CN108079273A - For postanesthetic nursing scrub cream of local skin and preparation method thereof - Google Patents
For postanesthetic nursing scrub cream of local skin and preparation method thereof Download PDFInfo
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- CN108079273A CN108079273A CN201810116286.8A CN201810116286A CN108079273A CN 108079273 A CN108079273 A CN 108079273A CN 201810116286 A CN201810116286 A CN 201810116286A CN 108079273 A CN108079273 A CN 108079273A
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention relates to medical anesthesia technical fields, more particularly, to postanesthetic nursing scrub cream of local skin and preparation method thereof, which includes the raw material of following parts by weight：Massage 8~12 parts of frosted particle, 5~10 parts of liposome, 1~3 part of D ribose, 45~60 parts of matrix; the massage frosted particle is modified shell powder supported mint extract; the nucleocapsid particles of outer cladding lipid layer and protective layer; the quality of the mint extract is the 5%~8% of massage frosted granular mass, and being loaded in the liposome has Chinese medicine preparation.Combination with massaging frosted particle of the present invention and load medicine liposome are acted on anaesthetic skin, can stimulate contraction of muscle, accelerate blood flow cycle, avoid triggering thrombus, alleviate the inadaptable sense that local skin is brought by anesthesia.
Description
Technical field
The present invention relates to medical anesthesia technical field, more particularly, to the postanesthetic nursing scrub cream of local skin and its
Preparation method.
Background technology
Anesthesia is pressed down by the reversible sexual function of a kind of nervous centralis and peripheral nervous system of drug or other methods generation
System mainly feels the forfeiture of the particularly pain sensation the characteristics of this inhibition, that is to say, that the meaning of anesthesia using drug or other
Method makes patient whole or part is temporarily lost with feeling, to achieve the purpose that painless progress operative treatment.
With the development of society, the demand that people treat minimal invasive operation and beauty treatment is increasing while right
The demand of nonpain treatment in therapeutic process is also increasingly stronger.And all with different degrees of pain in these therapeutic processes
Sense, pain virtually affect to the psychology of patient, generate Anxiety, therapeutic effect can be influenced when serious.Therefore,
Often by way of local anaesthesia to reduce the feeling of pain of patient.And the anesthetic dosage of local anaesthesia is often not easy to hold,
And everyone is different to the sensitivity of anesthetic, the time of sensory recovery is also different after anesthesia, therefore usually has patient performing the operation
After finishing in a very long time, site of anesthesia is still within narcosis, and showing as muscle cannot shrink, and action is inconvenient,
The effect of assist blood reflux is even lost, easily causes blood stagnant in the vein stasis of blood, triggers thrombus.Therefore, how to anaesthetize
After the completion of operation, promote site of anesthesia blood flow, stimulate contraction of muscle, it is the one of anesthetic care to ask greatly to alleviate anaesthetic effect
Topic.
The content of the invention
In view of this, the object of the present invention is to provide for the postanesthetic nursing scrub cream of local skin and its preparation side
Method, the nursing scrub cream combination with massaging frosted particle and load medicine liposome are acted on anaesthetic skin, can stimulate contraction of muscle,
Accelerate blood flow Xun Huan, avoid triggering thrombus, alleviate the inadaptable sense that local skin is brought by anesthesia.
The present invention solves above-mentioned technical problem by following technological means：
For the postanesthetic nursing scrub cream of local skin, the nursing scrub cream includes the raw material of following parts by weight：
Massage 8~12 parts of frosted particle, 5~10 parts of liposome, 1~3 part of D-ribose, 45~60 parts of matrix, the massage frosted particle
It is the nucleocapsid particles of modified shell powder supported mint extract, outer cladding lipid layer and protective layer, the matter of the mint extract
It measures to massage the 5%~8% of frosted granular mass, loading in the liposome has Chinese medicine preparation.
After local anaesthesia is performed the operation, for skin also in narcosis, there are certain difficulties for contraction of muscle, it is also possible to exist
Scrub cream is made with massaging the raw materials such as frosted particle by the liposome for having Chinese medicine preparation is loaded in the problem of neurotrosis, the present invention,
Be applied at anaesthetic skin, using the rubbing action for massaging frosted particle and skin surface, stimulate nerve make its recover as early as possible to
Normal condition, while can also stimulate blood circulation, avoids triggering thrombus, and the mint extract use in frosted particle is in skin
It is upper that there is refrigerant stimulation, it can further alleviate the narcosis of skin, it is promoted to recover as early as possible；In in liposome
The drug action of medicine preparation can further strengthen blood circulation, promote the reparation of neurotrosis.In addition, D-ribose be containing
The monose of five carbon atoms, is the important composition substance of ribonucleic acid, and the regeneration of formation and atriphos with adenylate has
Close relationship is one of most basic energy source of vital metabolic, can promote recovering again for ischemic tissue, effectively repairs fiber crops
Caused neurotrosis after liquor-saturated or operation, has calm and analgesic activity.
Further, the modified oyster shell whiting is that addition chitosan solution is compound obtained in oyster shell whiting, the modified oyster shell whiting
The mass ratio of middle oyster shell whiting and chitosan is 1:(0.1~0.4).
Oyster shell whiting is the biomineralization material of a kind of organo-mineral complexing, containing 5% protein and polysaccharide in composition,
With good organic compatibility, the oyster shell whiting after chitin modified not only has stronger absorption property, is extracted for peppermint
Object provides more attachment points, but also has effects that antibacterial.
Further, the main component of the lipid layer is phosphatidyl choline and cholesterol, and load has ginger in lipid layer
Extract, the quality of the Ginger P.E is the 2%~5% of massage frosted granular mass.
Phosphatidyl choline and cholesterol have good biocompatibility and biological degradability, can pass through skin keratin
Layer, deep skin is penetrated by the Ginger P.E of load, plays the role of stimulating promotion elimination narcose.
Further, the primary raw material of the protective layer is the quality of gelatin and sodium alginate, the gelatin and sodium alginate
Than for 6:1.
Gelatin is the powder formed by the collagenous portion degradation in the connective tissues such as animal skin, bone, sarolemma, flesh evil spirit, is belonged to
In the hydrophilic colloid of macromolecular；Sodium alginate is the by-product extracted from the kelp or sargassum of brown algae after iodine and mannitol
Object has stability, dissolubility, viscosity and security needed for pharmaceutical preparation auxiliary material.Gelatin and sodium alginate combination can be kept away
Exempt from mint extract and Ginger P.E volatilization.
Further, for the liposome using phosphatidyl choline and cholesterol as carrier, load has the Chinese medicine of repairing nerve damage
Preparation, the mass concentration of the Chinese medicine preparation is 10%~15%.
Further, the Chinese medicine preparation includes the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower.
The root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower are respectively provided with relaxing tendons and activating collaterals, promote blood flow and follow
The effect of ring, repairing nerve damage, acts on permeable stimulation nerve endings on skin, is further promoting local anaesthesia skin just
The recovery of normal state, clinical practice safe range is big, and has no toxic side effect.
Further, 2%~6% part of stearine, glycerine 15%~30%, cardanol 1% are contained in the matrix
~2%, beeswax 5%~10%, lauryl sodium sulfate 2%~5%, surplus are distilled water.
In addition, the invention also discloses the above-mentioned preparation method for the postanesthetic nursing scrub cream of local skin, to breast
Change addition lauryl sodium sulfate and distilled water in pot to stir to being completely dissolved, then raise temperature to 65~70 DEG C, add glycerine
Stearate, glycerine, cardanol emulsify 1~1.5h, are then cooled to 50~58 DEG C, add in beeswax constant temperature stirring 30min, cooling
To 20~25 DEG C, matrix is obtained；D-ribose and liposome is added in into matrix to stir and evenly mix, add massage frosted particle in
Stirred and evenly mixed under 2000rpm speed, remove bubble, vacuum sterilization to get to nursing scrub cream.
Further, it is described massage frosted particle prepare it is as follows：By shell particles dries pulverizing to 100 mesh sieves are crossed, add in
Distilled water stirs to get oyster shell whiting suspension, and chitosan is taken to add in the acetum of 5w% and is stirred, obtains chitosan solution, will
Chitosan solution is slowly dropped in oyster shell whiting suspension and stirs, and filters, vacuum drying, and grinding obtains modified oyster shell whiting；It takes thin
Lotus extract is added in deionized water and stirred and evenly mixed, and obtains peppermint extracting solution, and modified oyster shell whiting is added in into peppermint extracting solution and is stirred
Mixing is mixed, is dried in vacuo, obtaining load has the modification oyster shell whiting of mint extract；The ethyl alcohol that Ginger P.E is added in 2w% is molten
It is stirred in liquid, obtains ginger extract, phosphatidyl choline and cholesterol ultrasonic activation 30min are added in into ginger extract,
Then adding in load has the modification oyster shell whiting of mint extract, stirs and evenly mixs, is freeze-dried, obtains microparticle, gelatin is taken to add in
Stirring and dissolving in 40 DEG C of hot water, be subsequently agitated for add in microparticle homogeneous 30min, then dropwise instill 1.0w% sodium alginate it is molten
Liquid adjusts pH value to 6.0~6.5, stirs 30min, ice bath is cooled to 5~8 DEG C, adds in calcium chloride and continues to stir 20min, filters
Washing, it is lyophilized to obtain massage frosted particle.
Further, the liposome prepare it is as follows：Take the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, red
Spend it is clean, add deionized water decoct 30min, the dregs of a decoction being obtained by filtration continue plus deionized water decoct 20min, filtering, merge two
Secondary decoction filtrate, vacuum drying, obtains Chinese medicine preparation, and phosphatidyl choline and cholesterol is taken to add in 60~65 DEG C of deionized water
It stirs and evenly mixs, then addition Chinese medicine preparation stirs and evenly mixs to freeze and obtains carrying medicine liposome.
Nursing scrub cream, massage mill is made using massage frosted particle, liposome, D-ribose and cosmetic base in the present invention
Containing chitosan, mint extract and Ginger P.E in sand particle, chitosan has an antibacterial and anti-inflammation functions, Ginger P.E and
Mint extract, with reference to the rubbing action of frosted particle and skin surface, can be accelerated to stimulate nerve with effect of releiving is stimulated,
Accelerate plexus anesthesia state to recover, promote contraction of muscle, alleviate the sense of discomfort of anaesthetic skin.In addition, the scrub cream of the present invention
In liposome also containing repairing nerve damage, the cycling that promote blood flow, the liposome using phosphatidyl choline and cholesterol as
Carrier smoothly rapid osmotic can immerse skin, further improve repairing of neural injury effect, avoid triggering thrombus, reach only
The effect of pain.The nursing scrub cream of the present invention can stimulate contraction of muscle, accelerate blood flow Xun Huan, avoid triggering thrombus, alleviate
The inadaptable sense that local skin is brought by anesthesia, suitable for the nursing of local skin anesthesia.
Specific embodiment
Below with reference to specific embodiment, the present invention is described in detail：
The raw material for being used for the postanesthetic nursing scrub cream of local skin, including following parts by weight of the present invention：Massage mill
8~12 parts of sand particle, 5~10 parts of liposome, 1~3 part of D-ribose, 45~60 parts of matrix, wherein, massage frosted particle is modified
The nucleocapsid particles of shell powder supported mint extract, outer cladding lipid layer and protective layer, the quality of mint extract are ground for massage
The 5%~8% of sand granular mass, modified oyster shell whiting, which is that addition chitosan solution is compound in oyster shell whiting, to be made, in modified oyster shell whiting
The mass ratio of oyster shell whiting and chitosan is 1:(0.1~0.4), the main component of lipid layer are phosphatidyl choline and cholesterol, and
Load has Ginger P.E in lipid layer, and the quality of Ginger P.E is the 2%~5% of massage frosted granular mass, protective layer
Primary raw material for gelatin and sodium alginate, the mass ratio of gelatin and sodium alginate is 6:1；Liposome is with phosphatidyl choline and courage
Sterol is carrier, and load has the Chinese medicine preparation of repairing nerve damage, and the mass concentration of Chinese medicine preparation is 10%~15%, Chinese medicine system
Agent includes the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower；Contain stearine 2%~6% in matrix
Part, glycerine 15%~30%, cardanol 1%~2%, beeswax 5%~10%, lauryl sodium sulfate 2%~5%, surplus are
Distilled water.
The preparation method for the postanesthetic nursing scrub cream of local skin of the present invention is as follows：
Lauryl sodium sulfate is added in into emulsification pot and distilled water is stirred to being completely dissolved, and then raises temperature to 65~70
DEG C, it adds stearine, glycerine, cardanol and emulsifies 1~1.5h, be then cooled to 50~58 DEG C, add in beeswax constant temperature
30min is stirred, 20~25 DEG C is cooled to, obtains matrix；D-ribose and liposome is added in into matrix to stir and evenly mix, add by
The frosted particle that rubs stirs and evenly mixs under 2000rpm speed, remove bubble, vacuum sterilization to get to nursing scrub cream.
The nursing scrub cream of the present invention will be described by specific preparation method below：
Embodiment one
The preparation of modified oyster shell whiting：The remaining meat in mussel shell, oyster shell, scallop shell is taken out, is cleaned up, in 200
It is calcined at DEG C, crushing obtains shell particles, then obtains oyster shell whiting, take 5g shells shell particles dries pulverizing to 100 mesh sieves are crossed
Powder adds in 100g distilled water and stirs to get oyster shell whiting suspension, and 0.5g chitosans is taken to add in the acetic acid that 100mL concentration is 5w%
Stirring obtains chitosan solution, chitosan solution is slowly dropped in oyster shell whiting suspension and is stirred to dissolving in solution, mistake
Filter, vacuum drying, grinding obtain modified oyster shell whiting.
Massage the preparation of frosted particle：0.5g mint extracts is taken to add in 50mL deionized waters to stir and evenly mix, are obtained thin
Lotus extracting solution adds in 4g modification oyster shell whitings to peppermint extracting solution and stirs and evenly mixs, is dried in vacuo, obtaining load has mint extract
Modified oyster shell whiting；0.2g Ginger P.Es are added in the ethanol solution that 50mL concentration is 2w% and are stirred, obtain ginger extract,
1.8g phosphatidyl cholines and 0.5g cholesterol ultrasonic activation 30min are added in into ginger extract, then addition load has thin
The modification oyster shell whiting of lotus extract, stirs and evenly mixs, and freeze-drying obtains microparticle, takes in the hot water that 2.57g gelatin adds in 40 DEG C
Stirring and dissolving is subsequently agitated for adding in microparticle homogeneous 30min, then instillation 43mL concentration is molten for the sodium alginate of 1.0w% dropwise
Liquid, adjusting pH value to 6.0~6.5 stir 30min, and ice bath is cooled to 5~8 DEG C, add in 0.1g calcium chloride and continue to stir 20min,
Filtering and washing, it is lyophilized to obtain massage frosted particle.
The preparation of liposome：Take the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower in mass ratio 2.5:
1.5:2:3:1:1.5:2.5 clean, and immerse in deionized water and decoct 30min, and the dregs of a decoction being obtained by filtration continue plus deionization decocting
20min is boiled, is filtered, merging decocts filtrate twice, is dried in vacuo, obtains Chinese medicine preparation, take 7g phosphatidyl cholines and 2g cholesterol
It adds in 60~65 DEG C of deionized water and stirs and evenly mixs, then addition 1g Chinese medicine preparations stir and evenly mix to freeze and obtain carrying the micro- fat of medicine
Grain.
Nurse the preparation of scrub cream：2g lauryl sodium sulfate is added in into emulsification pot and 75g distilled water is stirred to complete
Dissolving, then raises temperature to 65~70 DEG C, adds 2g stearines, 15g glycerine, 1g cardanols emulsification 1h, then cools down
To 50~58 DEG C, 5g beeswaxs constant temperature stirring 30min is added in, 20~25 DEG C is cooled to, obtains matrix；It is added in into 45g matrix
1gD- ribose and 5g liposomes stir and evenly mix, and add 8g massage frosted particles and are stirred and evenly mixed under 2000rpm speed, except degassing
Bubble, vacuum sterilization to get to nursing scrub cream.
Embodiment two
The preparation of modified oyster shell whiting：The remaining meat in oyster shell, scallop shell, clam shell, freshwater mussel shell is taken out, cleaning is dry
Only, to be calcined at 200 DEG C, crushing obtains shell particles, then shell particles dries pulverizing is obtained oyster shell whiting to 100 mesh sieves are crossed,
5g oyster shell whitings is taken to add in 100g distilled water and stir to get oyster shell whiting suspension, it is 5w% that 1g chitosans is taken, which to add in 200mL concentration,
Acetum in stirring to dissolve, obtain chitosan solution, chitosan solution be slowly dropped in oyster shell whiting suspension and is stirred
It mixes, filters, vacuum drying, grinding obtains modified oyster shell whiting.
Massage the preparation of frosted particle：0.8g mint extracts is taken to add in 50mL deionized waters to stir and evenly mix, are obtained thin
Lotus extracting solution adds in 4g modification oyster shell whitings to peppermint extracting solution and stirs and evenly mixs, is dried in vacuo, obtaining load has mint extract
Modified oyster shell whiting；0.2g Ginger P.Es are added in the ethanol solution that 50mL concentration is 2w% and are stirred, obtain ginger extract,
1.5g phosphatidyl cholines and 0.5g cholesterol ultrasonic activation 30min are added in into ginger extract, then addition load has thin
The modification oyster shell whiting of lotus extract, stirs and evenly mixs, and freeze-drying obtains microparticle, takes in the hot water that 2.57g gelatin adds in 40 DEG C
Stirring and dissolving is subsequently agitated for adding in microparticle homogeneous 30min, then instillation 43mL concentration is molten for the sodium alginate of 1.0w% dropwise
Liquid adjusts pH value to 6.0~6.5, stirs 30min, ice bath is cooled to 5~8 DEG C, adds in 0.05g calcium chloride and continues to stir
20min, filtering and washing are lyophilized to obtain massage frosted particle.
The preparation of liposome：Take the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower in mass ratio 2:1.5:
2.5:3:1:1.5:2 clean, and immerse in deionized water and decoct 30min, and the dregs of a decoction being obtained by filtration continue plus deionized water decocts
20min, filtering, merging decoct filtrate twice, are dried in vacuo, obtain Chinese medicine preparation, take 7g phosphatidyl cholines and 1.7g cholesterol
It adds in 60~65 DEG C of deionized water and stirs and evenly mixs, then addition 1.3g Chinese medicine preparations stir and evenly mix to freeze and obtain carrying the micro- fat of medicine
Grain.
Nurse the preparation of scrub cream：5g lauryl sodium sulfate is added in into emulsification pot and 59g distilled water is stirred to complete
Dissolving, then raises temperature to 65~70 DEG C, adds 5g stearines, 20g glycerine, 1g cardanols emulsification 1.5h, then drops
Temperature adds in 10g beeswaxs constant temperature stirring 30min, is cooled to 20~25 DEG C, obtains matrix to 50~58 DEG C；It is added in into 50g matrix
2gD- ribose and 7g liposomes stir and evenly mix, and add 10g massage frosted particles and are stirred and evenly mixed under 2000rpm speed, are removed
Bubble, vacuum sterilization to get to nursing scrub cream.
Embodiment three
The preparation of modified oyster shell whiting：The remaining meat in oyster shell, scallop shell, clam shell, freshwater mussel shell is taken out, cleaning is dry
Only, to be calcined at 150 DEG C, crushing obtains shell particles, then shell particles dries pulverizing is obtained oyster shell whiting to 100 mesh sieves are crossed,
5g oyster shell whitings is taken to add in 100g distilled water and stir to get oyster shell whiting suspension, it is 5w% that 1g chitosans is taken, which to add in 200mL concentration,
Acetum in stirring to dissolve, obtain chitosan solution, chitosan solution be slowly dropped in oyster shell whiting suspension and is stirred
It mixes, filters, vacuum drying, grinding obtains modified oyster shell whiting.
Massage the preparation of frosted particle：0.8g mint extracts is taken to add in 50mL deionized waters to stir and evenly mix, are obtained thin
Lotus extracting solution adds in 4g modification oyster shell whitings to peppermint extracting solution and stirs and evenly mixs, is dried in vacuo, obtaining load has mint extract
Modified oyster shell whiting；0.3g Ginger P.Es are added in the ethanol solution that 50mL concentration is 2w% and are stirred, obtain ginger extract,
1.4g phosphatidyl cholines and 0.5g cholesterol ultrasonic activation 30min are added in into ginger extract, then addition load has thin
The modification oyster shell whiting of lotus extract, stirs and evenly mixs, and freeze-drying obtains microparticle, takes in the hot water that 2.57g gelatin adds in 40 DEG C
Stirring and dissolving is subsequently agitated for adding in microparticle homogeneous 30min, then instillation 43mL concentration is molten for the sodium alginate of 1.0w% dropwise
Liquid, adjusting pH value to 6.0~6.5 stir 30min, and ice bath is cooled to 5~8 DEG C, add in 0.1g calcium chloride and continue to stir 20min,
Filtering and washing, it is lyophilized to obtain massage frosted particle.
The preparation of liposome：Take the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower in mass ratio 2.5:
1.5:2:3:1:1.5:2.5 clean, and immerse in deionized water and decoct 30min, and the dregs of a decoction being obtained by filtration continue plus deionization decocting
20min is boiled, is filtered, merging decocts filtrate twice, is dried in vacuo, obtains Chinese medicine preparation, 7g phosphatidyl cholines and 1.7g courages is taken to consolidate
Alcohol is added in 60~65 DEG C of deionized water and stirred and evenly mixed, then add in 1.3g Chinese medicine preparations stir and evenly mix it is lyophilized obtain carrying medicine it is micro-
Fat granule.
Nurse the preparation of scrub cream：3g lauryl sodium sulfate is added in into emulsification pot and 62g distilled water is stirred to complete
Dissolving, then raises temperature to 65~70 DEG C, adds 5g stearines, 20g glycerine, 2g cardanols emulsification 1.5h, then drops
Temperature adds in 8g beeswaxs constant temperature stirring 30min, is cooled to 20~25 DEG C, obtains matrix to 50~58 DEG C；It is added in into 50g matrix
2gD- ribose and 8g liposomes stir and evenly mix, and add 10g massage frosted particles and are stirred and evenly mixed under 2000rpm speed, are removed
Bubble, vacuum sterilization to get to nursing scrub cream.
Example IV
The preparation of modified oyster shell whiting：The remaining meat in mussel shell, oyster shell, scallop shell, clam shell, freshwater mussel shell is taken out,
It cleans up, is calcined at 200 DEG C, crushing obtains shell particles, then shell particles dries pulverizing is obtained to 100 mesh sieves are crossed
Oyster shell whiting takes 5g oyster shell whitings to add in 100g distilled water and stirs to get oyster shell whiting suspension, 2g chitosans is taken to add in 50mL concentration
It is that stirring to dissolving, obtains chitosan solution in the acetum of 5w%, chitosan solution is slowly dropped to oyster shell whiting suspension
It stirs, filters in liquid, vacuum drying, grinding obtains modified oyster shell whiting.
Massage the preparation of frosted particle：0.8g mint extracts is taken to add in 50mL deionized waters to stir and evenly mix, are obtained thin
Lotus extracting solution adds in 4g modification oyster shell whitings to peppermint extracting solution and stirs and evenly mixs, is dried in vacuo, obtaining load has mint extract
Modified oyster shell whiting；0.5g Ginger P.Es are added in the ethanol solution that 50mL concentration is 2w% and are stirred, obtain ginger extract,
1.2g phosphatidyl cholines and 0.5g cholesterol ultrasonic activation 30min are added in into ginger extract, then addition load has thin
The modification oyster shell whiting of lotus extract, stirs and evenly mixs, and freeze-drying obtains microparticle, takes in the hot water that 2.57g gelatin adds in 40 DEG C
Stirring and dissolving is subsequently agitated for adding in microparticle homogeneous 30min, then instillation 43mL concentration is molten for the sodium alginate of 1.0w% dropwise
Liquid adjusts pH value to 6.0~6.5, stirs 30min, ice bath is cooled to 5~8 DEG C, adds in 0.05g calcium chloride and continues to stir
20min, filtering and washing are lyophilized to obtain massage frosted particle.
The preparation of liposome：Take the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower in mass ratio 2:1.5:
2.5:2:1:1.5:2.5 clean, and immerse in deionized water and decoct 30min, and the dregs of a decoction being obtained by filtration continue plus deionized water decocts
20min, filtering, merging decoct filtrate twice, are dried in vacuo, obtain Chinese medicine preparation, take 7g phosphatidyl cholines and 1.5g cholesterol
It adds in 60~65 DEG C of deionized water and stirs and evenly mixs, then addition 1.5g Chinese medicine preparations stir and evenly mix to freeze and obtain carrying the micro- fat of medicine
Grain.
Nurse the preparation of scrub cream：3g lauryl sodium sulfate is added in into emulsification pot and 51g distilled water is stirred to complete
Dissolving, then raises temperature to 65~70 DEG C, adds 6g stearines, 30g glycerine, 2g cardanols emulsification 1.5h, then drops
Temperature adds in 8g beeswaxs constant temperature stirring 30min, is cooled to 20~25 DEG C, obtains matrix to 50~58 DEG C；It is added in into 60g matrix
3gD- ribose and 10g liposomes stir and evenly mix, and add 12g massage frosted particles and are stirred and evenly mixed under 2000rpm speed, are removed
Bubble, vacuum sterilization to get to nursing scrub cream.
After anesthesia surgery, when the nursing scrub cream of the present invention is applied to anaesthetic skin surface, make in fingertip massage
Under, massage frosted particle and skin surface friction, first releasing Ginger P.E stimulates anaesthetic skin, then discharges peppermint and carries
Object is taken to soothe the skin, and accelerates plexus anesthesia state under the drug effect of liposome package and recovers, alleviates anaesthetic skin
Sense of discomfort.
The above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to preferred embodiment to this hair
It is bright to be described in detail, it will be understood by those of ordinary skill in the art that, it can modify to technical scheme
Or equivalent substitution, without departing from the objective and scope of technical solution of the present invention, the claim in the present invention should all be covered
Among scope.The present invention be not described in detail technology, shape, construction part be known technology.
Claims (10)
1. for the postanesthetic nursing scrub cream of local skin, which is characterized in that the nursing scrub cream includes following parts by weight
Several raw materials：Massage 8~12 parts of frosted particle, 5~10 parts of liposome, 1~3 part of D-ribose, 45~60 parts of matrix, the massage
Frosted particle is the nucleocapsid particles of modified shell powder supported mint extract, outer cladding lipid layer and protective layer, and the peppermint carries
The quality of object is taken to massage the 5%~8% of frosted granular mass, being loaded in the liposome has Chinese medicine preparation.
2. according to claim 1 be used for the postanesthetic nursing scrub cream of local skin, which is characterized in that the modified shellfish
Shell powder, which is that addition chitosan solution is compound in oyster shell whiting, to be made, and the mass ratio of oyster shell whiting and chitosan is in the modified oyster shell whiting
1:(0.1~0.4).
3. according to claim 2 be used for the postanesthetic nursing scrub cream of local skin, which is characterized in that the lipid layer
Main component for phosphatidyl choline and cholesterol, and load has Ginger P.E, the matter of the Ginger P.E in lipid layer
It measures to massage the 2%~5% of frosted granular mass.
4. according to claim 3 be used for the postanesthetic nursing scrub cream of local skin, which is characterized in that the protective layer
Primary raw material for gelatin and sodium alginate, the mass ratio of the gelatin and sodium alginate is 6:1.
5. according to claim 4 be used for the postanesthetic nursing scrub cream of local skin, which is characterized in that the liposome
Using phosphatidyl choline and cholesterol as carrier, the liposome load has the Chinese medicine preparation of repairing nerve damage, the Chinese medicine system
The mass concentration of agent is 10%~15%.
6. according to claim 5 be used for the postanesthetic nursing scrub cream of local skin, which is characterized in that the Chinese medicine system
Agent includes the root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower.
7. according to claim 6 be used for the postanesthetic nursing scrub cream of local skin, which is characterized in that in the matrix
Contain 2%~6% part of stearine, glycerine 15%~30%, cardanol 1%~2%, beeswax 5%~10%, dodecane
Base sodium sulphate 2%~5%, surplus are distilled water.
It is 8. special according to any preparation method for the postanesthetic nursing scrub cream of local skin of claim 1~7
Sign is, adds in lauryl sodium sulfate into emulsification pot and distilled water is stirred to being completely dissolved, then raise temperature to 65~70 DEG C,
It adds stearine, glycerine, cardanol and emulsifies 1~1.5h, be then cooled to 50~58 DEG C, add in the stirring of beeswax constant temperature
30min is cooled to 20~25 DEG C, obtains matrix；D-ribose is added in into matrix and liposome stirs and evenly mixs, and adds massage mill
Sand particle stirs and evenly mixs under 2000rpm speed, remove bubble, vacuum sterilization to get to nursing scrub cream.
9. the preparation method according to claim 8 for the postanesthetic nursing scrub cream of local skin, which is characterized in that
Preparing for the massage frosted particle is as follows：
By shell particles dries pulverizing to 100 mesh sieves are crossed, add in distilled water and stir to get oyster shell whiting suspension, chitosan is taken to add in
It is stirred in the acetum of 5w%, obtains chitosan solution, chitosan solution is slowly dropped in oyster shell whiting suspension and is stirred,
Filtering, vacuum drying, grinding obtain modified oyster shell whiting；Mint extract is taken to add in deionized water to stir and evenly mix, obtains peppermint
Extracting solution adds in modified oyster shell whiting to peppermint extracting solution and stirs and evenly mixs, is dried in vacuo, obtaining load has the modification of mint extract
Oyster shell whiting；Ginger P.E is added in the ethanol solution of 2w% and is stirred, ginger extract is obtained, is added in into ginger extract
Phosphatidyl choline and cholesterol ultrasonic activation 30min, then adding in load has the modification oyster shell whiting of mint extract, and stirring is mixed
Even, freeze-drying obtains microparticle, takes stirring and dissolving in the hot water of 40 DEG C of gelatin addition, is subsequently agitated for adding in microparticle homogeneous
30min, then the sodium alginate soln of 1.0w% is instilled dropwise, pH value is adjusted to 6.0~6.5, stirs 30min, ice bath is cooled to 5
It~8 DEG C, adds in calcium chloride and continues to stir 20min, filtering and washing is lyophilized to obtain massage frosted particle.
10. the preparation method according to claim 9 for the postanesthetic nursing scrub cream of local skin, feature exists
In preparing for the liposome is as follows：The root of bidentate achyranthes, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, beefwood-like clubmoss herb, nine layers of wind, Herba Solani Lyrati, safflower is taken to clean, add from
Sub- water decocts 30min, and the dregs of a decoction being obtained by filtration continue plus deionized water decocts 20min, filtering, and merging decocts filtrate twice, very
Sky is dry, obtains Chinese medicine preparation, phosphatidyl choline and cholesterol is taken to add in 60~65 DEG C of deionized water and stir and evenly mix, then
Addition Chinese medicine preparation stirs and evenly mixs to freeze and obtains carrying medicine liposome.
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