CN108355112A - 用于治疗胃溃疡的中药组合物及其制备方法和应用 - Google Patents
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Abstract
本发明涉及一种用于治疗胃溃疡的中药组合物及其制备方法和应用,所述组合物包括如下原料:乌贼骨、艾叶、三七、苍术、白芨、木瓜、茱萸、蒲公英、川牛膝、山药、黄连、石斛、甘草、枳壳、姜黄、桃仁、草蔻、甘松、柴胡、五灵脂、木香和白术。本发明的用于治疗胃溃疡的中药组合物,中药配伍严谨,各原料药相互影响,协同作用,具有温中健脾、活血散瘀、消肿止痛、舒肝和胃、祛风散寒、舒筋活络等多重疗效。还可以有效快速修复胃粘膜,对胃溃疡患者治疗效果显著。且安全可靠,无毒副作用,具有很好的商业前景。
Description
技术领域
本发明属于中药技术领域,具体涉及一种用于治疗胃溃疡的中药组合物及其制备方法和应用。
背景技术
胃溃疡是消化***常见疾病、多发病。病因复杂,多种因素所致。易复发,病程长,可并发出血、穿孔、幽门梗阻、恶变等并发症。主要表现为上腹痛、食欲不振、饭后胀满、恶心和呕吐、反酸、嗳气。随着现代社会经济发展的增速,人们竞争意识的增强,为了节约时间,造成现代人饮食失调,过度劳累、精神紧张、吸烟、酗酒等因素,使胃溃疡的发病率呈逐年上升趋势。目前治疗胃溃疡的药物种类繁多,例如克拉霉素、奥美拉唑、阿莫西林等西药,这些药物疗效好、见效快,但有些药物有一定的副作用,长期或大剂量服用对身体有一定的危害,而且难以起到根治的效果。
发明内容
本发明的一个目的在于提出一种用于治疗胃溃疡的中药组合物。
本发明的用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨20份~30份、艾叶20份~50份、三七10份~20份、苍术10份~20份、白芨10份~20份、木瓜25份~30份、茱萸20份~30份、蒲公英30份~40份、川牛膝10份~20份、山药15份~20份、黄连10份~20份、石斛20份~25份、甘草25份~30份、枳壳20份~30份、姜黄30份~40份、桃仁30份~40份、草蔻10份~20份、甘松10份~25份、柴胡25份~45份、五灵脂20份~30份、木香10份~30份和白术10份~20份。
本发明的用于治疗胃溃疡的中药组合物,中药配伍严谨,各原料药相互影响,协同作用,具有温中健脾、活血散瘀、消肿止痛、舒肝和胃、祛风散寒、舒筋活络等多重疗效。还可以有效快速修复胃粘膜,对胃溃疡患者治疗效果显著。且安全可靠,无毒副作用,具有很好的商业前景。
另外,本发明上述的用于治疗胃溃疡的中药组合物,还可以具有如下附加的技术特征:
作为本发明优选的实施方式,所述的用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨20份、艾叶50份、三七10份、苍术20份、白芨10份、木瓜30份、茱萸20份、蒲公英40份、川牛膝10份、山药20份、黄连10份、石斛25份、甘草25份、枳壳30份、姜黄30份、桃仁40份、草蔻10份、甘松25份、柴胡25份、五灵脂30份、木香10份和白术20份。
作为本发明优选的实施方式,所述的用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨30份、艾叶20份、三七20份、苍术10份、白芨20份、木瓜25份、茱萸30份、蒲公英30份、川牛膝20份、山药15份、黄连20份、石斛20份、甘草30份、枳壳20份、姜黄40份、桃仁30份、草蔻20份、甘松10份、柴胡45份、五灵脂20份、木香30份和白术10份。
作为本发明优选的实施方式,所述的用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨25份、艾叶35份、三七15份、苍术15份、白芨15份、木瓜27份、茱萸25份、蒲公英35份、川牛膝15份、山药17份、黄连15份、石斛23份、甘草27份、枳壳25份、姜黄35份、桃仁35份、草蔻15份、甘松17份、柴胡35份、五灵脂25份、木香20份和白术15份。
本发明的另一个目的在于提出所述的用于治疗胃溃疡的中药组合物的制备方法,包括如下步骤:将上述原料烘干,然后按照料液比为500g:1L加入水,然后加热至75℃~85℃,保温4h~8h,再将温度降低至常温,然后过滤并收集滤液,得到用于治疗胃溃疡的中药组合物。
进一步地,过滤时采用的滤膜的孔径为1μm~10μm。
进一步地,在烘干时,烘干温度为60℃~80℃,烘干时间为30min~60min。
本发明的再一个目的在于提出所述的方法在制备用于治疗胃溃疡的中药组合物中的应用。
本发明的附加方面和优点将在下面的描述中部分给出,部分将从下面的描述中变得明显,或通过本发明的实践了解到。
具体实施方式
下面详细描述本发明的实施例,所述实施例是示例性的,旨在用于解释本发明,而不能理解为对本发明的限制。
下述实施例中的实验方法,如无特殊说明,均为常规方法。
下述实施例中所用的试验材料,如无特殊说明,均为自常规试剂商店购买得到的。
下述实施例中所用的乌贼骨、艾叶、三七、苍术、白芨、木瓜、茱萸、蒲公英、川牛膝、山药、黄连、石斛、甘草、枳壳、姜黄、桃仁、草蔻、甘松、柴胡、五灵脂、木香和白术均符合中国药典(2015年版)一部正文各药材项下的有关规定。投料前,通过鉴定,各味药材实物与名称相符,质量符合标准。
实施例1
实施例1提出了一种用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨20份、艾叶50份、三七10份、苍术20份、白芨10份、木瓜30份、茱萸20份、蒲公英40份、川牛膝10份、山药20份、黄连10份、石斛25份、甘草25份、枳壳30份、姜黄30份、桃仁40份、草蔻10份、甘松25份、柴胡25份、五灵脂30份、木香10份和白术20份。
实施例1的用于治疗胃溃疡的中药组合物的制备方法,包括如下步骤:首先将所述原料混合后在60℃温度下烘干60min,然后按照料液比为500g:1L加入水,然后加热至75℃,保温8h,再将温度降低至常温,然后过滤并收集滤液,得到用于治疗胃溃疡的中药组合物。其中,过滤时采用的滤膜的孔径为1μm。
实施例2
实施例2提出了一种用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨30份、艾叶20份、三七20份、苍术10份、白芨20份、木瓜25份、茱萸30份、蒲公英30份、川牛膝20份、山药15份、黄连20份、石斛20份、甘草30份、枳壳20份、姜黄40份、桃仁30份、草蔻20份、甘松10份、柴胡45份、五灵脂20份、木香30份和白术10份。
实施例2的用于治疗胃溃疡的中药组合物的制备方法,包括如下步骤:首先将所述原料混合后在80℃温度下烘干30min,然后按照料液比为500g:1L加入水,然后加热至85℃,保温4h,再将温度降低至常温,然后过滤并收集滤液,得到用于治疗胃溃疡的中药组合物。其中,过滤时采用的滤膜的孔径为10μm。
实施例3
实施例3提出了一种用于治疗胃溃疡的中药组合物,包括如下重量份数的原料:乌贼骨25份、艾叶35份、三七15份、苍术15份、白芨15份、木瓜27份、茱萸25份、蒲公英35份、川牛膝15份、山药17份、黄连15份、石斛23份、甘草27份、枳壳25份、姜黄35份、桃仁35份、草蔻15份、甘松17份、柴胡35份、五灵脂25份、木香20份和白术15份。
实施例3的用于治疗胃溃疡的中药组合物的制备方法,包括如下步骤:首先将所述原料混合后在70℃温度下烘干45min,然后按照料液比为500g:1L加入水,然后加热至80℃,保温6h,再将温度降低至常温,然后过滤并收集滤液,得到用于治疗胃溃疡的中药组合物。其中,过滤时采用的滤膜的孔径为5μm。
毒性试验
选体重为18~22份、的小白鼠300只(雌雄各150只),分为3组,每组雌雄各25只,小白鼠背部去毛露出外表皮,去毛范围2cm×2cm,分别涂抹本发明实施例1至实施例3制备得到的中药组合物,给药剂量为0.5份,连续给药30天。给药期间及停药后1周时,观察白鼠生长状态和活动饮食,鉴定血液学、血液生化学、脏器组织结构以及尿常规等。结果发现所有小白鼠均健康生存,无任何毒副作用;解剖观察血象、肝功能、各脏器组织状态,与正常小白鼠比较无差异。实验证明,本发明提供的中药组合物无毒,用药安全可靠。
综上,本发明的用于治疗胃溃疡的中药组合物,中药配伍严谨,各原料药相互影响,协同作用,具有温中健脾、活血散瘀、消肿止痛、舒肝和胃、祛风散寒、舒筋活络等多重疗效。还可以有效快速修复胃粘膜,对胃溃疡患者治疗效果显著。且安全可靠,无毒副作用,具有很好的商业前景。
在本说明书的描述中,参考术语“一个实施例”、“一些实施例”、“示例”、“具体示例”、或“一些示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不必须针对的是相同的实施例或示例。而且,描述的具体特征、结构、材料或者特点可以在任一个或多个实施例或示例中以合适的方式结合。此外,在不相互矛盾的情况下,本领域的技术人员可以将本说明书中描述的不同实施例或示例以及不同实施例或示例的特征进行结合和组合。
尽管上面已经示出和描述了本发明的实施例,可以理解的是,上述实施例是示例性的,不能理解为对本发明的限制,本领域的普通技术人员在本发明的范围内可以对上述实施例进行变化、修改、替换和变型。
Claims (8)
1.一种用于治疗胃溃疡的中药组合物,其特征在于,包括如下重量份数的原料:乌贼骨20份~30份、艾叶20份~50份、三七10份~20份、苍术10份~20份、白芨10份~20份、木瓜25份~30份、茱萸20份~30份、蒲公英30份~40份、川牛膝10份~20份、山药15份~20份、黄连10份~20份、石斛20份~25份、甘草25份~30份、枳壳20份~30份、姜黄30份~40份、桃仁30份~40份、草蔻10份~20份、甘松10份~25份、柴胡25份~45份、五灵脂20份~30份、木香10份~30份和白术10份~20份。
2.根据权利要求1所述的用于治疗胃溃疡的中药组合物,其特征在于,包括如下重量份数的原料:乌贼骨20份、艾叶50份、三七10份、苍术20份、白芨10份、木瓜30份、茱萸20份、蒲公英40份、川牛膝10份、山药20份、黄连10份、石斛25份、甘草25份、枳壳30份、姜黄30份、桃仁40份、草蔻10份、甘松25份、柴胡25份、五灵脂30份、木香10份和白术20份。
3.根据权利要求1所述的用于治疗胃溃疡的中药组合物,其特征在于,包括如下重量份数的原料:乌贼骨30份、艾叶20份、三七20份、苍术10份、白芨20份、木瓜25份、茱萸30份、蒲公英30份、川牛膝20份、山药15份、黄连20份、石斛20份、甘草30份、枳壳20份、姜黄40份、桃仁30份、草蔻20份、甘松10份、柴胡45份、五灵脂20份、木香30份和白术10份。
4.根据权利要求1所述的用于治疗胃溃疡的中药组合物,其特征在于,包括如下重量份数的原料:乌贼骨25份、艾叶35份、三七15份、苍术15份、白芨15份、木瓜27份、茱萸25份、蒲公英35份、川牛膝15份、山药17份、黄连15份、石斛23份、甘草27份、枳壳25份、姜黄35份、桃仁35份、草蔻15份、甘松17份、柴胡35份、五灵脂25份、木香20份和白术15份。
5.制备权利要求1-4任一项所述的用于治疗胃溃疡的中药组合物的方法,其特征在于,包括如下步骤:将上述原料烘干,然后按照料液比为500g:1L加入水,然后加热至75℃~85℃,保温4h~8h,再将温度降低至常温,然后过滤并收集滤液,得到用于治疗胃溃疡的中药组合物。
6.根据权利要求5所述的用于治疗胃溃疡的中药组合物的制备方法,其特征在于,过滤时采用的滤膜的孔径为1μm~10μm。
7.根据权利要求5所述的用于治疗胃溃疡的中药组合物的制备方法,其特征在于,在烘干时,烘干温度为60℃~80℃,烘干时间为30min~60min。
8.权利要求5-7任一项所述的方法在制备用于治疗胃溃疡的中药组合物中的应用。
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CN104623518A (zh) * | 2013-11-11 | 2015-05-20 | 青岛食之礼中草药研究所 | 一种治疗胃溃疡的中药组合物 |
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CN1174717A (zh) * | 1996-08-23 | 1998-03-04 | 李建华 | 一种治疗胃病的中药 |
CN104623518A (zh) * | 2013-11-11 | 2015-05-20 | 青岛食之礼中草药研究所 | 一种治疗胃溃疡的中药组合物 |
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