chlorophyll, 1.6% of zinc glycinate, 2% of allantoin, 3% of sodium phytate, 2% of licorice extract, 1% of aloe barbadensis leaf extract, 2% of panax japonicus extract, 4% of excrementum passeris extract, 1.5% of mint extract and 1.8% of compound vitamin (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), 1 percent of yeast polypeptide, 2 percent of domiphen bromide, 1 percent of chlorhexidine, 1.4 percent of cetylpyridinium chloride, 2 percent of disodium lauroyl glutamate, 4074 percent of poloxamer, 1.5 percent of essence and the balance of water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407407 and essence, and stirring propylene glycol and sorbitol to obtain mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Example 4
The preparation method of the children oral care composition provided by the embodiment of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 3.5% of propylene glycol, 1.5% of sorbitol, 2.5% of disodium lauroyl glutamate, 0.4% of xylitol, 0.3% of glycyrrhizin, 1.6% of copper chlorophyllin, 1% of zinc glycinate, 2% of allantoin, 3% of sodium phytate, 3% of licorice extract, 1.5% of aloe barbadensis leaf extract, 2% of panax japonicus extract, 4% of lilac alba extract, 1% of mint extract and 1.8% of vitamin complex (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), the yeast polypeptide is 0.8 percent, the domiphen bromide is 3 percent, the chlorhexidine is 0.8 percent, the cetylpyridinium chloride is 1.6 percent, the disodium lauroyl glutamate is 2 percent, the poloxamer 4073 percent, the essence is 1.2 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407407 and essence, and stirring propylene glycol and sorbitol to obtain mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Example 5
The preparation method of the children oral care composition provided by the embodiment of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4% of propylene glycol, 1.5% of sorbitol, 4% of disodium lauroyl glutamate, 0.4% of xylitol, 0.5% of glycyrrhizin, 1.5% of copper chlorophyllin, 1.2% of zinc glycinate, 4% of allantoin, 2% of sodium phytate, 2% of licorice extract, 1.5% of aloe barbadensis leaf extract, 2.5% of panax japonicus extract, 6% of lilac alba extract, 1.5% of mint extract and 2.7% of compound vitamin (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.3 percent), the yeast polypeptide is 1.8 percent, the domiphen bromide is 2.5 percent, the chlorhexidine is 1.2 percent, the cetylpyridinium chloride is 1.8 percent, the disodium lauroyl glutamate is 2 percent, the poloxamer 4073 percent, the essence is 1 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407407 and essence, and stirring propylene glycol and sorbitol to obtain mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Example 6
The preparation method of the children oral care composition provided by the embodiment of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4.5% of propylene glycol, 1% of sorbitol, 3% of disodium lauroyl glutamate, 0.3% of xylitol, 0.5% of glycyrrhizin, 1.5% of copper chlorophyllin, 1.5% of zinc glycinate, 4% of allantoin, 2% of sodium phytate, 3% of licorice extract, 1.5% of aloe barbadensis leaf extract, 1.5% of panax japonicus extract, 4.5% of lilac alba extract, 0.75% of mint extract and 1.8% of compound vitamin (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), the yeast polypeptide is 1.2 percent, the domiphen bromide is 2.4 percent, the chlorhexidine is 0.8 percent, the cetylpyridinium chloride is 1.2 percent, the disodium lauroyl glutamate is 0.8 percent, the poloxamer 4073 percent, the essence is 1.2 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407 and essence, and stirring and mixing propylene glycol and sorbitol to obtain a mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Comparative example 1
The preparation method of the children oral care composition provided by the comparative example of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4.5% of propylene glycol, 1% of sorbitol and disodium lauroyl glutamate3%, xylitol 0.3%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, zinc glycinate 1.5%, allantoin 4%, sodium phytate 2%, Glycyrrhrizae radix extract 3%, Aloe barbadensis leaf extract 1.5%, rhizoma Panacis Japonici extract 1.5%, herba Menthae extract 0.75%, and vitamin complex 1.8% (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), the yeast polypeptide is 1.2 percent, the domiphen bromide is 2.4 percent, the chlorhexidine is 0.8 percent, the cetylpyridinium chloride is 1.2 percent, the potassium sorbate is 0.8 percent, the poloxamer 4073 percent, the essence is 1.2 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, folium Aloe Vera extract, rhizoma Panacis Japonici extract, herba Menthae extract, compound vitamins, yeast polypeptide, domiphen, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407 and essence, and stirring and mixing propylene glycol and sorbitol to obtain a mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Comparative example 2
The preparation method of the children oral care composition provided by the comparative example of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4.5% of propylene glycol, 1% of sorbitol, 3% of disodium lauroyl glutamate, 0.3% of xylitol, 0.5% of glycyrrhizin, 1.5% of copper chlorophyll, 1.5% of zinc glycinate, 4% of allantoin, 2% of sodium phytate, 3% of licorice extract, 4.5% of lilac alba extract, 0.75% of mint extract and 1.8% of compound vitamin (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), the yeast polypeptide is 1.2 percent, the domiphen bromide is 2.4 percent, the chlorhexidine is 0.8 percent, the cetylpyridinium chloride is 1.2 percent, the disodium lauroyl glutamate is 0.8 percent, the poloxamer 4073 percent, the essence is 1.2 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, flos Caryophylli extract, herba Menthae extract, compound vitamins, yeast polypeptide, domiphen, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407 and essence, and stirring and mixing propylene glycol and sorbitol to obtain a mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Comparative example 3
The preparation method of the children oral care composition provided by the comparative example of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4.5% of propylene glycol, 1% of sorbitol, 3% of disodium lauroyl glutamate, 0.3% of xylitol, 0.5% of glycyrrhizin, 1.5% of copper chlorophyllin, 1.5% of zinc glycinate, 4% of allantoin, 2% of sodium phytate, 1.5% of aloe barbadensis leaf extract, 4.5% of white clove extract, 0.75% of mint extract and 1.8% of vitamin complex (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), the yeast polypeptide is 1.2 percent, the domiphen bromide is 2.4 percent, the chlorhexidine is 0.8 percent, the cetylpyridinium chloride is 1.2 percent, the disodium lauroyl glutamate is 0.8 percent, the poloxamer 4073 percent, the essence is 1.2 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, aloe leaf extract, white clove extract, mint extract, multivitamin, yeast polypeptide, domiphen, chlorhexidine and cetylpyridinium chloride, adding distilled water of 45 ℃, and stirring to obtain a mixture A;
(3) mixing poloxamer 407 and essence, and stirring and mixing propylene glycol and sorbitol to obtain a mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Comparative example 4
The preparation method of the children oral care composition provided by the comparative example of the invention comprises the following steps:
(1) taking the following raw materials in percentage by weight: 4.5% of propylene glycol, 1% of sorbitol, 3% of disodium lauroyl glutamate, 0.3% of xylitol, 0.5% of glycyrrhizin, 1.5% of copper chlorophyllin, 1.5% of zinc glycinate, 4% of allantoin, 2% of sodium phytate, 3% of licorice extract, 1.5% of aloe barbadensis leaf extract, 1.5% of panax japonicus extract, 4.5% of lilac alba extract, 0.75% of mint extract and 1.8% of compound vitamin (vitamin C, vitamin H, folic acid, cyanocobalamine, vitamin B)3Pantothenic acid, vitamin B6Vitamin B2Vitamin B1The dosage of the composition is 0.2 percent), the yeast polypeptide is 1.2 percent, the lauroyl disodium glutamate is 0.8 percent, the poloxamer 4073 percent, the essence is 1.2 percent, and the balance is water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyll, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, folium Aloe Vera extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, compound vitamins, and yeast polypeptide, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407 and essence, and stirring and mixing propylene glycol and sorbitol to obtain a mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
Effect example 1
In order to further illustrate the beneficial effects of the invention, oral clinical tests are carried out on the children oral care compositions obtained in the embodiments 1-6 and the comparative examples 1-4, 100 patients with tooth sensitivity and oral ulcer are selected, wherein 50 men and 50 women are aged 20-60 years, and antibiotics are not taken in all cases in the near future; randomly dividing the mixture into ten groups, and respectively administering 200ml of corresponding gargle normal saline, 25g of the children oral care composition obtained in the invention examples 1-6 and the comparative examples 1-4; taking 10-15ml of normal saline each time, gargling for 2-3 minutes each time; twice a day: the product is used once after brushing teeth in the morning and evening, each time for 1min, and after use in 7 days, subjective symptoms are inquired, and the clinical test results are shown in Table 1.
TABLE 1 results of oral clinical tests on the oral care compositions for children obtained in examples 1 to 6 of the present invention and comparative examples 1 to 4
As can be seen from the results in table 1, the treatment effect of the children's oral care compositions obtained in examples 1 to 6 of the present invention is significantly better than that of the children's oral care compositions obtained in comparative examples 1 to 4, wherein the treatment effect of the children's oral care composition obtained in example 6 of the present invention is the best, and the children's oral care composition obtained in example 5 of the present invention is the next. The raw materials adopted in comparative examples 1 to 4 are only slightly different from the raw materials of examples 1 to 6 of the invention, but the treatment effects are far from each other, which shows that the proportion of the raw materials of the invention is not set randomly, but has synergistic effect, and the components have the best effect only when being matched, especially the matching of traditional Chinese medicine components (licorice extract, aloe barbadensis leaf extract, panax japonicus extract, lilac extract and mint extract) and cationic surfactants (domiphen, chlorhexidine and cetylpyridinium chloride).
In addition, stability tests show that the stability of the oral care composition for children is the best when the raw materials are in the weight percentage range of the invention of the embodiment 4-6.
Effect example 2
In order to further illustrate the beneficial effects of the invention, 100 children patients with oral problems such as dental caries, halitosis and ulcer in 9-12 years old are selected, the oral care compositions for children obtained in the embodiments 1-6 and the comparative examples 1-4 of the invention are used for 15 days and 2 times a day, and then the tested patients are tested, wherein the specific test steps are as follows:
saliva of 100 children patients who did not use the oral care compositions for children obtained in examples 1 to 6 and comparative examples 1 to 4 of the present invention and saliva of 15 days after using the oral care compositions for children obtained in examples 1 to 6 and comparative examples 1 to 4 were collected using sterile test tubes, and after the saliva samples were diluted with sterile PBS solutions, 0.2mL of the diluted saliva samples were applied to BHI agar plates, and after anaerobic culture at 37 ℃ for 72 hours, the BHI agar plates were eluted with 2mL of the sterile PBS solutions, and eluates were collected.
Blank control group: saliva obtained without using the oral care compositions for children obtained in examples 1 to 6 and comparative examples 1 to 4 of the present invention was diluted 10-fold with sterile PBS solution to 1X 10-6～5×10-6Obtaining bacterial suspension at mol/L, sucking 1mL of bacterial suspension, properly diluting, carrying out anaerobic culture at 37 ℃ for 72h, and then calculating the number of colonies.
Test groups: the eluates obtained by the above procedures were applied to the saliva of 15 days after the use of the children's oral care compositions obtained in examples 1 to 6 and comparative examples 1 to 4 of the present invention, respectively, and sterilized byPBS solution was diluted 10-fold to 1X 10-6～5×10- 6Obtaining bacterial suspension at mol/L, sucking 1mL of bacterial suspension, properly diluting, carrying out anaerobic culture at 37 ℃ for 72h, and then calculating the number of colonies.
The sterilization rate was calculated according to the following formula:
TABLE 2 statistical results of the bactericidal rates of the groups
| Grouping | Product(s) | Sterilizing rate (%) |
| Test group 1 | Children oral care composition obtained in example 1 | 88.78 |
| Test group 2 | EXAMPLE 2 oral Care compositions for Children obtained | 91.14 |
| Test group 3 | EXAMPLE 3 oral Care composition for Children obtained | 93.74 |
| Test group 4 | EXAMPLE 4 oral Care compositions for Children obtained | 96.48 |
| Test group 5 | EXAMPLE 5 oral Care composition for Children obtained | 98.24 |
| Test group 6 | EXAMPLE 6 oral Care compositions for Children obtained | 99.81 |
| Test group 7 | Children's oral care composition obtained in comparative example 1 | 54.21 |
| Test group 8 | Oral Care composition for Children obtained in comparative example 2 | 61.11 |
| Test group 9 | Oral Care composition for Children obtained in comparative example 3 | 52.37 |
| Test group 10 | Comparative example 4 oral Care composition for Children | 42.32 |
The above results show that the number of bacteria in saliva of children was significantly inhibited after 15 days using the children's oral care compositions of examples 1 to 6 of the present invention, wherein the children's oral care composition obtained in example 6 of the present invention had the best inhibitory effect on anaerobic bacteria in saliva, and the children's oral care compositions obtained in examples 4 to 5 of the present invention. The raw materials adopted in comparative examples 1 to 4 are only slightly different from the raw materials of examples 1 to 6 of the present invention, but the bactericidal effects are far from each other, which indicates that the mixture ratio of the raw materials of the present invention is not set at will, but has a synergistic effect, and the bactericidal effect is the best when the components are used in combination, especially the combination of the traditional Chinese medicine components (licorice extract, aloe barbadensis leaf extract, panax japonicus extract, lilac extract, mint extract) and the cationic surfactants (domiphen bromide, chlorhexidine, cetylpyridinium chloride). In conclusion, the children oral care composition provided by the embodiments 1 to 6 can effectively prevent dental caries, prevent and treat periodontitis and ulcer, clean oral cavity and strengthen teeth.
The embodiments of the present invention have been described in detail, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (1)
1. A method of preparing a children's oral care composition, comprising the steps of:
(1) taking the following raw materials in percentage by weight: 4.5% of propylene glycol, 1% of sorbitol, 3% of disodium lauroyl glutamate, 0.3% of xylitol, 0.5% of glycyrrhizin, 1.5% of copper chlorophyll, 1.5% of zinc glycinate, 4% of allantoin, 2% of sodium phytate, 3% of licorice extract, 1.5% of aloe barbadensis leaf extract, 1.5% of panax japonicus extract, 4.5% of lilac alba extract, 0.75% of mint extract, 0.2% of vitamin C, 0.2% of vitamin H, 0.2% of folic acid, 0.2% of cyanocobalamin, 30.2% of vitamin B, 0.2% of pantothenic acid, 60.2% of vitamin B, 20.2% of vitamin B, 10.2% of vitamin B, 1.2% of yeast polypeptide, 2.4% of domiphen, 0.8% of chlorhexidine, 1.2% of cetylpyridinium chloride, 0.8% of disodium lauroyl glutamate, 4073% of poloxamer, 1.2% of essence, and the balance water;
(2) mixing xylitol, glycyrrhizin, copper chlorophyllin, zinc glycinate, allantoin, sodium phytate, Glycyrrhrizae radix extract, Aloe Vera leaf extract, rhizoma Panacis Japonici extract, flos Caryophylli extract, herba Menthae extract, vitamin complex, yeast polypeptide, domiphen bromide, chlorhexidine, and cetylpyridinium chloride, adding 45 deg.C distilled water, stirring and mixing to obtain mixture A;
(3) mixing poloxamer 407 and essence, and stirring and mixing propylene glycol and sorbitol to obtain a mixture B;
(4) adding the mixture A into the mixture B, and stirring and mixing to obtain a mixture C;
(5) adding disodium lauroyl glutamate into the mixture C, and stirring and mixing to obtain a mixture D;
(6) adding potassium sorbate to mixture D, and mixing with stirring to obtain the children's oral care composition.
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