CN108126117A - 一种治疗脑梗塞的中药组合物 - Google Patents
一种治疗脑梗塞的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种治疗脑梗塞的中药组合物,其包括下述重量份数的中药原料:黄芪、益母草、豨莶草、地龙、当归、威灵仙、牛膝、蒺藜、白附子、僵蚕、赤芍、红花、桃仁、桂枝、桑枝、胆星、川芎、丹参、全蝎、穿山甲、天麻、九节菖蒲、大黄、防风、冬瓜子、木莲果和水蛭。本发明中的中药组合物按照一定的配比配伍组方,各组分通过相互协同,发挥奇效,具有活血化瘀、通经通络、行气止痛之功效,能有效的抑制脑组织缺血、缺氧、坏死等神经功能障碍,对由脑梗塞及其后遗症引起的头晕重压感、口眼歪斜、口角流涎、语言欠清和一侧上下肢活动受限等症状具有很好的治疗效果,且治愈后无遗留症状。本发明中采用的中药几乎不会产生任何副作用,安全可靠。
Description
技术领域
本发明属于中药技术领域,具体涉及一种治疗脑梗塞的中药组合物。
背景技术
脑梗塞是由于脑动脉粥样硬化,血管内膜损伤使脑动脉管腔狭窄,进而因多种因素使局部血栓形成,使动脉狭窄加重或完全闭塞,导致脑组织缺血、缺氧、坏死,引起神经功能障碍的一种脑血管病。脑梗塞是中老年人群中的常见病、多发病,是临床比较常见的心脑血管疾病,主要临床特征是语言障碍、偏瘫等神经性综合症。具有较高的致残率,严重影响患者的肢体运动功能。由于脑梗塞的发生,脑组织氧耗和血流供氧之间的平衡被打破,引起脑组织的缺血缺氧现象,导致脑组织死亡。同时,由于在无氧环境下脑组织对于葡萄糖的无氧分解,造成血浆、脑组织和脑脊液中的乳酸水平增高,进一步造成了脑组织的损伤,且容易引发脑水肿。脑梗塞具有发病率高、预后差的特点。
随着社会老龄化的进一步加剧,此类疾病的发病率逐年上升,并有发病年龄下降的趋势。目前,治疗脑梗塞的药物主要是西药,西药具有起效快、治疗针对性强等优点,但是大多数西药都会产生不同程度的耐药性、副作用明显,不适宜中老年脑梗塞患者长期服用防止复发的长效性治疗。因此研制治疗效果好且副作用小的中药组合物就具有重要的意义。
发明内容
本发明的目的在于提供一种疗效好且副作用小的治疗脑梗塞的中药组合物。
为达到上述技术目的,本发明的技术方案提供一种治疗脑梗塞的中药组合物,其包括下述重量份数的中药原料:
黄芪50~500份、益母草20~200份、豨莶草20~200份、地龙15~150份、当归12~120份、威灵仙12~120份、牛膝12~120份、蒺藜12~120份、白附子10~100份、僵蚕10~100份、赤芍10~100份、红花10~100份、桃仁10~100份、桂枝10~100份、桑枝10~100份、胆星10~100份、川芎10~100份、丹参10~100份、全蝎10~100份、穿山甲10~100份、天麻10~100份、九节菖蒲10~100份、大黄10~100份、防风8~80份、冬瓜子8~80份、木莲果6~60份、炒水蛭6-60份。
与现有技术相比,本发明的有益效果包括:本技术方案中的中药组合物是依据脑梗塞的形成特点研制而成,重用黄芪、益母草、当归益气养血,气引则血行;辅以豨莶草、威灵仙、全蝎、穿山甲和天麻祛风除湿,通络止痛;地龙、赤芍、红花、桃仁、丹参、川芎、大黄以及水蛭活血祛瘀通络;白附子、僵蚕和防风能祛风牵正颜面;牛膝、桂枝和桑枝,引血下行,强筋骨,行经活络达四肢;蒺藜、胆星、九节菖蒲、冬瓜子及木莲果,平肝化痰开窍;这25味药按照一定的配比配伍组方,各组分通过相互协同,发挥奇效,具有活血化瘀、通经通络、行气止痛之功效,能有效的抑制脑组织缺血、缺氧、坏死等神经功能障碍,对由脑梗塞及其后遗症引起的头晕重压感、口眼歪斜、口角流涎、语言欠清、一侧上下肢活动受限和无力瘫软麻木等症状具有很好的治疗效果,且治愈后无遗留症状。本技术方案中采用的中药几乎均对人体无害,几乎不会产生任何副作用,安全可靠。
具体实施方式
本实施例提供了一种治疗脑梗塞的中药组合物,其包括下述重量份数的中药原料:
黄芪50~500份、益母草20~200份、豨莶草20~200份、地龙15~150份、当归12~120份、威灵仙12~120份、牛膝12~120份、蒺藜12~120份、白附子10~100份、僵蚕10~100份、赤芍10~100份、红花10~100份、桃仁10~100份、桂枝10~100份、桑枝10~100份、胆星10~100份、川芎10~100份、丹参10~100份、全蝎10~100份、穿山甲10~100份、天麻10~100份、九节菖蒲10~100份、大黄10~100份、防风8~80份、冬瓜子8~80份、木莲果6~60份、水蛭6-60份;其中僵蚕为炙僵蚕,水蛭为炒水蛭。
各原料的药理功效如下:
黄芪:性温、味甘,归肺、脾经。具有补气固表,托毒排脓,利尿,生肌之功效。用于气虚乏力、久泻脱肛、自汗、水肿、子官脱垂、慢性肾炎蛋白尿、糖尿病、疮口久不愈合。
益母草:性辛、微寒、味苦,归肝、心包、膀胱经。具有活血调经,利尿消肿,清热解毒之功效。用于***,痛经经闭,恶露不尽,水肿尿少,疮疡肿毒。
豨莶草:又名火杴草;性辛、寒、味苦,归肝、肾经。具有祛风湿,通经络,清热解毒,降血压之功效。用于风湿痹痛,肢体麻木,中风,手足不遂,痈肿疮毒,湿疹瘙痒,高血压。
地龙:性寒、味咸,归肝经、脾经、膀胱经。具有清热,平肝,止喘,通络之功效。用于高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。
当归:性辛、温、味甘,归肝、心、脾经。具有补血活血,调经止痛,润肠通便之功效。用于血虚萎黄,眩晕心悸,***,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡。
威灵仙:性温、味苦、咸,归膀胱经、肝经。具有祛风湿,通经络,消痰涎,散癖积之功效。用于治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。
牛膝:性平、味甘、苦、酸,入肝、肾经。生用散瘀血,消痈肿。熟用补肝肾,强筋骨。生用:治淋病,尿血,经闭,症瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤。熟用:治腰膝骨痛,四肢拘挛,痿痹。
蒺藜:性温、味辛、苦,归肝经。具有散风,明目,下气,行血之功效。治头痛,身痒,目赤肿翳,胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。
白附子:性温、味辛,归胃、肝经。具有祛风痰,定惊搐,解毒散结止痛之功效。用于中风痰壅,口眼歪斜,语言涩謇,痰厥头痛,偏正头痛,喉痹咽痛,破伤风;外治瘰疬痰核,毒蛇咬伤。
僵蚕:性平、味辛、咸,归肝、肺、胃经。具有祛风定惊,化痰散结之功效。用于惊风抽搐,咽喉肿痛,皮肤瘙痒,颌下***炎,面神经麻痹。
赤芍:性微寒、味苦,归肝经。具有清热凉血,活血散瘀之功效。主治热入营血,身热发斑,血热吐衄,血滞经闭,痛经,癥瘕积聚,跌打损伤,瘀滞肿痛及热毒疮疡。
红花:性温、味辛,归心、肝经。具有活血通经,散瘀止痛之功效。用于经闭,痛经,恶露不行,症瘕痞块,跌扑损伤,疮疡肿痛。
桃仁:性平、味甘、苦,归心、肝、大肠经。具有活血祛瘀,润肠通便,止咳平喘之功效。用于经闭痛经,瘕瘕痞块,肺痈肠痈,跌扑损伤,肠燥便秘,咳嗽气喘。
桂枝:性温、味辛、甘,归心、肺、膀胱经。具有发汗解肌,温通经脉,助阳化气,平冲降气之功效。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
桑枝:性平、味苦,归肝经。具有祛风湿,利关节,行水气。治风寒湿痹,四肢拘挛,脚气浮肿,肌体风痒。
胆星:性凉、味辛、苦,归肝、胆、肺经。具有清火化痰,熄风定惊之功效。主治中风,惊风,癫痫,头痛,眩晕,喘嗽。
川芎:性温、味辛,归肝经、胆经、心包经。具有行气开郁,祛风燥湿,活血止痛之功效。治风冷头痛旋晕,难产,产后瘀阻块痛,痈疽疮疡,***,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,风湿痹痛。
丹参:性寒、味苦,归心、肝经。具有祛瘀止痛,活血通经,清心除烦之功效。用于***,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠,肝脾肿大,心绞痛。
全蝎:性平、味辛,归肝经。具有息风镇痉,攻毒散结,通络止痛之功效。用于小儿惊风,抽搐痉挛,中风口歪,半身不遂,破伤风,风湿顽痹,偏正头痛,疮疡,瘰疬。
穿山甲:性凉、味咸,入肝经、胃经。具有消肿溃痈,搜风活络,通经下乳之功效。治痈疽疮种,风寒湿痹,月经停闭,乳汁不通,外用止血。
天麻:性平、味甘,归肝经。具有息风、定惊之功效。治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊痫动风。
九节菖蒲:性温、味辛,归心、肝、脾经。具有化痰开窍,安神,宣湿醒脾,解毒之功效。主热病神昏,癫痫,气闭耳聋,多梦健忘,胸闷腹胀,食欲不振,风湿痹痛,痈疽,疥癣。
大黄:性寒、味苦,归脾、胃、大肠、肝、心包经。具有泻热毒,破积滞,行瘀血之功效。治实热便秘,谵语发托,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲亦,痈疡肿毒,疔疮,汤火伤。
防风:性温、味辛、甘,归膀胱、肝、脾经。具有解表祛风,胜湿,止痉之功效。用于感冒头痛,风湿痹痛,风疹瘙痒,破伤风。
冬瓜子:性寒,味甘,归肺、大肠经。具有润肺,化痰,消痈,利水之功效。治痰热咳嗽,肺痈,肠痈,淋病,水肿,脚气,痔疮,鼻面酒皶。
木莲果:性凉,味辛,归肺,大肠经。具有通便,止咳之功效。主治实热便闭;老人干咳。
水蛭:性平、味苦、咸,归肝经。具有破血、逐瘀、通经之功效。治蓄血,癥瘕,积聚,妇女经闭,干血成痨,跌扑损伤,目亦痛,云翳。
本实施例提供的治疗脑梗塞的中药组合物可与药学上可接受的载体结合,制备成常规制剂,例如:胶囊剂、口服液、散剂或颗粒剂,优选为制成水丸或蜜丸服用。
将上述中药组合物制成水丸或蜜丸的具体方法如下:
(1)按照各药物组分的配比称取各个组分;
(2)将步骤(1)中的僵蚕、全蝎、水蛭炒干后备用,同时将其他药材烘干后备用;
(3)将步骤(2)中所有药材研磨成药粉,加冷开水或者蜂蜜制成水丸或者蜜丸,然后烘干,即得脑梗丸。
用法用量:口服,每日3次,早中晚各1次,每次9g,饭后温开水送服;1个月为1个疗程,轻者服用1个疗程,重者服用2个疗程,症状基本痊愈。可再用2个疗程巩固治疗,无后遗症状。
在服药期间禁忌:禁食烟酒辛热发性之物。
下面将结合具体实施例对本发明提供的治疗脑梗塞的中药组合物予以进一步说明。下面描述的实施例是示例性的,仅用于解释本发明,而不能理解为对本发明的限制。
实施例1:
本实施例提供的治疗脑梗塞的中药组合物的原料组成及重量为:
黄芪250g、益母草100g、豨莶草100g、地龙75g、当归60g、威灵仙60g、牛膝60g、蒺藜60g、白附子50g、僵蚕50g、赤芍50g、红花50g、桃仁50g、桂枝50g、桑枝50g、胆星50g、川芎50g、丹参50g、全蝎50g、穿山甲50g、天麻50g、九节菖蒲50g、大黄50g、防风40g、冬瓜子40g、木莲果30g、水蛭30g。
将上述中药组合物制成水丸或蜜丸的具体方法如下:
(1)按照各药材的重量称取各种药材,备用;
(2)将步骤(1)中的僵蚕、全蝎、水蛭炒后,并将其他药材烘干后备用;
(3)将步骤(2)中所有药材研磨成药粉,加冷开水或者蜂蜜制成水丸或者蜜丸,然后烘干,即得脑梗丸。
实施例2:
本实施例提供的治疗脑梗塞的中药组合物的原料组成及重量为:
黄芪200g、益母草80g、豨莶草80g、地龙65g、当归48g、威灵仙48g、牛膝45g、蒺藜48g、白附子40g、僵蚕40g、赤芍40g、红花40g、桃仁45g、桂枝40g、桑枝40g、胆星40g、川芎40g、丹参40g、全蝎40g、穿山甲40g、天麻40g、九节菖蒲40g、大黄40g、防风25g、冬瓜子25g、木莲果18g、炒水蛭18g。
本实施例中的脑梗丸的制备方法工艺步骤与实施例1相同。
实施例3:
本实施例提供的治疗脑梗塞的中药组合物的原料组成及重量为:
黄芪300g、益母草140g、豨莶草140g、地龙100g、当归84g、威灵仙84g、牛膝72g、蒺藜72g、白附子70g、僵蚕70g、赤芍65g、红花65g、桃仁65g、桂枝60g、桑枝60g、胆星55g、川芎55g、丹参55g、全蝎55g、穿山甲55g、天麻55g、九节菖蒲55g、大黄55g、防风45g、冬瓜子45g、木莲果36g、炒水蛭36g。
本实施例中的脑梗丸的制备方法工艺步骤与实施例1相同。
实施例4:
本实施例提供的治疗脑梗塞的中药组合物的原料组成及重量为:
黄芪500g、益母草20g、豨莶草200g、地龙150g、当归12g、威灵仙120g、牛膝120g、蒺藜120g、白附子10g、僵蚕100g、赤芍100g、红花100g、桃仁10g、桂枝100g、桑枝100g、胆星100g、川芎100g、丹参100g、全蝎100g、穿山甲100g、天麻100g、九节菖蒲100g、大黄100g、防风80g、冬瓜子8g、木莲果60g、炒水蛭60g。
本实施例中的脑梗丸的制备方法工艺步骤与实施例1相同。
实施例5:
本实施例提供的治疗脑梗塞的中药组合物的原料组成及重量为:
黄芪50g、益母草200g、豨莶草20g、地龙15g、当归120g、威灵仙12g、牛膝12g、蒺藜12g、白附子100g、僵蚕10g、赤芍10g、红花10g、桃仁100g、桂枝10g、桑枝10g、胆星10g、川芎10g、丹参10g、全蝎10g、穿山甲10g、天麻10g、九节菖蒲10g、大黄10g、防风8g、冬瓜子80g、木莲果6g、炒水蛭6g。
本实施例中的脑梗丸的制备方法工艺步骤与实施例1相同。
临床研究
1、病例资料:选择诊断为脑梗塞的患者180例作为研究对象,研究设计采用分层随机分配,以年龄、性别、病情程度为分层因素,然后将入选的病人随机分为治疗1组、治疗2组、治疗3组、治疗4组、治疗5组、对照组。
治疗1组30例,其中,男18例,女12例,平均年龄58岁;轻度2例,中度23例,重度5例;
治疗2组30例,男16例,女14例,平均年龄57岁;轻度3例,中度23例,重度4例;
治疗3组30例,男15例,女15例,平均年龄58岁;轻度3例,中度24例,重度3例;
治疗4组30例,男17例,女13例,平均年龄57.5岁;轻度2例,中度25例,重度3例;
治疗5组30例,男18例,女12例,平均年龄56岁;轻度6例,中度20例,重度4例;
对照组30例,男15例,女15例,平均年龄58岁;轻度3例,中度25例,重度2例;
6组病例在性别、年龄、病程、病情程度以及其他临床特点经统计学分析,无显著差异,具有可比性。
2、治疗方法:
治疗组:治疗1~5组依次口服本发明实施例1~4的脑梗丸,每日3次,早中晚各1次,每次9g,饭后温开水送服;1个月为1个疗程。
对照组:给予常规治疗,根据病情调控血压,控制血糖,静脉溶栓,抗血小板,降纤,以及并发症处理和支持治疗,有球麻痹者给予鼻饲;同时配合神经功能康复训练和针灸理疗等,1个月为1个疗程。
观察项目:对头晕重压感,口眼歪斜,口角流涎,语言欠清,一侧上下肢活动受限,无力瘫软麻木等症状进行观察。
临床观察2个疗程后统计治疗结果。同时配合健康教育,控制饮食,指导患者早期康复锻练。
3、疗效判定:
治愈:上述症状全部消失,检查正常。
好转:上述症状减轻,机体功能有所恢复,检查改善或正常。
无效:上述症状及机体功能均无改善。
4、治疗效果
经过2个疗程的临床观察治疗后,治疗结果见表1。
表1治疗组的对照组疗效比较
组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
对照组 | 30 | 15 | 8 | 7 | 0 | 76.67% |
治疗1组 | 30 | 25 | 4 | 1 | 0 | 96.67% |
治疗2组 | 30 | 22 | 5 | 3 | 0 | 90% |
治疗3组 | 30 | 22 | 6 | 2 | 0 | 93.33% |
治疗4组 | 30 | 24 | 2 | 4 | 0 | 86.67% |
治疗5组 | 30 | 22 | 4 | 4 | 0 | 86.67% |
由表1可以看出,经过2个疗程的治疗后,治疗组的总有效率高达86.67%,最高可达到96.67%,而对照组的总有效率为76.67%,说明治疗组的总有效率明显优于对照组。另外,由表1也可以看出,本发明制得的药物能够安全有效治疗脑梗塞,且其中治疗1组的效果最好,治疗2和3组的效果次之,治疗4和5组的效果相比治疗1~3组的效果稍差一些。
上所述本发明的具体实施方式,并不构成对本发明保护范围的限定。任何根据本发明的技术构思所做出的各种其他相应的改变与变形,均应包含在本发明权利要求的保护范围内。
Claims (5)
1.一种治疗脑梗塞的中药组合物,其特征在于,其包括下述重量份数的中药原料:黄芪50~500份、益母草20~200份、豨莶草20~200份、地龙15~150份、当归12~120份、威灵仙12~120份、牛膝12~120份、蒺藜12~120份、白附子10~100份、僵蚕10~100份、赤芍10~100份、红花10~100份、桃仁10~100份、桂枝10~100份、桑枝10~100份、胆星10~100份、川芎10~100份、丹参10~100份、全蝎10~100份、穿山甲10~100份、天麻10~100份、九节菖蒲10~100份、大黄10~100份、防风8~80份、冬瓜子8~80份、木莲果6~60份、水蛭6~60份。
2.根据权利要求1所述的治疗脑梗塞的中药组合物,其特征在于,所述中药组合物包括下述重量份数的中药原料:黄芪200~300份、益母草80~140份、豨莶草80~140份、地龙65~100份、当归48~84份、威灵仙48~84份、牛膝45~72份、蒺藜48~72份、白附子40~70份、僵蚕40~70份、赤芍40~65份、红花40~65份、桃仁45~65份、桂枝40~60份、桑枝40~60份、胆星40~55份、川芎40~55份、丹参40~55份、全蝎40~55份、穿山甲40~55份、天麻40~55份、九节菖蒲40~55份、大黄40~55份、防风25~45份、冬瓜子25~45份、木莲果18~36份、水蛭18~36份。
3.根据权利要求1所述的治疗脑梗塞的中药组合物,其特征在于,所述中药组合物包括下述重量份数的中药原料:黄芪250g、益母草100g、豨莶草100g、地龙75g、当归60g、威灵仙60g、牛膝60g、蒺藜60g、白附子50g、僵蚕50g、赤芍50g、红花50g、桃仁50g、桂枝50g、桑枝50g、胆星50g、川芎50g、丹参50g、全蝎50g、穿山甲50g、天麻50g、九节菖蒲50g、大黄50g、防风40g、冬瓜子40g、木莲果30g、水蛭30g。
4.根据权利要求1~3任一项所述的治疗脑梗塞的中药组合物,其特征在于,所述中药组合物可与载体结合制备成丸剂、胶囊剂、口服液、散剂或颗粒剂。
5.根据权利要求4所述的治疗脑梗塞的中药组合物,其特征在于,所述中药组合物用水或者蜂蜜制成水丸或蜜丸服用。
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