CN108294025B - Bactericidal composition containing berberine and benzothiostrobin - Google Patents
Bactericidal composition containing berberine and benzothiostrobin Download PDFInfo
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- CN108294025B CN108294025B CN201810337248.5A CN201810337248A CN108294025B CN 108294025 B CN108294025 B CN 108294025B CN 201810337248 A CN201810337248 A CN 201810337248A CN 108294025 B CN108294025 B CN 108294025B
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- benzothiostrobin
- berberine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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Abstract
The invention provides a bactericidal composition containing berberine and benzothiostrobin, wherein the weight ratio of berberine to benzothiostrobin serving as effective active ingredients in the bactericidal composition is 1:20-20: 1.
Description
Technical Field
The invention belongs to the field of pesticides, and particularly relates to a bactericidal composition containing berberine and benzothiostrobin.
Background
Berberine is quaternary amine isoquinoline alkaloid, and mainly exists in Coptidis rhizoma of Ranunculaceae, cortex Phellodendri of Rutaceae, and radix Berberidis Amurensis of berberidaceae. The composition has good control effects on various diseases such as apple rot, ring spot, cucumber downy mildew, pumpkin powdery mildew, tomato gray mold, tea leaf cloud leaf blight, pepper phytophthora blight and the like; the results of indoor bioassay and field pesticide effect determination show that berberine has good control effects on tomato early blight, pepper anthracnose, tomato gray mold, cucumber powdery mildew and the like
The benzothiostrobin is a novel nicotinamide fungicide developed by Pasf company in Germany, has wide bactericidal spectrum and has protection and treatment effects. Belongs to succinate coenzyme Q reductase inhibitors in mitochondrial respiratory chain, is suitable for preventing and treating powdery mildew, gray mold, various rot diseases, brown rot diseases, root rot diseases and the like of rape, beans, vegetables, peanuts, potatoes, strawberries, cabbages, sunflowers, grapes, lawns, fruit trees and the like; the benzothiostrobin has no cross resistance with triazole fungicide.
Practical pesticide experience has shown that repeated and specific application of one active compound for controlling harmful fungi in many cases leads to a rapid selectivity of the fungal strains, and to reduce the risk of selectivity of resistant fungal strains, mixtures of different active compounds are currently commonly used for controlling harmful fungi. By combining active compounds with different action mechanisms, the resistance generation can be delayed, the application amount is reduced, and the control cost is reduced.
Disclosure of Invention
The invention aims to solve the problems of resistance and soil residue of the bactericide in practical application, screens out bactericides with different sterilization principles and compounds the bactericides to obtain a novel bactericide composition so as to improve the control effect of the bactericide, delay the generation of resistance, reduce the application amount and reduce the control cost.
The technical scheme provided by the invention is as follows:
a bactericidal composition containing berberine and benzothiostrobin is provided, wherein the weight ratio of berberine and benzothiostrobin as the effective active ingredients of the bactericidal composition is 1:20-20: 1.
The weight ratio of the berberine to the benzothiostrobin in the bactericidal composition containing the berberine and the benzothiostrobin is preferably 1-10: 10-1, and more preferably 1:5-5: 1.
The bactericidal composition containing berberine and benzothiostrobin of the invention has the effective active ingredient content accounting for 1-75% of the total weight.
The content of the effective active ingredients in the bactericidal composition containing the berberine and the benzothiostrobin accounts for 20 to 55 percent of the total weight, and the content is further optimized
The bactericidal composition containing the berberine and the benzothiostrobin can be combined with conventional agricultural auxiliary materials to be used to prepare an agriculturally usable preparation, and preferably, the bactericidal composition can be prepared into wettable powder, water dispersible granules, a suspending agent, an emulsion in water, a microemulsion and the like.
The auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent. The carrier is one, two or three of water, solvent or filler, and the water is preferably deionized water; the auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements, wherein the other functional auxiliary agents are selected from one or more of the antifreezing agent, the thickening agent, the stabilizing agent, the disintegrating agent and the defoaming agent.
The solvent is selected from one or more of vegetable oil, N-dimethylformamide, methanol, ethanol, ethylene glycol, propylene glycol, N-butanol, ethylene glycol butyl ether, acetone, cyclohexanone, N-methylpyrrolidone, toluene, xylene, ethyl acetate, dimethylacetamide, triethanolamine, acetonitrile, isopropylamine, methyl oleate and the like.
The filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate.
The surfactant is selected from one or more of an emulsifier, a dispersant, a wetting agent or a penetrant. The surfactant is a single agent or a compound preparation of a common nonionic surfactant or an anionic surfactant.
The emulsifier is selected from OP series phosphate (nonylphenol polyoxyethylene ether phosphate), 600# phosphate (phenylphenol polyoxyethylene ether phosphate), styrene polyoxyethylene ether ammonium sulfate, magnesium alkyldiphenyl ether disulfonate, triethanolamine salt, Nostoc 400# (benzyldimethylphenol polyoxyethylene ether), Nostoc 700# (alkylphenol formaldehyde resin polyoxyethylene ether), Ningru 36# (phenethylphenol formaldehyde resin polyoxyethylene ether), agricultural cream 1600# (phenethyl phenol polyoxyethylene polypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), agricultural cream 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether).
The dispersing agent is selected from one or a mixture of a plurality of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ether or glycerin fatty acid ester polyoxyethylene ether.
The wetting agent is selected from one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrant F, saponin powder, silkworm excrement or soapberry powder.
The penetrating agent is selected from one or a mixture of more of penetrating agent JFC (fatty alcohol-polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon.
The thickening agent is selected from one or a mixture of more of gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, xanthan gum, bentonite, silicon dioxide or magnesium aluminum silicate.
The antifreezing agent is a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea.
The defoaming agent is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds.
The disintegrating agent is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate.
The stabilizer is selected from one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate or triphenyl phosphate.
The bactericidal composition containing berberine and benzothiostrobin is used for preventing and treating crop diseases. Preferably used for preventing and treating diseases such as powdery mildew, downy mildew and the like.
Compared with the prior art, the invention has the following beneficial effects:
the composition has obvious synergistic effect when mixed; because the two single agents of the composition have great difference in chemical structure and completely different action mechanisms, the composition has no cross resistance and can delay the resistance problem caused by the single use of the two single agents; the composition of the invention is safe to crops and has good control effect. Experiments prove that the bactericide composition has stable chemical properties and obvious synergy, and shows obvious synergy and complementary action on a control object.
Detailed Description
The following detailed description of specific embodiments of the present invention is provided in conjunction with examples, but it should be understood that the scope of the present invention is not limited to the specific embodiments.
Test one: toxicity determination of berberine and benzothiostrobin compound on wheat powdery mildew
Test subjects: wheat powdery mildew. The test method comprises the following steps: the potting method is adopted. Wheat seedlings of three to four leaf stages with consistent growth vigor were selected, 3 pots of test wheat seedlings were selected for each treatment, and sprayed at 50PSI pressure using a Potter spray tower, approximately 5mL per pot. 5 concentration gradients were set for each agent. Inoculating the wheat powdery mildew disease leaves collected from the field 24h after the treatment of the medicament, uniformly shaking off conidia above the wheat seedlings for inoculation, and then putting the wheat seedlings into a greenhouse for cultivation. And 7d, surveying the disease index according to the incidence grading standard of the wheat powdery mildew, calculating the prevention and treatment effect, calculating the inhibition intermediate concentration EC50 by using a least square method, and calculating the cotoxicity coefficient (CTC) by using a Sun Yunpei method.
When CTC is less than or equal to 80, the composition shows antagonism, when CTC is less than or equal to 80, the composition shows additive action, when CTC is greater than or equal to 120, the composition shows synergistic action.
Measured virulence index (ATI) ═ standard agent EC 50/test agent EC50 x 100
Theoretical virulence index (TTI) ═ A agent virulence index x percent of A in the mixture + B agent virulence index x percent of B in the mixture
Co-toxicity coefficient (CTC) × 100 [ measured toxicity index (ATI) of the mixture)/Theoretical Toxicity Index (TTI) of the mixture ].
TABLE 1 toxicity test of berberine and benzothiostrobin combination on wheat powdery mildew
As can be seen from Table 1, the combination of berberine and benzothiostrobin has synergistic effect on wheat powdery mildew within the range of 1:20-20: 1; can effectively reduce the use amount of active ingredients.
Example 2: berberine and benzothiostrobin compound field control effect on grape downy mildew
Test subjects: downy mildew of grape
The test method comprises the following steps: each cell area was 66.7m2, repeated 3 times; the pesticide effect method for investigation before pesticide application and investigation after prevention and treatment comprises the following steps: randomly sampling 5 points in the test treatment area, grading the disease condition according to the relevant standards of the national field test, and calculating the control effect.
Test agent
Agent 1: 32% berberine benzothiostrobin water dispersible granule (berberine 16%, benzothiostrobin 16%, magnesium aluminum silicate 4%, calcium lignosulphonate 7%, bentonite 4%, urea 3%, light calcium carbonate to 100%)
Medicament 2: 30% berberine-benzothiostrobin suspension (berberine 20%, benzothiostrobin 10%, sodium tripolyphosphate 8%, xanthan gum 3.5%, glycerol 2%, silicone oil 2.5%, and water to 100%)
TABLE 2 field control of grape downy mildew with berberine and benzothiostrobin
As can be seen from Table 2, compared with the single use, the combination of berberine and benzothiostrobin can obviously improve the drug effect, reduce the dosage and the application times used per mu, reduce the burden of farmers, promote the yield and income increase of the farmers, better ensure the safe production of agriculture and protect the ecological environment.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (5)
1. A bactericidal composition containing berberine and benzothiostrobin is characterized in that the weight ratio of the berberine to the benzothiostrobin serving as effective active ingredients in the bactericidal composition is 1:10-10: 1.
2. The bactericidal composition containing berberine and benzothiostrobin according to claim 1, wherein the active ingredient content is between 1 and 75% of the total weight.
3. The bactericidal composition containing berberine and benzothiostrobin according to claim 2, wherein: wherein the content of effective active ingredients accounts for 20-55% of the total weight.
4. The bactericidal composition containing berberine and benzothiostrobin according to claim 2, wherein: the bactericide composition is prepared into wettable powder, water dispersible granules, suspending agents, aqueous emulsion and microemulsion.
5. The use of the bactericidal composition containing berberine and benzothiostrobin according to any one of claims 1-4 for controlling crop diseases.
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CN104396980A (en) * | 2014-10-24 | 2015-03-11 | 北京富力特农业科技有限责任公司 | Bactericide containing pyraclostrobin and application thereof |
CN105724399A (en) * | 2016-03-28 | 2016-07-06 | 天峨县平昌生态农业有限公司 | Sterilization composition containing berberine and azoxystrobin |
CN106962376A (en) * | 2017-04-14 | 2017-07-21 | 田德远 | A kind of bactericidal composition of containing trifloxystrobin and jamaicin |
CN107079915A (en) * | 2017-04-28 | 2017-08-22 | 佛山市瑞生通科技有限公司 | Composite bactericide and its application containing fluoxastrobin and jamaicin |
CN107136102A (en) * | 2017-06-29 | 2017-09-08 | 广西南宁黑泥巴农业科技有限公司 | A kind of bactericidal composition for preventing and treating bacterial leaf streak of rice |
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CN104396980A (en) * | 2014-10-24 | 2015-03-11 | 北京富力特农业科技有限责任公司 | Bactericide containing pyraclostrobin and application thereof |
CN105724399A (en) * | 2016-03-28 | 2016-07-06 | 天峨县平昌生态农业有限公司 | Sterilization composition containing berberine and azoxystrobin |
CN106962376A (en) * | 2017-04-14 | 2017-07-21 | 田德远 | A kind of bactericidal composition of containing trifloxystrobin and jamaicin |
CN107079915A (en) * | 2017-04-28 | 2017-08-22 | 佛山市瑞生通科技有限公司 | Composite bactericide and its application containing fluoxastrobin and jamaicin |
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