CN108294975A - A kind of alligator oil maintenance composition and its application - Google Patents
A kind of alligator oil maintenance composition and its application Download PDFInfo
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- CN108294975A CN108294975A CN201810284581.4A CN201810284581A CN108294975A CN 108294975 A CN108294975 A CN 108294975A CN 201810284581 A CN201810284581 A CN 201810284581A CN 108294975 A CN108294975 A CN 108294975A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of alligator oil maintenance composition, which mainly includes the component of following parts by weight：1 10 parts of alligator oil, 10 0.0001 0.01 parts of hexapeptide.The alligator oil maintenance composition can stimulate skin bFGF to express, and accelerate cell division and proliferation, wound healing；The tiny wound healing of skin can be remarkably promoted in cosmetics, increase skin smoothness, reduce microgroove by being applied, and have good maintenance effect.
Description
Technical field
The present invention relates to cosmetic field, it is specifically related to a kind of alligator oil maintenance composition and its application.
Background technology
With the continuous improvement of people's living standards, requirement of the people to good life also constantly pursue it is multi-functional, high-grade
Change.According to the trend of current cosmetics " returning to the Nature ", it is desirable to few raw material manually synthesized, be mostly used animal, plant,
The cosmetics of the natural waste in the sources such as microorganism.Current daily use chemicals industry develops new product, taps new markets for this
Important topic.
Crocodile is the ecological value, scientific value and the high wild animal of economic value.Crocodile whole body is all precious, crocodile skin
High leather can be made, crocodile meat has very high nutritive value and healthcare function, other histoorgans of crocodile are also different
Medicines and health protection function and value of exploiting and utilizing.Therefore, some countries actively develop crocodile aquaculture in the world.2003, I
The State Administration of Forestry of state have approved 3 kinds of crocodiles such as Nile crocodile, esturaine crocodile and Siam crocodile be included in first batch of 54 kinds can commercial exploitation it is wild dynamic
Object.
Modern research shows that：Alligator oil contains up to 70% or more unsaturated fatty acid, and aliphatic acid composition has deep-sea fish
The characteristics of, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA is commonly called as docosapentaenoic acid) content are higher；Alligator oil has antifreeze
Wound antibacterial anti-inflammatory, promotes blood circulation, the function of relaxing muscles and tendons and dispelling fatigue.Further to develop the purposes of alligator oil, the present invention
Inventor carried out a large amount of experiment, a kind of alligator oil maintenance composition unlike the prior art has as a result been made.Practice
It proves, the alligator oil maintenance composition can stimulate skin bFGF to express, and accelerate cell division and proliferation, and the surface of a wound is promoted to be cured
It closes；The tiny wound healing of skin can be remarkably promoted in cosmetics, increase skin smoothness, reduce microgroove by being applied, and be had
Good maintenance effect, so as to complete the present invention.
Invention content
The technical problem to be solved in the present invention is to provide a kind of alligator oil maintenances for having and promoting the tiny wound healing of skin
Composition.The specific technical solution for solving above-mentioned technical problem is as follows：
In a first aspect, the present invention provides a kind of alligator oil maintenance composition, which includes following weight
The component of part：1-10 parts of alligator oil, -10 0.0001-0.01 parts of hexapeptide；Wherein the alligator oil source is Nile crocodile, esturaine crocodile
With Siam crocodile.
In wherein some embodiments, the alligator oil maintenance composition further includes the component of following parts by weight：Aloe
1-10 parts of extract, 0.1-1 parts of borneol.
Second aspect, the alligator oil maintenance composition referred to the present invention provides first aspect present invention is in skin care item
Using.
The third aspect, the present invention also provides a kind of alligator oil Weifu pastes, including following components：0.1-10% parts by weight
Alligator oil maintenance composition that first aspect present invention refers to, the saualane of 5-35% parts by weight, 0.1-1% parts by weight beeswax,
The more acyl group adipic acids of double-two glycerine of the polyethylene of 0.1-1% parts by weight, the tocopherol of 0.1-5% parts by weight, 1-5% parts by weight
The pentaerythrite four of ester -2, the candelila wax of 0.1-5% parts by weight, the octyl dodecanol of 1-30% parts by weight, 1-10% parts by weight
Isostearate, the rice chaff oil of 0.1-2% parts by weight and surplus are isononyl isononanoate.
The advantageous effect that technical solution provided in an embodiment of the present invention is brought is：The alligator oil maintenance composition can pierce
Swash skin bFGF expression, accelerates cell division and proliferation, wound healing；Skin can be remarkably promoted in cosmetics by being applied
The tiny wound healing of skin increases skin smoothness, reduces microgroove, has good maintenance effect.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description.
In a first aspect, an embodiment of the present invention provides a kind of alligator oil maintenance composition, the composition includes following weight
The component of part：1-10 parts of alligator oil, -10 0.0001-0.01 parts of hexapeptide.
Alligator oil maintenance composition provided in an embodiment of the present invention by using alligator oil and hexapeptide -10 coordinate multiple
Match so that the composition can give full play to the Skin care benefits of each component, can stimulate skin bFGF express, accelerate cell division and
Proliferation, wound healing；Applied can be remarkably promoted in cosmetics the tiny wound healing of skin, increase skin it is smooth
Degree reduces microgroove, has good maintenance effect.
Wherein, " alligator oil " described in the embodiment of the present invention refers to the predominantly fatty acid composition that extraction obtains from crocodile
Raw material.
Wherein, " hexapeptide -10 " described in the embodiment of the present invention is a kind of polypeptide, by promote Laminin-5 synthesis,
Promote keratinocyte and fibroblastic proliferation, so that skin is restored to and compact, rich in gloss and elastic state.
In wherein some embodiments, the alligator oil maintenance composition further includes the component of following parts by weight：Aloe
1-10 parts of extract, 0.1-1 parts of borneol.
Alligator oil maintenance composition provided in an embodiment of the present invention, by adding again on the basis of alligator oil and hexapeptide -10
Maintenance effect of alligator oil maintenance composition can be effectively improved by entering aloe extract, borneol.
Wherein, " aloe extract " described in the embodiment of the present invention is for Liliaceae perennial evergreen succulent plant Curacao
Aloe Aloe vera L、Aloe ferox MillerAloe ferox MillOr stripe aloe veraAloe vera L.var. chinensis（Haw.）BergerThe concentrated dry product of juice in leaf.Bitter, it is cold in nature, enter liver, the heart, the spleen channel.Function：Clearly
Heat, defaecation, desinsection.It cures mainly：Constipation with heat retention, women's Amenorrhea, pediatric epilepsy scared, the hot malnutrition due to parasitic infestation of infantile malnutrition due to digestive disturbances or intestinalparasites, tinea sore, hemorrhoid complicated by anal fistula, atrophic rhinitis, scrofula
Scrofula.
Wherein, " borneol " described in the embodiment of the present invention also known as piece brain, orange slices, L-Borneol, kapur, MEIHUA BINGPIAN, castrated ram's cloth
Luo Xiang, plum blossom brain, borneol brain, Mei Bing etc. are by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves through steam distillation
And it recrystallizes and obtains.Also useful turpentine oil is obtained through a series of chemical method techniques.It can be used for closing card coma, swells for hot eyes
Bitterly, larynx numbness aphtha, be used for sore swell and ache curative, burst after do not hold back.
Second aspect, the embodiment of the present invention provide application of the above-mentioned alligator oil maintenance composition in preparing skin care item.
Alligator oil maintenance composition of the present invention has the bFGF expression of stimulation skin, accelerates cell division and proliferation, promotes wound
Face Healing, the common matrix of addition skin care item or carrier, can be made into cream, lotion, ointment, facial mask, Cleansing Foam, gel,
The cosmetics such as aqua.
The third aspect, the present invention provides a kind of alligator oil Weifu pastes, including following components：The sheet of 0.1-10% parts by weight
Alligator oil maintenance composition that invention first aspect refers to, the saualane of 5-35% parts by weight, 0.1-1% parts by weight beeswax,
The more acyl group adipic acids of double-two glycerine of the polyethylene of 0.1-1% parts by weight, the tocopherol of 0.1-5% parts by weight, 1-5% parts by weight
Ester -2, the candelila wax of 0.1-5% parts by weight, the octyl dodecanol of 1-30% parts by weight, the pentaerythrite four of 1-10% parts by weight are different
Stearate, the rice chaff oil of 0.1-2% parts by weight and surplus are isononyl isononanoate.Preparation method is easier, can be with
By following technological operation：Each raw material is weighed according to formula；Heating stirs lower dissolving, lysate is made；Then lysate is poured into
In packaging, room temperature is cooled to get finished product.
In wherein some embodiments, the alligator oil Weifu paste includes following components：The present invention of 1-5% parts by weight
Alligator oil maintenance composition, the saualane of 10-20% parts by weight, the beeswax of 0.3-0.7% parts by weight, the 0.3- that first aspect refers to
The polyethylene of 0.7% parts by weight, the tocopherol of 1-3% parts by weight, 2-4% parts by weight double more acyl group adipate esters -2 of-two glycerine,
Four isostearic acid of pentaerythrite of the candelila wax of 1-3% parts by weight, the octyl dodecanol of 10-20% parts by weight, 3-7% parts by weight
Ester, the rice chaff oil of 0.5-1.5% parts by weight and surplus are isononyl isononanoate.
The present invention will be further described through by specific embodiment below.In following specific examples, involved behaviour
Condition person is not specified, carries out according to conventional conditions or manufacturer's recommended conditions.It is raw materials used be not specified production firm and
Specification person is can be with conventional products that are commercially available.
Embodiment 1
A kind of alligator oil Weifu paste, including following components：0.1 parts by weight alligator oil maintenance composition, 35 parts by weight saualane,
The beeswax of 0.1 parts by weight, the polyethylene of 1 parts by weight, the tocopherol of 0.1 parts by weight, 5 parts by weight double more acyl groups of-two glycerine oneself
Four isostearic acid of pentaerythrite of two acid esters -2, the candelila wax of 0.1 parts by weight, the octyl dodecanol of 30 parts by weight, 1 parts by weight
Rice chaff oil, the 11.7 parts by weight isononyl isononanoates of ester, 2 parts by weight；The wherein described alligator oil composition is by alligator oil and hexapeptide-
The weight ratio of 10 compositions, the alligator oil and hexapeptide -10 is 1：0.01.
Embodiment 2
A kind of alligator oil Weifu paste, including following components：10 parts by weight alligator oil maintenance compositions, the saualane of 5 parts by weight, 1
The more acyl group adipic acids of double-two glycerine of the beeswax of parts by weight, the polyethylene of 0.1 parts by weight, the tocopherol of 5 parts by weight, 1 parts by weight
Ester -2, the candelila wax of 5 parts by weight, the octyl dodecanol of 1 parts by weight, the pentaerythritol tetraoctyl stearate of 10 parts by weight, 0.1
The rice chaff oil of parts by weight, the isononyl isononanoate of 47.9 parts by weight；The wherein described alligator oil composition is by alligator oil and hexapeptide -10
The weight ratio of composition, the alligator oil and hexapeptide -10 is 10：0.0001.
Embodiment 3
A kind of alligator oil Weifu paste, including following components：1 parts by weight alligator oil maintenance composition, 20 parts by weight saualane,
The beeswax of 0.7 parts by weight, the polyethylene of 0.3 parts by weight, the tocopherol of 1 parts by weight, 4 parts by weight double more acyl groups of-two glycerine oneself
Four isostearic acid of pentaerythrite of two acid esters -2, the candelila wax of 1 parts by weight, the octyl dodecanol of 20 parts by weight, 3 parts by weight
Rice chaff oil, the 32.5 parts by weight isononyl isononanoates of ester, 1.5 parts by weight；The wherein described alligator oil composition is by alligator oil, six
Peptide -10, aloe extract and borneol composition, the alligator oil, hexapeptide -10, aloe extract and borneol weight ratio
It is 5：0.005:0.1:1.
Embodiment 4
A kind of alligator oil Weifu paste, including following components：5 parts by weight alligator oil maintenance compositions, 10 parts by weight saualane,
The beeswax of 0.3 parts by weight, the polyethylene of 0.7 parts by weight, the tocopherol of 3 parts by weight, 2 parts by weight double more acyl groups of-two glycerine oneself
Four isostearic acid of pentaerythrite of two acid esters -2, the candelila wax of 3 parts by weight, the octyl dodecanol of 10 parts by weight, 7 parts by weight
The isononyl isononanoate of ester, the rice chaff oil of 0.5 parts by weight, 43.5 parts by weight；The wherein described alligator oil composition is by alligator oil, six
Peptide -10, aloe extract and borneol composition, the alligator oil, hexapeptide -10, aloe extract and borneol weight ratio
It is 5：0.005:1:0.1.
Embodiment 5
Effect detection is carried out to alligator oil Weifu paste of the present invention, is with the alligator oil Weifu paste prepared by embodiment 1-4
Experimental group 1-4；Using a commercially available cosmetics for laying claim to maintenance effect as control group 1；In addition setting control group 2-6.
Specifically, the formula of control group 2-5 is：
Control group 2
A kind of alligator oil Weifu paste, including following components：The saualane of 35 parts by weight, the beeswax of 0.1 parts by weight, 1 parts by weight
The small candle tree of polyethylene, the tocopherol of 0.1 parts by weight, the more acyl group adipate esters -2 of double-two glycerine of 5 parts by weight, 0.1 parts by weight
Rice chaff oil, 11.7 weights of wax, the octyl dodecanol of 30 parts by weight, the pentaerythritol tetraoctyl stearate of 1 parts by weight, 2 parts by weight
Measure part isononyl isononanoate.
Control group 3
A kind of alligator oil Weifu paste, including following components：0.1 parts by weight alligator oil maintenance composition, 35 parts by weight saualane,
The beeswax of 0.1 parts by weight, the polyethylene of 1 parts by weight, the tocopherol of 0.1 parts by weight, 5 parts by weight double more acyl groups of-two glycerine oneself
Four isostearic acid of pentaerythrite of two acid esters -2, the candelila wax of 0.1 parts by weight, the octyl dodecanol of 30 parts by weight, 1 parts by weight
Rice chaff oil, the 11.7 parts by weight isononyl isononanoates of ester, 2 parts by weight；The wherein described alligator oil composition is by alligator oil.
Control group 4
A kind of alligator oil Weifu paste, including following components：A kind of alligator oil Weifu paste, including following components：0.1 parts by weight maintenance
Composition, the saualane of 35 parts by weight, the beeswax of 0.1 parts by weight, the polyethylene of 1 parts by weight, the tocopherol of 0.1 parts by weight, 5 weights
Measure the more acyl group adipate esters -2 of double-two glycerine, the candelila wax of 0.1 parts by weight, the octyl dodecanol of 30 parts by weight, 1 weight of part
Measure the pentaerythritol tetraoctyl stearate of part, rice chaff oil, the 11.7 parts by weight isononyl isononanoates of 2 parts by weight；It is wherein described to repair
Shield composition is made of hexapeptide -10.
Control group 5
A kind of alligator oil Weifu paste, including following components：5 parts by weight alligator oil maintenance compositions, 10 parts by weight saualane,
The beeswax of 0.3 parts by weight, the polyethylene of 0.7 parts by weight, the tocopherol of 3 parts by weight, 2 parts by weight double more acyl groups of-two glycerine oneself
Four isostearic acid of pentaerythrite of two acid esters -2, the candelila wax of 3 parts by weight, the octyl dodecanol of 10 parts by weight, 7 parts by weight
The isononyl isononanoate of ester, the rice chaff oil of 0.5 parts by weight, 43.5 parts by weight；The wherein described alligator oil composition is by alligator oil, six
The weight ratio of peptide -10 and aloe extract composition, the alligator oil, hexapeptide -10 and aloe extract is 5：0.005:
1。
Control group 6
A kind of alligator oil Weifu paste, including following components：5 parts by weight alligator oil maintenance compositions, 10 parts by weight saualane,
The beeswax of 0.3 parts by weight, the polyethylene of 0.7 parts by weight, the tocopherol of 3 parts by weight, 2 parts by weight double more acyl groups of-two glycerine oneself
Four isostearic acid of pentaerythrite of two acid esters -2, the candelila wax of 3 parts by weight, the octyl dodecanol of 10 parts by weight, 7 parts by weight
The isononyl isononanoate of ester, the rice chaff oil of 0.5 parts by weight, 43.5 parts by weight；The wherein described alligator oil composition is by alligator oil, six
The weight ratio of peptide -10 and borneol composition, the alligator oil, hexapeptide -10 and borneol is 5：0.005: 0.1.
Experiment 1：This experiment is according to " arnebia root oils promote rabbit wound repair and basic fibroblast growth factor to express "
Positive of Pei Xianwu, Wang Kun etc., Journal of Chinese Integrative Medicine, 2006 the 1st interim, the 52-55 pages, on January 15th, 2006）Method
Determine the fiducial value of experimental group 1-4, control group 1-6 wound repair different times Wound healing rates（It is shown in Table 1）, wound repair not
The expression value of same time bFGF（It is shown in Table 2）.
The fiducial value of 1 wound repair different times Wound healing rate of table
The expression value of 2 wound repair different times bFGF of table
By table 1 and 2 it is found that compared with the control group, the alligator oil Weifu paste Wound healing rate prepared by experimental group 1-4 and surface of a wound group
The expression for knitting bFGF is substantially higher；Experimental group 1 is compared with control group 2-4 it is found that alligator oil and hexapeptide -10 share timeliness
Fruit is just apparent；Experimental group 4 is compared with control group 5-6 it is found that Radix Arnebiae extract and borneol joint, which are added, can effectively promote crocodile
The effect of oily maintenance composition.
Originally the experimental results showed that, the alligator oil Weifu paste prepared by 1-4 of the embodiment of the present invention can stimulate bFGF to express, and make
Cell division and proliferation accelerate, to accelerate wound healing.
Experiment 2：Volunteer's test on probation
Test object：The female middle-aged at age 35-55 Sui.Each test group is 20.
Test method：Take 3-5 grams of painting of paste that the alligator oil Weifu paste prepared by experimental group 1-4, control group 1-6 are provided
Inner forearm and crows feet area are smeared, twice daily, is persistently used 4 weeks.
Test event：Skin smoothness, wrinkle depth（Crow's feet area）, skin shine.Wherein skin smoothness degree, wrinkle
It is effective that line depth and skin shine, which are all improved,；Skin smoothness degree, wrinkle depth and skin shine have one
It is effective to be improved；Other is invalid.
Specific test effect is shown in Table 3.
3 volunteer of table tests effect
As seen from Table 3, compared with the control group, the skin-care effect of the alligator oil Weifu paste prepared by experimental group 1-4 is relatively apparent；It is real
Group 1 is tested compared with control group 2-4 it is found that skin effect is just apparent when alligator oil and hexapeptide -10 share；Experimental group 4 and control group
5-6 compares it is found that the skin effect that can effectively promote alligator oil maintenance composition is added in Radix Arnebiae extract and borneol joint.
During product test of the present invention, toxic side effect is not found, does not find irritation.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (4)
1. a kind of alligator oil maintenance composition, which is characterized in that the alligator oil maintenance composition includes following parts by weight
Component：1-10 parts of alligator oil, -10 0.0001-0.01 parts of hexapeptide；Wherein the alligator oil source is Nile crocodile, esturaine crocodile and Xian
Sieve crocodile.
2. alligator oil maintenance composition according to claim 1, which is characterized in that the alligator oil maintenance composition is also
Include the component of following parts by weight：1-10 parts of aloe extract, 0.1-1 parts of borneol.
3. application of the alligator oil maintenance composition as claimed in claim 1 or 2 in skin care item.
4. a kind of alligator oil Weifu paste, which is characterized in that including following components：Claims 1 or 2 institute of 0.1-10% parts by weight
The alligator oil maintenance composition stated, the saualane of 5-35% parts by weight, the beeswax of 0.1-1% parts by weight, 0.1-1% parts by weight it is poly-
Ethylene, the tocopherol of 0.1-5% parts by weight, the more acyl group adipate esters -2 of double-two glycerine of 1-5% parts by weight, 0.1-5% parts by weight
Candelila wax, the octyl dodecanol of 1-30% parts by weight, the pentaerythritol tetraoctyl stearate of 1-10% parts by weight, 0.1-2%
The rice chaff oil and surplus of parts by weight are isononyl isononanoate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810284581.4A CN108294975A (en) | 2018-04-02 | 2018-04-02 | A kind of alligator oil maintenance composition and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810284581.4A CN108294975A (en) | 2018-04-02 | 2018-04-02 | A kind of alligator oil maintenance composition and its application |
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| Publication Number | Publication Date |
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| CN108294975A true CN108294975A (en) | 2018-07-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353710A (en) * | 2020-11-18 | 2021-02-12 | 崔永吉 | Alligator oil polypeptide essential oil and preparation process thereof |
-
2018
- 2018-04-02 CN CN201810284581.4A patent/CN108294975A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353710A (en) * | 2020-11-18 | 2021-02-12 | 崔永吉 | Alligator oil polypeptide essential oil and preparation process thereof |
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