CN108096145A - A kind of delay aging drug composition and its preparation method and application - Google Patents
A kind of delay aging drug composition and its preparation method and application Download PDFInfo
- Publication number
- CN108096145A CN108096145A CN201810018765.6A CN201810018765A CN108096145A CN 108096145 A CN108096145 A CN 108096145A CN 201810018765 A CN201810018765 A CN 201810018765A CN 108096145 A CN108096145 A CN 108096145A
- Authority
- CN
- China
- Prior art keywords
- parts
- dried
- chinese medicine
- processing
- moutan bark
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of delay aging drug compositions and its preparation method and application, and the composition is mainly prepared in parts by weight by the following raw material：5~10 parts of 30~60 parts of purple sesame, 20~40 parts of moutan bark, 10~30 parts of ginseng, 5~10 parts of Radix Ophiopogonis and Schisandra chinensis；The present invention is by selecting a variety of traditional Chinese medicine ingredients with senile-resistant efficacy, compounded combination is carried out with optimal proportion according to monarch principle, each component is synergistic, improve the anti-aging effects of Chinese medicine composition, and it is processed according to the nature and flavor of different Chinese medicines, traditional extraction process is optimized, effectively improves the recovery rate of product, possesses wide prospect.
Description
Technical field
The present invention relates to cosmetic fields, relate generally to a kind of delay aging drug composition and its preparation method and application.
Background technology
Young skin mark the healthy and beautiful of people, and smooth, careful and flexible skin is that people chase jointly
Target.The aging of skin is a kind of natural law, although we cannot prevent the natural aging of skin, can pass through science
Effective measures alleviate the aging state of skin.
The traditional Chinese medical science is of long standing and well established to the research of the mechanism of aging.The traditional Chinese medical science thinks that aging belongs to Zi Ran Now as being with human five internal organs six
The hypodynamia of internal organs, from Inner to a series of variations of outer generation.These variations cause the function of human body increasingly to decline.Theory of traditional Chinese medical science
Recognize that woman is declined with yangming meridian to begin, it is aged for the external tendency for describing change with face, this is mainly due to the kidney qi cold of insufficiency type,
Caused by weakness of the spleen and the stomach, qi stagnation blood stasis, so the core of successive dynasties traditional Chinese medical science anti-aging is based on invigorating the kidney and spleen.In addition to help prescription,
Other prescriptions of selected parts, such as it is promoting blood circulation and removing blood stasis, dehumidifying resolving sputum, promoting the circulation of qi is soothing the liver, come reach it is anti-ageing preserve youthful looks, support member consolidate, macrobiosis of making light of one's life by commiting suicide
Purpose.
At present, people have begun to attempt using traditional Chinese medicine ingredients to be applied among the product of anti-aging, such as Chinese patent (Shen
Please number CN201210197127) " a kind of Chinese medicine composition with anti-senescence function and its in anti-aging cosmetics should
With ", which discloses the Chinese medicine composition and its methods for making and using same of a kind of anti-aging, and Chinese medicine composition of the invention is by Chinese holly
Qi extract, jasmine flower extract, Lotus Plumule P.E., radix-polygoni multiflori extract, Rhizoma Chuanxiong extract, forsythia suspense extraction, pipewort
Extract compounds, and has certain senile-resistant efficacy, but time-consuming for extraction process.
Such as a kind of Chinese patent (application number CN201410312669) " delay aging drug composition and its in cosmetics
Using ", which discloses the Chinese medicine composition and its methods for making and using same of a kind of anti-aging, Chinese medicine composition of the present invention
It is to be composed of mistletoe 10-50%, witch hazel 5-25%, sea-buckthorn 5-30%, wilsonii 3-25%, Radix Glycyrrhizae 5-25%,
Extraction process is similar with previous patent of invention, and there is also techniques to take problem.
Therefore, study a kind of Chinese medicine composition for being highly resistant to skin aging and offer is concisely and efficiently preparation method tool
Have broad application prospects and market value.
The content of the invention
In view of the deficiencies of the prior art with the demand in market, the present invention provides a kind of delay aging drug composition and its systems
Preparation Method and application, by selecting a variety of traditional Chinese medicine ingredients with senile-resistant efficacy, according to monarch principle with optimal proportion
Compounded combination is carried out, each component is synergistic, improves the anti-aging effects of Chinese medicine composition, and according to the nature and flavor of different Chinese medicines
It is processed, optimizes traditional extraction process, effectively improve the recovery rate of product, possess wide prospect.
In a first aspect, the present invention provides a kind of delay aging drug composition, the composition is in parts by weight mainly by such as
Lower raw material is prepared：30~60 parts of purple sesame, 20~40 parts of moutan bark, 10~30 parts of ginseng, 5~10 parts of Radix Ophiopogonis and Schisandra chinensis 5
~10 parts.
It is mild-natured using purple sesame as monarch in inventive formulation, it is nontoxic, it strengthens the body resistance to consolidate the constitution, strengthening by means of tonics, the work(such as promote longevity
Effect,《Sheng Nong's herbal classic》Middle theory：" purple sesame temperature sweet in flavor, main deafness, sharp joint, the refreshing strengthening the essence of guarantor, hard muscles and bones, good color, long term usage are made light of one's life by commiting suicide
Not old macrobiosis "；Using moutan bark as minister, cold nature is bitter, pungent, clearing heat and cooling blood, promoting blood circulation and removing blood stasis,《Japan hanako materia medica》In say it：
" remove pathogenic factor pleases color, clearance natural fibre line of meat blood vessels "；Ginseng is assistant, and ginseng is a kind of rare Chinese medicine《Sheng Nong's herbal classic》And《Compendium of Materia Medica》
It is on the books, there is enriching yin boost qi, cardiac stimulant of enriching blood, be known as " King of Herbs "；To make, Radix Ophiopogonis begins for Radix Ophiopogonis and Schisandra chinensis
It is loaded in《Sheng Nong's herbal classic》, have moisten the lung and nourish yin, the work(of reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire；Schisandra chinensis nature and flavor are sour, sweet, warm, have and receive
Astringent method, nourishing generate fluid are held back, the function of kidney calming is one of most widely used tonic Chinese herbal medicine of China's traditional Chinese medical science.
Modern medicine proves, containing polysaccharide, polypeptide, triterpenes isoreactivity substance in purple sesame fructification, have immunological regulation,
Hypoglycemic, reducing blood lipid, anti-oxidant, anti-aging and antitumor action, the L- rhamnoses that purple sesame is decomposed have enhancing corium-table
The bioactivity of skin bonding pad function；Containing flavones and Paeonol in moutan bark, there is promoting blood circulation decompression, anti-inflammatory sterilization is anti-oxidant
The effect of with free radical is removed；Ginseng contains the active skull cap components such as saponin(e, polysaccharide, polypeptide, can with anti-diabetic, it is anti-it is fat,
Enhance immune function, remove free radical, promote microcirculation and with skin effect；Radix Ophiopogonis contain steroid saponin, flavones, polysaccharide,
Sterol, amino acid isoreactivity ingredient have and improve hypoxia-bearing capability, antibacterial, promote immunization；Schisandra chinensis contains lignanoid, has
Machine acid, volatile oil, polysaccharide isoreactivity ingredient, it is immune and other effects with liver protection, anti-aging, enhancing.
More than all medicines share, it is synergistic, can tonifying middle-Jiao and Qi, heat clearing and blood circulation promoting, nourishing Yin and promoting production of body fluid, can effectively be mended for skin
Nutrition is filled, promotes skin microcirculation, oxidation and removing free radicals, final realize promotes skin vigor, resist aging and maintenance flesh
The effect of skin, makes an addition to the Chinese medicine composition of the present invention in cosmetics, and it is notable to resist effect.
The parts by weight of the purple sesame are 30~60 parts, for example, can be 30 parts, 32 parts, 35 parts, 37 parts, 39 parts, 40 parts,
43 parts, 45 parts, 47 parts, 50 parts, 53 parts, 55 parts, 57 parts or 60 parts.
The parts by weight of the moutan bark are 20~40 parts, for example, can be 20 parts, 23 parts, 25 parts, 27 parts, 30 parts, 33
Part, 35 parts, 37 parts or 40 parts.
The parts by weight of the ginseng are 10~30 parts, for example, can be 10 parts, 13 parts, 15 parts, 17 parts, 20 parts, 23 parts,
25 parts, 27 parts or 30 parts.
The parts by weight of the Radix Ophiopogonis are 5~10 parts, such as can be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts.
The parts by weight of the Schisandra chinensis are 5~10 parts, such as can be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts.
Preferably, the composition is mainly prepared in parts by weight by the following raw material：40~50 parts of purple sesame, moutan bark
25~40 parts, 10~20 parts of ginseng, 5~8 parts of 5~8 parts of Radix Ophiopogonis and Schisandra chinensis.
Preferably, the composition is mainly prepared in parts by weight by the following raw material：40~45 parts of purple sesame, moutan bark
25~30 parts, 15~20 parts of ginseng, 6~8 parts of 6~8 parts of Radix Ophiopogonis and Schisandra chinensis.
Second aspect, the present invention provides a kind of method for preparing Chinese medicine composition as described in relation to the first aspect, including walking as follows
Suddenly：
(1) medicinal material processing：By after each component medicinal material processing as described in first aspect Chinese medicine composition parts by weight mixed powder
Broken sieving, obtains medicinal material mixture；
(2) extract：The medicinal material mixture that step (1) obtains is added in ethyl alcohol, refluxing extraction, centrifugation removal supernatant
Liquid, vacuum drying are placed on ultrasonic extraction in deionized water；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure, and obtains the delay aging drug
Composition.
Preferably, the concocting method of step (1) each component medicinal material is as follows：
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 3~5 it is small when, then
At a temperature of 50~70 DEG C drying 8~12 it is small when, natural drying, and 50~70 DEG C it is secondary be dried to be completely dried until, treat
With；
The processing of (2 ') moutan bark：Moutan bark is taken, is washed with deionized water only, is dried, moutan bark is added to volumetric concentration
For in 5~20% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is (5~10):1, it mixes thoroughly rear bored, puts and slow boiling is used in pot
Fried dry is heated, taking-up cools for use；
The processing of (3 ') Radix Ophiopogonis：Fresh Radix Ophiopogonis is taken, net rear peeling is washed with deionized water, removes fibrous root and the Radix Ophiopogonis heart, is put into concentration
It is scalded 5~10 minutes when immersion 8~12 is small in 1%~3% sodium chloride solution, to pull out to be put into after draining in boiling water, after picking up
It is cooled down with 20~30 DEG C of cold water, is dried to is completely dried for use at 50~70 DEG C afterwards；
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into quality
Concentration is in 3~5% acetic acid solution, and the weight percent of Schisandra chinensis and acetic acid solution is 1:(1~5), sealing, water proof heating
1~5 it is small when, take out be dried at 50~70 DEG C be completely dried it is for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, at 40~55 DEG C
It is dried to until being completely dried, for use.
Wherein, step (the 1 ') temperature is 50~70 DEG C, for example, can be 50 DEG C, 54 DEG C, 58 DEG C, 60 DEG C, 64 DEG C, 68
DEG C or 70 DEG C.
Wherein, the time of step (the 1 ') drying for 8~12 it is small when, such as when can be 8 small, 9 it is small when, 10 it is small when,
11 it is small when or 12 it is small when.
Wherein, the concentration of alcohol described in step (2 ') is 5~20%, for example, can be 5%, 6%, 7%, 8%, 9%,
10%th, 12%, 14%, 16%, 18% or 20%.
Wherein, the weight percent described in step (2 ') is (5~10):1, such as can be 5:1、6:1、7:1、8:1、9:
1 or 10:1.
Wherein, the concentration described in step (3 ') is 1%, 2% or 3%.
Wherein, the soaking time described in step (3 ') for 8 it is small when, 9 it is small when, 10 it is small when, 11 it is small when or 12 it is small when.
Wherein, the time scalded in step (the 3 ') boiling water is 5~10 minutes, such as can be 5 minutes, 6 minutes, 7 points
Clock, 8 minutes, 9 minutes or 10 minutes.
Wherein, the temperature of step (the 3 ') cooling is 20~30 DEG C, for example, can be 20 DEG C, 22 DEG C, 24 DEG C, 26 DEG C,
28 DEG C or 30 DEG C.
Wherein, the temperature of step (the 3 ') drying be 50~70 DEG C, such as can be 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C or
70℃。
Wherein, step (the 4 ') acetic acid concentration is 3~5%, such as can be 3%, 4% or 5%.
Wherein, step (the 4 ') weight percent is 1:(1~5), such as can be 1:1、1:2、1:3、1:4 or 1:5.
Wherein, step (the 4 ') heating time for 1~5 it is small when, such as when can be 1 small, 2 it is small when, 3 it is small when, 4 it is small when
Or 5 it is small when.
Wherein, the temperature of step (the 5 ') drying is 40~55 DEG C, for example, can be 40 DEG C, 43 DEG C, 45 DEG C, 47 DEG C,
50 DEG C, 53 DEG C or 55 DEG C.
Preferably, the aperture of step (1) described sieving be 70-90 mesh, such as can be 70 mesh, 75 mesh, 80 mesh, 85 mesh or
90 mesh are preferably 80 mesh.
Preferably, the volumetric concentration of step (2) described ethyl alcohol is 40-97%, for example, can be 40%, 45%, 50%,
55%th, 60%, 70%, 80%, 90%, 95% or 97%, it is preferably 50%-95%.
Preferably, the solid-liquid ratio of step (2) described refluxing extraction is 1:(1~12), such as can be 1:1、1:2、1:3、
1:4、1:6、1:8、1:9、1:10 or 1:12, it is preferably 1:(1~10).
Preferably, the temperature of step (2) described refluxing extraction is 35~75 DEG C, for example, can be 35 DEG C, 38 DEG C, 40 DEG C,
45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C or 75 DEG C, be preferably 40~70 DEG C.
Preferably, step (2) the vacuum drying temperature is 35~75 DEG C, for example, can be 35 DEG C, 38 DEG C, 40 DEG C,
45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C or 75 DEG C, be preferably 40~70 DEG C.
Preferably, the number of step (2) described refluxing extraction is 1~5 time, such as can be 1 time, 2 times, 3 times, 4 times or 5
It is secondary, it is preferably 1~3 time.
Preferably, the time of step (2) described refluxing extraction is 1~5h, such as can be 1 time, 2 times, 3 times, 4 times every time
Or 5 times, it is preferably 1~3 time.
Preferably, the power of step (2) ultrasound be 180~820W, such as can be 180W, 190W, 200W,
220W, 400W, 600W, 700W or 800W are preferably 200~800W.
Preferably, the solid-liquid ratio of step (2) described ultrasonic extraction is 1:(12~38), such as can be 1:12、1:15、1:
20、1:25、1:30、1:35 or 1:38, it is preferably 1:(15~35).
Preferably, the temperature of step (2) described ultrasonic extraction is 25~75 DEG C, for example, can be 25 DEG C, 28 DEG C, 30 DEG C,
35 DEG C, 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 70 DEG C or 75 DEG C, be preferably 30~70 DEG C.
Preferably, the time of step (2) described ultrasonic extraction be 15~65min, such as can be 15min, 20min,
30min, 40min, 45min, 50min, 60min or 65min are preferably 20~60min.
Preferably, step (3) temperature being concentrated under reduced pressure is 25~55 DEG C, for example, can be 25 DEG C, 30 DEG C, 35 DEG C,
40 DEG C, 50 DEG C or 55 DEG C, be preferably 30~50 DEG C.
Preferably, liquid and the weight percent of the medicinal material mixture of step (1) after being concentrated under reduced pressure described in step (3) are
1:(1~15), such as can be 1:1、1:3、1:5、1:10、1:13 or 1:15, it is preferably 1:(1~10).
As optimal technical scheme, the present invention provides a kind of method for preparing Chinese medicine composition as described in relation to the first aspect, bag
Include following steps：
(1) medicinal material processing：The weight percent of Chinese medicine composition as described in first aspect after each component medicinal material processing is mixed
Conjunction pulverizes and sieves, and the aperture of sieve is 70~90 mesh, obtains medicinal material mixture.
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 3~5 it is small when, then
When 50~70 DEG C of drying 8~12 are small, natural drying afterwards, and 50~70 DEG C it is secondary be dried to be completely dried until, for use.
The processing of (2 ') moutan bark：Moutan bark is taken, is washed with deionized water only, is dried, moutan bark is added to volumetric concentration
For in 5~20% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is (5~10):1, it mixes thoroughly rear bored, puts and slow boiling is used in pot
Fried dry is heated, taking-up cools for use.
The processing of (3 ') Radix Ophiopogonis：Fresh Radix Ophiopogonis is taken, net rear peeling is washed with deionized water, removes fibrous root and the Radix Ophiopogonis heart, is put into concentration
It scalds 5~10 minutes when immersion 8~12 is small in 1~3% sodium chloride solution, to pull out to be put into after draining in boiling water, is used after picking up
20~30 DEG C of cold water cooling, is dried at 50~70 DEG C is completely dried for use afterwards.
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into quality
Concentration is in 3~5% acetic acid solution, and the weight percent of Schisandra chinensis and acetic acid solution is 1:(1~5), sealing, water proof heating
1~5 it is small when, take out be dried at 50~70 DEG C be completely dried it is for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, at 40~55 DEG C
It is dried to until being completely dried, for use.
(2) extract：The medicinal material mixture that step (1) obtains is added in the ethyl alcohol that volumetric concentration is 40%-97%,
Refluxing extraction 1~5 time under the conditions of 35~75 DEG C, every time 1~5h, solid-liquid ratio 1:(1~12), centrifugation removal supernatant, will be heavy
Shallow lake is dried in vacuo at a temperature of 35~75 DEG C, rear to put into deionized water, is carried out the ultrasound that power is 180~820W and is carried
It takes, solid-liquid ratio 1:(12~38), the temperature of ultrasonic extraction is 25~75 DEG C, and the time is 15~65min；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure at a temperature of 25~55 DEG C
It is 1 to the weight percent of liquid and step (1) Chinese medicine mixture:(1~15) obtains the extraction of delay aging drug composition
Object.
The third aspect, the present invention provide a kind of Chinese medicine composition as described in relation to the first aspect answering in cosmetics are prepared
With.
Preferably, the additive amount of the Chinese medicine composition is calculated as 0.1~10% with mass fraction, such as can be 0.1%,
0.5%th, 1%, 2%, 3%, 4%, 5%, 8% or 10%, it is preferably 0.5~5%.
Compared with prior art, the present invention has the advantages that：
(1) Chinese medicine composition provided by the invention efficiently uses traditional Chinese medicine ingredients, and five kinds of component synergy are mutually promoted,
Nutrition needed for skin is fundamentally supplemented, promotes skin microcirculation, oxidation and removing free radicals are high to superoxide anion clearance rate
Up to more than 86%, to Scavenging action to hydroxyl free radical 90% or so, skin moisture is maintained to reach, enhances elasticity of skin and light
The effect of changing skin pattern；
(2) preparation method provided by the invention can rectify a deviation to the processing of various Chinese medicines medicinal material pharmacological property or increase drug ingedient,
The effect of so as to preferably play medicinal material, ultrasonic wave extraction mode can accelerate active ingredient to enter solvent, so as to be conducive to effectively
The extraction of ingredient, wherein polysaccharide extract rate improve more than 30%, and polyphenol recovery rate improves 35% or so, and shortens extraction time,
Effectively increase the extraction efficiency of active matter.
Specific embodiment
Further to illustrate the technological means and its effect of the invention taken, below in conjunction with being preferably implemented for the present invention
Example is come the technical solution that further illustrates the present invention, but the present invention is not limited in scope of embodiments.
Embodiment 1
A kind of Chinese medicine composition (I) with senile-resistant efficacy, is made of the component for including following parts by weight：Purple sesame 50
Part, 30 parts of moutan bark, 10 parts of ginseng, 5 parts of Radix Ophiopogonis, 5 parts of Schisandra chinensis；
(1) medicinal material processing：The weight percent of Chinese medicine composition as described in first aspect after each component medicinal material processing is mixed
Conjunction pulverizes and sieves, and the aperture of sieve is 70 mesh, obtains medicinal material mixture；
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 3 it is small when, then exist
When 50 DEG C of drying 8 are small, natural drying afterwards, and 50 DEG C it is secondary be dried to be completely dried until, for use.
The processing of (2 ') moutan bark：Moutan bark is taken, is washed with deionized water only, is dried, moutan bark is added to volumetric concentration
For in 5% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is 5:1, it mixes thoroughly rear bored, puts in pot and heat fried dry with slow boiling,
Taking-up cools for use；
The processing of (3 ') Radix Ophiopogonis：Fresh Radix Ophiopogonis is taken, net rear peeling is washed with deionized water, removes fibrous root and the Radix Ophiopogonis heart, is put into concentration
It is scalded 5 minutes when immersion 8 is small in 1% sodium chloride solution, to pull out to be put into after draining in boiling water, the cold water after picking up with 20 DEG C is cold
But, it is dried to and is completely dried for use at 50 DEG C afterwards；
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into quality
Concentration is in 3% acetic acid solution, and the weight percent of Schisandra chinensis and acetic acid solution is 1:1, sealing when water proof heating 1 is small, takes
Go out to be dried at 50 DEG C and be completely dried for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, is dried at 40 DEG C
Until being completely dried, for use；
(2) extract：The medicinal material mixture that step (1) obtains is added in the ethyl alcohol that volumetric concentration is 40%, at 35 DEG C
Under the conditions of refluxing extraction 1 time, each 1h, solid-liquid ratio 1:1, centrifugation removal supernatant carries out at a temperature of being deposited in 35 DEG C
Vacuum drying, it is rear to put into deionized water, carry out the ultrasonic extraction that power is 180W, solid-liquid ratio 1:12, the temperature of ultrasonic extraction
It spends for 25 DEG C, the time is 15~65min；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure into medicine at a temperature of 25 DEG C
The weight percent of liquid and step (1) Chinese medicine mixture is 1:1, obtain delay aging drug composition extract.
Embodiment 2
A kind of Chinese medicine composition (II) with senile-resistant efficacy, is made of the component for including following parts by weight：Purple sesame
40 parts, 30 parts of moutan bark, 20 parts of ginseng, 5 parts of Radix Ophiopogonis, 5 parts of Schisandra chinensis；
(1) medicinal material processing：The weight percent of Chinese medicine composition as described in first aspect after each component medicinal material processing is mixed
Conjunction pulverizes and sieves, and the aperture of sieve is 90 mesh, obtains medicinal material mixture；
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 5 it is small when, then exist
When 70 DEG C of drying 12 are small, natural drying afterwards, and 70 DEG C it is secondary be dried to be completely dried until, for use；
The processing of (2 ') moutan bark：Moutan bark is taken, is washed with deionized water only, is dried, moutan bark is added to volumetric concentration
For in 20% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is 10:1, it mixes thoroughly rear bored, puts to be heated with slow boiling in pot and fry
Dry, taking-up cools for use；
The processing of (3 ') Radix Ophiopogonis：Fresh Radix Ophiopogonis is taken, net rear peeling is washed with deionized water, removes fibrous root and the Radix Ophiopogonis heart, is put into concentration
It is scalded 10 minutes when immersion 12 is small in 1~3% sodium chloride solution, to pull out to be put into after draining in boiling water, with 30 DEG C after picking up
Cold water cools down, and is dried to is completely dried for use at 70 DEG C afterwards；
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into quality
Concentration is in 5% acetic acid solution, and the weight percent of Schisandra chinensis and acetic acid solution is 1:5, sealing when water proof heating 5 is small, takes
Go out to be dried at 70 DEG C and be completely dried for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, is dried at 55 DEG C
Until being completely dried, for use；
(2) extract：The medicinal material mixture that step (1) obtains is added in the ethyl alcohol that volumetric concentration is 40%-97%,
Refluxing extraction 5 times under the conditions of 75 DEG C, each 5h, solid-liquid ratio 1:12, centrifugation removal supernatant will be deposited at a temperature of 75 DEG C
It is dried in vacuo, it is rear to put into deionized water, carry out the ultrasonic extraction that power is 820W, solid-liquid ratio 1:38, ultrasonic extraction
Temperature for 75 DEG C, time 65min；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure into medicine at a temperature of 55 DEG C
The weight percent of liquid and step (1) Chinese medicine mixture is 1:15, obtain delay aging drug composition extract.
Embodiment 3
A kind of Chinese medicine composition (III) with senile-resistant efficacy, is made of the component for including following parts by weight：Purple sesame
45 parts, 25 parts of moutan bark, 10 parts of ginseng, 10 parts of Radix Ophiopogonis, 10 parts of Schisandra chinensis；
(1) medicinal material processing：The weight percent of Chinese medicine composition as described in first aspect after each component medicinal material processing is mixed
Conjunction pulverizes and sieves, and the aperture of sieve is 80 mesh, obtains medicinal material mixture；
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 3~5 it is small when, then
When 60 DEG C of drying 10 are small, natural drying afterwards, and 60 DEG C it is secondary be dried to be completely dried until, for use；
The processing of (2 ') moutan bark：Moutan bark is taken, is washed with deionized water only, is dried, moutan bark is added to volumetric concentration
For in 10% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is 8:1, it mixes thoroughly rear bored, puts in pot and heat fried dry with slow boiling,
Taking-up cools for use；
The processing of (3 ') Radix Ophiopogonis：Fresh Radix Ophiopogonis is taken, net rear peeling is washed with deionized water, removes fibrous root and the Radix Ophiopogonis heart, is put into concentration
It is scalded 5~10 minutes when immersion 10 is small in 2% sodium chloride solution, to pull out to be put into after draining in boiling water, with 25 DEG C after picking up
Cold water cools down, and is dried to is completely dried for use at 60 DEG C afterwards；
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into quality
Concentration is in 3~5% acetic acid solution, and the weight percent of Schisandra chinensis and acetic acid solution is 1:(1~5), sealing, water proof heating
3 it is small when, take out be dried at 60 DEG C be completely dried it is for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, is dried at 45 DEG C
Until being completely dried, for use；
(2) extract：The medicinal material mixture that step (1) obtains is added in the ethyl alcohol that volumetric concentration is 40%-97%,
Refluxing extraction 3 times under the conditions of 55 DEG C, each 3h, solid-liquid ratio 1:6, centrifugation removal supernatant will be deposited at a temperature of 55 DEG C
It is dried in vacuo, it is rear to put into deionized water, carry out the ultrasonic extraction that power is 200W, solid-liquid ratio 1:20, ultrasonic extraction
Temperature for 55 DEG C, time 40min；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure into medicine at a temperature of 35 DEG C
The weight percent of liquid and step (1) Chinese medicine mixture is 1:7, obtain delay aging drug composition extract.
Embodiment 4
A kind of Chinese medicine composition (IV) with senile-resistant efficacy, is made of the component for including following parts by weight：Purple sesame
30 parts, 20 parts of moutan bark, 30 parts of ginseng, 6 parts of Radix Ophiopogonis, 6 parts of Schisandra chinensis；
Preparation method is identical with embodiment 3.
Embodiment 5
A kind of Chinese medicine composition (V) with senile-resistant efficacy, is made of the component for including following parts by weight：Purple sesame
60 parts, 40 parts of moutan bark, 15 parts of ginseng, 8 parts of Radix Ophiopogonis, 8 parts of Schisandra chinensis；
Preparation method is identical with embodiment 3.
The delay aging drug composition that comparative example 1 is extracted using traditional extraction mode
A kind of Chinese medicine composition with senile-resistant efficacy, is made of the component for including following parts by weight：50 parts of purple sesame,
30 parts of moutan bark, 10 parts of ginseng, 5 parts of Radix Ophiopogonis, 5 parts of Schisandra chinensis.
Preparation method is as follows：
(1) it will by weight percentage be mixed after various fresh Chinese medicine material drying, smash, cross 80 mesh sieves, obtain medicinal material mixture,
It preserves for use；
(2) medicinal material mixture is added to volumetric concentration as 80% ethanol water weight, solid-liquid ratio 1：10, at 80 DEG C
It is extracted 3 times under temperature conditionss, extracts 1.5h every time, filtered, merging filtrate obtains extracting solution；
(3) extracting solution under 60 DEG C of temperature conditionss is concentrated under reduced pressure into the 1/5 of original volume, obtains concentrate, will be concentrated
Resin model is the macroreticular resin column purification of D101 or AB-8 on liquid, and collected volume fraction is 70% ethanol elution part；
(4) be concentrated under reduced pressure under the conditions of 50 DEG C medicinal material mixture weight percent in liquid and step (1) is 1：10,
Obtain the Chinese medicine composition extract with antipollution.
The preparation of 2 single medicinal material purple sesame extract of comparative example
The Chinese medicine material purple sesame 100g after processing is weighed, 80 mesh sieves is smashed it through, Chinese medicine material purple sesame is added to 500g
Volumetric concentration is refluxing extraction 3 times under the conditions of 65 DEG C in 95% ethyl alcohol, and each 2h centrifuges removal supernatant, is deposited in 50
It is dried in vacuo under the conditions of DEG C, by dry herb powder input deionized water, is extracted with ultrasonic extraction, control ultrasonic power
For 600W, extraction solid-liquid ratio is 1:25, Extracting temperature is 60 DEG C, and extraction time is 60 minutes, and said extracted liquid is centrifuged and is removed
Precipitation, merging filtrate are concentrated under reduced pressure into liquid at 40 DEG C as 10g, obtain single medicinal material purple sesame extract.
The preparation of 3 single medicinal material Cortex Moutan extract of comparative example
In addition to raw material is moutan bark, other steps are identical with comparative example 2.
The preparation of 4 single medicinal material ginseng extract of comparative example
In addition to raw material is ginseng, other steps are identical with comparative example 2.
The preparation of 5 single medicinal material ophiopogon japonicus extract of comparative example
In addition to raw material is Radix Ophiopogonis, other steps are identical with comparative example 2.
The preparation of 6 single medicinal material Schisandra chinens P.E of comparative example
In addition to raw material is Schisandra chinensis, other steps are identical with comparative example 2.
Comparative example 7
A kind of Chinese medicine composition with senile-resistant efficacy, is made of the component for including following parts by weight：Purple sesame 51.25
Part, 31.25 parts of moutan bark, 11.25 parts of ginseng, 6.25 parts of Radix Ophiopogonis；
Preparation method is the same as embodiment 3.
Comparative example 8
A kind of Chinese medicine composition with senile-resistant efficacy, is made of the component for including following parts by weight：Moutan bark 40
Part, 30 parts of ginseng, 10 parts of Radix Ophiopogonis, 10 parts of Schisandra chinensis；
Preparation method is the same as embodiment 3.
Comparative example 9
A kind of Chinese medicine composition with senile-resistant efficacy, is made of the component for including following parts by weight：55 parts of purple sesame,
20 parts of ginseng, 10 parts of Radix Ophiopogonis, 10 parts of Schisandra chinensis；
Preparation method is the same as embodiment 3.
Comparative example 10
A kind of Chinese medicine composition with senile-resistant efficacy, is made of the component for including following parts by weight：50 parts of purple sesame,
30 parts of moutan bark, 6 parts of Radix Ophiopogonis, 6 parts of Schisandra chinensis；
Preparation method is identical with embodiment 3.
Comparative example 11
A kind of Chinese medicine composition with senile-resistant efficacy, is made of the component for including following parts by weight：60 parts of purple sesame,
40 parts of moutan bark, 23 parts of ginseng, 8 parts of Schisandra chinensis；
Preparation method is identical with embodiment 3.
Experiment test
The contrast test of 1 recovery rate
The measure of 1.1 polysaccharide
The measure of extract polysaccharide uses phenol-sulfuric acid and colorimetric method, with glucose as a standard product.
1.1.1 the preparation of standard sample solution
Precision weighs 105 DEG C of dryings to the glucose control product 100mg of constant weight, is placed in 100mL volumetric flasks, adds appropriate amount of water
Make dissolving and constant volume, precision is drawn above-mentioned solution 10mL, is settled to molten to get the standard items of 100 μ g/mL in 100mL volumetric flasks
Liquid.
1.1.2 the preparation of standard curve
The Glucose standards of 0.1mL, 0.2mL, 0.3mL, 0.4mL, 0.5mL, 0.6mL, 0.7mL are pipetted with pipette precision
Product solution is respectively placed in 10mL cuvettes, and successively plus water becomes 2m L, and another plus 1.0mL 5% phenol shakes up, rapidly
Each 5mL of the concentrated sulfuric acid is added dropwise, shakes up, in color development at room temperature 20min, with blank correction zero point, its absorbance is detected at 489nm, is obtained
Regression equation y=1.17682x-0.05366, r=0.99948.
Polysaccharide extract rate (%)=measurement concentration × extension rate × extracting liquid volume/raw material dry weight × 100%
1.2 flavones contents measure
1.2.1 the preparation of reference substance solution
Rutin sophorin reference substance 0.0252g is taken, is dissolved with 60% ethyl alcohol, then is settled to 50mL to obtain the final product, the drafting of standard curve
Accurate measuring reference substance solution 0.5mL, 1.0mL, 1.5mL, 2.0mL, 2.5mL, put in 10mL volumetric flasks, sequentially add respectively
5% sodium nitrite solution of 0.3mL, 6min is placed after shaking up；Then plus 10% liquor alumini chloridi of 0.3mL shake up after place
6min, then add 4% sodium hydroxide solution of 4mL, it with 60% ethyl alcohol constant volume, shakes up, after placing 15min, is made with corresponding reagent empty
White ginseng ratio measures absorbance at 510nm wavelength, and with rutin sophorin concentration (x) for abscissa, absorbance (y) is ordinate, is carried out
Linear regression obtains regression equation：Y=9.846x-0.010 (r=0.9997), show rutin sophorin concentration 0.0252~
With absorbance in good linear relation in the range of 0.1260mg/mL；
Extracting flavonoids rate (%)=measurement concentration × extension rate × extracting liquid volume/raw material dry weight × 100%
1.3 recovery rate contrast tests
1 recovery rate contrast table of table
It can be drawn from table 1, the present invention is apparent with the polysaccharide extract rate of ultrasonic extraction and polyphenol recovery rate by processing
Higher than traditional water alcohol method, and it can effectively shorten extraction time, wherein polysaccharide extract rate improves more than 30%, polyphenol recovery rate
35% or so is improved, without high temperature in extraction process, is avoided because of destruction of the high temperature to active matter molecular structure, in a short time
The bioactivity of traditional Chinese medicine ingredients is kept, is a kind of comparatively ideal novel technology for extracting of Chinese medical extract industrial production, is conducive to promote
Using.
A kind of preparation of 6 anti-aging face cream of embodiment
Table 2 provides the anti-aging face cream formula of the Chinese medicine composition containing the present invention；
Table 2
Its preparation method：
(1) Sodium Hyaluronate in glycerine is uniformly dispersed in advance, parahydroxyacet-ophenone is added in advance in 1,3-BDO
Heat of solution is to transparent；
(2) by Butyrospermum parkii fruit fat, avocado oil, saualane, Cer NP, tocopherol acetate, phytosterol, red
Bisabol and evening primrose oil dissolve by heating uniform at 40 DEG C；
(3) by oil phase raw material arachidic alcohol glucoside, PEG-100 stearates, stearine, cetearyl glucose
Glycosides, cetostearyl alcohol and caprylic/capric triglyceride put into oil phase pot and are heated to 80 DEG C, and stirring is complete to dissolving；
(4) 1,3-BDO, Sodium Hyaluronate and other Aqueous Phase Raw Materials handled well through step (1) are put into emulsification pot to add
For heat to 80 DEG C, stirring is complete to dissolving；
(5) oil phase of step (3) is quickly pumped into agitated kettle, persistently stirs and open with the rate of 1000~2000rpm
Begin to cool down, the oil phase and ring five dimethyl silicone polymer of step (2) are added, after addition, with the speed of 4000~6000rpm
Rate emulsifying 5~10 minutes；
(6) treat that temperature is cooled to 45 DEG C, add in addition phase, stirring is to being uniformly dissolved；
(7) vacuum defoamation after temperature is down to 35 DEG C examines the physical and chemical indexes such as color, fragrance, appearance, after the assay was approved
200 mesh filtering and dischargings.
A kind of preparation of 7 anti-aging mask of embodiment
Table 3 provides the anti-aging face paste film formulation of the Chinese medicine composition containing the present invention；
Its preparation method：
(1) Sodium Hyaluronate and xanthans are uniformly dispersed in glycerine in advance, by parahydroxyacet-ophenone in 1,3- fourths two
It is dissolved by heating in alcohol to transparent；
(2) mixture of step (1) and other Aqueous Phase Raw Materials are put into water phase pot and is heated to 80 DEG C, stirring is to having dissolved
Entirely；
(3) oil-phase component is mixed and is slightly heated to being completely dissolved；
(4) oil phase of step (3) is quickly pumped into agitated kettle, it is equal with the rate of 4000~6000rpm after addition
Matter emulsifies 5~10 minutes, is persistently stirred with the rate of 1000~2000rpm and starts to cool down；
(5) treat that temperature is cooled to 50 DEG C, add in parahydroxyacet-ophenone and 1,3-BDO, stir to substantially uniformity, treat temperature
Degree is cooled to 45 DEG C, adds in addition mutually and with the rate emulsifying 3 minutes of 4000~6000rpm；
(6) vacuum defoamation after temperature is down to 35 DEG C examines color, the physical and chemical indexes such as fragrance, appearance, after the assay was approved
200 mesh filtering and dischargings.
Embodiment 8
Compared with Example 6, except the delay aging drug composition of addition is changed to the Chinese medicine composition of embodiment 3, addition
It measures as outside 3%, other conditions are same as Example 6.
Embodiment 9
Compared with Example 6, except the delay aging drug composition of addition is changed to the Chinese medicine composition of embodiment 4, addition
It measures as outside 5%, other conditions are same as Example 6.
A kind of preparation of common face cream of comparative example 12
Table 4 provides the common face cream formula for not containing the Chinese medicine composition of the present invention；
Table 4
Its preparation method：
(1) Sodium Hyaluronate in glycerine is uniformly dispersed in advance, parahydroxyacet-ophenone is added in advance in 1,3-BDO
Heat of solution is to transparent；
(2) by Butyrospermum parkii fruit fat, avocado oil, saualane, Cer NP, tocopherol acetate, phytosterol, red
Bisabol and evening primrose oil dissolve by heating uniform at 40 DEG C；
(3) by oil phase raw material arachidic alcohol glucoside, PEG-100 stearates, stearine, cetearyl glucose
Glycosides, cetostearyl alcohol and caprylic/capric triglyceride put into oil phase pot and are heated to 80 DEG C, and stirring is complete to dissolving；
(4) 1,3-BDO, Sodium Hyaluronate and other Aqueous Phase Raw Materials handled well through step (1) are put into emulsification pot to add
For heat to 80 DEG C, stirring is complete to dissolving；
(5) oil phase of step (3) is quickly pumped into agitated kettle, persistently stirs and open with the rate of 1000~2000rpm
Begin to cool down, the oil phase and ring five dimethyl silicone polymer of step (2) are added, after addition, with the speed of 4000~6000rpm
Rate emulsifying 5~10 minutes；
(6) treat that temperature is cooled to 45 DEG C, add in addition phase, stirring is to being uniformly dissolved；
(7) vacuum defoamation after temperature is down to 35 DEG C examines the physical and chemical indexes such as color, fragrance, appearance, after the assay was approved
200 mesh filtering and dischargings.
Experiment detection
2nd, the contrast test of Green Tea Extract
The preparation of 2.1 samples
The Chinese medical extract of embodiment 1 and comparative example 2~11 is made into the sample solution that concentration is 1% respectively, is carried out down
It tests in face.
2.2 pairs of ultra-oxygen anion free radical Scavenging activity evaluations
The Tris-HCl buffer solution 4.5mL of 0.05mol/L pH=8.2 are taken, 20min is preheated in 25 DEG C of water-baths, then is added
Enter 1mL samples and the pyrogallol solution of 0.4mL 25mmol/L, after mixing, 5min is reacted in 25 DEG C of water-baths, adds in 8mol/
The HCl 1.0mL of L terminate reaction.Reference is made with Tris-HCl buffer solutions, absorbance, blank control 1mL are surveyed at 299nm
The solvent of sample substitutes sample；
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100%；
A1 is the absorbance of blank control in formula, and A2 is the absorbance of sample；
The Scavenging activity evaluation of 2.3 pairs of hydroxy radicals
2mmol/L FeSO are sequentially added in 25mL colorimetric cylinders43mL, 1mmol/L H2O23mL shakes up, and is subsequently added into
6mmol/L salicylic acid 3mL, shake up, and are taken out after 37 DEG C of heating water bath 15min, survey its absorbance；It is separately added into certain density
Prepare liquid shakes up, and continues heating water bath 15min, takes out and surveys its absorbance, and following formula is prepare liquid to the clear of hydroxy radical (OH)
Except rate：
Scavenging action to hydroxyl free radical (%)=[A1-A2- (A1-A3)]/A1 × 100%；
A1 is the absorbance of reaction system before non-dosing product in formula；A2 is the absorbance that sample removes system after OH
Value；A3 is the absorbance that system after OH is removed in blank control；
The contrast test of 2.4 sample Green Tea Extracts
5 free radical scavenging activity functional evaluation result of table
As shown in Table 5, embodiment Chinese medicine composition provided by the invention is up to more than 86% to superoxide anion clearance rate,
To Scavenging action to hydroxyl free radical 90% or so, illustrate the present invention Chinese medicine composition have it is significant remove free radical effect, it is but right
Lack any component in single medicinal material and composition in ratio, it is unsatisfactory to the clearance rate of free radical, illustrate between composition
Synergistic effect it is notable, Chinese medicine composition higher than single medicinal material or lacks any superoxide anion and Scavenging action to hydroxyl free radical
The composition of component has good anti-aging effects.
3rd, skin moisture content and skin moisture are lost in the test of (TEWL)
The preparation of 3.1 samples
The composition of embodiment 6 and comparative example 12 is configured to sample respectively, carries out experiment below；
3.2 test equipment
The skin moisture content Corneometer tests of German Courage+Khazaka companies (German CK companies) manufacture
Probe, the skin moisture of German Courage+Khazaka companies (German CK companies) manufacture are lost in (TEWL) Tewameter
TM300 test probes；
3.3 test method
Moisture content is tested using universally acknowledgedMethod-capacitance method, it is that principle is base
In water (81) and the dielectric constant of other materials (<7) variation is quite big, and according to the difference of water content, the measurement of suitable shape is used
Capacitor can change with the variation of the capacitance of skin, and the capacitance of skin is in the range of measurement, thus
The water content of skin can be measured.
Skin moisture is lost in TEWL and is very important parameter to the function of assessing skin aging.With the aging of skin,
The water holding capacity of skin continuously decreases, the easier drying of skin, and the numerical value that skin moisture is lost in TEWL is lower, test philosophy
From Fick Fick'ss law of diffusion；
3.4 experiment early-stage preparations
Ripe age aging skin women 60 is chosen, the age was at 45~55 years old.It is randomly divided into 2 groups, every group 30, before recipient site
Any product (cosmetics or topical drug or health products for oral administration) cannot be used within 15 days.Before experiment, it is desirable that subject cleans cleaning
Facial area and when 2 is small after cleaning enters 22 ± 1 DEG C of temperature, sit quietly 30min in the constant temperature and humidity room of humidity 50 ± 5%, and
Keep relaxation state.
3.5 facial area water contents and moisture loss (TEWL) efficacy assessment
Half of face test is carried out by random table in experiment, one side is the embodiment 6 containing Chinese medical extract, and opposite side is comparison
Example 12, the left and right nasolabial groove part for choosing volunteer carry out skin moisture content measuring and moisture loss (TEWL) test, take 3
The average value of value is lost in the data (D0) of (TEWL) as the data (D0) and nasolabial groove skin moisture of nasolabial groove water content.It surveys
After examination, volunteer need to be by that will use, and a side face smears a kind of product, and another side face smears another product, in use, making
With the right hand smear the right facial area, using left hand smear left side facial area, forbid cross contamination and on request daily morning and evening 2 times into
Row product is smeared, continuous 28 days on probation, and the 14th day (D14) and the 28th day (D28) of experiment is required to be paid a return visit.Each time
The lighting condition of point should be consistent：Curtain is closed, appropriate illumination.Subject is in bed recumbency.The inclined angle of bed is each
Time point should all be consistent, and the position of bed must mark on the ground, to ensure the uniformity of the position of D14 and D28, together
The test of one volunteer is completed by same survey crew；
3.6 experimental result
6 experimental results change rate unit (%) of table
| Test index | Embodiment 6 | Comparative example 12 |
| D14 water contents | 18.35 | 10.32 |
| D28 water contents | 22.81 | 12.19 |
| D14TEWL | -17.85 | -6.3 |
| D28TEWL | -20.30 | -8.4 |
It is shown by 6 data of table, the result of half face test evaluation of human body clearly can contrast embodiment 6 and comparative example 12
The effect of difference, the face cream containing Chinese medicine composition becomes apparent from the repair of skin moisturizing ability than blank model, can have
The increase cuticula moisture content water content of effect reduces keratoderma to extraneous moisture loss amount, promoted skin moist degree and
Smoothness, it is effective to alleviate skin aging situation, by experiments have shown that, other embodiment also has similar effect.
4th, normal individual trial evaluation experimental
4.1 experimental method
The result on trial that 3 will be tested carries out normal individual trial evaluation, sample is carried out during use moisturizing degree, glossiness,
Degree of compacting and anti-wrinkle effect evaluation, wherein highest is divided into 5, minimum to be divided into 1；
4.2 experimental result
Evaluation table on probation is filled according to sensory evaluation.Half face experiment evaluation table on probation is collected, statistical result is shown in Table 7：
7 normal individual trial evaluation result average value of table
By 7 result of table as it can be seen that the result of half face test evaluation of human body clearly can compare embodiment 6 and comparative example 12
The effect of difference, embodiment is to effect in terms of the improvement of moisturizing degree, glossiness, degree of compacting and anti-wrinkle effect all it is obvious that showing
Face cream containing Chinese medicine composition extract of the present invention has effects that good anti-aging and nourishes, can allow dry, coarse, loose
The skin of relaxation is restored to water and moistens soft and smooth, gloss exquisiteness, full health status of compacting.
In conclusion delay aging drug composition provided by the invention, a variety of in senile-resistant efficacy by selecting
Medicine ingredient carries out compounded combination according to monarch principle with optimal proportion, and each component is synergistic, improves Chinese medicine composition
Anti-aging effects, have effects that good anti-aging and nourish, can allow it is dry, coarse, relaxation skin be restored to water moisten
Soft and smooth, gloss is fine and smooth, full health status of compacting, and preparation method provided by the invention carries out big gun according to the nature and flavor of different Chinese medicines
System, optimizes traditional extraction process, effectively improves the recovery rate of product, possess wide prospect.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all fall within protection scope of the present invention and the open scope.
Claims (10)
1. a kind of delay aging drug composition, which is characterized in that the composition is mainly prepared in parts by weight by the following raw material
It obtains：5~10 parts of 30~60 parts of purple sesame, 20~40 parts of moutan bark, 10~30 parts of ginseng, 5~10 parts of Radix Ophiopogonis and Schisandra chinensis.
2. Chinese medicine composition according to claim 1, which is characterized in that the composition is in parts by weight mainly by as follows
Raw material is prepared：40~50 parts of purple sesame, 25~40 parts of moutan bark, 10~20 parts of ginseng, 5~8 parts of Radix Ophiopogonis and Schisandra chinensis 5~8
Part.
3. Chinese medicine composition according to claim 1 or 2, which is characterized in that in parts by weight mainly by the following raw material system
It is standby to obtain：6~8 parts of 40~45 parts of purple sesame, 25~30 parts of moutan bark, 15~20 parts of ginseng, 6~8 parts of Radix Ophiopogonis and Schisandra chinensis.
A kind of 4. method for preparing the Chinese medicine composition as any one of claim 1-3, which is characterized in that including walking as follows
Suddenly：
(1) medicinal material processing：By after each component medicinal material processing as any one of claim 1-3 Chinese medicine composition parts by weight
Co-grinding sieves, and obtains medicinal material mixture；
(2) extract：The medicinal material mixture that step (1) obtains is added in ethyl alcohol, refluxing extraction, centrifugation removal supernatant, very
Sky drying is placed on ultrasonic extraction in deionized water；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure, and obtains the delay aging drug combination
Object.
5. according to the method described in claim 4, it is characterized in that, the concocting method of step (1) each component medicinal material is as follows：
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 3~5 it is small when, then 50
~70 DEG C drying 8~12 it is small when, natural drying, and 50~70 DEG C it is secondary be dried to be completely dried until, for use；
The processing of (2 ') moutan bark：Take moutan bark, be washed with deionized water net, dry, by moutan bark be added to volumetric concentration for 5~
In 20% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is (5~10):1, it mixes thoroughly rear bored, puts and heated with slow boiling in pot
Fried dry, taking-up cool for use；
The processing of (3 ') Radix Ophiopogonis：Fresh Radix Ophiopogonis is taken, net rear peeling is washed with deionized water, removes fibrous root and the Radix Ophiopogonis heart, is put into concentration as 1%
Impregnated in~3% sodium chloride solution 8~12 it is small when, pull out to be put into after draining in boiling water and scald 5~10 minutes, after picking up with 20~
30 DEG C of cold water cooling, is dried at 50~70 DEG C is completely dried for use afterwards；
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into mass concentration
For in 3~5% acetic acid solution, the weight percent of Schisandra chinensis and acetic acid solution is 1:(1~5), sealing, water proof heating 1~5
Hour, take out be dried at 50~70 DEG C be completely dried it is for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, is dried at 40~55 DEG C
Until being completely dried, for use.
6. method according to claim 4 or 5, which is characterized in that the aperture of step (1) described sieving is 70-90 mesh, excellent
Elect 80 mesh as；
Preferably, the volumetric concentration of step (2) described ethyl alcohol is 40-97%, is preferably 50-95%；
Preferably, the solid-liquid ratio of step (2) described refluxing extraction is 1:(1~12) is preferably 1:(1~10)；
Preferably, the temperature of step (2) described refluxing extraction is 35~75 DEG C, is preferably 40~70 DEG C；
Preferably, step (2) the vacuum drying temperature is 35~75 DEG C, is preferably 40~70 DEG C；
Preferably, the number of step (2) described refluxing extraction is 1~5 time, is preferably 1~3 time.
7. according to the method any one of claim 4-6, which is characterized in that the time of step (2) described refluxing extraction
It it is preferably 1~3 time for 1~5h every time；
Preferably, the power of step (2) ultrasound is 180~820W, is preferably 200~800W；
Preferably, the solid-liquid ratio of step (2) described ultrasonic extraction is 1:(12~38) are preferably 1:(15~35)；
Preferably, the temperature of step (2) described ultrasonic extraction is 25~75 DEG C, is preferably 30~70 DEG C；
Preferably, the time of step (2) described ultrasonic extraction is 15~65min, is preferably 20~60min；
Preferably, step (3) temperature being concentrated under reduced pressure is 25~55 DEG C, is preferably 30~50 DEG C；
Preferably, the weight percent of liquid and the medicinal material mixture of step (1) after being concentrated under reduced pressure described in step (3) is 1:(1
~15) it is preferably, 1:(1~10).
8. according to the method any one of claim 4-7, which is characterized in that specifically comprise the following steps：
(1) medicinal material processing：By after each component medicinal material processing as any one of claim 1-3 Chinese medicine composition parts by weight
Number co-grinding sieving, the aperture of sieve is 70~90 mesh, obtains medicinal material mixture；
The processing of (1 ') ginseng：Take fresh ginseng, be washed with deionized water net, remove supporting root fibrous root, steam 3~5 it is small when, then 50
When~70 DEG C of drying 8~12 are small, natural drying afterwards, and 50~70 DEG C it is secondary be dried to be completely dried until, for use.
The processing of (2 ') moutan bark：Take moutan bark, be washed with deionized water net, dry, by moutan bark be added to volumetric concentration for 5~
In 20% ethyl alcohol, the weight percent of moutan bark and ethyl alcohol is (5~10):1, it mixes thoroughly rear bored, puts and heated with slow boiling in pot
Fried dry, taking-up cool for use.
The processing of (3 ') Radix Ophiopogonis：Take fresh Radix Ophiopogonis, be washed with deionized water it is net after peeling, remove fibrous root and the Radix Ophiopogonis heart, be put into concentration for 1~
When immersion 8~12 is small in 3% sodium chloride solution, pulls out to be put into after draining in boiling water and scald 5~10 minutes, with 20~30 after picking up
DEG C cold water cooling, be dried to afterwards at 50~70 DEG C be completely dried it is for use.
The processing of (4 ') Schisandra chinensis：Fresh schisandra chinensis is taken, impurity and carpopodium is removed, is cleaned and drained with deionization, steeped into mass concentration
For in 3~5% acetic acid solution, the weight percent of Schisandra chinensis and acetic acid solution is 1:(1~5), sealing, water proof heating 1~5
Hour, take out be dried at 50~70 DEG C be completely dried it is for use；
The processing of (5 ') purple sesame：Purple sesame fructification is taken, removes impurity and sawdust, is washed with deionized water only, is dried at 40~55 DEG C
Until being completely dried, for use.
(2) extract：The medicinal material mixture that step (1) obtains is added in the ethyl alcohol that volumetric concentration is 40-97%, 35~75
Refluxing extraction 1~5 time under the conditions of DEG C, every time 1~5h, solid-liquid ratio 1:(1~12), centrifugation removal supernatant, will be deposited in 35
It is dried in vacuo at a temperature of~75 DEG C, it is rear to put into deionized water, carry out the ultrasonic extraction that power is 180~820W, material
Liquor ratio is 1:(12~38), the temperature of ultrasonic extraction is 25~75 DEG C, and the time is 15~65min；
(3) concentrate：Said extracted liquid is centrifuged into removal precipitation, merging filtrate is concentrated under reduced pressure into medicine at a temperature of 25~55 DEG C
The weight percent of liquid and step (1) Chinese medicine mixture is 1:(1~15) obtains delay aging drug composition extract.
9. a kind of application of Chinese medicine composition as any one of claim 1-3 in cosmetics are prepared.
10. according to the application in claim 9, which is characterized in that the additive amount of the Chinese medicine composition is calculated as with mass fraction
0.1~10%, it is preferably 0.5~5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810018765.6A CN108096145A (en) | 2018-01-09 | 2018-01-09 | A kind of delay aging drug composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810018765.6A CN108096145A (en) | 2018-01-09 | 2018-01-09 | A kind of delay aging drug composition and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108096145A true CN108096145A (en) | 2018-06-01 |
Family
ID=62218391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810018765.6A Pending CN108096145A (en) | 2018-01-09 | 2018-01-09 | A kind of delay aging drug composition and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108096145A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091544A (en) * | 2018-09-28 | 2018-12-28 | 安徽汇中州中药饮片有限公司 | Cortex moutan process of preparing technique |
| CN109157501A (en) * | 2018-09-25 | 2019-01-08 | 深圳市宝迪生物工程有限公司 | A kind of composition of the anti-aging of the extract containing stem cell and application |
| CN109316417A (en) * | 2018-10-17 | 2019-02-12 | 广东轻工职业技术学院 | A kind of delay aging drug composition fermentation magma and preparation and application |
| CN112604027A (en) * | 2020-12-22 | 2021-04-06 | 北京金莎科技有限公司 | Nutrient solution for comprehensively solving facial collapse |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098291A (en) * | 1993-07-31 | 1995-02-08 | 四川省中药研究所 | The anti-senility Chinese patent medicine |
| CN101011528A (en) * | 2007-02-01 | 2007-08-08 | 四川美大康药业股份有限公司 | Chinese medicine preparation for boosting qi and nourishing yin, nourishing blood and promoting blood circulation, and its preparation method |
| CN104490712A (en) * | 2014-10-28 | 2015-04-08 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with anti-aging effect and application thereof in cosmetics |
| CN106309917A (en) * | 2016-09-27 | 2017-01-11 | 杭州本草养正堂生物科技有限公司 | Compound preparation with efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases and preparation method of compound preparation |
-
2018
- 2018-01-09 CN CN201810018765.6A patent/CN108096145A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098291A (en) * | 1993-07-31 | 1995-02-08 | 四川省中药研究所 | The anti-senility Chinese patent medicine |
| CN101011528A (en) * | 2007-02-01 | 2007-08-08 | 四川美大康药业股份有限公司 | Chinese medicine preparation for boosting qi and nourishing yin, nourishing blood and promoting blood circulation, and its preparation method |
| CN104490712A (en) * | 2014-10-28 | 2015-04-08 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with anti-aging effect and application thereof in cosmetics |
| CN106309917A (en) * | 2016-09-27 | 2017-01-11 | 杭州本草养正堂生物科技有限公司 | Compound preparation with efficacy of resisting aging and preventing cardiovascular and cerebrovascular diseases and preparation method of compound preparation |
Non-Patent Citations (3)
| Title |
|---|
| 中国环境科学学会编: "《中国环境科学学会学术年会论文集 2009第4卷》", 30 June 2009, 北京航空航天大学出版社 * |
| 国家食品药品监督管理总局执业药师资格认证中心组织编写: "《中药学专业知识 1》", 28 February 2015, 中国医药科技出版社 * |
| 彭茹洁等: "植物多酚提取、分离纯化及其分析方法的研究进展", 《机电信息》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109157501A (en) * | 2018-09-25 | 2019-01-08 | 深圳市宝迪生物工程有限公司 | A kind of composition of the anti-aging of the extract containing stem cell and application |
| CN109091544A (en) * | 2018-09-28 | 2018-12-28 | 安徽汇中州中药饮片有限公司 | Cortex moutan process of preparing technique |
| CN109316417A (en) * | 2018-10-17 | 2019-02-12 | 广东轻工职业技术学院 | A kind of delay aging drug composition fermentation magma and preparation and application |
| CN109316417B (en) * | 2018-10-17 | 2022-11-29 | 广东轻工职业技术学院 | Anti-aging traditional Chinese medicine composition fermented raw juice and preparation and application thereof |
| CN112604027A (en) * | 2020-12-22 | 2021-04-06 | 北京金莎科技有限公司 | Nutrient solution for comprehensively solving facial collapse |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103705421B (en) | A kind of milk moisturizing anti-aging cream and manufacture method thereof | |
| CN108096145A (en) | A kind of delay aging drug composition and its preparation method and application | |
| CN107669564A (en) | It is a kind of that there is reparative regeneration, replenishing water and preserving moisture, the skin care compositions of anti-aging | |
| CN106420531B (en) | It is a kind of containing hiding schizonepeta have effects that the Chinese traditional medicine composition extract of skin whitening, moisturizing and application | |
| CN106265385A (en) | A kind of submissive glossy shampoo composite and application thereof | |
| CN104083317B (en) | A kind of white young tea leaves eye-care frost and preparation method thereof | |
| CN104784507A (en) | Traditional Chinese medicine composition with multiple cosmetic effects and application | |
| KR20090005479A (en) | Composition for promoting hair growth | |
| CN101804165A (en) | Preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and preparation method thereof | |
| CN108272707A (en) | A kind of Chinese herbal medicine hair conditioner and preparation method thereof | |
| CN115531272B (en) | Antioxidant composition derived from alpine plants and preparation method and application thereof | |
| CN103919711A (en) | Oolong anti-aging whitening cream and preparation method thereof | |
| CN105535507A (en) | Skin care product containing folium artemisiae argyi extract and preparation method and application thereof | |
| CN109316417A (en) | A kind of delay aging drug composition fermentation magma and preparation and application | |
| CN103749818B (en) | A kind of sealwort hypoglycemic health protection tea and preparation method thereof | |
| CN108670933B (en) | Skin care composition with moisturizing, whitening and anti-aging functions and application thereof | |
| CN106726993B (en) | Chinese medicine hair cream and preparation method | |
| CN105831637A (en) | Anti-radiation mulberry, wolfberry and jujube composite, preparation method and application thereof | |
| CN115006336B (en) | Plant shampoo capable of preventing hair loss, strengthening hair, removing dandruff and relieving itching and preparation method thereof | |
| CN106511176A (en) | Natural plant care hair blacking cream and preparation method thereof | |
| CN1857415A (en) | Health product for women to delay senility and its preparing process | |
| CN102743313B (en) | Natural medicinal composition for delaying skin aging and application thereof | |
| CN104857377B (en) | Improve Chinese medical extract of fatty liver and preparation method thereof and massage cream | |
| CN106666733A (en) | Nourishing paste with functions of producing blood, tonifying kidney, blacking hair and strengthening physique | |
| KR101429049B1 (en) | A Composition for Improving Beauty of Skin Using Red Ginseng Extraxts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Guangzhou Science City in Guangdong province 510000 Ke Lin Lu Guangzhou high tech Industrial Development Zone No. 15 Applicant after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: Guangzhou Science City in Guangdong province 510000 Ke Lin Lu Guangzhou high tech Industrial Development Zone No. 15 Applicant before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180601 |