CN107691456B - Bactericidal composition containing fluoxastrobin and shenqinmycin - Google Patents
Bactericidal composition containing fluoxastrobin and shenqinmycin Download PDFInfo
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- CN107691456B CN107691456B CN201710853744.1A CN201710853744A CN107691456B CN 107691456 B CN107691456 B CN 107691456B CN 201710853744 A CN201710853744 A CN 201710853744A CN 107691456 B CN107691456 B CN 107691456B
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- shenqinmycin
- fluoxastrobin
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/88—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a bactericidal composition, which comprises active ingredients of fluoxastrobin and shenqinmycin in a weight ratio of 1:40-40:1, preferably 1:20-20: 1. The composition has obvious synergistic effect and can be used for preventing and treating sclerotinia rot of colza.
Description
Technical Field
The invention belongs to the field of agricultural chemistry, and particularly relates to a bactericidal composition containing fluoxastrobin and shenqinmycin.
Background
Sclerotinia rot of colza is a disease caused by a fungus of the family sclerotinia of the order ascomycetes, order mollicutes. The disease is a worldwide disease, mainly occurring in regions where the rape grows relatively cold and humid, but also occurring frequently in warm and dry climates, and the winter rape region in Asia is relatively severe. In main rape production areas of Jiangsu, Anhui, Shanghai, Zhejiang, Hunan, Hubei and Jiangxi and the like, sclerotinia rot of rape is particularly serious, the common incidence rate is 10% -30%, and can reach 80% when the incidence rate is serious, so that serious yield reduction can be caused, the oil content is sharply reduced, and the yield and the quality of the rape are seriously influenced. Although some medicaments are available for preventing the sclerotinia rot of colza, the long-term use of the medicaments causes the resistance of germs to the medicaments, so that the control effect is reduced, and the search for an economic and effective bactericide for the resistant sclerotinia rot of colza is urgent.
Fluoxastrobin, the english name, fluxastrobin, is a broad-spectrum systemic stem and leaf treatment bactericide developed by bayer crop science, has protection and treatment effects, can inhibit the respiration of fungus mitochondria, and is most effective in early fungal infection stages such as spore germination, germ tube growth and hyphal growth period. The fluoxastrobin has excellent systemic activity, can be quickly absorbed and can be uniformly transferred to the top of the leaf, so that the fluoxastrobin has good rain wash resistance.
The Shenqinmycin, the name of which is Shenqinmycin in English, is a novel microbial pesticide independently developed in China, is a microbial antibiotic secreted by pseudomonas fluorescens M18, and has the main effective component of phenazine-1-carboxylic acid. The antibiotic has strong inhibiting effect on various plant pathogenic bacteria.
Practice proves that the chemical pesticide single agent is easy to have resistance problem after long-term use, so that the dosage is continuously increased, the risk is increased, and the environmental ecological safety is not facilitated. Compounding the pesticide active ingredients with different structure types is an effective way for solving the problems of cost, resistance and the like in the application process of a single pesticide at present. The compound synergistic formula is good, can improve the actual prevention and treatment effect, reduces the using amount of pesticides, is beneficial to delaying the generation of resistance, and is an important means for scientifically preventing and treating plant diseases and insect pests. At present, no document report on the combined use of fluoxastrobin and shenqinmycin exists at home and abroad.
Disclosure of Invention
The invention provides a bactericidal composition containing fluoxastrobin and shenqinmycin, which overcomes the defects of large medicament dosage, serious environmental pollution, high pathogenic bacteria resistance generation speed and the like of a single bactericide.
The composition provided by the invention has obvious synergistic effect, can reduce the using amount of medicaments, reduce the cost and reduce the harm to the environment.
In order to solve the problems in the prior art, the invention provides the following technical scheme:
the active ingredients of the bactericidal composition comprise fluoxastrobin and shenqinmycin, and the weight ratio of the fluoxastrobin to the shenqinmycin is 1:40-40: 1. The preferable ratio is 1:20-20: 1; more preferably the ratio is 1:10-10: 1.
The bactericidal composition also comprises agriculturally acceptable auxiliaries, and the weight percentage of the active ingredients is 1-90%. Preferably, the weight percentage of the active ingredients is 10-70%; more preferably 35-65%.
In the bactericidal composition, the auxiliary agent comprises a dispersing agent, an emulsifying agent, a disintegrating agent, a stabilizing agent, an antifreezing agent, a defoaming agent, a film forming agent, a wetting agent, a synergist, a penetrating agent, a filler and a solvent.
The bactericidal composition can be prepared into an agriculturally acceptable proper preparation; the preferable preparation formulation is wettable powder, missible oil, water dispersible granules, suspending agent, granules, microemulsion or aqueous emulsion.
The bactericidal composition is used for preventing and treating crop diseases. Is especially suitable for preventing and treating diseases of crops such as fruit trees, wheat, rice, vegetables, rape and the like, such as sclerotinia rot of colza, wheat powdery mildew, powdery mildew of cucumber, gray mold of strawberry, black spot of cabbage, early blight of tomato, alternaria leaf spot of apple, pear scab, white rot of grape, rice blast and the like.
Compared with the prior art, the invention has the following beneficial effects:
the bactericidal composition has obvious synergistic effect after being mixed, improves the control effect, enlarges the control spectrum and is beneficial to overcoming and delaying the generation of drug resistance of pathogenic bacteria. The composition of the invention is mixed with pesticide to reduce the dosage, thereby reducing the cost and lightening the pollution to the environment, having good safety and meeting the safety requirement of pesticide preparations.
Detailed Description
The following detailed description of specific embodiments of the present invention is provided in conjunction with examples, but it should be understood that the scope of the present invention is not limited to the specific embodiments.
Example 1: 48% fluoxastrobin-shenqinmycin water dispersible granule
24% of fluoxastrobin, 24% of shenqinmycin, 8.5% of calcium lignosulphonate, 4.5% of polycarboxylate, 2% of nekal, 1% of sodium alginate and the balance of bentonite to 100%. The active ingredients, the auxiliary agents and the fillers are uniformly mixed according to the proportion of the formula, and are crushed into powder through airflow, a certain amount of water is added for mixing and extruding the powder to form materials, and the materials are dried and screened to obtain the composite material.
Example 2: 30% fluoxastrobin-shenqinmycin suspension
25% of fluoxastrobin, 5% of shenqinmycin, 7% of sodium methyl naphthalene sulfonate formaldehyde condensate, 13% of lignosulfonate, 4% of xanthan gum, 2% of organosilicon, 10% of glycerol and the balance of water to make up to 100%. The raw medicine, the wetting dispersant, the thickening agent, the carrier, the water and the like are uniformly mixed according to the proportion of the formula and are ground or sheared at a high speed to obtain the compound.
Example 3: 40% fluoxastrobin-shenqinmycin wettable powder
10% of fluoxastrobin, 30% of shenqinmycin, 6% of nekal, 14% of sodium dodecyl sulfate, 6% of white carbon black and the balance of attapulgite to 100%. The active ingredients, the dispersing agent, the wetting agent, the carrier and the like are uniformly mixed according to the proportion of the formula, and the mixture is obtained after air flow crushing.
Example 4: 30% fluoxastrobin-shenqinmycin emulsion in water
29% of fluoxastrobin, 1% of shenqinmycin, 8% of N-methyl pyrrolidone, 6% of sodium dodecyl benzene sulfonate, 600# 10% of agricultural emulsion and water for supplementing to 100%; adding the raw medicine, the solvent and the emulsifier together to dissolve the raw medicine, the solvent and the emulsifier into a uniform oil phase; mixing the water-soluble component with water to obtain a water phase; mixing the oil phase and the water phase under high-speed stirring.
Bioassay example 1: indoor toxicity determination of fluoxastrobin and shenqinmycin on sclerotinia rot of colza
Test subjects: the test sclerotinia sclerotiorum is obtained by separating and purifying the pathogenic rape plants in the field. The test method comprises the following steps: hypha growth rate method. Preparing a series of drug solutions to be tested, uniformly mixing 1mL of the solution and 9mL of the heated and melted PSA culture medium, pouring the mixture into a culture dish with the diameter of 7.5cm, and preparing a flat plate; an equal amount of sterile water was used as a control. Then, attaching the sclerotinia sclerotiorum slices to the sclerotinia sclerotiorum, culturing the sclerotinia sclerotiorum slices in an incubator at 25 ℃ for 5 days, measuring the diameter of a bacterial colony, comparing the inhibition degrees of different concentrations on the sclerotinia sclerotiorum hyphae, calculating the inhibition rate of the drug to be measured on the growth of the hyphae, and calculating EC50 by taking the logarithm of the concentration as an independent variable and the inhibition percentage as a dependent variable. Calculating the virulence index and the cotoxicity coefficient (CTC) of the medicament according to the Sun Yunpei method.
When the CTC is less than or equal to 80, the composition shows antagonism, when the CTC is more than 80 and less than 120, the composition shows additive action, and when the CTC is more than or equal to 120, the composition shows synergistic action.
Measured virulence index (ATI) ═ standard agent EC 50/test agent EC50 x 100
Theoretical virulence index (TTI) ═ A agent virulence index x percent of A in the mixture + B agent virulence index x percent of B in the mixture
Co-toxicity coefficient (CTC) ═ measured toxicity index (ATI) of the mixture/Theoretical Toxicity Index (TTI) of the mixture x 100
The results of the virulence determination are shown in table 1 below.
TABLE 1 indoor virulence test results for fluoxastrobin and shenqinmycin against sclerotinia rot of colza
As shown in Table 1, the weight ratio of fluoxastrobin to shenqinmycin in the bactericidal composition is in the range of 1:40-40:1, and the cotoxicity coefficients are both greater than 120, namely the composition has obvious synergistic effect on sclerotinia rot of colza.
Bioassay example 2: field control effect of fluoxastrobin and shenqinmycin on sclerotinia rot of colza
The test method comprises the following steps: referring to table 2, the test agents and the dosages are compared with clear water as a blank; spraying for 2 times at full bloom stage and final full bloom stage of rape, and the area of the field plot is 30m 2. The experiment was repeated 3 times. When the rape is harvested, the disease index of the sclerotinia rot of the rape is investigated according to the disease grading standard of the sclerotinia rot of the rape, and the prevention effect is calculated. The test results are shown in the following table
TABLE 2 results of the field control of Sclerotinia sclerotiorum by fluoxastrobin and shenqinmycin
The above description is only a preferred embodiment of the present invention, and it is obvious to those skilled in the art that modifications may be made without departing from the scope of the present invention, and such modifications are also within the scope of the present invention.
Claims (5)
1. The application of the bactericidal composition for preventing and treating crop diseases is characterized in that active ingredients in the bactericidal composition comprise fluoxastrobin and shenqinmycin, and the weight ratio of the fluoxastrobin to the shenqinmycin is 1:5-1: 1; the disease is sclerotinia rot of colza.
2. The use according to claim 1, wherein the fungicidal composition further comprises agriculturally acceptable adjuvants, the active ingredients being present in an amount of 1 to 90% by weight.
3. Use according to claim 2, characterized in that the active ingredient is present in a percentage by weight of 10 to 70%.
4. Use according to claim 2, characterized in that the auxiliaries comprise dispersants, emulsifiers, disintegrants, stabilizers, antifreezes, antifoams, film formers, wetting agents, synergists, penetrants, fillers or solvents.
5. Use according to claim 4, characterized in that: the dosage form prepared by the composition is wettable powder, missible oil, water dispersible granules, suspending agents, granules, microemulsion or aqueous emulsion.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710853744.1A CN107691456B (en) | 2017-09-15 | 2017-09-15 | Bactericidal composition containing fluoxastrobin and shenqinmycin |
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| CN201710853744.1A CN107691456B (en) | 2017-09-15 | 2017-09-15 | Bactericidal composition containing fluoxastrobin and shenqinmycin |
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| CN107691456A CN107691456A (en) | 2018-02-16 |
| CN107691456B true CN107691456B (en) | 2020-10-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108378069A (en) * | 2018-05-09 | 2018-08-10 | 惠州市梦芭迪工业产品设计中心(普通合伙) | A kind of bactericidal composition |
Citations (4)
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|---|---|---|---|---|
| CN103155925A (en) * | 2011-12-18 | 2013-06-19 | 深圳诺普信农化股份有限公司 | Sterilization composite containing phenazino-1-carboxylic acid |
| CN103238608A (en) * | 2012-02-08 | 2013-08-14 | 陕西美邦农药有限公司 | Sterilization composition containing fluoxastrobin and antibiotics |
| CN103271050A (en) * | 2013-06-19 | 2013-09-04 | 北京燕化永乐农药有限公司 | Compound bactericide |
| CN105557725A (en) * | 2015-12-18 | 2016-05-11 | 广东中迅农科股份有限公司 | Sterilizing composition containing Zhongshengmycin and fluoxastrobin |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103155925A (en) * | 2011-12-18 | 2013-06-19 | 深圳诺普信农化股份有限公司 | Sterilization composite containing phenazino-1-carboxylic acid |
| CN103238608A (en) * | 2012-02-08 | 2013-08-14 | 陕西美邦农药有限公司 | Sterilization composition containing fluoxastrobin and antibiotics |
| CN103271050A (en) * | 2013-06-19 | 2013-09-04 | 北京燕化永乐农药有限公司 | Compound bactericide |
| CN105557725A (en) * | 2015-12-18 | 2016-05-11 | 广东中迅农科股份有限公司 | Sterilizing composition containing Zhongshengmycin and fluoxastrobin |
Non-Patent Citations (3)
| Title |
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| 柏亚罗.氟嘧菌酯专利已于 1 月份到期国内企业纷纷启动产品登记工作.《农药市场信息》.2017,(第8期),第32-33页. * |
| 氟嘧菌酯专利已于 1 月份到期国内企业纷纷启动产品登记工作;柏亚罗;《农药市场信息》;20170401(第8期);第32-33页 * |
| 申嗪霉素对油菜菌核病菌生物学活性的初步研究;郑文君等;《农药学学报》;20110215;第13卷(第1期);第28-32页 * |
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Inventor after: Wang Changqing Inventor after: Xia Mingming Inventor after: Huang Sheng Inventor after: Zhang Songying Inventor before: Xia Mingming Inventor before: Huang Sheng Inventor before: Zhang Songying |
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Effective date of registration: 20200903 Address after: 712100 Luli Incubation Park, east section of Wuhu Road, Yangling Demonstration Zone, Xianyang City, Shaanxi Province Applicant after: Shaanxi Dacheng crop protection Co.,Ltd. Address before: 230036 G-5, No. 1, No. 888, Xiang Yuan City, No. 888, West Road, Wangjiang Road, Anhui high tech Zone, 3204 Applicant before: ANHUI GUERTE TECHNOLOGY Co.,Ltd. |
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