CN108195833A - A kind of uric acid detection device - Google Patents
A kind of uric acid detection device Download PDFInfo
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- CN108195833A CN108195833A CN201611122280.9A CN201611122280A CN108195833A CN 108195833 A CN108195833 A CN 108195833A CN 201611122280 A CN201611122280 A CN 201611122280A CN 108195833 A CN108195833 A CN 108195833A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/80—Indicating pH value
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Abstract
The present invention discloses a kind of uric acid detection device, and including housing, solid-state test-strips and test of light source device, housing has the first opening, the first storage cavity and test chamber, and the first storage cavity is connected with test chamber；Solid-state test-strips, which stack, to be arranged in the first storage chamber body, and curing thereon has the reagent for reacting and testing pH value with calcium ion, iodide ion, phosphate radical；Test of light source device is arranged in housing, and in test chamber, for being detected to being placed on the uric acid ingredient dripped in the test-strips in test chamber.Reagent premature cure is on the test strip, only the uric acid of acquisition need to directly be dripped on the test strip, it reacts with reagent, reaction product is irradiated by test of light source device, according to product to the light absorption of different wave length, to determine the calcium ion in uric acid, iodide ion, phosphate content and the pH value of uric acid, convenient for being detected whenever and wherever possible come the ingredient to uric acid, simplify the test process of uric acid.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of uric acid detection device.
Background technology
Uric acid is the final product of purine metabolism in human body, in human body without physiological function, in human body purine it is main come
Source has diet and nucleoprotein to decompose.Under normal circumstances, mainly there is kidney excretion, remaining discharges body through enteron aisle, skin, hair etc.
Outside, gout, hyperlipidemia, malignant hematologic disease, kidney disease, chronic leukemia etc. clinically reflect uric acid content liter
Height, thus can be used as the important finger index of the diagnosis cause of disease by testing the component of uric acid.
Mainly there are iodide ion, phosphate ion, calcium ion and pH value, test urine to the index of composition test in uric acid at present
The method of sour component is mainly titration, reduction method or enzyme process etc., but above-mentioned detection method is required for specific ring indoors
It is carried out under border, the equipment of test uric acid ingredient is mainly Biochemical Analyzer.For example, Chinese patent literature CN102901833A is disclosed
Biochemical Analyzer, including babinet, be divided into two regions in the cavity of babinet, a region is detection zone, in detection zone
Monitor station is provided with, test of light source device is set on monitor station；Another region is the storage area for storing reaction reagent,
Stent in storage area is set, multiple mounting holes are set on stent, the Reagent Tube equipped with reaction reagent is mounted on the installation of stent
Kong Shang.It when detecting uric acid, needs by uric acid solution drips to be detected in test strips, reaction reagent is taken out from storage region
It is reacted with the uric acid in test strips, detection light source detection is used after reaction.
But above-mentioned uric acid test device, reaction reagent is individually placed, still stores as a solution, if desired
When being detected at any time to the uric acid of human body inside outdoor or family, it is also necessary to individually reaction reagent is taken out, it is anti-with uric acid
It could be detected after answering so that entire detection process is inconvenient, when going out, not readily portable solution reaction reagent, while entirely examine
Survey the complicated of device, it is impossible to realize the operation of automation.
Invention content
Therefore, the technical problem to be solved in the present invention is to overcome uric acid test device in the prior art, detects uric acid
Process is inconvenient, it is complicated the problem of.
For this purpose, the present invention provides a kind of uric acid detection device, including
Housing has at least one first opening and the first storage cavity being in communication with the outside through the described first opening
And test chamber, the first storage cavity are connected with the test chamber；
Solid-state test-strips to be at least one, stacked and are arranged in the first storage chamber body, curing thereon have at least with calcium
Ion, iodide ion, phosphate radical react and test the reagent of pH value；
Test of light source device is arranged in the housing, and in the test chamber, for being placed on the inspection
The uric acid ingredient dripped in the test-strips surveyed in cavity is detected.
Preferably, above-mentioned uric acid detection device, the solid-state test-strips include dielectric base, are disposed in parallel in described exhausted
Working electrode and reference electrode in edge substrate, the reagent layer being arranged on the working electrode and reference electrode top surface,
Curing has the reagent on the reagent layer.
It is further preferred that above-mentioned uric acid detection device, the reagent layer is divided into few four detection zones, described in four
Detection zone is respectively calcium ion detection zone, iodide ion detection zone, phosphate radical detection zone, pH value detection zone, each detection zone
On curing have the reagent.
Preferably, above-mentioned uric acid detection device is additionally provided with detection platform, the test of light source in the test chamber
Device face is arranged on the top of the detection platform；
The mobile mechanism being arranged in the test chamber is further included, the mobile mechanism is used for the solid-state test-strips
It is transferred in the detection platform out of described first storage chamber body.
It is further preferred that above-mentioned uric acid detection device, the mobile mechanism includes being arranged in the test chamber
The first driver on wall surface and the gripper components being arranged on the power output shaft of first driver, the crawl
Component applies adsorption to the solid-state test-strips.
Preferably, above-mentioned uric acid detection device is also set up in the test chamber outside along first opening direction
The sliding rail of extension, the sliding block being slidably arranged on the sliding rail, the detection platform are fixed on the sliding block, the sliding rail energy
Enough through the described first opening stretching or the housing of retracting.
Preferably, above-mentioned uric acid detection device also has the second storage cavity, second storage chamber in the housing
Stent is provided in vivo, the mounting hole for placing sampler is opened up on the stent；
There is the second opening that the described second storage cavity is in communication with the outside on the housing；
First opening and the upper sealed set of the described second opening have dismountable cover.
Preferably, above-mentioned uric acid detection device, set on the housing display and with the test of light source device
The controller being all connected with the display.
Preferably, above-mentioned uric acid detection device, the test of light source device include light source emitter and reception device；
And/or
Heating component is also set up in the test chamber.
Technical solution of the present invention has the following advantages that：
1. uric acid detection device provided by the invention is filled including housing, at least one solid-state test-strips and test of light source
It puts, wherein, housing has at least one first opening and the first storage cavity being in communication with the outside through the first opening and detection
Cavity, the first storage cavity are connected with test chamber；Solid-state test-strips, which stack, to be arranged in the first storage chamber body, and curing thereon has
The reagent of pH value is at least reacted and tested with calcium ion, iodide ion, phosphate radical；Test of light source device is arranged in housing,
And in test chamber, for being detected to being placed on the uric acid ingredient dripped in the test-strips in test chamber.
The uric acid detection device of this structure will be reacted and be surveyed with calcium ion, iodide ion, the phosphate radical in uric acid solution
The reagent premature cure for trying pH value on the test strip, in the ingredient for detecting uric acid, only needs collection in worksite uric acid, and uric acid is straight
It connects drippage on the test strip, reacts with reagent, reaction product is irradiated by test of light source device, according to product to difference
The light absorption of wavelength, to determine the calcium ion in uric acid, iodide ion, phosphate content and the pH value of uric acid, convenient at any time with
Ground is detected come the ingredient to uric acid, simplifies the test process of uric acid, is carried convenient for outgoing.
2. uric acid detection device provided by the invention, the solid-state test-strips include dielectric base, are disposed in parallel in described
Working electrode and reference electrode in dielectric base, the reagent being arranged on the working electrode and reference electrode top surface
Layer, curing on the reagent layer has the reagent.The uric acid detection device of this structure, working electrode and ingredient in uric acid
Reaction is learned, the product after reaction is compared by illumination, and with reference electrode, more accurately obtains calcium ion, the iodine in uric acid
The pH value of ion, phosphate content and uric acid.
3. uric acid detection device provided by the invention, also set up along first opening direction and extend outwardly in test chamber
Sliding rail, the sliding block being slidably arranged on the sliding rail, the detection platform is fixed on the sliding block, and the sliding rail can be through
First opening is stretched out or the housing of retracting.When needing to detect uric acid, sliding rail is stretched out through first outlet outside housing, will be adopted
The uric acid of collection is dropped in the test-strips on sliding block, it is possible to start the detection of uric acid ingredient, it is easy to operation.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution of the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is the structure diagram of the uric acid detection device provided in the embodiment of the present invention 1；
Fig. 2 is the structure diagram of the uric acid detection device middle casing provided in the embodiment of the present invention 1；
Fig. 3 is the structure diagram of the solid-state test-strips in the uric acid detection device provided in the embodiment of the present invention 1；
Reference sign：1- housings；11- first is open；12- second is open；13- first stores cavity；14- second is deposited
Put cavity；15- test chambers；2- test-strips；21- substrates；22- working electrodes；23- reference electrodes；24- reagent layers；3- light sources
Test device；4- detection platforms；5- stents；61- sliding rails；62- sliding blocks；7- displays；8- controllers；9- heating components.
Specific embodiment
Technical scheme of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's all other embodiments obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " " center ", " on ", " under ", "left", "right", " vertical ",
The orientation or position relationship of the instructions such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, merely to
Convenient for the description present invention and simplify description rather than instruction or imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is only used for description purpose, and it is not intended that instruction or hint relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected；It can
To be mechanical connection or be electrically connected；It can be directly connected, can also be indirectly connected by intermediary, Ke Yishi
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.
As long as in addition, technical characteristic involved in invention described below different embodiments non-structure each other
It can be combined with each other into conflict.
Embodiment 1
The present embodiment provides a kind of uric acid detection device, as depicted in figs. 1 and 2, including housing 1, solid-state test-strips 2, light
Source test device 3, mobile mechanism, heating component 9, display 7 and controller 8.
Wherein, the tool of housing 1 is there are one the first opening 11, the first storage 13 He of cavity being in communication with the outside through the first opening 11
Test chamber 15 and second stores cavity 14, and the first storage cavity 13 is connected with test chamber 15.In second storage cavity 14
Stent 5 is provided with, the mounting hole for placing sampler (such as syringe) is opened up on stent 5；Have on housing 1 and deposited second
Put the second opening 12 that cavity 14 is in communication with the outside；Sealed set has dismountable lid in first opening 11 and the second opening 12
Body.
Multiple solid-state test-strips 2, which stack, to be arranged in the first storage cavity 13, as shown in figure 3, solid-state test-strips 2 are included absolutely
Edge substrate 21, the working electrode 22 and reference electrode 23 being disposed in parallel in dielectric base 21 are arranged on working electrode 22 and ginseng
Than the reagent layer 24 on 23 top surface of electrode, on reagent layer 24 curing have with calcium ion, iodide ion, phosphate radical react and
Test the reagent of pH value.Wherein, the ingredient on working electrode 22 is by water-insoluble redox electron mediator, carbon dust and resin group
Into；Water-insoluble redox electron mediator is preferably water-insoluble ferrocene, and resin is preferably acrylic resin.Reference electricity
The ingredient of pole 23 is silver or silver chlorate.Reagent layer 24 is divided into four detection zones, four detection zones be respectively calcium ion detection zone,
Iodide ion detection zone, phosphate radical detection zone, pH value detection zone, curing has reagent on each detection zone.Reagent includes cow's serum
Albumen, electron mediator, bonding agent, PH buffers, electronic media is of fine quality to be selected as the potassium ferricyanide, and bonding agent is polyvinyl alcohol, uses
In bovine serum albumin, electron mediator and PH buffers are bonded in working electrode 22 and reference electrode 23；PH buffer solutions
Preferably potassium dihydrogen phosphate.
As shown in Figure 1, setting is slidably arranged in along the first opening outwardly extending sliding rail 61 in 11 directions in test chamber 15
Sliding block 62 on sliding rail 61 is provided with detection platform 4 on sliding block 62, and sliding rail 61 can be stretched out through the first opening 11 or retraction housing
1.For example, sliding rail 61 is driven towards or away from the first 11 directions of opening movement using cylinder.
Mobile mechanism includes the first driver being arranged on 15 internal face of test chamber and is arranged on the first driver
Power output shaft on gripper components, gripper components to solid-state test-strips 2 apply adsorption, by first store cavity
Solid test strip 2 in 13 is transferred in detection platform 4.Preferably, the first driver is cylinder, and gripper components are preferably inhaled
Disk.
Test of light source device 3 is arranged in test chamber 15, including light source emitter and reception device, light source transmitting dress
Put the surface for being located at detection platform 4 with reception device, light source emitter irradiation light in detection platform 4, in test-strips 2
Product after solidified reagents are reacted with uric acid can absorb the light of different wave length, so as to learn the component content in uric acid, receive
The information that light source emitter detects is fed back to controller 8 and shown on the display 7 by device.Preferably display 7 is set
It puts on housing 1, controller 8 is electrically connected with reception device and display 7.
Heating component 9 is also set up in test chamber 15, heating component 9 is preferably thermoelectricity occasionally thermal resistance wire so that test chamber
The environment of required temperature is heated in body 15, is reacted convenient for the reagent in test-strips 2 with uric acid.
The uric acid detection device of this embodiment, when needing to uric acid composition detection, by the cover in the first opening 11
It opens, the cylinder driving sucker in test chamber 15, which is stored towards first in cavity 13, to be moved, and a test-strips 2 are adsorbed and are being inhaled
On disk, and under the driving of cylinder, test-strips 2 are transferred in detection platform 4, sliding block 62 slides into close the first of sliding rail 61
It is open at 11, and is stretched out outside housing 1 with sliding rail 61, take out sampler out of second storage cavity 14, sampler is by the urine of acquisition
Acid is dropped on four detection zones of test-strips 2, and in 61 retraction test chamber 15 of sliding rail, sliding block 62 slides into light source emitter
Underface；Heating component 9 is opened at this time so that reaching required temperature in test chamber 15, after candidate agent has been reacted with uric acid,
Light source emitter irradiate product, according to different products absorb different wave length light, come determine the calcium ion in uric acid, iodine from
The result of detection is handled and will treated signal transmission by the pH value of son, phosphate content and uric acid, reception device
To controller 8, while show on the display 7.This uric acid detection device by by reagent premature cure in test-strips 2, outside
Go out when carrying without carrying of liquids reaction reagent, convenient for being detected whenever and wherever possible come the ingredient to uric acid, simplify the survey of uric acid
Examination process carries convenient for outgoing.
In addition, four detection zones are individually demarcated, the substance that the ion detected as needed is formed after being reacted with reagent,
Each detection zone is irradiated respectively using not sharing the same light, and improves the accuracy of required detection ingredient in each detection zone.
As interchangeable embodiment, above-mentioned heating component 9 can also be that infrared heater or radiator come pair
It is heated in test chamber 15.As deformation, above-mentioned heating component 9 can also be not provided with, such as in outdoor application, when
Outdoor proper temperature, reagent can also be reacted with uric acid, the setting of heating component 9, convenient for reacting for quickening reagent and uric acid
Speed.
As interchangeable embodiment, test of light source device 3 can also be the equipment in the existing test for uric acid,
As long as by illumination product, the principle of the light of different wave length is absorbed according to different products, the detection to obtain uric acid ingredient is set
It is standby.
The second above-mentioned storage cavity 14 can also be not provided with as interchangeable embodiment, on housing 1, sampler is made
It is spare for ancillary equipment, so that housing 1 is small, carried convenient for outgoing.
As interchangeable embodiment, detection platform 4 in test chamber 15 can also be only set, be not provided with above-mentioned cunning
Rail 61 and sliding block 62 when needing to test uric acid, are directly dropped in the uric acid of acquisition in test-strips 2 through the first opening 11.
As interchangeable embodiment, above-mentioned gripper components can also be gas nozzle or other can be to test-strips 2
Apply the component of adsorption.As the deformation of the first driver, the first driver can also be motor.As mobile mechanism
Deformation, mobile mechanism can also be other existing moving structures, such as manipulator or pallet.As further replaceable
Embodiment, above-mentioned mobile mechanism can also be not provided with, two first openings 11 are opened up on housing 1, correspond respectively to the
One storage cavity 13 and test chamber 15, need to only open the cover in the first opening 11, first be stored the test in cavity 13
Item 2 is removed and placed in detection platform 4.It further deforms, detection platform 4 can also be not provided in test chamber 15, directly
It connects and test-strips 2 is placed in test chamber 15.
As interchangeable embodiment, multiple detection zones can also be divided on reagent layer 24, to the calcium in uric acid from
Son, iodide ion, phosphate radical, pH value are tested, and can also in addition set a detection zone, for detect urinate it is miscellaneous in ingredient.
As deformation, reagent layer 24 can not also divide multiple detection zones, and the ingredient of uric acid is detected in same detection zone,
The precision opposite sectors detection of detection can reduce.
As deformation, solid test strip 2 in addition to the above described configuration, can also only include reagent layer 24, be not provided with work
Electrode 22 and reference electrode 23.For cured reagent in reagent layer 24, can replacement ingredient be carried out according to actually detected demand,
But it is had in reagent containing to calcium ion, iodide ion, phosphate radical, pH value are detected in uric acid ingredient.
Preferably, the shape of above-mentioned housing 1 is preferably tubular or other shapes.
As interchangeable embodiment, as long as above-mentioned uric acid detection device includes housing 1, solid test strip 2 in fact
With test of light source device 3.Wherein, housing 1 has at least one first opening 11, the above-mentioned first storage cavity 13 and inspection
Survey cavity 15；At least one solid-state test-strips 2, which stack, to be arranged in the first storage cavity 13, thereon curing have at least with calcium from
Son, iodide ion, phosphate radical react and test the reagent of pH value；Test of light source device 3 is arranged in institute's housing 1, and is located at
In test chamber 15, for being detected to the uric acid ingredient dripped in the test-strips 2 being placed in test chamber 15.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or
Among changing still in the protection domain of the invention.
Claims (9)
1. a kind of uric acid detection device, which is characterized in that including
Housing (1) has at least one first opening (11) and first is deposited through what the described first opening (11) was in communication with the outside
Cavity (13) and test chamber (15) are put, the first storage cavity (13) is connected with the test chamber (15)；
Solid-state test-strips (2) are at least one, stack and are arranged in the first storage cavity (13), curing thereon has at least
The reagent of pH value is reacted and tested with calcium ion, iodide ion, phosphate radical；
Test of light source device (3) is arranged in the housing (1), and in the test chamber (15), for being placed on
The uric acid ingredient dripped in test-strips (2) in the test chamber (15) is detected.
2. uric acid detection device according to claim 1, it is characterised in that：The solid-state test-strips (2) include the base that insulate
Bottom (21), the working electrode (22) and reference electrode (23) being disposed in parallel in the dielectric base (21), is arranged on the work
Make the reagent layer (24) on electrode (22) and reference electrode (23) top surface, curing on the reagent layer (24) has the examination
Agent.
3. uric acid detection device according to claim 2, it is characterised in that：The reagent layer (24) is divided at least four
Detection zone, four detection zones are respectively calcium ion detection zone, iodide ion detection zone, phosphate radical detection zone, pH value detection zone,
Curing has the reagent on each detection zone.
4. uric acid detection device according to any one of claim 1-3, it is characterised in that：
Detection platform (4) is additionally provided in the test chamber (15), test of light source device (3) face is arranged on the inspection
Survey the top of platform (4)；
The mobile mechanism being arranged in the test chamber (15) is further included, the mobile mechanism is used for the solid-state test-strips
(2) it is transferred in the detection platform (4) out of described first storage cavity (13).
5. uric acid detection device according to claim 4, it is characterised in that：The mobile mechanism includes being arranged on the inspection
The first driver surveyed on cavity (15) internal face and the crawl section being arranged on the power output shaft of first driver
Part, the gripper components apply adsorption to the solid-state test-strips (2).
6. uric acid detection device according to claim 4 or 5, it is characterised in that：It is also set up in the test chamber (15)
Along the described first opening outwardly extending sliding rail in (11) direction (61), the sliding block (62) being slidably arranged on the sliding rail (61),
The detection platform (4) is fixed on the sliding block (62), the sliding rail (61) can through described first opening (11) stretch out or
It retracts the housing (1).
7. the uric acid detection device according to any one of claim 1-6, it is characterised in that：Also have in the housing (1)
There is the second storage cavity (14), be provided with stent (5) in the second storage cavity (14), open up and be used on the stent (5)
Place the mounting hole of sampler；
There is the second opening (12) that the described second storage cavity (14) is in communication with the outside on the housing (1)；
Sealed set has dismountable cover in first opening (11) and second opening (12).
8. the uric acid detection device according to any one of claim 1-7, it is characterised in that：It is set on the housing (1)
Display (7) and the controller (8) being all connected with the test of light source device (3) and the display (7).
9. the uric acid detection device according to any one of claim 1-8, it is characterised in that：The test of light source device
(3) including light source emitter and reception device；And/or
Heating component (9) is also set up in the test chamber (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611122280.9A CN108195833A (en) | 2016-12-08 | 2016-12-08 | A kind of uric acid detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611122280.9A CN108195833A (en) | 2016-12-08 | 2016-12-08 | A kind of uric acid detection device |
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| Publication Number | Publication Date |
|---|---|
| CN108195833A true CN108195833A (en) | 2018-06-22 |
Family
ID=62572651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611122280.9A Pending CN108195833A (en) | 2016-12-08 | 2016-12-08 | A kind of uric acid detection device |
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| CN (1) | CN108195833A (en) |
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Application publication date: 20180622 |