CN108187183A - A kind of built-in medical supersonic thromboembolism treatment instrument - Google Patents

A kind of built-in medical supersonic thromboembolism treatment instrument Download PDF

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CN108187183A
CN108187183A CN201711405495.6A CN201711405495A CN108187183A CN 108187183 A CN108187183 A CN 108187183A CN 201711405495 A CN201711405495 A CN 201711405495A CN 108187183 A CN108187183 A CN 108187183A
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ultrasonic
indwelling
waveguide
built
ultrasonic wave
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CN108187183B (en
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刘细宝
汪跃群
郁涛
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715th Research Institute of CSIC
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715th Research Institute of CSIC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16886—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body for measuring fluid flow rate, i.e. flowmeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22088—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

The present invention relates to the field of medical instrument technology, a kind of built-in medical supersonic thromboembolism treatment instrument, including infusion apparatus, ultrasonic load-on module and ultrasonic indwelling waveguide.The front shroud and ultrasonic transformer of ultrasonic transducer in ultrasonic load-on module are made using TC4 titanium alloy materials, and the intermediate through-hole for being equipped with diameter of phi 1mm.Ultrasonic wave indwelling waveguide enters intravascular from the blood vessel upstream end for having thrombus along blood flow direction.The part both sides digging that ultrasonic wave indwelling waveguide enters blood vessel has several duck eyes, so as to directly emit ultrasonic wave in the blood vessel for have embolus, then is equipped with thrombolytics ablation thrombus.Experiments verify that treatment of thrombotic disorders have it is non-invasive, it is easy to operate, reusable.Only part plays a role ultrasonic energy inside, and the through lesion of ultrasonication and drug, thrombolytic effect is good, while small to damaging surrounding tissue, the great advantages that safety is without side-effects to have no adverse reaction etc..

Description

A kind of built-in medical supersonic thromboembolism treatment instrument
Technical field
The present invention relates to the field of medical instrument technology, specifically a kind of built-in medical supersonic thromboembolism treatment instrument.
Background technology
According to reliable statistics, there are about 3.3 hundred million hypertensive patients in China, account for about the 23.6% of total population, than the people in the entire U.S. Mouth is more, and with the aggravation of aging, ratio also will increase further.In famous Yalta Conference, Rossfu, Stalin Three big giants is reconstructed world structure with mound gill, however, they die of the disease of cardiovascular and cerebrovascular induction respectively.Hypertension is just Blood narrowed blood vessels encounter obstructed flow it is not smooth when, lateral pressure is higher by normal value caused by vascular wall.Hypertension can be selected Core, the organs such as brain, kidney, eye are injured as target, here it is " target organ injuries ".In short, every ground for having artery Side is likely to be attacked.It after atherosclerotic plaque accumulation to a certain extent, is easily impacted by blood flow, plaque rupture and and blood Pipe is detached from, and forms embolus, occluding vascular.It is exactly coronary heart disease in case of cardiovascular coronary artery is being supplied；If it happens It is exactly cerebral thrombus, headstroke in brain.
In addition, haemodialysis is one of main renal replacement therapies method of patients with renal failure, one is established effectively Vascular access be premise that haemodialysis is smoothed out, vascular access is referred to as the lifeline of uremic patient by someone.It is good Good vascular access requirement blood flow reaches 200-300ml/min, and to often result in blood flow insufficient for thrombus, and then causes dialysis It is insufficient.Therefore, thrombus is the main reason for vascular access is caused to fail.
For this purpose, elimination thrombus reduces blood pressure, recovery vascular patency is particularly important.Artificial mechanism method has sacculus at present Catheterization and surgery embolectomy, but the complication such as massive haemorrhage are easily caused, and operation risk is of high cost greatly, easily send out repeatedly Make.Therefore, clinically mostly using drug oral or drop promoting blood circulation and removing blood stasis, such as safflower, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Notoginseng, leech, A Si Woods or tissue plasminogen activation proenzyme, prourokinase (Pro-UK) etc..But it is that can only prevent or slowly effect, thrombolysis Time grows (often week age).
Then occurs new ultrasound thrombolysis art in the market.It is main to utilize the mechanical oscillation of ultrasonic wave, cavitation effect, micro- electricity The energy such as shearing force, microbeam stream are flowed, then the pharmacological action of thrombolytics is coordinated to make thrombus rupture dissolving, vascular embolization leads to again.It is a kind of Such as the external therapeutic ultrasound (ETUS) of high frequency low energy, such as the patent of " Shenzhen Well.D Medical Electronics Co., Ltd. " application Number for " CN203898961U " patent of invention it is entitled " thromboembolism treatment probe ", exactly probe is placed outside at occluding vascular, The ultrasonic wave of probe transmitting passes through couplant and skin heart to handle embolus.When power is larger, patient skin has bright Show scorching hot sense of discomfort；Thrombolytic effect is undesirable when power is smaller.Also a kind of such as microvesicle acoustic contrast promotes external supersonic to disappear Melt thrombus, such as the patent of invention of the Patent No. " CN205548629U " of " Guangzhou General Hospital Guangzhou Military Command " application is entitled On the one hand " a kind of ultrasonic microbubble cavitation thrombus dissolving system " exactly emits ultrasonic wave in vitro, on the other hand injection is super in the blood vessels Acoustic wave excitation contrast agent and thrombolytics.This is a kind of mode of the combination of inner and outside, promotes the ablation of thrombus really, improves effect Fruit, but patient still feels scorching hot discomfort, without playing the performance advantage of ultrasonic wave to greatest extent.
Invention content
It is an object of the invention to overcome the shortcomings of the prior art, and a kind of built-in medical supersonic thrombolysis is provided and is controlled Treat instrument.
The purpose of the present invention is by following technical solution to complete：This built-in medical supersonic thromboembolism treatment instrument, Mainly include infusion apparatus, ultrasonic load-on module, ultrasonic indwelling waveguide.Physiological saline or thrombolytics are loaded in infusion pump, it is defeated Liquid pump connects exhaust chamber, and the fast sensor of exhaust chamber connection drop drips fast sensor connection heater, heater connection ultrasonic transduction Device, ultrasonic transducer are driven by supersonic generator, and ultrasonic transducer connects ultrasonic wave indwelling waveguide, ultrasonic wave by hose clamp Indwelling waveguide the blood vessel upstream end for having thrombus along blood flow direction enter it is intravascular, ultrasonic wave indwelling waveguide enters blood vessel Part both sides dig have several duck eyes.
The infusion apparatus includes the fast sensor of infusion pump, exhaust chamber, drop and heater, as shown in Figure 1.
The ultrasound load-on module includes the driving power and ultrasonic transducer of power adjustable.
The ultrasonic transducer includes ultrasonic vibrator and ultrasonic transformer.The front shroud and ultrasonic transformer of ultrasonic vibrator select TC4 Titanium alloy, the piezo ceramic element of ultrasonic vibrator selects power emission material in P4, because of the acoustic impedance Z of TC4 titanium alloys4= 2.71X107The acoustic impedance Z of pa*s/m and piezoelectric ceramics P45=3X107Pa*s/m is approached, and is specifically shown in the following table 1 material properties.
1 material properties of table
Material Seawater Z1 Polyurethane Z2 Blood Z3 TC4 titanium alloys Z4 Piezoelectric ceramics Z5
The velocity of sound (m/s) 1500 1520 1570 6100 4000
Density (kg/m3) 1026 1031 1054 4450 7500
Acoustic impedance (pa*s/m) 1.54X106 1.57X106 1.65X106 2.71X107 3X107
For the scheme one of the ultrasonic transducer as shown in Fig. 2, overall length is 58.5mm, shirt rim maximum gauge is Φ 25mm, humorous Vibration frequency is fs=69.8kHz, and performance test curve is as shown in figure 3, the entire intermediate through-hole for beating diameter of phi 2mm.Experimental result Show that power is less than normal, thrombolytic effect is undesirable.
Scheme two as an optimization is as shown in figure 4, overall length is 178.5mm, and chuck maximum gauge is Φ 25mm, only in luffing The hole of the long 95mm of inverted "L" shape, diameter of phi 1.5mm are beaten on bar.The experimental results showed that power improves, but thrombolytic effect is still paid no attention to Think.
Scheme three as an optimization is as shown in figure 5, overall length is 204mm, and chuck maximum gauge is still Φ 25mm, entire transducing The through-hole of diameter of phi 1mm is beaten among device, is flowed through convenient for medicament and loads ultrasonic energy, while considered level of processing.It adopts Above structure is emulated with finite element analysis software Ansys.Limit element artificial module is initially set up, as shown in fig. 6, transducing Equivalent stress cloud atlas when device vibrates is as shown in fig. 7, the resonant frequency of emulation is fs=54kHz.Actual performance test curve such as Fig. 8 Shown, resonant frequency fs=56kHz belongs to the nominal error that material parameter is set.The experimental results showed that program energy converter Output power is powerful, the big excellent effect of amplitude, therefore final scheme of the final choice scheme three as the present invention.
The ultrasound indwelling waveguide selects polyurethane material.Infusion is that physiological saline adds thrombolytics, specific object With adding different thrombolytics and slightly difference, thus it is existing with seawater with reference to simulating, about Z1=1.54X106pa*s/m.And blood Acoustic impedance Z3=1.65X106Pa*s/m, the acoustic impedance Z of polyurethane2=1.57X106Pa*s/m, three is almost consistent, and Z2Just For Z1And Z3Between.It is assumed that plane wave vertical incidence on two kinds of different uniform dielectric faces, then sound wave passes through polyurethane wave from liquid medicine The transmission loss twice of conduit incidence blood and TL (dB) are：
1 data of table substitute into formula 1, transmission loss and TL very littles, almost can be ignored.So ultrasonic indwelling waveguide choosing Use polyurethane material.
For ease of to ultraviolet blood irradiation sound wave and thrombolytics, enhancing ultrasound thrombolysis effect, the both sides of ultrasonic waveguide are respectively dug a hole Opening, as shown in figure 9, the adjacent two holes spacing in the same side is
And the openings position of side is just in the centre of two openings position of opposite side, as
Beneficial effects of the present invention are：
1st, infusion pump have half squeeze function and ripple compensation technology, make infusion evenly, error it is small, can keep for a long time Pipeline elasticity and flow rate accuracy.
2nd, the liquid flowed through can be heated to 40-50 DEG C and adjustable by heater, and specific adjust can be according to winter in summer environment temperature Depending on patient's personal feeling.
3rd, the present invention has treatment of thrombotic disorders non-invasive, and easy to operate, reusable and ultrasonic energy is only Inside part play a role, the through lesion of ultrasonication and drug, thrombolytic effect is good, and treatment time is short, and surrounding tissue is damaged Hinder small, securely and reliably to wait great advantages.
Description of the drawings
Fig. 1 is the ultrasound thrombolysis therapeutic equipment structure diagram of the present invention.
Fig. 2 is one figure of ultrasonic transducer scheme of the present invention.
Fig. 3 is the testing impedance curve graph of the ultrasonic transducer scheme one of the present invention.
Fig. 4 is two figure of ultrasonic transducer scheme of the present invention.
Fig. 5 is three figure of ultrasonic transducer scheme of the present invention.
Fig. 6 is the simulation model figure of the ultrasonic transducer scheme three of the present invention.
Fig. 7 is the equivalent stress cloud atlas of the ultrasonic transducer scheme three of the present invention.
Fig. 8 is the testing impedance curve graph of the ultrasonic transducer scheme three of the present invention.
The ultrasonic indwelling waveguide that Fig. 9 is the present invention is dug a hole spacing figure.
Reference sign：Infusion pump 1, physiological saline or thrombolytics 2, the fast sensor 4 of drop, heater 5, surpass exhaust chamber 3 Sonic transducer 6, supersonic generator 7, hose clamp 8, ultrasonic indwelling waveguide 9, thrombus 10, blood vessel 11, hole 12, ultrasonic vibrator 13rd, ultrasonic transformer 14, front shroud 15, through-hole 16.
Specific embodiment
Detailed introduction is done to the present invention below in conjunction with attached drawing：
As shown in drawings, this built-in medical supersonic thromboembolism treatment instrument mainly includes infusion pump 1, is contained in infusion pump 1 There are physiological saline or thrombolytics 2.Infusion pump 1 connects exhaust chamber 3, and the fast sensor 4 of the connection drop of exhaust chamber 3 drips fast sensor 4 and connects Heater 5, heater 5 connect ultrasonic transducer 6, and ultrasonic transducer 6 is driven by supersonic generator 7.Ultrasonic transducer 6 passes through Hose clamp 8 connects ultrasonic wave indwelling waveguide 9.Hose clamp 8 can ensure that ultrasonic transducer 6 and ultrasonic wave indwelling waveguide 9 in vibration It is not easily to fall off.Ultrasonic wave indwelling waveguide 9 enters along blood flow direction in blood vessel 11 in 11 upstream end of blood vessel for having thrombus 10.It is super The part both sides digging that sound wave indwelling waveguide 9 enters blood vessel 11 has several duck eyes 12.
In the specific implementation, the liquid flowed through can be heated to 40-50 DEG C and adjustable by heater 5, and specific adjust can foundation Depending on winter in summer environment temperature and patient's personal feeling.
As shown in figure 5, ultrasonic transducer 6 includes ultrasonic vibrator 13 and ultrasonic transformer 14, ultrasonic vibrator 13 includes without only limiting In front shroud 15, front shroud 15 and ultrasonic transformer 14 are made using TC4 titanium alloy materials.Ultrasonic vibrator 13 and ultrasonic transformer 14 Centre is equipped with the through-hole 16 of diameter of phi 1mm.The overall length of ultrasonic transducer 6 is 204mm, resonant frequency fs=56kHz.
As shown in figure 9, ultrasonic wave indwelling waveguide 9 selects polyurethane material to be made.Ultrasonic wave indwelling waveguide 9 Both sides, which are dug, several duck eyes 12, the adjacent two holes spacing 26.8mm in the same side.And the openings position of side is just in two hole of opposite side The centre of mouth position, the i.e. adjacent two holes spacing of heteropleural are 13.4mm.
It is understood that it will be understood by those skilled in the art that technical scheme of the present invention and inventive concept are subject to The protection domain of appended claims of the invention should all be belonged to replacement or change.

Claims (5)

1. a kind of built-in medical supersonic thromboembolism treatment instrument, it is characterised in that：Mainly include infusion pump (1), contained in infusion pump (1) Equipped with physiological saline or thrombolytics (2), infusion pump (1) connection exhaust chamber (3), the fast sensor (4) of exhaust chamber (3) connection drop, drop Fast sensor (4) connection heater (5), heater (5) connection ultrasonic transducer (6), ultrasonic transducer (6) are occurred by ultrasonic wave Device (7) drives, and ultrasonic transducer (6) connects ultrasonic wave indwelling waveguide (9), ultrasonic wave indwelling waveguide (9) by hose clamp (8) Enter in blood vessel (11) along blood flow direction in blood vessel (11) upstream end for having thrombus (10), ultrasonic wave indwelling waveguide (9) into The part both sides digging for entering blood vessel (11) has several duck eyes (12).
2. built-in medical supersonic thromboembolism treatment instrument according to claim 1, it is characterised in that：The heater (5) The liquid flowed through can be heated to 40-50 DEG C and adjustable.
3. built-in medical supersonic thromboembolism treatment instrument according to claim 1, it is characterised in that：The ultrasonic transducer (6) including ultrasonic vibrator (13) and ultrasonic transformer (14), ultrasonic vibrator (13) includes without being only limitted to front shroud (15), front shroud (15) it is made with ultrasonic transformer (14) using TC4 titanium alloy materials.
4. built-in medical supersonic thromboembolism treatment instrument according to claim 3, it is characterised in that：The ultrasonic vibrator (13) and among ultrasonic transformer (14) through-hole (16), resonant frequency fs=56kHz are equipped with.
5. built-in medical supersonic thromboembolism treatment instrument according to claim 1, it is characterised in that：The ultrasonic wave indwelling Waveguide (9) selects polyurethane material to be made, and the both sides of ultrasonic wave indwelling waveguide (9), which are dug, several duck eyes (12), and The openings position of side is just in the centre of two openings position of opposite side.
CN201711405495.6A 2017-12-22 2017-12-22 Built-in medical ultrasonic thrombolysis therapeutic apparatus Active CN108187183B (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109374752A (en) * 2018-11-20 2019-02-22 中国航发贵州黎阳航空动力有限公司 A kind of ultrasonic probe apparatus
CN111772730A (en) * 2020-06-22 2020-10-16 合肥市第二人民医院 Thrombolytic drainage device
WO2021018074A1 (en) * 2019-07-30 2021-02-04 清华大学 Vortex catheter thrombolytic system, and thrombolytic method thereof
CN113974765A (en) * 2021-10-22 2022-01-28 清华大学 Intervention type thrombus removal device and thrombolysis promoting module

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EP0251512B1 (en) * 1986-06-09 1994-08-31 The Regents Of The University Of California Apparatus for removing gallstones
CN1216910A (en) * 1996-04-24 1999-05-19 加利福尼亚大学董事会 Opto-acoustic thrombolysis
CN201959333U (en) * 2011-02-25 2011-09-07 陈兰 Novel device for thrombolysis treatment of arteriovenous internal fistula
CN204523385U (en) * 2014-12-26 2015-08-05 中国船舶重工集团公司第七一五研究所 A kind of ultrasonic atomization transducer
CN205548629U (en) * 2016-03-24 2016-09-07 ***广州总医院 Bolt system is dissolved to supersound microbubble cavitation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251512B1 (en) * 1986-06-09 1994-08-31 The Regents Of The University Of California Apparatus for removing gallstones
CN1216910A (en) * 1996-04-24 1999-05-19 加利福尼亚大学董事会 Opto-acoustic thrombolysis
CN201959333U (en) * 2011-02-25 2011-09-07 陈兰 Novel device for thrombolysis treatment of arteriovenous internal fistula
CN204523385U (en) * 2014-12-26 2015-08-05 中国船舶重工集团公司第七一五研究所 A kind of ultrasonic atomization transducer
CN205548629U (en) * 2016-03-24 2016-09-07 ***广州总医院 Bolt system is dissolved to supersound microbubble cavitation

Cited By (4)

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