CN1082916A - The method to modify taste of Chinese herb rhubarb - Google Patents
The method to modify taste of Chinese herb rhubarb Download PDFInfo
- Publication number
- CN1082916A CN1082916A CN 93106959 CN93106959A CN1082916A CN 1082916 A CN1082916 A CN 1082916A CN 93106959 CN93106959 CN 93106959 CN 93106959 A CN93106959 A CN 93106959A CN 1082916 A CN1082916 A CN 1082916A
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- medicine
- radix
- rhizoma rhei
- taste
- bitterness
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Abstract
The method to modify taste of Chinese herb rhubarb is the research that belongs to the Chinese herbal medicine clathrate, has the Chinese patent medicine taste of this flavor medicine of Radix Et Rhizoma Rhei bitter especially in the patent medicine, in order to solve the bitterness problem, utilizes novel enclose material beta-schardinger dextrin-, and Radix Et Rhizoma Rhei is carried out enclose.Reduce the zest of medicine so widely, covered the bitterness of medicine, increased stability of drug, increased curative effect; Be convenient to take; Increase dissolubility etc.
Description
The present invention is the research that belongs to the Chinese herbal medicine clathrate.
Well-known Radix Et Rhizoma Rhei is root and the rhizome of Polygonaceae herbaceos perennial sorrel Rheum palmatum L Rheum tanguticum R tanguticum Maxim exReg or Rheum officinale Rofficinale Baill, sorrel and Rheum tanguticum medical material claim Beijing University's Huang, main product is in Qinghai, Gansu and other places, the Rheum officinale medical material claims RADIX ET RHIZOMA RHEI OFFICILALIS, and main product is in Sichuan.
Meridian distribution of property and flavor: bitter, cold.Return spleen, stomach, large intestine, liver, heart channel.
Effect: heat and toxic materials clearing away, clearing away heat-fire, detoxifcation, blood circulation promoting and blood stasis dispelling.
Up to the present, the Chinese patent medicine of this flavor medicine of Radix Et Rhizoma Rhei is arranged in the patent medicine, taste is all bitter especially.And yet there are no flavoring report both at home and abroad to the Radix Et Rhizoma Rhei bitterness.
The present invention is the clathration of utilization-cyclodextrin, corrects the bitterness of Radix Et Rhizoma Rhei, makes it to reach the purpose of covering the Radix Et Rhizoma Rhei bitterness.
Cyclodextrin cyclodextrin(is called for short CD) be present noticeable a kind of food and medicinal novel enclose material.It is a kind of product that is obtained after enzymolysis, cyclization by starch, by the glucose more than six with α-1, the banded cyclic oligomer sugar compounds of 4 glycoside bonds, white crystalline powder for water solublity, irreducibility, wherein modal is alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin is respectively 6,7,8 glucose molecules and constitutes.-cyclodextrin is made up of 7 glucose monomers.Growing the stereochemical structure that has confirmed it that resonates with X-line diffraction and nuclear is ring dress hollow garden tubular, is hydrophobic region in the tube of garden, and different, the empty internal diameter of beta-schardinger dextrin-is 7-8 to the diameter in cavity with the cyclodextrin kind
,, form the feature of clathrate because this structure has it and holds in other shape and big or small lyophobic dust molecule that is fit to or the group embedding cavity.Cyclodextrin is conduct " host molecule " in clathrate; In its garden tube, other material molecule is got up as " enclosed molecule " enclose; Old friends are referred to as " divide ascus " visually also to be had and is called " ultra micro capsule ".Radix Et Rhizoma Rhei is as enclosed molecule, by beta-cyclodextrin inclusion compound.Because the framing structure of Radix Et Rhizoma Rhei molecule is the C-C bond distance of phenyl ring is 1.28
, and-internal diameter of cyclodextrin is 7-8
So Radix Et Rhizoma Rhei can be come in by enclose fully.After material is by cyclodextrin inclusion compound, increased stability of drug, reduced the zest of medicine, cover the bad flavor of smelling of medicine, increase the various physicochemical properties such as dissolubility of medicine.
Because this outstanding effect of cyclodextrin becomes it and has the enclose material that extensive use is worth, and causes multiple in the world industry, especially the very big attention of food and medicine industry.
Beta-schardinger dextrin-is guaranteeing on the basis without any side effects to its effective ingredient that original bitterness is disappeared, and its preparation is easy to take.
The present invention has reduced the zest of medicine widely, covers the bitterness of medicine, increases stability of drug; Increase curative effect; Be convenient to take; Increase dissolubility etc.
Production technology of the present invention is:
Rhubarb adds 70%-75% ethanol lixiviate 2 times, soaks 2hr at every turn, and quantity of solvent is 1; 4-8 doubly.Medicinal residues are outwelled, and merging filtrate closes solution enclose filtrate with beta-schardinger dextrin-is full, beta-schardinger dextrin-saturated solution=1: 1-4, stir mixed liquor.Concentrating under reduced pressure, temperature gets dry extract at 45-75 ℃, is used for the Chinese patent medicine raw material.
Claims (1)
- A kind of method to modify taste of novel Radix Et Rhizoma Rhei is characterized in that: utilize beta-schardinger dextrin-that Radix Et Rhizoma Rhei is wrapped platform.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93106959 CN1082916A (en) | 1993-06-18 | 1993-06-18 | The method to modify taste of Chinese herb rhubarb |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93106959 CN1082916A (en) | 1993-06-18 | 1993-06-18 | The method to modify taste of Chinese herb rhubarb |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1082916A true CN1082916A (en) | 1994-03-02 |
Family
ID=4986512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93106959 Pending CN1082916A (en) | 1993-06-18 | 1993-06-18 | The method to modify taste of Chinese herb rhubarb |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1082916A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353939C (en) * | 2006-01-05 | 2007-12-12 | 昆明积大制药有限公司 | Antidepressant composition containing citalopram and cyclodextrin |
| CN108721388A (en) * | 2017-04-20 | 2018-11-02 | 广州市上为医药科技有限公司 | A kind of preparation method for improving antiphlogistic bezoar buccal tablet mouthfeel and improving its curative effect |
| CN108719596A (en) * | 2018-04-19 | 2018-11-02 | 广州市正百饲料科技有限公司 | A kind of feed addictive, preparation method and the feed for piglet preventing suckling piglet diarrhea |
-
1993
- 1993-06-18 CN CN 93106959 patent/CN1082916A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353939C (en) * | 2006-01-05 | 2007-12-12 | 昆明积大制药有限公司 | Antidepressant composition containing citalopram and cyclodextrin |
| CN108721388A (en) * | 2017-04-20 | 2018-11-02 | 广州市上为医药科技有限公司 | A kind of preparation method for improving antiphlogistic bezoar buccal tablet mouthfeel and improving its curative effect |
| CN108719596A (en) * | 2018-04-19 | 2018-11-02 | 广州市正百饲料科技有限公司 | A kind of feed addictive, preparation method and the feed for piglet preventing suckling piglet diarrhea |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |