CN106377716A - 一种治疗痢疾的中药组合物 - Google Patents
一种治疗痢疾的中药组合物 Download PDFInfo
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Abstract
本发明属于中药技术领域。本发明的目的是根据中医对痢疾的认识机理，提供一种治疗痢疾的中药组合物，其特征在于，该中药组合物是采用下列重量份配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲10‑30份、四季青5‑25份、无花果10‑30份、徐长卿5‑25份、鸡冠花5‑25份、草豆蔻5‑20份、椿皮5‑25份、黄珠子草5‑20份、肉豆蔻5‑25份、溪黄草5‑25份、紫金牛5‑25份、使君子5‑25份、五倍子5‑20份、马齿苋5‑25份、鸡屎藤5‑25份、木贼5‑25份、老鹳草10‑30份、槐花5‑25份、马鞭草5‑25份、甘草5‑15份。本发明的中药组合物配伍科学、组方精炼，具有健脾和胃、凉血止痢、消食化积、收敛止血、清热利湿、行气止痛的功效，对治疗痢疾具有良好的治疗效果，经统计，其有效率达94%。
Description
技术领域
本发明属于中药技术领域，具体涉及一种治疗痢疾的中药组合物。
背景技术
痢疾，古称肠辟、滞下，为急性肠道传染病之一。痢疾多发于夏秋季节，是因感受湿热病毒，积滞肠腑，脂膜血络受伤，以腹痛、腹泻，里急后重，大便呈赤白粘冻或脓血；相当于细菌性痢疾或肠阿米巴病。痢疾的一般表现为精神、食欲差，下痢拉稀或水样带血粪便，体温稍高，并且粪便中有粘液，恶臭；慢性痢疾者体形消瘦，发育不良，病程长。痢疾是世界上，尤其是发展中国家重要的传染病之一，全球每年的病例超过1.6 亿，并导致100 万患者死亡。目前，西医治疗痢疾常采用氟哌酸、庆大霉素、黄连素和复方新诺明，有一定的疗效，但同时也有一定的副作用；中医治疗痢疾常用芍药汤、骨芩汤或白头翁汤等，副作用小，但疗效不是十分理想。
发明内容
本发明的目的在于提供一种配制简便、成本低、疗效显著、对人体无毒副作用的治疗痢疾的中药组合物。
为了实现上述目的，本发明提供的技术方案：
一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量份配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲10-30份、四季青5-25份、无花果10-30份、徐长卿5-25份、鸡冠花5-25份、草豆蔻5-20份、椿皮5-25份、黄珠子草5-20份、肉豆蔻5-25份、溪黄草5-25份、紫金牛5-25份、使君子5-25份、五倍子5-20份、马齿苋5-25份、鸡屎藤5-25份、木贼5-25份、老鹳草10-30份、槐花5-25份、马鞭草5-25份、甘草5-15份。
本发明的优选技术方案是：一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量份配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲20份、四季青15份、无花果20份、徐长卿15份、鸡冠花15份、草豆蔻10份、椿皮15份、黄珠子草10份、肉豆蔻15份、溪黄草15份、紫金牛15份、使君子15份、五倍子10份、马齿苋15份、鸡屎藤15份、木贼15份、老鹳草20份、槐花15份、马鞭草15份、甘草10份。
祖国医学认为痢疾多由湿热之邪，内伤脾胃，致脾失健运，胃失消导，更挟积滞，酝酿肠道所致。所以，本发明以健脾和胃、凉血止痢、消食化积、收敛止血、清热利湿、行气止痛为治疗原则。本发明中药组合物中：神曲具有健脾和胃、消食调中的功效；四季青具有清热解毒、生肌敛疮、活血止血的功效；无花果具有清热生津、健脾开胃、解毒消肿的功效；徐长卿具有镇痛、止咳、利水消肿、活血解毒的功效；鸡冠花具有收涩止血、止带、止痢的功效；草豆蔻具有温中散寒、行气止痛、燥湿健脾的功效；椿皮具有清热燥湿、涩肠止泻、止血止带的功效；黄珠子草具有健脾消积、利尿通淋、清热解毒的功效；肉豆蔻具有温中涩肠、行气消食的功效；溪黄草具有清热利湿、凉血散瘀的功效；紫金牛具有止咳化痰、祛风解毒、活血止痛的功效；使君子具有健脾胃、除虚热、消积杀虫的功效；五倍子具有敛肺降火、涩肠止泻、敛汗止血、收湿敛疮的功效；马齿苋具有清热解毒、凉血止痢、除湿通淋的功效；鸡屎藤具有祛风除湿、消食化积、解毒消肿、活血止痛的功效；木贼具有疏风清热、凉血止血、明目退翳的功效；老鹳草具有祛风湿、通经络、止泻痢的功效；槐花具有凉血止血、清肝泻火的功效；马鞭草具有清热解毒、活血散瘀、利水消肿的功效；甘草具有补脾益气、清热解毒、祛痰止咳、调和诸药的功效。本发明精选药物组方，其药物组分经辩证配伍，在作用上相互佐助，共奏健脾和胃、凉血止痢、消食化积、收敛止血、清热利湿、行气止痛的功效，对痢疾的治疗达到标本兼治。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。本发明遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证和中药品不良反应（ADR）安全性评价，其疗效显著，安全可靠，药性平和，未出现毒副作用，有效率达94%，治愈率78%。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲20g、四季青15g、无花果20g、徐长卿15g、鸡冠花15g、草豆蔻10g、椿皮15g、黄珠子草10g、肉豆蔻15g、溪黄草15g、紫金牛15g、使君子15g、五倍子10g、马齿苋15g、鸡屎藤15g、木贼15g、老鹳草20g、槐花15g、马鞭草15g、甘草10g。
实施例2
一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲15g、四季青20g、无花果10g、徐长卿20g、鸡冠花5g、草豆蔻15g、椿皮10g、黄珠子草20g、肉豆蔻5g、溪黄草25g、紫金牛10g、使君子20g、五倍子5g、马齿苋25g、鸡屎藤10g、木贼20g、老鹳草15g、槐花25g、马鞭草5g、甘草12g。
实施例3
一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲25g、四季青5g、无花果30g、徐长卿10g、鸡冠花25g、草豆蔻5g、椿皮20g、黄珠子草12g、肉豆蔻25g、溪黄草5g、紫金牛20g、使君子10g、五倍子15g、马齿苋5g、鸡屎藤20g、木贼10g、老鹳草25g、槐花5g、马鞭草20g、甘草6g。
实施例4
一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲10g、四季青25g、无花果15g、徐长卿20g、鸡冠花10g、草豆蔻20g、椿皮5g、黄珠子草15g、肉豆蔻10g、溪黄草25g、紫金牛5g、使君子25g、五倍子12g、马齿苋30g、鸡屎藤5g、木贼25g、老鹳草10g、槐花20g、马鞭草10g、甘草15g。
上述中药组合物的服用方法：取上述重量配比的中药原料混合后，采用传统煎制中药的方式取其药汁400ml，一日一剂，分早、晚两次空腹温服。五天为一疗程。
本发明以实施例1所给出的一种治疗痢疾的中药组合物，做临床疗效总结如下：
一、一般性资料：本中药组合物应用于临床观察病例150例，男86例，女64例，年龄15～65岁。
二、诊断依据：
1、腹痛、里急后重，便次增多。大便常有脓血粘冻；
2、急性痢疾发病骤急，可伴有恶寒发热；慢性痢疾则反复发作，迁延不愈；
3、常见于夏秋季节，多有饮食不洁史；
4、急性菌痢，血白细胞总数及中性粒细胞增高；
5、大便常规检查、可见白细胞及红细胞并有巨噬细胞。大便培养有痢疾杆菌生长；
6、肠阿米巴病的新鲜大便可找到阿米巴滋养体或包囊。
7、必要时作X线钡剂造影及直肠、结肠镜检查，有助于鉴别诊断。
三、疗效标准：
1、治愈：症状消失，大便镜检正常，培养连续3次阴性；
2、有效：症状消失或减轻，大便镜检正常，培养致病菌转阴或未转阴；
3、无效：临床症状及大便镜检无改善。
四、治疗效果：该临床观察病例中，服药2-5个疗程，痊愈117例，随访未见复发；有效24例，无效9例。治疗期间对中药品临床引起各类型的过敏反应、疑为药物引起人体各***、器官、组织的功能和形态方面的异常、疑为药物引起癌症等致突变反应、药物的依赖性以及认为重要或有价值的其他不良反应进行了评价，即中药品不良反应（ADR）评价，未发生不良反应和毒副作用。
五、典型病例：
病例1：
张某，女，41 岁。患者自述：近期出现腹痛，里急后重，大便赤白脓血，每日数次到数十次，***灼热，并伴恶寒发热。诊见：舌红，苔黄腻，脉滑数。大便培养有痢疾杆菌生长。确诊为：痢疾。服用本发明中药组合物制备的药剂2个疗程，腹痛减轻，大便次数减少；继续服用2个疗程，症状消失，痊愈。
病例2 ：
姜某，男，52岁。腹痛剧烈，大便呈鲜紫脓血，气味腐臭，并伴有烦躁不安，面色苍白，四肢发冷等症状。诊见：舌质红绛，苔黄燥，脉滑数。大便常规检查、可见白细胞及红细胞并有巨噬细胞。确诊为：痢疾。服用本发明中药组合物制备的药剂2个疗程，腹痛得到缓解，便血减少，面色恢复正常，四肢发冷症状消失；继续服用3个疗程，所有症状完全消失，痊愈。
Claims (2)
1.一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量份配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲10-30份、四季青5-25份、无花果10-30份、徐长卿5-25份、鸡冠花5-25份、草豆蔻5-20份、椿皮5-25份、黄珠子草5-20份、肉豆蔻5-25份、溪黄草5-25份、紫金牛5-25份、使君子5-25份、五倍子5-20份、马齿苋5-25份、鸡屎藤5-25份、木贼5-25份、老鹳草10-30份、槐花5-25份、马鞭草5-25份、甘草5-15份。
2.根据权利要求1所述一种治疗痢疾的中药组合物，其特征在于：该中药组合物是采用下列重量份配比的中药原料采用传统煎制中药的方式取其药汁制成：神曲20份、四季青15份、无花果20份、徐长卿15份、鸡冠花15份、草豆蔻10份、椿皮15份、黄珠子草10份、肉豆蔻15份、溪黄草15份、紫金牛15份、使君子15份、五倍子10份、马齿苋15份、鸡屎藤15份、木贼15份、老鹳草20份、槐花15份、马鞭草15份、甘草10份。
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| CN107158366A (zh) * | 2017-05-16 | 2017-09-15 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | 一种适于7‑18岁人群服用的止泻药剂及其制备方法和药物配方 |
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| CN107158365A (zh) * | 2017-05-16 | 2017-09-15 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | 一种适于50‑70岁人群服用的止泻药剂及其制备方法和药物配方 |
| CN107158366A (zh) * | 2017-05-16 | 2017-09-15 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | 一种适于7‑18岁人群服用的止泻药剂及其制备方法和药物配方 |
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