CN108186404A - A kind of vulva washing lotion containing polylysine and preparation method thereof - Google Patents
A kind of vulva washing lotion containing polylysine and preparation method thereof Download PDFInfo
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- CN108186404A CN108186404A CN201810046116.7A CN201810046116A CN108186404A CN 108186404 A CN108186404 A CN 108186404A CN 201810046116 A CN201810046116 A CN 201810046116A CN 108186404 A CN108186404 A CN 108186404A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention discloses a kind of vulva washing lotion containing polylysine, the vulva washing lotion is made of the raw material of following weight percent：0.1 5wt% of ε polylysines, 2 15wt% of moisturizing lubricant, 0.1 0.2wt% of surfactant, 0.5 1.5wt% of borneol, 0.05 0.09wt% of vitamin E, surplus is pure water；The pH value of the vulva washing lotion is 4.5 5.5；And provide preparation method.The washing lotion have the advantages that quick, good antimicrobial effect, to human temperature and it is harmless, have no toxic side effect, be not easy repeatedly, which is free of antibiotic, has no drug resistance after use.
Description
Technical field
Daily personal care product technical field of the present invention, and in particular, to a kind of vulva washing lotion and its system containing polylysine
Preparation Method.
Background technology
The sanitation and hygiene of male and female pudendum are particularly significant, and the cuticula of private parts is than relatively thin, other than general sweat gland, private parts
There are many more special sebum bodies of gland, these bodies of gland under hair can also secrete sweat, easily grows with infecting bacterial virus, causes
The diseases such as itching, inflammation, through clinical examination, often due to infected Candida albicans, Chlamydia, mycoplasma, diplococcus or other
Bacterium causes；Nursing due to some notional errors and not in time, the problem of leading to private parts such as the itching of female vulva vagina,
Peculiar smell, secretion increase, swelling and pain and male's infection easily cause the diseases such as balanitis, and private parts infection has repeatability, gives
Patient brings considerable distress.
A few days ago for the treatment of private parts infection generally based on external application Western medicine, these drugs mostly containing first nitre mile, gram mould mile
Antibiotic or sanitizer chemical are waited, Western medicine, which is used for a long time, can damage the organs such as liver kidney, and easily produce germ
Raw drug resistance destroys vagina and causes the mutual restricting relation between flora and lead to flora imbalance, and destruction vagina is self-cleaning and defends energy
Power leads to Relapse rate, it is impossible to thoroughly eradicate.
Lotion product is mostly Chinese herbal and crude drugs preparations, by largely anti-come restraining and sterilizing bacteria or collocation using clearing heat and detoxicating Chinese medicine
Raw element, fungicide thoroughly rapidly to kill bacterium.But often effect is slow for pure Chinese herbal medicine washing lotion, simply clearing heat and detoxicating,
The destruction of reverse side can be caused to female reproductive system.And add the product of fungicide or antibiotic, though effect is fast, side effect compared with
Greatly.In addition, especially women privates could maintain its stable state in the range of certain acid-base balance, although some washing lotions have sterilization
Function, but private parts microenvironment can be destroyed, it is damaged the self-cleaning function of private parts.
Epsilon-polylysine antimicrobial spectrum is wide, has to gram-positive bacteria, Gram-negative bacteria, Candida albicans, mould etc.
Certain fungistatic effect, epsilon-polylysine are not easy the antibacterial effect of gram-negative Escherichia coli, salmonella inhibited to other
Fruit is very good, and it also has inhibiting effect to heat resistance bacillus and some viruses.Epsilon-polylysine can turn by metabolism
Become lysine, lysine is one of essential amino acid, can promote human development, enhancing immune function, and be improved
The effect of pivot nerve fiber function.
At present, commercially available epsilon-polylysine preparation has no vagina medicinal preparation, and therefore, preparation one kind is without side-effects, takes effect
Convenient private parts washing lotion is prepared soon to be of great significance.
Invention content
First purpose of the present invention is to overcome drawbacks described above, provides a kind of vulva washing lotion containing polylysine,
Have the advantages that quick, good antimicrobial effect, to human temperature and it is harmless, have no toxic side effect, be not easy repeatedly, which is free of antibiosis
Element has no drug resistance after use.
Second object of the present invention is to provide the preparation method of above-mentioned vulva washing lotion.
The purpose of the present invention implements by the following technical programs：
A kind of vulva washing lotion containing polylysine, the vulva washing lotion are made of the raw material of following weight percent：
Epsilon-polylysine 0.1-5wt%, moisturizing lubricant 2-15wt%, surfactant 0.1-0.2wt%, borneol 0.5-
1.5wt%, vitamin E 0.05-0.09wt%, surplus are pure water；The pH value of the vulva washing lotion is 4.5-5.5.
Further, the moisturizing lubricant includes propylene glycol, glycerine and/or sodium hyaluronate.
Further, the surfactant includes neopelex, sophorolipid and/or lecithin.
Further, it is 4.5-5.5 with the pH value of lactic acid or sodium lactate adjusting vulva washing lotion.
The preparation method of the above-mentioned vulva washing lotion containing polylysine, described method includes following steps：
(1) by surfactant is molten, vitamin E is dissolved in absolute ethyl alcohol, alcoholic solution is poured into pure water stirring, removes solution
In ethyl alcohol, be cooled to room temperature, obtain aqueous surfactant solution；
(2) epsilon-polylysine is added in the aqueous surfactant solution that step (1) obtains, is stirred evenly at 40-50 DEG C,
It is completely dissolved epsilon-polylysine；
(3) moisturizing lubricant, borneol are added in into the mixed liquor that step (2) obtains, is stirred at 40-50 DEG C；
(4) with the mixed liquor pH value that lactic acid or sodium lactate regulating step (3) obtain to 4.5-5.5, sterilize to get.
Further, in the step (1), the minimizing technology of ethyl alcohol heats 6- for 80-90 DEG C of water bath with thermostatic control in solution
10min。
Further, in the step (3), the rate of the stirring is 200-400r/min, time 1-3min.
Epsilon-polylysine is a kind of biological bacteriostatic agent, and scope of restraining fungi is wide, can kill staphylococcus aureus, large intestine bar
The a series of pathogenic microorganisms such as bacterium, Pseudomonas aeruginosa, Candida albicans has antibacterial, the effect of anti-inflammatory.Epsilon-polylysine is edible
With, thus safety higher, it also has no toxic side effect to human body applied to private parts washing lotion.
Moisturizing lubricant has lubricating action, has soapy feeling, and the dosage form to be formed is made to have toughness and protectiveness, as
Moisturizer can keep longer wetting time, and sliding capability is good, can extend agent after mucous membrane local efficacy, raising use
Level of comfort has good lubricant effect.
Surfactant can be substantially reduced the surface tension of solvent when addition is seldom, change the interface shape of object system
State, can generate wetting, a series of effects such as emulsification, blistering, solubilising and dispersion, strengthen the using effect of washing lotion.
Borneol can play bacteriostasis to a certain extent, can also stimulate the cold receptor of nerve endings when in use and produce
Raw food sense, and reflectivity cause the variation of deep tissue blood vessel and play the role of anti-inflammatory, eliminate pruritus of vagina, dispelling abnormal flavor.
Vitamin E is also known as tocopherol, has very strong antioxidation, can remove free radical, protect the steady of cell membrane
It is qualitative.In addition vitamin E can be good at repairing the vagina mucosa of patient, enhance vagina local blood circulation, and vagina is kept to glue
Film lubrication and resistivity.
PH adjusting agent is at least one of lactic acid and sodium lactate, by adjusting the pH value of washing lotion, reduces the thorn to mucous membrane
Swash, the natural ph balancing of privates is safeguarded in help.
The invention has the advantages that：
Vulva washing lotion provided by the invention containing polylysine has the following advantages that compared with prior art：
(1) carry out what collocation was produced using containing ingredients such as epsilon-polylysine, moisturizing lubricant, surfactant, borneols
Private parts washing lotion, each raw material make the bacteriostasis property of the washing lotion reach best, maximum by synergistic effect, and by adjusting acid-base value
Degree safeguards pudendum cleaning；
(2) be applicable not only to the nursing of men and women's daily pudendum cleaning, and suitable for various gynaecological imflammations, vaginitis, trichomonad,
The prevention in itch, peculiar smell, mould, wound, operation, postpartum etc. and cleaning-nursing；
(3) vitamin E added in has very strong antioxidation, can remove free radical, protect the stabilization of cell membrane
Property, it can be good at repairing the vagina mucosa of patient, enhance vagina local blood circulation, keep vagina mucosa lubrication and resist energy
Power；
(4) preparation process is simple, the ingredient contained by the washing lotion in 110 DEG C of high-temperature process 15min, biocidal property also not by
It influences, facilitates sterilizing, be conducive to produce in batches.
Specific embodiment
The preferred embodiment of the present invention is illustrated below, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Epsilon-polylysine reagent in the embodiment of the present invention, producer are Shanghai Yuan Ye bio tech ltd S20435-
1g is filled, molecular formula (C6H12N2O)n。
Embodiment 1
It weighs：Epsilon-polylysine 0.1g, propylene glycol 2g, neopelex 0.1g, borneol 0.5g, vitamin E
0.05g, pure water 100mL.
(1) by neopelex, vitamin E in absolute ethyl alcohol, alcoholic solution is poured into pure water stirring, 80 DEG C of perseverances
Tepidarium 6min removes the ethyl alcohol in solution, is cooled to room temperature, and aqueous surfactant solution is made.
(2) epsilon-polylysine is added in the aqueous surfactant solution in (1), 40 DEG C of waters bath with thermostatic control stir evenly, make ε-
Polylysine is completely dissolved.
(3) propylene glycol, borneol, 40 DEG C of waters bath with thermostatic control, 200r/min stirrings 1min are added in in (2).
(4) pH value for adding in lactic acid regulating step (3) is 4.5.
(5) solution obtained (4) is subjected to sterilization treatment.
Embodiment 2
It weighs：Epsilon-polylysine 3g, glycerine 8g, sophorolipid 0.15g, borneol 1g, vitamin E 0.07g, pure water
100mL。
(1) sophorolipid, vitamin E are dissolved in absolute ethyl alcohol, alcoholic solution is poured into pure water stirring, 85 DEG C of waters bath with thermostatic control
8min removes the ethyl alcohol in solution, is cooled to room temperature, and aqueous surfactant solution is made.
(2) epsilon-polylysine is added in the aqueous surfactant solution in (1), 45 DEG C of waters bath with thermostatic control stir evenly, make ε-
Polylysine is completely dissolved.
(3) glycerine, borneol, 45 DEG C of waters bath with thermostatic control, 300r/min stirrings 2min are added in in (2).
(4) pH value for adding in sodium lactate regulating step (3) is 5.
(5) solution obtained (5) is subjected to sterilization treatment.
Embodiment 3
It weighs：Epsilon-polylysine 5g, sodium hyaluronate 15g, lecithin 0.2g, borneol 1.5g, vitamin E 0.09g, pure water
100mL。
(1) lecithin, vitamin E are dissolved in absolute ethyl alcohol, alcoholic solution is poured into pure water stirring, 90 DEG C of waters bath with thermostatic control
10min removes the ethyl alcohol in solution, is cooled to room temperature, and aqueous surfactant solution is made.
(2) by epsilon-polylysine, add in the aqueous surfactant solution in (1), 50 DEG C of waters bath with thermostatic control stir evenly, make ε-
Polylysine is completely dissolved.
(3) sodium hyaluronate, borneol, 50 DEG C of waters bath with thermostatic control, 400r/min stirrings 3min are added in in (2).
(4) pH value for adding in lactic acid regulating step (3) is 5.5.
(5) solution obtained (3) is subjected to sterilization treatment.
Bacteriostatic experiment
1 experiment material
The vulva washing lotion containing epsilon-polylysine being prepared by example 1, example 2, example 3.
2 supply the preparation of examination bacterium
In the superclean bench of desinfection chamber, respectively by Candida albicans, staphylococcus aureus, Escherichia coli and green pus
Bacillus is seeded in beef extract culture solution, and routine culture is carried out at 28-30 DEG C.
3 experimental methods
Diffusion method is punched using agar, sterile petri dish will be poured into after the beef extract medium sterilization processing added with agar
In, after its solidification 100 μ L Candida albicans, staphylococcus aureus, Escherichia coli and green pus bar are drawn with Sterile pipette
Bacterium is added to for examination bacterium on culture dish, and coating is uniform, and each strain does three groups.After coating, with the sterilizing stainless steel of outer diameter 2mm
Card punch punches on culture medium.With micro sample adding appliance difference extraction embodiment 1, embodiment 2, embodiment 3 containing ε-poly- bad ammonia
In the 50 μ L injection holes of pudendum-cleaning lotion of acid, blank control group injects 50 μ L sterile waters, is then respectively placed at 30 DEG C and cultivates for 24 hours,
Antibacterial circle diameter (bacteriostatic diameter mm meters) is measured, using 3 average values as antibacterial circle diameter.It the results are shown in Table 1.
The fungistatic effect of vulva washing lotion of the table 1 containing epsilon-polylysine
As shown in Table 1, the fungistatic effect of the vulva washing lotion containing epsilon-polylysine of embodiment 3 is best.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although with reference to aforementioned reality
Example is applied the present invention is described in detail, it for those skilled in the art, still can be to aforementioned each implementation
Technical solution recorded in example modifies or carries out equivalent replacement to which part technical characteristic.All essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (7)
1. a kind of vulva washing lotion containing polylysine, which is characterized in that the vulva washing lotion by following weight percent raw material
It is made：
Epsilon-polylysine 0.1-5wt%, moisturizing lubricant 2-15wt%, surfactant 0.1-0.2wt%, borneol 0.5-
1.5wt%, vitamin E 0.05-0.09wt%, surplus are pure water；The pH value of the vulva washing lotion is 4.5-5.5.
2. the vulva washing lotion according to claim 1 containing polylysine, which is characterized in that the moisturizing lubricant includes third
Glycol, glycerine and/or sodium hyaluronate.
3. the vulva washing lotion according to claim 1 containing polylysine, which is characterized in that the surfactant includes ten
Dialkyl benzene sulfonic acids sodium, sophorolipid and/or lecithin.
4. the vulva washing lotion according to claim 1 containing polylysine, which is characterized in that adjusted with lactic acid or sodium lactate outer
The pH value of cloudy washing lotion is 4.5-5.5.
5. the preparation method of vulva washing lotion of the claim 1-4 any one of them containing polylysine, which is characterized in that the side
Method includes the following steps：
(1) by surfactant is molten, vitamin E is dissolved in absolute ethyl alcohol, alcoholic solution is poured into pure water stirring, is removed in solution
Ethyl alcohol is cooled to room temperature, and obtains aqueous surfactant solution；
(2) epsilon-polylysine is added in step (1) obtained aqueous surfactant solution, is stirred evenly at 40-50 DEG C, make ε-
Polylysine is completely dissolved；
(3) moisturizing lubricant, borneol are added in into the mixed liquor that step (2) obtains, is stirred at 40-50 DEG C；
(4) with the mixed liquor pH value that lactic acid or sodium lactate regulating step (3) obtain to 4.5-5.5, sterilize to get.
6. the preparation method of the vulva washing lotion according to claim 5 containing polylysine, which is characterized in that the step
(1) in, the minimizing technology of ethyl alcohol heats 6-10min for 80-90 DEG C of water bath with thermostatic control in solution.
7. the preparation method of the vulva washing lotion according to claim 5 containing polylysine, which is characterized in that the step
(3) in, the rate of the stirring is 200-400r/min, time 1-3min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810046116.7A CN108186404A (en) | 2018-01-17 | 2018-01-17 | A kind of vulva washing lotion containing polylysine and preparation method thereof |
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| CN201810046116.7A CN108186404A (en) | 2018-01-17 | 2018-01-17 | A kind of vulva washing lotion containing polylysine and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695598A (en) * | 2004-05-11 | 2005-11-16 | 北京花安适女性保健科技有限公司 | Nursing liquid for females and preparation method |
| CN102028705A (en) * | 2010-11-01 | 2011-04-27 | 西藏贝珠雅药业有限公司 | Gynecologic article containing biological antifungal components |
-
2018
- 2018-01-17 CN CN201810046116.7A patent/CN108186404A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695598A (en) * | 2004-05-11 | 2005-11-16 | 北京花安适女性保健科技有限公司 | Nursing liquid for females and preparation method |
| CN102028705A (en) * | 2010-11-01 | 2011-04-27 | 西藏贝珠雅药业有限公司 | Gynecologic article containing biological antifungal components |
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