CN108095715A - A kind of passive intracranial pressure monitoring system of implantation type wireless - Google Patents
A kind of passive intracranial pressure monitoring system of implantation type wireless Download PDFInfo
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- CN108095715A CN108095715A CN201711374483.1A CN201711374483A CN108095715A CN 108095715 A CN108095715 A CN 108095715A CN 201711374483 A CN201711374483 A CN 201711374483A CN 108095715 A CN108095715 A CN 108095715A
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- intracranial pressure
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
- A61B5/031—Intracranial pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0462—Apparatus with built-in sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Computer Networks & Wireless Communication (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Neurology (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The invention discloses a kind of passive intracranial pressure monitoring systems of implantation type wireless, including intracranial pressure monitor, vitro detection instrument, the intracranial pressure monitor is implanted into encephalic, including shell, pressure sensor and circuit module, the pressure sensor is piezoresistive pressure sensor, the shell top and bottom are equipped with thin highly elastic layer, the circuit module includes wireless charging module, signal transmitting module and signal processing module, the pressure sensor is connected by long conducting wire with the circuit module, the intracranial pressure monitor is connected by wireless signal with the vitro detection instrument, it the advantage is that：The working time of monitoring device can significantly be extended, it reduces the risk infected during patient's use, save expense of the patient in this medical services content, improve accuracy, convenience that clinician judges the state of an illness, improve neurosurgery work quality, improve clinical academic research level.
Description
Technical field
The present invention relates to the field of medical instrument technology, and in particular to a kind of passive intracranial pressure monitoring system of implantation type wireless
System.
Background technology
The pressure of cerebrospinal fluid in intracranial pressure, i.e. cranial cavity is normally 100 ~ 150 millimeters of water, 10 ~ 15 millimetress of mercury, due to
It is present in cavum subarachnoidale and intracisternal cerebrospinal fluid between cranial cavity wall and brain tissue, and in spider web in the ventricles of the brain and spinal cavity
Hypostegal cavity communicates, so the hydrostatic pressing of cerebrospinal fluid can represent intracranial pressure, usually when intracranial pressure is continued above 180 millimeters of water
When, the duration more than 5 minutes, clinically referred to as increased intracranial pressure.Increased intracranial pressure can cause a series of physiological function
Disorderly and pathological change, shows as the symptoms such as katzeniammer, vomiting, therefore, monitors patient's intracranial pressure value accurately and in time, right
It has very important significance in the clinical diagnosis state of an illness and guiding treatment.
Most of neurosurgery clinical unit unconditionally carries out intracranial pressure and directly measures, and the unit that can carry out largely is adopted
With the method in the semi-open implantation cranial cavity of pressure probe, but the risk that infects of this method is high, during pressure probe use
Between short, patient economy burden weight.Lack clinical position critical therapies index, have become the dilemma in clinical position.
Chinese patent（105832327 A of patent No. CN）A kind of passive monitoring intracranial pressure system of implantation type wireless is disclosed,
Including：Intracranial pressure sensor, for perceiving intracranial pressure force value, external patch type reader is generated with intracranial pressure sensor
Mutual Inductance Coupling, instrumentation, the outer patch type reader of connector detect the resonant frequency of intracranial pressure sensor, draw cranium
Interior pressure value, the passive monitoring intracranial pressure system of implantation type wireless of the invention, is connected with external equipment without conducting wire and conduit, keeps away
The risk of generation intracranial infection is exempted from, without limitation on the normal activity of patient；It is that it is powered, it can be achieved that long that battery, which need not be used,
Time supervision；The presser sensor capacitance of LC resonance formula pressure sensor is MEMS structure, small, at low cost；External patch type
Reader uses flexible PCB printed coil, and light-weight, thickness is thin and bending is good, will not cause sense of discomfort to patient.The hair
The problem of bright, is 1, needs patch type reader outside cranium outer patch upper body, and patient is easy to described external in overturning body season
Patch type reader comes off, and causes device that can not work normally；2nd, intracranial pressure sensor surface out-of-flatness, is subject to intracranial pressure
Be distributed inconsistent, easily generate measurement error, and this for intracranial pressure detect this measurement high to precision requirement for be
It is not allowed to.
The content of the invention
To solve the above-mentioned problems, the invention discloses one kind to be not required external patch reader, and intracranial pressure is measured
The more accurate passive intracranial pressure monitoring system of implantation type wireless.
In order to realize more than technique effect, the invention discloses a kind of passive intracranial pressures of implantation type wireless to monitor system,
Including intracranial pressure monitor, vitro detection instrument, the intracranial pressure monitor is implanted into encephalic, including shell, pressure sensor
And circuit module, the pressure sensor are piezoresistive pressure sensor, the shell upper and lower ends are equipped with thin highly elastic layer, institute
Stating circuit module includes wireless charging module, signal transmitting module and signal processing module, and the pressure sensor is led by length
Line is connected with the circuit module, and the intracranial pressure monitor is connected by wireless signal with the vitro detection instrument, described
Vitro detection device is sending external radio frequency electric field, institute close to the position of the intracranial pressure monitor to the wireless charging module
It states and generates induced voltage on the sensor wireless radio circuit coil on wireless charging module, after the induced voltage is rectified
As the power supply of the intracranial pressure monitor, the signal transmitting module and signal processing module start after power supply electrifying
Work, the signal processing module read the resistance value of the piezoresistive pressure sensor output, and the resistance value passes through signal
Processing module is amplified after modulation, and the vitro detection instrument, the thin high resiliency are sent to by the signal transmitting module
Layer, which can play the role of concentrating, to be transferred and average pressure, inconsistent right so as to reduce the surface undulation due to stiff dough, loading angle
The measurement that hard sensor generates influences.
Preferably, the piezoresistive pressure sensor is polymer thick film device, and the polymer thick film device includes mark
The end of a thread, upper film, lower film, top substrate, base substrate and sensor wall, it is thick that the trace head is arranged at the polymer
One end of film device is formed with the first interdigital object and the second interdigital object, first interdigital on the upper film
Object and the second interdigital object bottom lead to trace respectively, and the trace connects the trace head, scribbled on the lower film
Pressure drag ink, the upper film are attached in the top substrate, and the lower film is attached in the base substrate, the sensor
The edge of wall along the top substrate and base substrate is formed between the top substrate and base substrate, the pressure resistance type
The surface of pressure sensor depressed deformation after stress, the pressure drag ink intersect the first interdigital object and second
It is short-circuit between finger-shaped material, resistance sizes and the pressure resistance type pressure between the first interdigital object and the second interdigital object
The size for the power that force snesor surface is subject to is inversely proportional.
Preferably, the upper film and lower film are made of flexible polymer material, and the top substrate is ultra-thin rigidity
Material is made.
Preferably, the polymer thick film device is disc-shaped, and the sensor wall is contact adhesive.
Preferably, the trace head and trace are made of silver-colored polymer thick film inks silk-screen printing.
Preferably, the shell of the intracranial pressure monitor uses silica gel packaging.
Preferably, the thin highly elastic layer is PDMS macromolecule layers, and the PDMS macromolecule layers are dimethyl silicone polymer,
It is at low cost, using simple, with having good adhesiveness between the silica gel on the shell of the intracranial pressure monitor, and have
There is good chemical inertness.
Preferably, the circuit module is formed on flexible PCB, and signal transmitting module is RFID tag transponder,
Including microchip, sensor port and antenna, the sensor port connects the trace head by the long conducting wire.
Preferably, the flexible polymer material is PET, and the PET is polyethylene terephthalate, described poly- pair
Ethylene terephthalate has good electrical insulating property, creep resistance, resistance to fatigue resistance, and good stability of the dimension is on preferable
Film and lower film making material.
Preferably, the vitro detection instrument is intelligent mobile terminal equipment, and the intelligent terminal includes smart mobile phone
Application program and the smart mobile phone for inserting NFC improve the portability of equipment.
Preferably, the vitro detection instrument is intelligent mobile terminal equipment, and the intelligent terminal is included based on tablet
The application software and tablet computer of computer improve the portability of equipment.
Benefit of the invention is：1st, it can significantly extend the working time of monitoring device, occur when reducing patient's use
The risk of infection saves expense of the patient in this medical services content；2nd, improvement clinician judges the state of an illness accurate
Property, promoted monitoring patient's intracranial pressure convenience；3rd, neurosurgery work quality is improved, improves clinical academic research level；4、
Intracranial pressure monitor is fully implanted in patient's encephalic, is connected without conducting wire or conduit with vitro detection instrument, reduces monitoring process
The middle risk that intracranial infection occurs；5th, the case surface of the interior pressure monitor is formed with PDMS macromolecule layers, it is possible to reduce by
The error of inconsistent generation is distributed in pressure.
Description of the drawings
Fig. 1 uses schematic diagram for a kind of passive intracranial pressure monitoring system of implantation type wireless；
Fig. 2 is the pressure sensor inside Structure explosion diagram；
Fig. 3 is the side view of the pressure sensor；
1.1st, scalp；1.2nd, skull；1.3rd, endocranium；2.1st, circuit module；2.2nd, long conducting wire；2.3rd, pressure sensor；2.31、
Upper film；2.32nd, the first interdigital object；2.33rd, the second interdigital object；2.34th, sensor wall；2.35th, lower film；
2.36th, trace head；2.371, upper substrate；2.372, lower substrate；2.38th, PDMS macromolecule layers；2.39, trace；2.310, pressure
Sensitizing range；3rd, vitro detection instrument；4th, shell.
Specific embodiment
In order to which the object, technical solutions and advantages of the present invention are more clearly understood, below in conjunction with specific embodiment, and join
According to attached drawing, the present invention will be described in further detail.
As shown in Figure 1, the present invention provides a kind of passive intracranial pressures of implantation type wireless to monitor system, when can reach long
Between intracranial pressure power effect, and on the daily life of patient without influence.The passive intracranial pressure monitoring of a kind of implantation type wireless
System, including intracranial pressure monitor and vitro detection instrument 3, the intracranial pressure monitor includes circuit module 2.1, long conducting wire
2.2nd, pressure sensor 2.3, in the present embodiment, flat of the circle that the circuit module is diameter 35mm, the circuit module
2.1 are placed between skull 1.2 and scalp 1.1, and the pressure sensor 2.3 is placed between the skull 1.2 and endocranium 1.3,
The long conducting wire 2.2 links together the pressure sensor 2.3 and circuit module 2.1 through the skull 1.2, the body
Outer detector 3 is placed in human external, and concrete operations mode is after patient is treated surgically, and passes through the vitro detection instrument
3 pairs of 2.3 schools zero of pressure sensor input patient information, in operative region bone window edge, 1.3 outside of endocranium and skull
The pressure sensor 2.3 is placed in 1.2 gap, circuit module is inserted in the gap of the scalp 1.1 and skull 1.2
2.1, the pressure sensor 2.3 draws long conducting wire 2.2, the long conducting wire 2.2 through the perforate on the skull 1.2 with it is described
Circuit module 2.1 connects, and after scalp 1.1 sutures, the intracranial pressure monitor is fully implanted in human body.
As shown in figure 3,4 outside of upper/lower terminal shell of the pressure sensor 2.3 is formed with thin highly elastic layer, it is described thin
Highly elastic layer is PDMS macromolecule layers 2.38, and the PDMS macromolecule layers 2.38 can play the work concentrated and transferred with average pressure
With so as to reduce the surface undulation due to stiff dough, the inconsistent measurement generated on hard sensor of loading angle influences, in this reality
It applies in example, the thickness of the PDMS macromolecule layers is 0.30mm.
The circuit module 2.1 includes wireless charging module, signal transmitting module and signal processing module, the intracranial pressure
Power monitor is connected by wireless signal with the vitro detection instrument 3, and the vitro detection device 3 is supervised close to the intracranial pressure
The position for surveying device sends external radio frequency electric field to the wireless charging module, and the sensor wireless on the wireless charging module is penetrated
Induced voltage is generated on frequency circuit coil, becomes the power supply of the intracranial pressure monitor after the induced voltage is rectified,
The signal transmitting module and signal processing module are started to work after power supply electrifying, described in the signal processing module reading
The resistance value that pressure sensor 2.3 exports, the resistance value is amplified by signal processing module after modulation, by the letter
Number sending module is sent to the vitro detection instrument 3.
As shown in Figures 2 and 3, the pressure sensor 2.3 is piezoresistive pressure sensor, the pressure drag type pressure sensing
Device is polymer thick film device, and the polymer thick film device includes trace first 2.36, upper film 2.31, lower film 2.35, top
Portion's substrate 2.371, base substrate 2.372 and sensor wall 2.34, the trace first 2.36 are arranged at the polymer thick film
One end of device in the present embodiment, pressure sensitive area 2.310, the pressure-sensitive area is formed on the upper film 2.31
The size in domain 2.310 is 5.08 square millimeters, and the first interdigital object 2.32 and the second interdigital object 2.33 are located at institute
It states 2.310 top of pressure sensitive area and is close to pressure sensitive area 2.310, the first interdigital object 2.32 and second is handed over
2.33 bottom of interdigitated object leads to trace 2.39 respectively, and the trace 2.39 connects the trace first 2.36, the lower film
Pressure drag ink is scribbled on 2.35, the upper film 2.31 is attached in the top substrate 2.371, and the lower film 2.35 is attached to institute
It states in base substrate 2.372, side of the sensor wall 2.34 along the top substrate 2.371 and base substrate 2.372
Edge is formed between the top substrate 2.371 and base substrate 23.72, the surface of the piezoresistive pressure sensor stress it
Depressed deformation afterwards, the pressure drag ink make short circuit between the first interdigital object 2.32 and the second interdigital object 2.33,
Resistance sizes between the first interdigital object 2.32 and the second interdigital object 2.33 are sensed with the pressure drag type pressure
The size for the power that device surface is subject to is inversely proportional.
The upper film 2.31 and lower film 2.35 are made of flexible polymer material, and the top substrate 2.371 is super
Thin rigid material is made, and ultra-thin rigid material described in the present embodiment is makrolon, in another embodiment of the invention,
The ultra-thin rigid material is thin metal.
In the present embodiment, the polymer thick film device be disc-shaped, a diameter of 6mm, the sensor wall 2.34
For contact adhesive.
The trace first 2.36 and trace 2.39 are made of silver-colored polymer thick film inks silk-screen printing, in the another of the present invention
In embodiment, the trace first 2.36 and trace 2.39 are made of gold plated copper.
The shell 4 of the intracranial pressure monitor uses silica gel packaging.
The thin highly elastic layer 2.38 is PDMS macromolecule layers, and the PDMS macromolecule layers are dimethyl silicone polymer, into
This is low, using simple, with having good adhesiveness between the silica gel on the shell 4 of the intracranial pressure monitor, and has
There is good chemical inertness.
The circuit module 2.1 is formed on flexible PCB, and signal transmitting module is RFID tag transponder, including
Microchip, sensor port and antenna, the sensor port connect the trace head by the long conducting wire.
The flexible polymer material be PET, the PET be polyethylene terephthalate, the poly- terephthaldehyde
Sour glycol ester has good electrical insulating property, creep resistance, resistance to fatigue resistance, and good stability of the dimension is preferable upper film
2.31 and lower 2.32 making material of film.
In another embodiment of the invention, the flexible polymer material is polyimides.
The vitro detection instrument 3 is intelligent mobile terminal equipment, and the intelligent terminal includes smart mobile phone application journey
Sequence and the smart mobile phone for inserting NFC improve the portability of equipment.
In another embodiment of the invention, the vitro detection instrument 3 be intelligent mobile terminal equipment, the intelligent terminal
Equipment includes application software and tablet computer based on tablet computer, improves the portability of equipment.
Claims (10)
1. a kind of passive intracranial pressure monitoring system of implantation type wireless, it is characterised in that：It is external to examine including intracranial pressure monitor
Instrument is surveyed, the intracranial pressure monitor is implanted into encephalic, including shell, pressure sensor and circuit module, the pressure sensor
For piezoresistive pressure sensor, the shell top and bottom are equipped with thin highly elastic layer, and the circuit module includes wireless charging
Module, signal transmitting module and signal processing module, the pressure sensor are connected by long conducting wire with the circuit module, institute
Intracranial pressure monitor is stated to be connected with the vitro detection instrument by wireless signal.
2. a kind of passive intracranial pressure monitoring system of implantation type wireless as described in claim 1, it is characterised in that：The pressure drag
Formula pressure sensor is polymer thick film device, and the polymer thick film device includes trace head, upper film, lower film, top
Substrate, base substrate and sensor wall, the trace head are arranged at one end of the polymer thick film device, the upper film
On be formed with the first interdigital object and the second interdigital object, the first interdigital object and the second interdigital object bottom point
Trace is not led to, and the trace connects the trace head, scribbles pressure drag ink on the lower film, the upper film is attached to institute
It states in top substrate, the lower film is attached in the base substrate, and the sensor wall is along the top substrate and bottom
The edge of portion's substrate is formed between the top substrate and base substrate.
3. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 2, it is characterised in that：It is described thin
Film and lower film are made of flexible polymer material, and the top substrate is made of ultra-thin rigid material.
4. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 2, it is characterised in that：The polymerization
Object thick film device is disc-shaped, and the sensor wall is contact adhesive.
5. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 2, it is characterised in that：The trace
Head and trace are made of silver-colored polymer thick film inks silk-screen printing.
6. a kind of passive intracranial pressure monitoring system of implantation type wireless as described in claim 1, it is characterised in that：The encephalic
The shell of pressure monitor uses silica gel packaging.
7. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 6, it is characterised in that：The thin height
Elastic layer is PDMS macromolecule layers.
8. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 2, it is characterised in that：The circuit
Module is formed on flexible PCB, signal transmitting module be RFID tag transponder, including microchip, sensor port and
Antenna, the sensor port connect the trace head by the conducting wire.
9. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 3, it is characterised in that：The flexibility
Polymer material is PET.
10. a kind of passive intracranial pressure monitoring system of implantation type wireless as claimed in claim 8, it is characterised in that：The body
Outer detector is intelligent mobile terminal equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711374483.1A CN108095715A (en) | 2017-12-19 | 2017-12-19 | A kind of passive intracranial pressure monitoring system of implantation type wireless |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711374483.1A CN108095715A (en) | 2017-12-19 | 2017-12-19 | A kind of passive intracranial pressure monitoring system of implantation type wireless |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108095715A true CN108095715A (en) | 2018-06-01 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109717862A (en) * | 2018-12-29 | 2019-05-07 | 江苏集萃智能传感技术研究所有限公司 | Implanted monitoring intracranial pressure device and monitoring system and its application method |
| CN110013241A (en) * | 2019-04-26 | 2019-07-16 | 侯立军 | Intracranial pressure Multi probe monitors system |
| WO2022055455A1 (en) * | 2020-09-11 | 2022-03-17 | Ege Universitesi | Intracranial pressure monitoring device |
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Effective date of registration: 20221207 Address after: 201405 No.33, Lane 159, Taiye Road, Fengxian District, Shanghai Applicant after: Shanghai Rongzhuo Medical Technology Co.,Ltd. Address before: 215000 building 3, No. 1368, Wuzhong Avenue, Yuexi street, Wuzhong Economic Development Zone, Suzhou City, Jiangsu Province Applicant before: SUZHOU HONGHAO MEDICAL TECHNOLOGY CO.,LTD. |
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