CN108283603A - A kind of preparation method of labour protection cold cream - Google Patents
A kind of preparation method of labour protection cold cream Download PDFInfo
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Abstract
The invention discloses a kind of preparation methods of labour protection cold cream, belong to cosmetic field.The present invention utilizes tetraethyl orthosilicate, 3 methacryloxypropyl trimethoxy silanes prepare support carrier monodisperse hybrid silica microballoon, then in one layer of molecularly imprinted polymer of its surface graft, carbon-carbon double bond is introduced in the synthesis process, solvent used only has water, a small amount of ethyl alcohol and ammonium hydroxide, it is dispersed in polymeric solution, initiator thermal initiation, most afterwards through Soxhlet extraction, methanol acetic acid elutes, remove template molecule, it is using allantoin as template molecule, selective identification, absorption, detach the active material in yam skin, achieve the purpose that the enrichment of active material, it is generated without noxious material during extraction, no solvent residue, skin surface is protected.The present invention solves exceeded for the middle mercury in current labour protection cold cream, lead, arsenic content, and majority is higher containing hormonal components, containing toxin, the problem of causing to stimulate and injure to skin.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of preparation method of labour protection cold cream.
Background technology
Cold cream, one of skin type cosmetic product.Cold cream is mostly used to protect skin and supplement skin nutrition.The change of weather
Change can cause sebaceous glands and sweat gland secretion abnormal, and the surface of skin will become coarse.Autumn and winter very cold, air are dry
Dry, sebum secretion significantly reduces, and skin is easy drying, furfur, dry and cracked and corrugation.Often work, skin friction, it is dry that skin loses profit
Dry and form chap, there are a large amount of dust and harmful substance can also damage skin in working environment.With people's living standard
It improves, the nursing of skin is also increasingly paid attention to.
Currently, cold cream various types available on the market, but be directed to and be engaged in the labour ring such as outdoor environment and workshop
Skin nursing products in terms of the labour protection of the severe working populations in border are seldom, these products only have single moisture retention crack prevention
Effect, and price and materials are cheap, mostly chemical agent synthesizes, and middle mercury, lead in cold cream, arsenic content are exceeded, is such as used as shield
Containing toxin, and the problem of causing to stimulate to skin and injuring is used for a long time, to human body in preservative sodium benzoate in skin product
It causes centainly to injure.Therefore, producing a kind of special cold cream of labour protection without irritation deleterious material has prodigious city
Field demand.
Invention content
The technical problems to be solved by the invention：It is exceeded for the middle mercury in current labour protection cold cream, lead, arsenic content, it is more
Number is higher containing hormonal components, containing toxin, the problem of causing to stimulate and injure to skin, provides a kind of system of labour protection cold cream
Preparation Method.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of preparation method of labour protection cold cream, which is characterized in that the preparation method includes the following steps：
（1）Take tetraethyl orthosilicate in mass ratio 1：1：20 are added 3- methacryloxypropyl trimethoxy silanes, ultrapure
Water mixes, and is stirred in 400 rpm, 25 ~ 30 DEG C, adds the ammonium hydroxide of tetraethyl orthosilicate quality 8 ~ 10%, be stirred,
Centrifugation, takes precipitation to be washed with distilled water, and is dried in vacuo, obtains dried object；
（2）Take allantoin, acrylamide in mass ratio 1：4：50 ~ 60 are added n,N-Dimethylformamide, are warming up to 30 ~ 40 DEG C and surpass
Sound, then be cooled to 0 ~ 3 DEG C and be stirred, obtains stirring mixture, take 100 ~ 120 parts of stirring mixtures, 2 ~ 4 parts of dried objects, 0.4 ~
0.8 part of ethylene glycol dimethacrylate, 4 ~ 7 parts of azo-bis-isobutyl cyanides, 18 ~ 20 parts of methanol, are passed through nitrogen protection, in 65 ~ 70
It DEG C is stirred, obtains mixture；
（3）Take mixture in mass ratio 10：3~4：1 ~ 2 addition methanol, acetic acid obtain extract, take in 80 ~ 90 DEG C of Soxhlet extractions
Yam skin in mass ratio 10：5：1 is added ultra-pure water, ethyl alcohol, and in 30 ~ 40 DEG C of ultrasounds, centrifugation takes supernatant rotary evaporation, takes rotation
Turn evaporant in mass ratio 1：10 addition n,N-Dimethylformamide are stirred, and are obtained sample solution, are taken extract in mass ratio 1：
10 are added methanol, must fill column liquid, take dress column liquid that polypropylene solid-phase extraction column is added, add sample solution and eluted, eluted, take
Elution liquid nitrogen blows concentration, obtains concentrate；
（4）According to the mass fraction, 5 ~ 10 parts of three esters of palmitic acid, 5 ~ 8 parts of Miglyol 812Ns, 3 ~ 5 parts of coenzyme are taken
Q10,8 ~ 12 portions of concentrates, are warming up to 70 ~ 75 DEG C and are stirred, obtain mixture A, according to the mass fraction, take 3 ~ 5 parts of octyl-decyls
Glucoside, 5 ~ 15 parts of Quaternary Ammonium Salt of Chitosan, 70 ~ 80 parts of deionized waters, are stirred in 75 ~ 80 DEG C, obtain mixture B, take mixed
Close object A in mass ratio 1：1 addition mixture B is stirred, and homogeneous is cooled to room temperature, and obtains cooling thing；
（5）According to the mass fraction, 15 ~ 18 parts of saualanes, 20 ~ 30 parts of mink oil, 4 ~ 6 parts of cetostearyl alcohols, 3 ~ 5 parts of vitamins are taken
E acetic acid esters is stirred in 70 ~ 75 DEG C, obtains cold cream oil phase matrix object, according to the mass fraction, take 50 ~ 60 parts of ultra-pure waters, 12 ~
15 parts of glycerine, 0.8 ~ 1.5 part of water-solubleazone, 6 ~ 9 parts of 1,3-BDOs, are stirred in 75 ~ 80 DEG C, obtain cold cream water phase base
Body object takes cold cream oil phase matrix object, cold cream water phase matrix object, cooling thing in mass ratio 1：4：3 mixing, are stirred in 45 ~ 50 DEG C
Mixing is mixed, labour protection cold cream is both obtained.
Compared with other methods, advantageous effects are the present invention：
（1）The present invention prepares support carrier first with tetraethyl orthosilicate, 3- methacryloxypropyl trimethoxy silanes
Monodisperse hybrid silica microballoon introduces carbon in the synthesis process then in one layer of molecularly imprinted polymer of its surface graft
Carbon double bond, solvent used only have water, a small amount of ethyl alcohol and ammonium hydroxide to be dispersed in polymeric solution, initiator thermal initiation, at single point
It dissipates hybrid silica microsphere surface and carries out polymerisation, form polymer layer, trace cavity and site are formed in surface aggregate layer,
Most afterwards through Soxhlet extraction, methanol acetic acid elution removes template molecule, using allantoin as template molecule, selective knowledge
Not, it adsorbs, the active material in separation yam skin, achievees the purpose that the enrichment of active material, without Toxic during extraction
Matter generates, and no solvent residue protects skin surface, and main active material is the final production of purine metabolism in yam skin
Object, tool protection skin, it is anti-inflammatory and except cutin the effect of, the wettability power and keratoprotein of skin keratinocytes cementin can be increased
The hydratability of molecule, makes keratin decompose, and cell division accelerates, and chrotoplast and tissue growth, labour protection crowd is promoted to exist for a long time
Open air works, skin friction, and skin, which loses profit drying, can form chap wound, and wound tissue is newborn to be accelerated, and wound accelerates
Healing, non-stimulated to wound surface, more mildly, can ease pain reparation, make skin or organized renewing true colours；
（2）The present invention is added Co-Q10 and carries out compounding as cold cream active ingredient, is used as high-efficiency antioxidant agent, has and protect
Skin cell activity is held, promotes cell newly at the effect of metabolism, by the way that three ester of palmitic acid, Caprylic Capric three is added
Ester, octyl-decyl glucoside by solid-state and liquid fat Hybrid Heating, then through crystallisation by cooling, form nano-lipid carrier, right
Active ingredient is embedded, can long-acting performance face cream obtain performance, skin surface formed one layer of fine and close film, reduce skin
Moisture distribute, to improve performance of keeping humidity, at the same play thickening, stabilization effect, be added Quaternary Ammonium Salt of Chitosan, by quiet
Electro ultrafiltration is surface modified cold cream active ingredient, nano-lipid carrier, and dispersal events process, can increase caused by being swollen
Add cold cream active ingredient in the concentration gradient of absorption site, consistency is big, so the solid sense of its appearance is preferable, when smearing
Provoking property, wire drawing sense and refer to that adhesive force is good, the absorbability after smearing enhances therewith, has been not added in preparation process of the present invention
Poison and irritation additive, cold cream lotion are stablized, long-acting can be preserved, and act on skin surface and absorb fast, formation long-effective protection.
Specific implementation mode
A kind of preparation method of labour protection cold cream, includes the following steps：
（1）Take tetraethyl orthosilicate in mass ratio 1：1：20 are added 3- methacryloxypropyl trimethoxy silanes, ultrapure
Water mixes, and is stirred 2 ~ 3 h in 400 rpm, 25 ~ 30 DEG C, the mass fraction for adding tetraethyl orthosilicate quality 8 ~ 10% is
28% ammonium hydroxide is stirred 1 ~ 2h, and centrifugation takes precipitation to be washed with distilled water, and is dried in vacuo, obtains dried object；
（2）Take allantoin, acrylamide in mass ratio 1：4：50 ~ 60 are added n,N-Dimethylformamide, are warming up to 30 ~ 40 DEG C and surpass
20 ~ 30min of sound, then be cooled to 0 ~ 3 DEG C and be stirred 10 ~ 12h, stirring mixture is obtained, 100 ~ 120 parts of stirring mixtures, 2 ~ 4 are taken
Part dried object, 0.4 ~ 0.8 part of ethylene glycol dimethacrylate, 4 ~ 7 parts of azo-bis-isobutyl cyanides, 18 ~ 20 parts of methanol, are passed through nitrogen
Protection, is stirred 18 ~ 24 h in 65 ~ 70 DEG C, obtains mixture；
（3）Take mixture in mass ratio 10：3~4：1 ~ 2 addition methanol, acetic acid must be extracted in 80 ~ 90 DEG C of 5 ~ 6h of Soxhlet extraction
Object takes yam skin in mass ratio 10：5：1 is added ultra-pure water, ethyl alcohol, and in 30 ~ 40 DEG C of 30 ~ 40min of ultrasound, centrifugation takes supernatant
Rotary evaporation takes rotary evaporation object in mass ratio 1：10 addition n,N-Dimethylformamide are stirred 30 ~ 40min, obtain loading
Liquid takes extract in mass ratio 1：10 are added methanol, must fill column liquid, take dress column liquid that polypropylene solid-phase extraction column is added, add
Sample solution is eluted, is eluted, and is taken elution liquid nitrogen to blow concentration, is obtained concentrate；
（4）According to the mass fraction, 5 ~ 10 parts of three esters of palmitic acid, 5 ~ 8 parts of Miglyol 812Ns, 3 ~ 5 parts of coenzyme are taken
Q10,8 ~ 12 portions of concentrates, are warming up to 70 ~ 75 DEG C and are stirred 2 ~ 3h, obtain mixture A, according to the mass fraction, take 3 ~ 5 parts of octyls
Decyl glucoside, 5 ~ 15 parts of Quaternary Ammonium Salt of Chitosan, 70 ~ 80 parts of deionized waters, are stirred 30 ~ 40min in 75 ~ 80 DEG C, obtain
Mixture B takes mixture A in mass ratio 1：1 addition mixture B is stirred 5 ~ 10min, then at 100MPa homogeneous, is cooled to
Room temperature obtains cooling thing；（5）According to the mass fraction, 15 ~ 18 parts of saualanes, 20 ~ 30 parts of mink oil, 4 ~ 6 parts of cetostearyl alcohols, 3 are taken
~ 5 parts of vitamin e acetates are stirred 20 ~ 30min in 70 ~ 75 DEG C, obtain cold cream oil phase matrix object, according to the mass fraction,
50 ~ 60 parts of ultra-pure waters, 12 ~ 15 parts of glycerine, 0.8 ~ 1.5 part of water-solubleazone, 6 ~ 9 parts of 1,3-BDOs are taken, in 75 ~ 80 DEG C of stirrings
1 ~ 2h is mixed, cold cream water phase matrix object is obtained, takes cold cream oil phase matrix object, cold cream water phase matrix object, cooling thing by quality
Than 1：4：3 mixing, 20 ~ 30min is stirred in 45 ~ 50 DEG C, both obtains labour protection cold cream.
Embodiment 1
（1）Take tetraethyl orthosilicate in mass ratio 1：1：20 are added 3- methacryloxypropyl trimethoxy silanes, ultrapure
Water mixes, and 2h is stirred in 400 rpm, 25 DEG C, adds the ammonia that the mass fraction of tetraethyl orthosilicate quality 8% is 28%
Water is stirred 1h, and centrifugation takes precipitation to be washed with distilled water, and is dried in vacuo, obtains dried object；
（2）Take allantoin, acrylamide in mass ratio 1：4：50 are added n,N-Dimethylformamide, are warming up to 30 DEG C of ultrasounds
20min, then be cooled to 0 DEG C and be stirred 10h, obtains stirring mixture, take 100 parts of stirring mixtures, 2 parts of dried objects, 0.4 part two
Methacrylic acid glycol ester, 4 parts of azo-bis-isobutyl cyanides, 18 parts of methanol, are passed through nitrogen protection, and 18 h are stirred in 65 DEG C,
Obtain mixture；
（3）Take mixture in mass ratio 10：3：1 addition methanol, acetic acid obtain extract, take yam skin in 80 DEG C of Soxhlet extraction 5h
In mass ratio 10：5：1 is added ultra-pure water, ethyl alcohol, and in 30 DEG C of ultrasound 30min, centrifugation takes supernatant rotary evaporation, and rotation is taken to steam
Send out object in mass ratio 1：10 addition n,N-Dimethylformamide are stirred 30min, obtain sample solution, take extract in mass ratio 1：
10 are added methanol, must fill column liquid, take dress column liquid that polypropylene solid-phase extraction column is added, add sample solution and eluted, eluted, take
Elution liquid nitrogen blows concentration, obtains concentrate；
（4）According to the mass fraction, take 5 parts of three esters of palmitic acid, 5 parts of Miglyol 812Ns, 3 parts of Co-Q10s, 8 parts it is dense
Contracting liquid is warming up to 70 DEG C and is stirred 2h, obtains mixture A, according to the mass fraction, takes 3 portions of octyl-decyl glucosides, 5 parts of seasons
Ammonium salt chitosan, 70 parts of deionized waters, are stirred 30min in 75 DEG C, obtain mixture B, take mixture A in mass ratio 1：1 adds
Enter mixture B and be stirred 5min, then at 100MPa homogeneous, is cooled to room temperature, obtains cooling thing；
（5）According to the mass fraction, 15 parts of saualanes, 20 parts of mink oil, 4 parts of cetostearyl alcohols, 3 parts of vitamin e acetates are taken, in
70 DEG C are stirred 20min, obtain cold cream oil phase matrix object, according to the mass fraction, take 50 parts of ultra-pure waters, 12 parts of glycerine, 0.8 part
Water-solubleazone, 6 parts of 1,3-BDOs, 1h is stirred in 75 DEG C, is obtained cold cream water phase matrix object, is taken cold cream oil phase matrix
Object, cold cream water phase matrix object, cooling thing in mass ratio 1：4：3 mixing, 20min is stirred in 45 DEG C, both obtains labour protection skin care
Cream.
Embodiment 2
（1）Take tetraethyl orthosilicate in mass ratio 1：1：20 are added 3- methacryloxypropyl trimethoxy silanes, ultrapure
Water mixes, and 3 h are stirred in 400 rpm, 30 DEG C, adds the ammonia that the mass fraction of tetraethyl orthosilicate quality 10% is 28%
Water is stirred 2h, and centrifugation takes precipitation to be washed with distilled water, and is dried in vacuo, obtains dried object；
（2）Take allantoin, acrylamide in mass ratio 1：4：60 are added n,N-Dimethylformamide, are warming up to 40 DEG C of ultrasounds
30min, then be cooled to 3 DEG C and be stirred 12h, obtains stirring mixture, take 120 parts of stirring mixtures, 4 parts of dried objects, 0.8 part two
Methacrylic acid glycol ester, 7 parts of azo-bis-isobutyl cyanides, 20 parts of methanol, are passed through nitrogen protection, and 24 h are stirred in 70 DEG C,
Obtain mixture；
（3）Take mixture in mass ratio 10：4：2 addition methanol, acetic acid obtain extract, take yam skin in 90 DEG C of Soxhlet extraction 6h
In mass ratio 10：5：1 is added ultra-pure water, ethyl alcohol, and in 40 DEG C of ultrasound 40min, centrifugation takes supernatant rotary evaporation, and rotation is taken to steam
Send out object in mass ratio 1：10 addition n,N-Dimethylformamide are stirred 40min, obtain sample solution, take extract in mass ratio 1：
10 are added methanol, must fill column liquid, take dress column liquid that polypropylene solid-phase extraction column is added, add sample solution and eluted, eluted, take
Elution liquid nitrogen blows concentration, obtains concentrate；
（4）According to the mass fraction, take 10 parts of three esters of palmitic acid, 8 parts of Miglyol 812Ns, 5 parts of Co-Q10s, 12 parts
Concentrate is warming up to 75 DEG C and is stirred 3h, obtains mixture A, according to the mass fraction, take 5 portions of octyl-decyl glucosides, 15 parts
Quaternary Ammonium Salt of Chitosan, 80 parts of deionized waters, are stirred 40min in 80 DEG C, obtain mixture B, take mixture A in mass ratio 1：1
Mixture B is added and is stirred 10min, then at 100MPa homogeneous, is cooled to room temperature, obtains cooling thing；
（5）According to the mass fraction, 18 parts of saualanes, 30 parts of mink oil, 6 parts of cetostearyl alcohols, 5 parts of vitamin e acetates are taken, in
75 DEG C are stirred 30min, obtain cold cream oil phase matrix object, according to the mass fraction, take 60 parts of ultra-pure waters, 15 parts of glycerine, 1.5 parts
Water-solubleazone, 9 parts of 1,3-BDOs, 2h is stirred in 80 DEG C, is obtained cold cream water phase matrix object, is taken cold cream oil phase matrix
Object, cold cream water phase matrix object, cooling thing in mass ratio 1：4：3 mixing, 30min is stirred in 50 DEG C, both obtains labour protection skin care
Cream.
Embodiment 3
（1）Take tetraethyl orthosilicate in mass ratio 1：1：20 are added 3- methacryloxypropyl trimethoxy silanes, ultrapure
Water mixes, and 2.5h is stirred in 400 rpm, 27.5 DEG C, and the mass fraction for adding tetraethyl orthosilicate quality 9% is 28%
Ammonium hydroxide is stirred 1.5h, and centrifugation takes precipitation to be washed with distilled water, and is dried in vacuo, obtains dried object；
（2）Take allantoin, acrylamide in mass ratio 1：4：55 are added n,N-Dimethylformamide, are warming up to 35 DEG C of ultrasounds
25min, then be cooled to 1.5 DEG C and be stirred 11h, obtains stirring mixture, take 110 parts of stirring mixtures, 3 parts of dried objects, 0.6 part
Ethylene glycol dimethacrylate, 5.5 parts of azo-bis-isobutyl cyanides, 19 parts of methanol, are passed through nitrogen protection, are stirred in 67.5 DEG C
21 h, obtain mixture；
（3）Take mixture in mass ratio 10：3.5：1.5 addition methanol, acetic acid obtain extract, take in 85 DEG C of Soxhlet extraction 5.5h
Yam skin in mass ratio 10：5：1 is added ultra-pure water, ethyl alcohol, and in 35 DEG C of ultrasound 35min, centrifugation takes supernatant rotary evaporation, takes
Rotary evaporation object in mass ratio 1：10 addition n,N-Dimethylformamide are stirred 35min, obtain sample solution, take extract by matter
Measure ratio 1：10 be added methanol, must fill column liquid, take dress column liquid addition polypropylene solid-phase extraction column, add sample solution eluted,
Elution takes elution liquid nitrogen to blow concentration, obtains concentrate；
（4）According to the mass fraction, 7.5 parts of three esters of palmitic acid, 6.5 parts of Miglyol 812Ns, 4 parts of Co-Q10s, 10 are taken
Part concentrate, is warming up to 72.5 DEG C and is stirred 2.5h, obtain mixture A, according to the mass fraction, take 4 parts of octyl-decyl glucose
Glycosides, 10 parts of Quaternary Ammonium Salt of Chitosan, 75 parts of deionized waters, are stirred 35min in 77.5 DEG C, obtain mixture B, take mixture A by
Mass ratio 1：1 addition mixture B is stirred 7.5min, then at 100MPa homogeneous, is cooled to room temperature, obtains cooling thing；
（5）According to the mass fraction, 16.5 parts of saualanes, 25 parts of mink oil, 5 parts of cetostearyl alcohols, 4 parts of vitamin e acetates are taken,
Be stirred 25min in 72.5 DEG C, obtain cold cream oil phase matrix object, according to the mass fraction, take 55 parts of ultra-pure waters, 13.5 parts it is sweet
Oil, 1.15 parts of water-solubleazones, 7.5 parts of 1,3-BDOs, 1.5h is stirred in 77.5 DEG C, obtains cold cream water phase matrix object,
Take cold cream oil phase matrix object, cold cream water phase matrix object, cooling thing in mass ratio 1：4：3 mixing, are stirred in 47.5 DEG C
25min both obtains labour protection cold cream.
Comparative example：The cold cream of Dongyang City company production.
PH value is tested：The labour protection cold cream to the present invention and the cold cream of comparative example use acid-base value respectively（PH value）It surveys
It is fixed, acid-base value（PH）Faintly acid is skin friendly, and weak acid refers to the acid of incomplete ionization in the solution.Such as common HA goes to indicate acid,
That is in aqueous solution in addition to ionizing out proton H+Outside, still there is HA quite a lot in solution.Following below formula can indicate
This relationship：HA（aq）↔H+（aq）+A-（aq）
For its solution when balance, the relationship of reactant and product can use acidity coefficient（Ka）It indicates as follows：
Ka=[H+][A-]/[HA]
Ka is bigger（Or pKa value is smaller）, with regard to representing the hydrogen ion having the more（H+）It generates, pH value is also just smaller.Weak acid
Ka values are about between 10-4 ~ 10-14 or pKa value is more than 4.Test result is shown in Table 1.
Table 1：
| Test event | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example |
| PH value/pKa | 4 | 6 | 5 | 3~6 |
Harmful chemical component is tested：Embodiment group and contrast groups respectively randomly select 20 parts of cold creams, by chemical composition detect lead,
Mercury, arsenic content.Test result is shown in Table 2.
Table 2：
| Test result | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example |
| Lead content test result（Mg/kg） | 22 | 30 | 27 | 38~46 |
| Mercury content test result（Mg/kg） | 0.3 | 0.7 | 0.5 | 0.9~1.1 |
| Arsenic content measuring result（Mg/kg） | 3 | 7 | 5 | 8~11 |
Security test：
Test method：Choose 30 people of tested crowd, women, millworker between 30 ~ 60 years old, subjects skin's health, no skin
Sick allergies meet subject and volunteer inclusion criteria.Test specimen is cold cream prepared by the embodiment of the present invention.Select qualification
Skinanalysis apparatus, according to《Cosmetics health specification》Middle dermoreaction grade scale records its result.Experimental result：Human skin
Protection test result is shown：Each group subject is tested by skin care prepared by embodiment, is observed at 0.5,6,12,24,48 hour
Dermoreaction illustrates that the labour protection cold cream is safe to use wherein 0 skin adverse reaction occurs.
In conclusion the labour protection cold cream of the present invention complies fully with requirement, it is worth promoting and uses.
Claims (1)
1. a kind of preparation method of labour protection cold cream, which is characterized in that the preparation method includes the following steps：
Take tetraethyl orthosilicate in mass ratio 1：1：20 are added 3- methacryloxypropyl trimethoxy silanes, ultra-pure water mixes
It closes, is stirred in 400 rpm, 25 ~ 30 DEG C, adds the ammonium hydroxide of tetraethyl orthosilicate quality 8 ~ 10%, be stirred, centrifuge,
It takes precipitation to be washed with distilled water, is dried in vacuo, obtains dried object；
Take allantoin, acrylamide in mass ratio 1：4：50 ~ 60 are added n,N-Dimethylformamide, are warming up to 30 ~ 40 DEG C of ultrasounds,
It is cooled to 0 ~ 3 DEG C again to be stirred, obtains stirring mixture, takes 100 ~ 120 parts of stirring mixtures, 2 ~ 4 parts of dried objects, 0.4 ~ 0.8
Part ethylene glycol dimethacrylate, 4 ~ 7 parts of azo-bis-isobutyl cyanides, 18 ~ 20 parts of methanol, are passed through nitrogen protection, are stirred in 65 ~ 70 DEG C
Mixing is mixed, mixture is obtained；
Take mixture in mass ratio 10：3~4：1 ~ 2 addition methanol, acetic acid obtain extract, take Chinese yam in 80 ~ 90 DEG C of Soxhlet extractions
Skin in mass ratio 10：5：1 is added ultra-pure water, ethyl alcohol, and in 30 ~ 40 DEG C of ultrasounds, centrifugation takes supernatant rotary evaporation, and rotation is taken to steam
Send out object in mass ratio 1：10 addition n,N-Dimethylformamide are stirred, and are obtained sample solution, are taken extract in mass ratio 1：10 add
Enter methanol, column liquid must be filled, takes dress column liquid that polypropylene solid-phase extraction column is added, add sample solution and eluted, eluted, take elution
Liquid nitrogen blows concentration, obtains concentrate；
According to the mass fraction, take 5 ~ 10 parts of three esters of palmitic acid, 5 ~ 8 parts of Miglyol 812Ns, 3 ~ 5 parts of Co-Q10s, 8 ~
12 portions of concentrates are warming up to 70 ~ 75 DEG C and are stirred, obtain mixture A, according to the mass fraction, take 3 ~ 5 parts of octyl-decyl glucose
Glycosides, 5 ~ 15 parts of Quaternary Ammonium Salt of Chitosan, 70 ~ 80 parts of deionized waters, are stirred in 75 ~ 80 DEG C, obtain mixture B, take mixture A by
Mass ratio 1：1 addition mixture B is stirred, and homogeneous is cooled to room temperature, and obtains cooling thing；
According to the mass fraction, 15 ~ 18 parts of saualanes, 20 ~ 30 parts of mink oil, 4 ~ 6 parts of cetostearyl alcohols, 3 ~ 5 parts of vitamin E second are taken
Acid esters is stirred in 70 ~ 75 DEG C, obtains cold cream oil phase matrix object, according to the mass fraction, takes 50 ~ 60 parts of ultra-pure waters, 12 ~ 15
Part glycerine, 0.8 ~ 1.5 part of water-solubleazone, 6 ~ 9 parts of 1,3-BDOs, are stirred in 75 ~ 80 DEG C, obtain cold cream water phase matrix
Object takes cold cream oil phase matrix object, cold cream water phase matrix object, cooling thing in mass ratio 1：4：3 mixing, in 45 ~ 50 DEG C of stirrings
Mixing both obtains labour protection cold cream.
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