CN108096422A - A kind of Chinese medicine composition for treating senile dementia and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating senile dementia and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of special effect Chinese composition for treating senile dementia and preparation method thereof, 15 30 parts of 25 parts of ginseng, the fruit of Chinese wolfberry that the Chinese medicine composition contains following parts by weight, 12 15 parts of mulberry fruit, 10 15 parts of prepared rhizome of rehmannia, 10 20 parts of dogwood fruit, 15 30 parts of RHIIZOMA DIOSCOREAE from Henan of China, 5 10 parts of grass-leaved sweetflag, 5 10 parts of Radix Polygalae, 5 10 parts of Rhizoma Chuanxiong, obtain 15 kinds of compositions such as 15 20 parts of a kind of reed mentioned in ancient books, 10 12 parts of rhizoma alismatis, 10 15 parts of evodia rutaecarpa, 10 20 parts of the fleece-flower root, 5 15 parts of safflower at 25 parts of Radix Astragali.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating senile dementia and its preparation side
Method.
Background technology
Senile dementia or senile A Ercihai Summerside sick (Alzheimer ' s disease, AD) are worldwide old age
The common disease of people, the clinical manifestation of AD is chronic brain syndrome, main characterized by hypomnesia, cognitive disorder, personality denaturation
Pathology is that atrophy of cerebral cortex, nerve cell and cynapse are lost, and extracellular senile plaque expelling, characteristic intracellular neurofibrillary tangle
And cerebrovascular amyloidosis；Diseased region is distributed mainly on hippocampus, amygdaloid nucleus, cortex etc. and intelligence, the relevant key of learning and memory
Position.The pathogenesis of AD is unclear, it is now recognized that with neurotransmitter disorder, gene mutation, radical damage, nerve cell
Apoptosis, amyloid-beta deposition and tau protein abnormal phosphorylation etc. are related.
The drug for the treatment of senile dementia AD mainly has (1) acetylcholine enzyme inhibitor (Acetyl at present
cholinesterase inhibitors,AChEIs)；(2) nmda antagonist；(3) other Semagacestat
(LY450139), ACC-001 etc..Curative effect is shown in generally.The human monoclonal antibodies developed at present are primarily to remove intracerebral
Amyloid-beta, although prevention even reverses the process of Alzheimer disease.But it finds dangerous, exists very after experiment
Big side effect.
With going deep into for scientific research, it is increasingly recognised that senile dementia can not be solved with doctor trained in Western medicine prescription target spot theory
The problem of disease, the most erious adverse reaction of doctor trained in Western medicine, somewhat expensive, social economical burden are big.More more targets of composition multipath of traditional Chinese medicine
The complex treatment of point has obvious experience and advantage (Gao et al, 2013).It is insane in senile dementia category traditional Chinese medicine
Mad and dull-witted scope.The traditional Chinese medical science thinks that this disease is caused by vital essence loss, YANG-orifices failing to be nourished or visceral dysfunction.Traditional Chinese medicine is pre-
Anti- treatment senile dementia has deep history, and the differential diagnosis in tcm of senile dementia is analyzed, then shows as two aspects of actual situation.
Void is mainly kidney deficiency and deficiency of qi and blood, and real is mainly hemostasis, convulsive seizure due to phlegm-fire.
Chinese patent CN105561108A, CN101797351A and CN97117052.5 etc. disclose different several control
The pharmaceutical composition of senile dementia is treated, the component of these compositions has rhodiola root, akebi, the fleece-flower root, Herba Epimedii, ginseng, stone
Various peroral dosage forms are made in calamus, pueraria lobata, Rhizoma Chuanxiong etc..Chinese patent CN200510002971.0, which is disclosed, a kind of treats old age
The Chinese medicine preparation of dementia, it contains the Chinese medicine material of following weight：20-40 parts of prepared fleece flower root, 20-30 parts of lotus leaf,
10-25 parts of Herba Cistanches, 10-25 parts of earthworm, 5-20 parts of Radix Rhapontici seu Radix Echinopsis, preparation method is processed into clear cream including prepared fleece flower root；Lotus leaf, meat desert
Rong, Radix Rhapontici seu Radix Echinopsis decoct extraction and clear cream are made；Dry cream is made in the two merging, and earthworm processing is made dry cream and merges again with foregoing dry cream, system
Into finished product.Chinese patent CN02112711.5 discloses a kind of group for the prevention senile dementia being made of Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis
Close object.The Chinese herbal product of above-mentioned treatment senile dementia is focused on adjusting too much, and relative reduction plays the drug of therapeutic effect
Proportion affects pharmic function performance, so effect is slow, the course for the treatment of is long, and effect is less preferable.
The content of the invention
The object of the present invention is to provide a kind of Chinese medicine compositions for treating senile dementia.
It is a further object of the present invention to provide a kind of preparation methods for treating senile dementia Chinese medicine composition.
A kind of Chinese medicine composition for being used to treat senile dementia, the Chinese medicine composition component include (Unit Weight part)：
2-8 parts of ginseng, 10-30 parts of the fruit of Chinese wolfberry, 5-15 parts of mulberry fruit, 2-15 parts of Radix Astragali, 5-15 parts of prepared rhizome of rehmannia, 10-20 parts of dogwood fruit, Huai Shan
15-30 parts of medicine, 5-20 parts of grass-leaved sweetflag, 5-15 parts of Rhizoma Chuanxiong, obtain 10-20 parts of a kind of reed mentioned in ancient books, 5-20 parts of rhizoma alismatis, evodia rutaecarpa 5- at 5-15 parts of Radix Polygalae
20 parts, 10-20 parts of the fleece-flower root, 5-15 parts of safflower.
Preferably, the Chinese medicine composition component includes：2-5 parts of ginseng, 15-30 parts of the fruit of Chinese wolfberry, 12-15 parts of mulberry fruit, Huang
2-5 parts of stilbene, 10-15 parts of prepared rhizome of rehmannia, 10-20 parts of dogwood fruit, 15-30 parts of RHIIZOMA DIOSCOREAE from Henan of China, 5-10 parts of grass-leaved sweetflag, 5-10 parts of Radix Polygalae, river
5-10 parts of rhizome of chuanxiong obtains 15-20 parts of a kind of reed mentioned in ancient books, 10-12 parts of rhizoma alismatis, 10-15 parts of evodia rutaecarpa, 10-20 parts of the fleece-flower root, 5-15 parts of safflower.
The Chinese medicine composition preparation method of the present invention is as follows including step：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is crushed, puts in supercritical extract device and extracts by fluid of carbon dioxide
It takes, extract is spare；
2) Radix Astragali is taken, is added water to cook, filters, is concentrated to give concentrate 1；
3) dogwood fruit, Radix Polygalae is taken to add water to cook filtering, filtrate concentration adds ethyl alcohol that alcohol content is made to be filtered, filter up to 65~75%
Ethyl alcohol is recovered under reduced pressure in liquid, and the concentrate 2 for being concentrated into relative density 1.05~1.10 is spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, crushes, adds ethyl alcohol, is impregnated, diacolation, percolate is collected, ethyl alcohol is recovered under reduced pressure, is concentrated into
The concentrate 3 of relative density 1.05~1.10, it is spare；
5) step 2) concentrate 1, step 3) concentrate 2 and step 4) concentrate 3 are taken, mixes, is concentrated into relative density
1.30~1.35 medicinal extract is put in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, spare；
6) step 5) extract powder is taken, adds in the mixing of step 1) extract, grinding is uniform, obtains the Chinese traditional medicine composition of the present invention
Object.
Preferably, in the step 1) in supercritical extract device using carbon dioxide as fluid extraction 4~6 it is small when.
Preferably, supercritical extract device extraction conditions is 20~30Mpa of extraction pressure, Extracting temperature 40 in the step 1)
~50 DEG C.
Preferably, it is to decoct 2~3 times with 8~10 times of water that water described in the step 2), which decocts, every time 1.5~2 it is small when.
Preferably, water described in the step 3) decoct for plus 8~10 times of water decoct 2~3 times, every time 1.5~2 it is small when.
Preferably, in the step 3) plus ethyl alcohol makes the volume content of alcohol up to 65~75%.
Preferably, ethyl alcohol is added in the step 4) to add the ethyl alcohol that the volume content of 10~15 times of volumes is 65~75%
Aqueous solution.
Preferably, when dip time described in the step 4) is 18~30 small.
The density of concentrate and medicinal extract is measured in temperature for 60~65 DEG C.
Ethanol content is volume by volume (v/v) content in the present invention, such as 65~75% ethyl alcohol are that ethyl alcohol volume accounts for
The ethanol-water solution of 65-75%.
Add ethyl alcohol make alcohol content up to 65~75% be refer to after ethyl alcohol is added in, ethyl alcohol volume accounts for 65~75% in feed liquid.
Wherein present invention additionally comprises include effective active composition of the present composition as other drugs or health products
The pharmaceutical composition being prepared, it is 0.1-99.9% that active ingredient, which accounts for weight percent, remaining is pharmaceutically acceptable load
Body.
Certain preparation can be made with reference to various carriers such as excipients or adjuvant in the composition of the present invention, preferably oral
Preparation, such as capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, paste
Excipient of the present invention, such as adhesive, filler, diluent, tablet agent, lubricant, disintegrant, coloring
Agent, flavoring agent and wetting agent if necessary can be coated tablet.
Applicable filler includes cellulose, mannitol, lactose and other similar fillers.Suitable disintegrant bag
Include starch, polyvinylpyrrolidone and starch derivatives, such as sodium starch glycollate.Suitable lubricant includes, such as firmly
Fatty acid magnesium.Suitable pharmaceutically acceptable wetting agent includes lauryl sodium sulfate.
Can solid oral composition be prepared by common methods such as mixing, filling, tablettings.Work can be made by carrying out mixing repeatedly
Property substance be distributed in entirely using a large amount of fillers those compositions in.
Chinese medicine composition of the present invention is according to the empirical studies achievement of forefathers, just simultaneous according to Chinese medicine heresy
Care for, benefiting qi and removing blood stasis, kidney-tonifying and brain tonic principle research and development screening, research and development drug it is at low cost, it is evident in efficacy, do not produce any toxic side effects.
Chinese medicine composition of the present invention is controlled to support and is combined into principle based on controlling, and has reasonable recipe, compatibility simplifies,
Curative for effect, the advantages for the treatment of both principal and secondary aspect of disease, be conducive to efficient absorption of the human body to drug, for it is weakness of the spleen and the stomach, be busy with one's work, spare oneself
The crowd of medicine provides multiple choices.
Radix Astragali temperature spleen, warm kidney, solid and gas in Traditional Chinese medicine composition formula of the present invention；Evodia rutaecarpa is tonified the liver and kidney, and puckery essence is solid
It is de-；Radix Polygalae, grass-leaved sweetflag inducing resuscitation intelligence development, slit phlegm of having one's ideas straightened out；Rhizoma alismatis promoting qi circulation and removing obstruction in the collateral；Fleece-flower root qualcomm meridian, profit blood vessels；The fruit of Chinese wolfberry, safflower
Anti-aging, anti anoxia.More than Chinese medicine through scientific composition to patients of senile dementia good effect, suitable for 50 years old or more patient.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all
Belong to the scope of protection of the invention.
Embodiment 1
Ginseng 3g, fruit of Chinese wolfberry 15g, mulberry fruit 12g, Radix Astragali 3g, prepared rhizome of rehmannia 10g, dogwood fruit 10g, RHIIZOMA DIOSCOREAE from Henan of China 15g, grass-leaved sweetflag
5g, Radix Polygalae 5g, Rhizoma Chuanxiong 5g, a kind of reed mentioned in ancient books 15g, rhizoma alismatis 10g, evodia rutaecarpa 10g, fleece-flower root 10g, safflower 5g are obtained.
More than weight medicinal material is weighed, prepares Chinese medicine composition of the present invention in accordance with the following methods：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is ground into coarse powder, is put in supercritical extract device using carbon dioxide as stream
When body extraction 4~6 is small, extract is spare, and supercritical extract device extraction conditions is 20~30Mpa of extraction pressure, Extracting temperature 40
~50 DEG C, 4~6hr of extraction time；
2) take Radix Astragali that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering, filtrate concentration
It is spare to 1.05~1.10 concentrate of relative density；
3) take dogwood fruit, Radix Polygalae that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering,
Filtrate concentrates, and adds ethyl alcohol that alcohol content is made to be stood, filtration, decompression filtrate recycling ethanol is concentrated into relative density up to 65~75%
1.05~1.10 concentrates, it is spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, is ground into coarse powder, adds 10~15 times of 65~75% ethyl alcohol, when dipping 18~30 is small after, into
Row diacolation, collect percolate, ethyl alcohol is recovered under reduced pressure, is concentrated into relative density 1.05~1.10, concentrate, it is spare；
5) step 2) concentrate, step 3) concentrate and step 4) concentrate are taken, mix, be concentrated into relative density 1.30~
1.35, the medicinal extract of gained is put in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, spare；
6) step 5) extract powder is taken, adds in step 1) extract, mixed grinding is uniform, obtains in senile dementia
Drug composition.
Embodiment 2
Ginseng 4g, fruit of Chinese wolfberry 20g, mulberry fruit 15g, Radix Astragali 5g, prepared rhizome of rehmannia 15g, dogwood fruit 15g, RHIIZOMA DIOSCOREAE from Henan of China 20g, grass-leaved sweetflag
8g, Radix Polygalae 8g, Rhizoma Chuanxiong 8g, a kind of reed mentioned in ancient books 18g, rhizoma alismatis 12g, evodia rutaecarpa 12g, fleece-flower root 12g, safflower 8g are obtained.
More than weight medicinal material is weighed, prepares Chinese medicine composition of the present invention in accordance with the following methods：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is ground into coarse powder, is put in supercritical extract device using carbon dioxide as stream
When body extraction 4~6 is small, extract is spare, and supercritical extract device extraction conditions is 20~30Mpa of extraction pressure, Extracting temperature 40
~50 DEG C, 4~6hr of extraction time；
2) take Radix Astragali that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering, filtrate concentration
It is spare to the concentrate of relative density 1.05~1.10；
3) take dogwood fruit, Radix Polygalae that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering,
Filtrate concentrates, and adds ethyl alcohol that alcohol content is made to be stood, filtration, decompression filtrate recycling ethanol is concentrated into relative density up to 65~75%
1.05~1.10 concentrates, it is spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, is ground into coarse powder, adds 10~15 times of 65~75% ethyl alcohol, when dipping 18~30 is small after, into
Row diacolation, collect percolate, ethyl alcohol is recovered under reduced pressure, is concentrated into relative density 1.05~1.10, concentrate, it is spare；
5) step 2) concentrate, step 3) concentrate and step 4) concentrate are taken, mix, be concentrated into relative density 1.30~
1.35, the medicinal extract of survey is put in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, spare；
6) step 5) extract powder is taken, adds in step 1) extract, mixed grinding is uniform, obtains in senile dementia
Drug composition.
Embodiment 3
Ginseng 2g, fruit of Chinese wolfberry 30g, mulberry fruit 5g, Radix Astragali 15g, prepared rhizome of rehmannia 5g, dogwood fruit 20g, RHIIZOMA DIOSCOREAE from Henan of China 20g, grass-leaved sweetflag
10g, Radix Polygalae 8g, Rhizoma Chuanxiong 8g, a kind of reed mentioned in ancient books 18g, rhizoma alismatis 12g, evodia rutaecarpa 15g, fleece-flower root 12g, safflower 8g are obtained.
More than weight medicinal material is weighed, prepares Chinese medicine composition of the present invention in accordance with the following methods：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is ground into coarse powder, is put in supercritical extract device using carbon dioxide as stream
When body extraction 4~6 is small, extract is spare, and supercritical extract device extraction conditions is 20~30Mpa of extraction pressure, Extracting temperature 40
~50 DEG C, 4~6hr of extraction time；
2) take Radix Astragali that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering, filtrate concentration
It is spare to the concentrate of 1.05~1.10,60~65 DEG C of surveys of relative density；
3) take dogwood fruit, Radix Polygalae that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering,
Filtrate concentrates, and adds ethyl alcohol that alcohol content is made to be stood, filtration, decompression filtrate recycling ethanol is concentrated into relative density up to 65~75%
1.05~1.10, the concentrate of survey is spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, is ground into coarse powder, adds 10~15 times of 65~75% ethyl alcohol, when dipping 18~30 is small after, into
Row diacolation, collect percolate, ethyl alcohol is recovered under reduced pressure, is concentrated into relative density 1.05~1.10, concentrate, it is spare；
5) step 2) concentrate, step 3) concentrate and step 4) concentrate are taken, mix, be concentrated into relative density 1.30~
1.35, the medicinal extract of survey is put in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, spare；
6) step 5) extract powder is taken, adds in step 1) extract, mixed grinding is uniform, obtains in senile dementia
Drug composition.
Embodiment 4
Ginseng 8g, fruit of Chinese wolfberry 10g, mulberry fruit 5g, Radix Astragali 2g, prepared rhizome of rehmannia 15g, dogwood fruit 20g, RHIIZOMA DIOSCOREAE from Henan of China 20g, grass-leaved sweetflag
8g, Radix Polygalae 10g, Rhizoma Chuanxiong 10g, a kind of reed mentioned in ancient books 20g, rhizoma alismatis 20g, evodia rutaecarpa 5g, fleece-flower root 20g, safflower 15g are obtained.
More than weight medicinal material is weighed, prepares Chinese medicine composition of the present invention in accordance with the following methods：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is ground into coarse powder, is put in supercritical extract device using carbon dioxide as stream
When body extraction 4~6 is small, extract is spare, and supercritical extract device extraction conditions is 20~30Mpa of extraction pressure, Extracting temperature 40
~50 DEG C, 4~6hr of extraction time；
2) take Radix Astragali that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering, filtrate concentration
It is spare to the concentrate of 1.05~1.10,60~65 DEG C of surveys of relative density；
3) take dogwood fruit, Radix Polygalae that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering,
Filtrate concentrates, and adds ethyl alcohol that alcohol content is made to be stood, filtration, decompression filtrate recycling ethanol is concentrated into relative density up to 65~75%
1.05~1.10, the concentrate of survey is spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, is ground into coarse powder, adds 10~15 times of 65~75% ethyl alcohol, when dipping 18~30 is small after, into
Row diacolation, collect percolate, ethyl alcohol is recovered under reduced pressure, is concentrated into relative density 1.05~1.10, concentrate, it is spare；
5) step 2) concentrate, step 3) concentrate and step 4) concentrate are taken, mix, be concentrated into relative density 1.30~
1.35, the medicinal extract of survey is put in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, spare；
6) step 5) extract powder is taken, adds in step 1) extract, mixed grinding is uniform, obtains in senile dementia
Drug composition.
Embodiment 5
Ginseng 5g, fruit of Chinese wolfberry 20g, mulberry fruit 15g, Radix Astragali 5g, prepared rhizome of rehmannia 15g, dogwood fruit 15g, RHIIZOMA DIOSCOREAE from Henan of China 30g, grass-leaved sweetflag
20g, Radix Polygalae 15g, Rhizoma Chuanxiong 15g, a kind of reed mentioned in ancient books 18g, rhizoma alismatis 12g, evodia rutaecarpa 20g, fleece-flower root 12g, safflower 8g are obtained.
More than weight medicinal material is weighed, prepares Chinese medicine composition of the present invention in accordance with the following methods：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is ground into coarse powder, is put in supercritical extract device using carbon dioxide as stream
When body extraction 4~6 is small, extract is spare, and supercritical extract device extraction conditions is 20~30Mpa of extraction pressure, Extracting temperature 40
~50 DEG C, 4~6hr of extraction time；
2) take Radix Astragali that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering, filtrate concentration
It is spare to the concentrate of 1.05~1.10,60~65 DEG C of surveys of relative density；
3) take dogwood fruit, Radix Polygalae that 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when, merge Aqueous extracts, filtering,
Filtrate concentrates, and adds ethyl alcohol that alcohol content is made to be stood, filtration, decompression filtrate recycling ethanol is concentrated into relative density up to 65~75%
1.05~1.10, the concentrate of survey is spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, is ground into coarse powder, adds 10~15 times of 65~75% ethyl alcohol, when dipping 18~30 is small after, into
Row diacolation, collect percolate, ethyl alcohol is recovered under reduced pressure, is concentrated into relative density 1.05~1.10, concentrate, it is spare；
5) step 2) concentrate, step 3) concentrate and step 4) concentrate are taken, mix, be concentrated into relative density 1.30~
1.35, the medicinal extract of survey is put in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, spare；
6) step 5) extract powder is taken, adds in step 1) extract, mixed grinding is uniform, obtains in senile dementia
Drug composition.
Embodiment 6
The present invention composition and its dosage form prepare treat senile dementia in terms of on application be embodied in it is following
In test example.
Method and result
To normal mouse and SAMP8 presenility mouse Jumping test, the Y types water maze and influence for growing survival period.
Positive drug：Positive drug：Piracetam Tablet (piracetam, manufacturer：Hubei Huahzong Medicine Co., Ltd,
0.4g/ pieces, people's dosage are 4.8g/kg/d)
Experimental animal
SAMP8 presenility mouse, SAMR1 normal mouses, half male and half female, 18-22g, 7 monthly ages.
Laboratory apparatus
Electronic balance (model：AL104, Mettler-Toledo Instrument (Shanghai) Co., Ltd.)；Natural drug separation is pure
Change device (BUCHI Syncore)；Mouse diving tower instrument (XZC-5Q types, Shandong Academy of Medical Sciences's maintenance of equipment supply station)；Y type water
Labyrinth.
Data statistics
SD X ± the expressions of the data of each group, are analyzed using single factor test variance test.Divided between two groups with t inspections
Analysis.
Contrast experiment one:
The embodiment of the present invention 1 is respectively taken to obtain for senile dementia Chinese medicine composition 500mg, in the drug respectively
It adds in 20 times of distilled water and is made into stoste 1.
According to formula (thizoma curculiginis 10g, Fructus Corni 8g, fleece-flower root 10g, the Chuan Bi Collettii of ZL 201410259569.X specifications
Each raw material is mixed and made into powder by 8g, sealwort 12g, Morinda officinalis 8g, Chinese yam 8g, dipsaci,fructus 8g, Radix Salviae Miltiorrhizae 20g, the ratio of Radix Codonopsis 12g
End) Chinese medicine composition is prepared, Chinese medicine composition 500mg is taken, 20 times of distilled water is separately added into the drug and is matched somebody with somebody
Into stoste 2.
Totally 50 mouse are tested, are randomly divided into 5 groups, every group of 10 animals are respectively that (10 SAMR1 are small for Normal group
Mouse normal saline 40ml/kg gavages), drug-positive control group (0.72g/kg gavages), (SAMP8 mouse are normal for control group
Physiological saline 40ml/kg gavages), experimental group 1, experimental group 2.
Wherein experimental group 1 and 2 is respectively to use stoste 1, stoste oral administration gavage in 2 morning, and mouse is connected in a manner of oral administration gavage
Continuous administration 20 days, the dosage gavage of 40ml/kg, once a day, training in the 20th day.Drug is given when before training 1 is small.Every batch of is real
Testing each group has 1 mouse to be administered, operation repetitive, and so on.First 5 mouse are respectively put into diving tower instrument during training
In 5 grid, environment first being adapted to 3 minutes, being then electrified to, after mouse is shocked by electricity, majority jumps onto diving tower, escapes electric shock.Animal is more
Copper grid are contacted to get an electric shock using mouse biped simultaneously when number jumps off platform again, is considered as wrong reaction, training 5 minutes, and records 5 points
Electric shock number in clock, 24 it is small when after retest, record test result by observation index of incubation period and electric shock number.
Jumping test as a result,
* P compared with the control group<0.05, * * P compared with the control group<0.01
Experiment conclusion：The experimental results showed that drug-positive control group, experimental group 1 (stoste 1) and experimental group 2 (stoste 2)
Jumping test result is than control group there were significant differences (P<0.05), illustrate that the ability of learning and memory of mouse after medication improves.It is real
The Jumping test result for testing 1 (stoste 1) of group is slightly poorer but better than experimental group 2 (stoste 2) than drug-positive control group.
Contrast experiment two:
Influence to normal mouse and SAMP8 mouse aging Y type water maze laboratories
Take the preparation of the embodiment of the present invention 1 obtains the Chinese medicine composition 500mg for senile dementia, in the drug
It is separately added into 20 times of distilled water and is made into stoste 1.
According to formula (thizoma curculiginis 10g, Fructus Corni 8g, fleece-flower root 10g, the Chuan Bi Collettii of ZL 201410259569.X specifications
Each raw material is mixed and made into powder by 8g, sealwort 12g, Morinda officinalis 8g, Chinese yam 8g, dipsaci,fructus 8g, Radix Salviae Miltiorrhizae 20g, the ratio of Radix Codonopsis 12g
End) Chinese medicine composition is prepared, Chinese medicine composition 500mg is taken, 20 times of distilled water is separately added into the drug and is matched somebody with somebody
Into stoste 2.
Totally 50 mouse are tested, are randomly divided into 5 groups, every group of 10 animals are respectively that (10 SAMR1 are small for Normal group
Mouse normal saline 40ml/kg gavages), drug-positive control group (0.72g/kg gavages), (SAMP8 mouse are normal for control group
Physiological saline 40ml/kg gavages), experimental group 1, experimental group 2.
Wherein experimental group 1 and experimental group 2 are respectively to use stoste 1,2 oral administration gavage of stoste, and mouse is in a manner of oral administration gavage
Successive administration 20 days, the dosage gavage of 40ml/kg, training in the 20th day.1h proceeds by Y types water maze instruction after administration in 20 days
Practice.Mouse be placed on 27 ± 2 DEG C of water temperature, depth of water 10cm Y type water mazes in, there is platform in one side, is arrived at mouse in 15 seconds flat
Platform is correct response, rests 10 seconds after arrival platform and repeats training, every mouse is trained 10 times altogether, calculates its correct response
Rate, 24 it is small when after test its remember holding situation, 48 it is small when after test its memory consolidation situation.By 10 mouse in same group just
Final result of the average value of true reactivity as the group.
Y type water maze laboratory results
* P compared with the control group<0.05, * * P compared with the control group<0.01
Experiment conclusion：The experimental results showed that the Y of drug-positive control group, experimental group 1 (stoste 1) and experimental group 2 (stoste 2)
Type water maze laboratory result is than control group there were significant differences (P<0.05), illustrate that the ability of learning and memory of mouse after medication improves
.The Y type water maze laboratories result of experimental group 1 (stoste 1) is slightly poorer but better than experimental group 2 (stoste 2) than drug-positive control group.
Contrast experiment three:
Influence to normal mouse and SAMP8 mouse aging survival periods
Take the preparation of the embodiment of the present invention 1 obtains the Chinese medicine composition 500mg for senile dementia, in the drug
It is separately added into 20 times of distilled water and is made into stoste 1.
According to formula (thizoma curculiginis 10g, Fructus Corni 8g, fleece-flower root 10g, the Chuan Bi Collettii of ZL 201410259569.X specifications
Each raw material is mixed and made into powder by 8g, sealwort 12g, Morinda officinalis 8g, Chinese yam 8g, dipsaci,fructus 8g, Radix Salviae Miltiorrhizae 20g, the ratio of Radix Codonopsis 12g
End) Chinese medicine composition is prepared, Chinese medicine composition 500mg is taken, 20 times of distilled water is separately added into the drug and is matched somebody with somebody
Into stoste 2.
Totally 50 mouse are tested, are randomly divided into 5 groups, every group of 10 animals are respectively that (10 SAMR1 are small for Normal group
Mouse normal saline 40ml/kg gavages), drug-positive control group (0.72g/kg gavages), (SAMP8 mouse are normal for control group
Physiological saline 40ml/kg gavages), experimental group 1, experimental group 2.
Wherein experimental group 1, experimental group 2 are respectively to use stoste 1,2 oral administration gavage of stoste, and mouse is connected in a manner of oral administration gavage
Continue administration 20 days, the dosage gavage of 40ml/kg is observed after mouse is discontinued and grows to death later, after recording every mouse drug withdrawal
Growth survival period, will after the drug withdrawal of 10 mouse in same group grow survival period average value as the group final result.
Grow survival period experimental result
| Group | Growth survival period (my god) |
| Normal group (SAMR1) | 88** |
| Drug-positive compares | 59** |
| Experimental group 1 | 56** |
| Experimental group 2 | 53** |
| Control group | 43 |
* P compared with the control group<0.05, * * P compared with the control group<0.01
Experiment conclusion：The experimental results showed that drug-positive control group, experimental group 1 (stoste 1) and experimental group 2 (stoste 2)
Survival period experimental result is grown than control group there were significant differences (P<0.05), illustrate that the growth survival ability of mouse after medication improves
.The growth survival period experimental result of experimental group 1 (stoste 1) is slightly than drug-positive control group difference but than experimental group 2 (stoste 2)
It is good.
Embodiment 7
Chinese medicine composition for senile dementia prepared by Example 1 adds in equivalent starch, sucrose and stearic acid
Magnesium, granulation are packed into capsule to get capsule.
Embodiment 8
Chinese medicine composition for senile dementia prepared by Example 1, with starch, sodium carboxymethylcellulose, talcum
Powder is uniformly mixed, and granulation, tabletting is up to tablet.
Embodiment 9
Chinese medicine composition for senile dementia prepared by Example 1 with syrup 4g, is dissolved in the pure water of 100ml
In, homogeneous, filtering, by high-temperature short-time sterilization (135 DEG C, 4s).Sterile filling, packing.Oral liquid is made.
Group component in above-described embodiment and right can need to expand or shrink ratio simultaneously according to production.
Claims (10)
1. a kind of Chinese medicine composition for being used to treat senile dementia, it is characterised in that the Chinese medicine composition contains by following weight
Measure the component of part proportioning：2-8 parts of ginseng, 10-30 parts of the fruit of Chinese wolfberry, 5-15 parts of mulberry fruit, 2-15 parts of Radix Astragali, 5-15 parts of prepared rhizome of rehmannia, mountain
10-20 parts of cornus, 15-30 parts of RHIIZOMA DIOSCOREAE from Henan of China, 5-15 parts of Radix Polygalae, 5-15 parts of Rhizoma Chuanxiong, obtain 10-20 parts of a kind of reed mentioned in ancient books, rhizoma alismatis at 5-20 parts of grass-leaved sweetflag
5-20 parts, 5-20 parts of evodia rutaecarpa, 10-20 parts of the fleece-flower root, 5-15 parts of safflower.
2. Chinese medicine composition as described in claim 1, it is characterised in that weight therein is：2-5 parts of ginseng, matrimony vine
15-30 parts sub-, 12-15 parts of mulberry fruit, 2-5 parts of Radix Astragali, 10-15 parts of prepared rhizome of rehmannia, 10-20 parts of dogwood fruit, 15-30 parts of RHIIZOMA DIOSCOREAE from Henan of China, stone
5-10 parts of calamus, 5-10 parts of Radix Polygalae, obtain 15-20 parts of a kind of reed mentioned in ancient books, 10-12 parts of rhizoma alismatis, 10-15 parts of evodia rutaecarpa, the fleece-flower root at 5-10 parts of Rhizoma Chuanxiong
10-20 parts, 5-15 parts of safflower.
3. the preparation method of Chinese medicine composition described in claim 1, it is characterised in that the preparation method includes the following steps：
1) ginseng, the fruit of Chinese wolfberry, mulberry fruit, prepared rhizome of rehmannia are taken, is crushed, is put in supercritical extract device using carbon dioxide as fluid extraction, carry
Take object spare；
2) Radix Astragali is taken, is added water to cook, filters, is concentrated to give concentrate 1；
3) dogwood fruit, Radix Polygalae is taken to add water to cook filtering, filtrate concentration adds ethyl alcohol to make the volume content of containing alcohol up to 65~75%, mistake
Filter, decompression filtrate recycling ethanol, the concentrate 2 for being concentrated into relative density 1.05~1.10 are spare；
4) Rhizoma Chuanxiong, grass-leaved sweetflag are taken, crushes, adds ethyl alcohol, is impregnated, diacolation, percolate is collected, ethyl alcohol is recovered under reduced pressure, is concentrated into opposite
The concentrate 3 of density 1.05~1.10, it is spare；
5) the step 2) concentrate 1, the step 3) concentrate 2 and the step 4) concentrate 3 are taken, is mixed
It closes, is concentrated into the medicinal extract of relative density 1.30~1.35, puts in vacuum crawler formula drying machine and dry, pulverize to obtain extract powder, it is spare；
6) the step 5) extract powder is taken, adds in the mixing of the step 1) extract, grinding is uniform, obtains described
Chinese medicine composition.
4. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that supercritical extract in the step 1)
In device using carbon dioxide as fluid extraction 4~6 it is small when.
5. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that supercritical extract in the step 1)
Device extraction conditions is 20~30Mpa of extraction pressure, 40~50 DEG C of Extracting temperature.
6. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that water described in the step 2) decocts
To decoct 2~3 times with 8~10 times of water, every time 1.5~2 it is small when.
7. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that water described in the step 3) decocts
For 8~10 times of water is added to decoct 2~3 times, every time 1.5~2 it is small when.
8. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that in the step 3) plus ethyl alcohol makes alcohol
Volume content up to 65~75%.
9. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that ethyl alcohol is added in the step 4) is
The volume content for adding in 10~15 times of volumes is 65~75% ethanol water.
10. the preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that when being impregnated described in the step 4)
Between for 18~30 it is small when.
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| CN116549543A (en) * | 2023-06-12 | 2023-08-08 | 云南润苍生科技有限公司 | Compound antioxidant product containing American ginseng and preparation method and application thereof |
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