CN102091258B - Chinese medicinal composition for dispelling scars and preparation method thereof - Google Patents

Chinese medicinal composition for dispelling scars and preparation method thereof Download PDF

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CN102091258B
CN102091258B CN2011100502697A CN201110050269A CN102091258B CN 102091258 B CN102091258 B CN 102091258B CN 2011100502697 A CN2011100502697 A CN 2011100502697A CN 201110050269 A CN201110050269 A CN 201110050269A CN 102091258 B CN102091258 B CN 102091258B
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radix
medicine
blood
cicatrix
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CN102091258A (en
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吴强
李�杰
张召菊
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Jiangxi Bofen Medical Devices Co ltd
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Abstract

The invention discloses a Chinese medicinal composition for dispelling scars. The composition is prepared from oral administration medicaments and externally-applied medicaments, wherein the oral administration medicaments comprise but are not limited to the following raw material medicaments: angelica dahurica, peach seed, largehead atractylodes rhizome, job stears, Chinese angelica, Szechuan lovage rhizome, dipsacus asperoides, glabrous sarcandra herb, achyranthes root, earthworm, ground beetle, codonopsis pilosula, rhizoma drynariae, williams elder twig and white paeony root; and the externally-applied medicaments comprise but are not limited to the following raw material medicaments: dragon's blood, myrrh, safflower, Chinese angelica, suberect spatholobus stem, rose mallow root, pseudoginseng root, dipsacus asperoides, spreading hedyotis herb, frank incense, angelica dahurica, pearl, root of red-rooted salvia, williams elder twig, loofah sponge, rose and cortex moutan. The Chinese medicinal composition is used for treating various burn scares and various scars formed after surgery and trauma and has the effects of activating blood and dissolving stasis, relaxing tendons and activating collaterals, detoxicating and diminishing swelling, softening hardness to dissipate stagnation, inhibiting scar hyperplasia, relieving scar itching, and softening the scars.

Description

Chinese medicine composition of a kind of dispeling scar and preparation method thereof
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly Chinese medicine composition of a kind of dispeling scar and preparation method thereof.
Background technology
Cicatrix is that the detrimental effect of factors such as physics, biology, chemistry is in the human body skin soft tissue; Cause the major injury of skin soft tissue and can not be fully voluntarily normally repair, changeing by what the fibrous tissue replacement reparation stayed promptly influences the local symptom that outward appearance influences function again.What cicatrix brought to the patient is huge human body misery and psychic pain, the cicatrix of especially burning, leaving over after the scald, severe trauma.Several years of scar hyperplasia phase almost let the patient suffer untold misery.The atrophy phase then makes the patient changed beyond recognition again, and dysfunction causes the great body of patient, heart double combination obstacle people in daily life, work, on human body surface, to leave over various cicatrixes down because of reasons such as wound, burn, operation, treatment skin ulcers.The human body cicatrix roughly reduces following several kinds: the epidermis no concave-convex is the calm scars of the dark brown variation of color of the leather purplish-black; The mottle trace of the concavo-convex and dark brown variation of purplish-black of epidermis; High protruding hard and " pimple property " cicatrix that reddish violet changes of epidermis; The protruding hard reddish violet of the spontaneous height of epidermis changes, and constantly enlarges the mound formula skin tumour of unlimited development etc.Though the disease that cicatrix can not be serious, the influence beauty treatment brings misery to the patient, causes sorry.At present, though various medicines are arranged, all have weak curative effect, the problem, particularly " pimple property " skin tumour of side effect are arranged, at present with " radioactivity " therapy, or operative treatment all can not get satisfied effect.The medicine of the treatment cicatrix of selling on the market anaphylaxis occurs through regular meeting, and therapeutic effect is not obvious, and curative effect is slow.
Synthesizing and the secretion minimizing of adhesion molecules such as E-selectin, ICAM-1, VCAM-1, comprise that the synthetic and secretion increase of the various metalloproteases of collagenase is to cause the molecular biology of chronic refractory wound surface pathological change basis; Interleukin 8 (IL-8), interleukin 10 (IL-10) content are very high, with the form of autocrine tissue repair are played inhibitory action, and fibroblast produces the collagen effect and weakens, and the wound surface apoptosis increases.Aspect treatment; Can promote wound healing though in the common wound of animal, add the somatomedin of above-mentioned promotion wound healing; But the effect of clinic trial is also bad; Its main cause is to have a large amount of protease of metalloproteases that comprise to exist in the refractory wound surface, and the latter has decomposed the endogenous somatomedin of wound emiocytosis and the exogenous growth factor of adding, thereby causes speed of wound healing to slow down or stop.
Removing the scar product and can only making moderate progress to the cicatrix connective tissue of existing market do not reach and recovers original function of organization and original appearance fully.And the laser that the modern medicine beauty treatment is taked, grinding fills the treatment cicatrix also can only cure the symptoms, not the disease, and only simply improves the size of some cicatrixes, can not eliminate vestige fully, makes sufferer painful more.Now market and the clinical medicine that all presses for a kind of obvious dispeling scar can be treated various types of burn scar, and the various cicatrixs of operation, the formation of wound later stage.It will have following function: the function of blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, removing toxic substances and promoting subsidence of swelling, software eliminating stagnation, inhibition scar hyperplasia, alleviation cicatrix pruritus, softening cicatrix.But the Chinese medicine preparation of research and development is all not satisfactory now.
Summary of the invention
Technical problem to be solved by this invention is: at present clinically; Cicatrix is the difficult problem that department of dermatologry is difficult to capture always; Remove scar product and beauty treatment, the operation etc. of existing market can only make moderate progress to the cicatrix connective tissue, do not reach and recover original function of organization fully; Press for a kind of medicine of the cicatrix that can be greatly improved.External-applied ointment of the present invention is applied in skin surface, makes medicine quick penetration skin surface get into skin corium, forms the connective tissue of cicatrix before decomposing; Reparation broken fiber tissue; The collagen structure that can recover the skin basal layer for oral administration makes its proper alignment, keeps level and smooth and gloss, elasticity and the toughness of skin; Treat various types of burn scar, and the various cicatrixs that form of operation, wound later stage.Has following function: the function of blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, removing toxic substances and promoting subsidence of swelling, software eliminating stagnation, inhibition scar hyperplasia, alleviation cicatrix pruritus, softening cicatrix.
For solving the problems of the technologies described above; It is a kind of when cicatrization that the present invention provides, and promptly behind the wound healing, cicatrix does not form preceding or the cicatrization initial stage uses; Evident in efficacy; Can play softening, inhibition cicatrix, reduce the effect of pigmentation, prevent scar contracture and the Chinese medicine composition that reduces odd-shaped generation.The Chinese medicine composition of dispeling scar of the present invention; Be made up of endo-medicine and external used medicine, various crude drug include but are not limited in the said endo-medicine: the Radix Angelicae Dahuricae, Semen Persicae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, Herba Sarcandrae, Radix Achyranthis Bidentatae, Pheretima, Eupolyphaga Seu Steleophaga, Radix Codonopsis, Rhizoma Drynariae, Ramulus Sambuci Williamsii and the Radix Paeoniae Alba;
Various crude drug include but are not limited in the external used medicine: Sanguis Draxonis, Myrrha, Flos Carthami, Radix Angelicae Sinensis, Caulis Spatholobi, Radix Urenae Lobatae, Radix Notoginseng, Radix Dipsaci, Herba Hedyotidis Diffusae, Olibanum, the Radix Angelicae Dahuricae, Margarita, Radix Salviae Miltiorrhizae, Ramulus Sambuci Williamsii, Retinervus Luffae Fructus, Flos Rosae Rugosae and Cortex Moutan.
The Chinese medicine composition of said dispeling scar, the ratio of weight and number of various crude drug can be 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts in Semen Persicae, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Semen Coicis, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis, 10～20 parts of Herba Sarcandraes, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Pheretimas, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Radix Codonopsis, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of the Radix Paeoniae Albas in the endo-medicine;
The ratio of weight and number of various crude drug can be 10～30 parts of Sanguis Draxonis, 10～30 parts of Myrrhas, 10～30 parts on Flos Carthami, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Caulis Spatholobis, 10～30 parts of Radix Urenae Lobataes, 10～30 parts of Radix Notoginseng, 10～30 parts of Radix Dipsacis, 10～30 parts of Herba Hedyotidis Diffusaes, 10～30 parts of Olibanums, 10～30 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Margaritas, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Ramulus Sambuci Williamsii, 10～30 parts of Retinervus Luffae Fructuss, 10～30 parts of Flos Rosae Rugosaes, 10～30 parts of Cortex Moutans in the external used medicine.
The Chinese medicine composition of said dispeling scar, the ratio of weight and number of various crude drug can also be 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts in Semen Persicae, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Semen Coicis, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis, 10～15 parts of Herba Sarcandraes, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Pheretimas, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Radix Codonopsis, 10～15 parts of Rhizoma Drynariae, 10～15 parts of Ramulus Sambuci Williamsii, 10～15 parts of the Radix Paeoniae Albas in the endo-medicine;
The ratio of weight and number of various crude drug can also be 10～30 parts of Sanguis Draxonis, 10～30 parts of Myrrhas, 10～30 parts on Flos Carthami, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Caulis Spatholobis, 10～30 parts of Radix Urenae Lobataes, 10～30 parts of Radix Notoginseng, 10～30 parts of Radix Dipsacis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Olibanums, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Margaritas, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Flos Rosae Rugosaes, 10～20 parts of Cortex Moutans in the external used medicine.
The Chinese medicine composition of said dispeling scar, the ratio of weight and number of various crude drug also can be 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts in Semen Persicae, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Semen Coicis, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Dipsacis, 10～20 parts of Herba Sarcandraes, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Pheretimas, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Radix Codonopsis, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of the Radix Paeoniae Albas in the endo-medicine;
The ratio of weight and number of various crude drug also can be 10～20 parts of Sanguis Draxonis, 10～20 parts of Myrrhas, 10～20 parts on Flos Carthami, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Radix Urenae Lobataes, 10～20 parts of Radix Notoginseng, 10～20 parts of Radix Dipsacis, 10～30 parts of Herba Hedyotidis Diffusaes, 10～30 parts of Olibanums, 10～30 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Margaritas, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Ramulus Sambuci Williamsii, 10～30 parts of Retinervus Luffae Fructuss, 10～30 parts of Flos Rosae Rugosaes, 10～30 parts of Cortex Moutans in the external used medicine.
The endo-medicine dosage form of the Chinese medicine composition medicine of said dispeling scar can: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster, cream or drop; External used medicine dosage form: unguentum, tincture, liniment, loose powder agent, membrane or ointment.
For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing of Chinese medicine composition of dispeling scar, and the dosage form of said external used medicine is an ointment; Its preparation method comprises: the crude drug of getting the said ratio of weight and number except that Margarita soaked 1-2 hour, placed multi-function extractor then, and the 5-10 that decocts amount of water for the first time and be medical material doubly; Decoct, when being heated to 100 ℃, pick up counting; After little the boiling 2 hours, emit medicinal liquid, put in the fluid reservoir from the feed opening filtration; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, cooling; Crushing pearl is added in the extractum tinning behind the ultraviolet radiation sterilizing.
For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing of Chinese medicine composition of dispeling scar, and the dosage form of said oral preparations is a capsule, and method for preparing comprises:
A. said crude drug is put into the pulverizer grinding and sieving,
B. the remaining particulate matter in back that will sieve is put into the ethanol heating and refluxing extraction 2 times;
C. get the medicinal residues behind the above-mentioned ethanol extraction again, add the water heating and refluxing extraction 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
Among the said step a, can said crude drug be put into and cross 120 order dusting covers after pulverizer is pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects through the raw material fine powder of 120 mesh sieves subsequent use.
Among the said step b, can the remaining particulate matter in back that sieve be put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5～7 times of amounts, each 1～2 hour, 2 extracting solution merged leave standstill; Among the said step c, it is 5～7 times of water gaging heating and refluxing extraction 2 times that the medicinal residues that above-mentioned ethanol extraction is crossed add the weight portion rate, each 1～2 hour, 2 extracting solution is merged leave standstill.
In the said steps d, can above-mentioned two kinds of extracting solution be merged 1.38 o'clock filtrating when the concentrating under reduced pressure relative density is 50 ℃～60 ℃; Reclaim ethanol; With gained filtrating adjustment proportion to 1.06, feed spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m 2, the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
The method for using of ointment of the present invention: behind the wound healing; Cicatrix does not form preceding or the cicatrization initial stage, wipes away driedly after the wound surface that will heal cleans up, and it is thick that ointment of the present invention evenly is applied to the about 1～2mm in affected part; And in addition appropriateness massage 5～10 minutes; Help drug absorption, every day 3～5 times, 3 months is a course of treatment.Wound healing can be used, medication more early, and curative effect is good more, and treatment cycle is short more, and continuous use effect 2 courses of treatment is better.Cicatrix has formed or the cicatrix later stage, instruct down the specialist, and according to situation such as the position of scar hyperplasia and complication, methods such as cooperation functional exercise are carried out Comprehensive Treatment.During using the cicatrix health-care paste, avoid ichthyophagy, shrimp, suffering, the food that stimulates such as peppery.
Ointment of the present invention is through a large amount of clinical verifications, and behind wound healing, cicatrix does not form preceding or the cicatrization initial stage uses, and is evident in efficacy, can play softening, suppress cicatrix, reduce the effect of pigmentation,, prevent scar contracture and reduce odd-shaped generation.Ointment of the present invention is applied in skin surface, makes medicine quick penetration skin surface get into skin corium, forms the connective tissue of cicatrix before decomposing; Reparation broken fiber tissue; Recover the collagen structure of skin basal layer, make its proper alignment, keep level and smooth and gloss, elasticity and the toughness of skin; Treat various types of burn scar, and the various cicatrixs that form of operation, wound later stage.Has following function: the function of blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, removing toxic substances and promoting subsidence of swelling, software eliminating stagnation, inhibition scar hyperplasia, alleviation cicatrix pruritus, softening cicatrix.
The clinical therapeutic efficacy of ointment of the present invention is in particular in: this product is through a large amount of clinical verifications, and is safe in utilization, without any side effects; The early stage use of cicatrix can be played softening cicatrix, alleviates the uncomfortable sensations such as sufferings of cicatrix; To the cicatrix that has formed, can protect cicatrix skin effectively, improve partial microcirculation, the tight bundle sense behind the alleviation cicatrix, the reparation of vesicle behind the promotion cicatrix, the hypertrophy rate of reduction cicatrix, patient's quality of life behind the raising burn-healing.Therefore, the present invention has low, the nonirritant of treatment cost, effect is obvious, treatment speed is fast, can eliminate comedo, skin care, slow down aging fully, makes the skin pale advantage of exquisiteness that becomes.Removing the scar product and can only making moderate progress to the cicatrix connective tissue of existing market do not reach and recovers original function of organization and original appearance fully.And the present invention has the when injected organism tissue of inducing organ original position reproduction; The organizational structure that sets back and the effect that recovers original function of organization; Therefore, utilize pure Chinese medicinal preparation of the present invention can realize removing that scar is seamless, the non-pigmented effect in the flat hole of anti-acne, its infiltration, molten, the reparation of disappearing, reductive effect; Directly dissolve the connective tissue of cicatrix; For the regenerative cell of potential creates the spatial material conditions of regeneration, supply with the material of original position histoorgan original position reproduction, reach, anti-acne flat hole non-pigmented effect seamless except that scar.
The specific embodiment
Cicatrix is the inevitable outcome in the human body processes of wound repair, from broad sense, does not have the healing of wound without cicatrix.The main component of scar tissue is a fibrin.The generation of scar tissue collagen and deposition have increased the intensity of wound, are useful from the general extent.If scar tissue forms insufficient; Damaged tissues can not get normal tension force; Can cause many complication thus, weak like the cicatrix of incision of abdominal wall healing, split or the outside gradually bulging of abdomen content and form abdominal hernia again in the cicatrix place.On the contrary, if cicatrix excessively forms, old serious profile or the major issue on the function of causing.Its essence and characteristic depended in the harm of cicatrix, and to the fixation of the secondary of deep tissue.Thereby cicatrix is with respect to the preceding tissue of damage, incomplete replacement always.From mechanical angle, its anti-epistasis weakens; From the nutrition angle, caused the alternative obstacle of oxygen and nutrient substance; See from functional perspective, cause that the deformity of damaged tissues and dysfunction see from angle attractive in appearance, caused the destruction of profile.We propose the pathogenic theory of cicatrix wound surface " void, heresy, the stasis of blood, corruption " on tradition " putrefaction-removing granulation-promoting ", " promoting tissue regeneration by removing blood stasis " Therapeutic Principle's basis, and are the academic viewpoint of principle of treatment with " tonify deficiency granulation promoting ", " blood stasis dispelling granulation promoting ".Cicatrix is to represent skin once to receive post-traumatic vestige, and this wound can be that wound causes, and also possibly be that operation is necessary; Just different because of wound degree; Whether smooth-going agglutination is, and wound position on human body is different, and formed cicatrix just has the difference of the degree that obviously differs in size; Especially with the progress of person modern society, like to be beautiful and not only represent a kind of right, also represent a kind of respect the oneself; Cicatrix is one of modal problem in the beauty and shaping surgery; Except the influence of outward appearance, in fact there are many cicatrixes to have painful pruritus, pain and dry and cracked, if the unfortunate scar contracture (scar contracture) that produces; More can advance one do not influence extremities joint activity or face normal function, these cicatrixes are must active treatment.
Chinese medicine has long history and good curative effect to treating acne; The successive dynasties medical literature was all done elaboration to this; Not only accumulated abundant clinical experience, summed up tall and erect medicable a large amount of side's medicines and relevant dosage form, and risen to theoretical level; Confirm the etiology and pathogenesis of ulcer and the method for determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, formed characteristic theoretical system.As summed up the ulcer healing rule of " corruption dispels that flesh is given birth to, the flat skin of flesh long "; Pay attention to the early stage putrefaction removing of ulcer, the later stage expelling pus and promoting granulation; And recognize that the qi and blood prosperity and decline of local woanded surface, stagnation of QI-blood are most important to wound healing.But " corruption " gone difficult problems such as " new flesh " living or difficult life and cicatrization still can not be resolved.
For the use mechanism of the short wound healing of external Chinese medicine, the traditional Chinese medical science has saying of " removing the necrotic tissue and promoting granulation being snuggled up to pus and put on flesh ".Existing research shows that external Chinese medicine can promote wound surface to secrete a large amount of consistence things, i.e. " pus ", in wound healing mid-term, this kind " pus " liquid is many more, and then wound healing is fast more.At present; Domestic research to the short wound healing effect of Chinese medicine also mainly concentrates on the mechanism research of " snuggling up to pus puts on flesh "; Attempt some cells, the chemical mediator that in wound healing, play an important role to be regulated and improved aspects such as influence factor to experimentize and observe, set forth external Chinese medicine and more create mechanism through external Chinese medicine.At present, studying the more more side of wound medicine has benefiting qi and nourishing blood side's medicines such as decoction of four noble drugs, SIWU TANG, BAZHEN TANG, and it is prolonged to be used for ulcer; Granulation promoting is slow, Mental fatigue cardiopalmus, lack of appetite; The deficient pulse person, square medicines such as external SHENGJISAN, SHENGFU GAO can be received extraordinary clinical effectiveness really.Chinese medicine is very abundant about the argumentation of putrefaction-removing granulation-promoting method; As comparatively clearly having proposed notion, method and the indication of " eliminating pus and slough " in " Liu Juanzi Guiyi Fang, Liu Juanzi cautery therapy with heated needle should " first; And be loaded with the square medicine of eliminating pus and sloughs such as " take out pus loose ", be the beginning of putrefaction-removing granulation-promoting therapy.After this ancient Chinese medicine doctor has successively carried out further abundant to this therapy and has discussed, and proposes like Golden Mirror of Medicine: " rotten person, bad meat also ... corruption does not go then newly not give birth to, and lid can have been contaminated meat also with corruption ... cover the medicine of putrefaction removing, be infections section key medicine also." explained that the medicine at putrefaction removing has at that time just become infections section key medicine.Prescriptions Worth Thousand Gold for Emergencies has clearly proposed the first putrefaction removing notion of granulation promoting again: " after husband's carbuncle is bad, the meat of evil person is arranged, suitable Ungula Sus domestica soup flush away is dirty, and the inferior meat extract of tiing up looses, and after evil meat goes, applies SHENGJISAN, and four limits of rubbing have made meat speed give birth to." spell out in " surgery opens profound ": " interior have carrion to stop more, lost meat, prohibits if pain is difficult for all carbuncle cane poison and syphilis of the bone, ecthyma inguinal bubo, furuncle etc.; It is if late going, rotten further ... " factors such as carbuncle, cane poison cause the generation of " carrion " (slough), and " carrion " (slough) can " lose meat " again conversely.This shows that ancients recognize that for a long time slough itself is exactly one of cause of disease that forms slough, corruption does not go then flesh not give birth to, and the understanding of this and modern medicine is corresponding to.Wang's machine is said in " surgery reason example ": " after pus goes out, not most with searching pus removing toxic substances medicine as if pus, just use granulation promoting, be engaged in that it is early healed, then poison is most, must not break again." " so eliminating pus and slough " be the precondition of " expelling pus and promoting granulation ", have only slough to take off to the greatest extent after, use " simmering the pus method " again and just can play the effect that promotes wound healing.
The present invention advocates " promoting tissue regeneration by removing blood stasis " on the treatment cicatrix, proposes " blood stasis dispelling granulation promoting ", " tonify deficiency granulation promoting " theory, has established the Therapeutic Method of " benefiting qi and removing blood stasis " in view of the above.Treat chronic refractory wound surface and can obviously promote and the acceleration wound healing supporting vital QI and dispersing blood stasis side; Reduce cicatrization; Improve healing quality, obtained remarkable result, solved the clinical difficult problem of Chinese medicine " putrefaction-removing granulation-promoting " therapy " only rotten and flesh difficulty is given birth to or do not given birth to "; Widen the approach of treating acne, improved and developed " more wound is theoretical " of Chinese medicine.
The effect mechanism of the Chinese crude drug that is adopted is: so the present invention chooses blood circulation promoting and blood stasis dispelling, and reducing swelling and alleviating pain, the Chinese crude drug of operation QI and blood is arranged in pairs or groups meticulously; Through vital energy regualting and blood circulation-promoting, transfer smooth QI and blood, dredging the meridian, hold concurrently with nourishing the liver and kidney; Human body is adjusted to lastingly, stable equilibrium between yin and yang, the state that QI and blood is unobstructed.Thereby reach skin care, blood circulation promoting and blood stasis dispelling, beautify the purpose of appearance.Radix Salviae Miltiorrhizae, Radix Astragali QI invigorating in the side, the hemopoietic the lucid yang sending up, Semen Persicae liver and kidney tonifying, benefit vital essence; Radix Angelicae Sinensis, Radix Paeoniae Alba replenishing blood and nourishing liver, kidney nourishing and blood enriching, Semen Coicis, Fructus Jujubae invigorating the spleen and replenishing QI YIN nourishing detumescence; Caulis Spatholobi, Radix Urenae Lobatae, the Flos Rosae Rugosae regulating menstruation and nourishing blood, activating blood circulation to dissipate blood stasis beautifies appearance; The invigorating the liver and kidney of Radix Paeoniae Alba yin nourishing blood; Margarita resolving depression clearing away damp-heat; Fructus Rubi is tonified Qi of the kidney, Rhizoma Chuanxiong regulating menstruation and nourishing blood, pain relieving.Retinervus Luffae Fructus detumescence skin care; Herba Albiziae has been spent tired, arresting convulsion, the impaired reparation of the useful meridians of Radix Dipsaci.The useful taste of the Rhizoma Atractylodis Macrocephalae, Flos Carthami, Lignum Sappan is dispelled to swell and invigorates blood circulation.The Margarita arresting convulsion is calmed the nerves, and the ability nourishes rough skin, repairs destructive meridians rapidly, muscles and bones.Oral medicine is made laws with treating both the principal and secondary aspects of a disease; Blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain science compatibility, external also is intended to detumescence; The function of blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, removing toxic substances and promoting subsidence of swelling, software eliminating stagnation, inhibition scar hyperplasia, alleviation cicatrix pruritus, softening cicatrix, and certain cosmetic result is arranged.
Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Rhizoma Chuanxiong is hot, temperature.Return liver, gallbladder, pericardium channel.The function blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, and the ability promoting blood circulation to remove blood stasis is the good medicine that nourishes blood.
Semen Persicae is bitter, and is sweet, puts down the special medicine that closes for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicineization justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and the body profit can be grown dryness of the intestine.If gross weight grinds many usefulness, walk Liver Channel, main broken blood-retention, water month by month; And pain all over, extremity wood numbness, left hemiplegia, left sufficient patient; Relax through the promoting the circulation of blood of invigorating blood circulation with it, the merit of eliminating blood stasis to promote regeneration of blood is arranged,, go into large intestine if few usefulness is mashed in peeling; Control blood depletion and just close, the dry dyschezia of blood with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.
Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carried it: monarch, and sweet in the mouth, suffering, nontoxic.Can main big migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, removes cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.
Radix Dipsaci, the Chinese medicine name is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, because of ability " synthetism of continuous folding " is gained the name.Excavate autumn, removes root head and fibrous root, with low baking temperature baking to half-dried, when banking up " diaphoresis " to inner virescence, oven dry again." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians decide in tonifying liver, bone and muscle strengthening, end in the warp (muscles and bones) and ache, and are antiabortive, control the married woman leucorrhea, tissue regeneration promoting blood, and removing blood stasis with potent drugs blood, the stillborn fetus that falls, the cough-relieving hemoptysis of coughing is controlled red white turbid urine.”
The Chinese medicine that Semen Coicis is commonly used. be again generally, the food often eaten, the property slightly sweet flavor is slightly cold, and effects such as inducing diuresis to remove edema, spleen invigorating are dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus are arranged, and is damp-clearing drug commonly used.Semen Coicis is to mend the medicinal good merchantable brand of body.According to medical department assay, Semen Coicis contains protein 16.2%, fat 4.6%, saccharide 79.2%.Be a kind of nourishing food with Semen Coicis stewed pig's feet, Os Sus domestica and chicken winter.Cooking congee with Semen Coicis summer or make cold drink ice Semen Coicis, is again the clear tonic of body-building of well relieving summer heat.The kind Renhe root of Semen Coicis can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is put down in writing in Compendium of Material Medica: Semen Coicis can " invigorating spleen and reinforcing stomach, wind prevailing over dampness be removed in the tonifying the lung heat clearing away.The food of cooking a meal is controlled cold air.Fry in shallow oil drink, the diuresis pyretic stranguria." in recent years, a large amount of scientific research and clinical practices prove that Semen Coicis still is a kind of cancer therapy drug, Preliminary Identification, and it presses down rate to controlling of cancer and can reach more than 35%." Compendium of Material Medica meaning Semen Coicis " skin care is stayed and held, makes light of one's life by commiting suicide and prolong life for invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, expelling wind and dampness ".
The Radix Paeoniae Alba goes into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.
Pheretima: Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.It is fanatical dry to cure mainly height, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid the good effect that cloperastine is breathed heavily of deciding is arranged.
The Radix Angelicae Dahuricae: meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Be used for wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.Be used for headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus."Japan Hanako Materia Medica": governance red eyes and pterygium, and fill Tailou fall, broken blood places, make new blood, milk carbuncle, hair back, scrofula, intestinal wind, hemorrhoids fistula, abscess, wound, scabies, myogenic pain, to face Shao-defect scar.
The Radix Achyranthis Bidentatae drug effect is high, and Li Shizhen (1518-1593 A.D.) is said it: the merit of nourishing, and like the power of cattle.Radix Achyranthis Bidentatae abnormal smells from the patient picric acid is flat, cures mainly cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, the gonalgia unable to flex and stretch the extremities, and by vim and vigour, the fire of getting mildewed in warm conditions is mashed, and clothes are made light of one's life by commiting suicide anti-old for a long time.1. wherein contained alkaloid has good hypotensive effect.2. contained ecdysterone can improve liver function, reduces plasma cholesterol, and the effect of cell activity enhancing is arranged.3. be rich in Inokopolyose the effect of tangible enhancing humoral immune function is arranged.4. to the human body low or body of gland atrophy of zinc, endocrine function that manganese causes for want of, pathological changes such as poor growth, sexual impotence, infertile, habitual abortion have curative effect preferably.5. have antiinflammatory and analgesic activity.6. has the function that the calculus of gallbladder, kidney, bladder, urethra is dissolved and excreted.7. its effective ingredient has certain excited uterus, anti-aging effects.8. diuresis, spasmolysis.So good medicine that its blood circulation promoting and blood stasis dispelling simply is healthy and strong." detailed outline is picked up any lost article from the road ": blood circulation promoting and blood stasis dispelling, wide muscle, reason traumatic injury.
Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.The kidney invigorating bone strengthening continues and hinders pain relieving.Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, and the muscles and bones folding is hindered; The external treatment alopecia areata, vitiligo.The kidney invigorating is invigorated blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus." property of medicine opinion ": " poison in the main bone, wind blood pain, the five kinds of over strain six types of severe debility disease, hands is not received, upper heat and lower cold." " book on Chinese herbal medicine just ": " treated the bone poison of being possessed, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism, so that the weak pain of two flaccidity of the lower limbs.
Ramulus Sambuci Williamsii: effects such as anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, the synthetism of stimulating the menstrual flow are arranged, be used to treat various diseases associated with inflammation, rheumatic arthritis, lumbago and skelalgia, sore swollen toxin pneumonia, appendicitis, acute cellulitis, tumor, traumatic injury, fracture etc.Tang Materia Medica: " main folding is hindered, and reuniting the fractured tendons and bones removes pruritus due to wind pathogen, dental caries.Can be bath soup.″
Radix Codonopsis property is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power ability spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not grown greasyly partially, inspires clear sun, gas in the vibration, and do not have dry fraud just.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can the lung benefiting consolidating superficial resistance.The Radix Codonopsis QI invigorating can only the spleen invigorating QI invigorating, the power of no consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali does not then have the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis does not have the diuretic effect.This two flavors medicine share can invigorating the spleen and replenishing QI, improves resistance.
Eupolyphaga Seu Steleophaga becomes, and is cold; Slightly poisonous.Return Liver Channel.Function cures mainly removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Be used for the muscles and bones folding and hinder blood stasis amenorrhea, lump in the abdomen mass in the abdomen." Medical Treasures of the Golden Chamber ": control the patient suffering from five overstrains being extremely weak and thin, abdominal distention can not diet, dyspepsia, sorrow, impairment of fluid-retention, injury due to sexual activity, internal impairment caused by hunger, impairment caused by overstrain, meridians Rong Wei impairment of QI, blood stasis in the interior, squamous and dry skin, dark complexion around the eyes.Easing middle-JIAO and tonifying for deficiency.
Herba Sarcandrae: nature and flavor slightly warm in nature, bitter in the mouth, suffering.Function cures mainly anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.Be used for pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.English name: use ERBA SARCANDRAE.Zoopery shows; Herba Sarcandrae can improve the energy metabolism of tumor cell and tumor-bearing mice, improves activity of catalase, and the oxygen-consuming capacity of cancerous cell and tumor mice is had direct repression; Therefore, the main effect of Herba Sarcandrae is to improve energy metabolism and realize antitumaous effect.This medicine of half intracorporal method proof contacts 2h external with oncocyte, can stop oncocyte in the intravital growth and breeding ability of mice.Heavy dose of Herba Sarcandrae all has certain immunosuppressive action to macrophage system, T lymphocyte and bone-marrow-derived lymphocyte.Low dose then can raise immunity, and immunologic function is had regulating action.
External used medicine is introduced:
Herba Hedyotidis Diffusae is Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia again.Mildly bitter flavor, sweet, cold.Go into stomach, large intestine, small intestine meridian, the clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, sweet cold eliminating damp-heat has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Generally be used to treat sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also be used for the puckery pain of pyretic stranguria, dysuria.Be the good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.
The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to have good hemostasia effect, significant hemopoietic function with hemostasia and dissipation blood stasis, reducing swelling and alleviating pain; Can tighten and improve the arteria coronaria microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being regarded as the treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews promptly ending of mashed net for catching birds or fish immediately, and bruise the person promptly dissipate.If when receiving cane, clothes one, two money earlier, then the blood centre of punch not should be obeyed it behind the cane especially, and obey also good puerperal.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work that blood ends because of applying the blood that looses because of blood stasis.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization.”
Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or vexed interior the expanding of blood, the sudden syncope with rigidity is that all puerperal, non-Flos Carthami can not be decided at card as extremely.All friendship like the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending; Or skin infection sufferings and swollen burst uneasyly, are cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred; Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain; The thrombosis of inhibition, antiinflammatory, analgesic effect are arranged, have the vasoconstrictive effect of eliminating epinephrine, norepinephrine, " tonneau passages through which vital energy circulates " effect is arranged.
Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; The women has through uncomfortable; Dysmenorrhea.Be the good medicine of invigorating blood circulation.
Cortex Moutan is bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Cortex Moutan branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.These article function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Cortex Moutan can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.
The Myrrha blood blood stasis removing that looses, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, suffering, flat.1. " property of medicine opinion ": " bitter in the mouth is hot." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is hot, and temperature is nontoxic." 3. " Kaibao Bencao ": " and bitter in the mouth, flat, nontoxic." go into liver, spleen, the heart, kidney channel.1. " Bencao Jingshu ": " go into meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " go into spleen, kidney two warps." 3. " book on Chinese herbal medicine is looked for the truth ": " go into the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness detoxifcation.
Olibanum is arduous, temperature.Regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": it be swollen to treat the edema due to wind pathogen poison, removes bad odor.Treat the urticaria poison of itching."Herbal Supplements": cure deafness, stroke lockjaw, woman, blood, wine can be made, the rationale for air-cooled, only the large intestine vent bleach, eliminate the Order sores treatment.Control to fall and pounce on folding muscle and tendon injury bone: Olibanum, each Qian Wufen of true Myrrha, Radix Angelicae Sinensis, Flos Carthami, each three money of Semen Persicae.Be decocted in water for oral dose.
The Sanguis Draxonis promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation is held back skin ulcer.Control treating swelling and pain by traumatic injury, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.Tang Materia Medica: main the five internal organs pathogen, leukorrhagia, pain relieving, removing mass blood, gold creation meat.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae looses, and cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.Radix Salviae Miltiorrhizae main component TANSHINONES has blood vessel dilating, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.
The Radix Angelicae Dahuricae: meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Be used for wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.Be used for headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus."Japan Hanako Materia Medica": governance red eyes and pterygium, and fill Tailou fall, broken blood places, make new blood, milk carbuncle, hair back, scrofula, intestinal wind, hemorrhoids fistula, abscess, wound, scabies, myogenic pain, to face Shao-defect scar.
Margarita: Margarita has effects such as the arresting convulsion of calming the nerves, the nebula that makes eye bright, removing toxic substances and promoting granulation, and modern study shows that also Margarita all has unique effect at aspects such as improving body immunity, slow down aging, freckle removing and whitening, supplement calcium.The arresting convulsion of calming the nerves, the heat clearing away YIN nourishing makes eye bright, detoxifcation.1. relieving palpitation arresting convulsion is applicable to palpitation with fear palpitation with a distress feeling, epilepsy infantile convulsion.2. liver heat removing makes eye bright except that nebula, with controlling ophthalmic diseasess such as conjunctival congestion and swelling pain, pterygium, many externals.3. convergence granulation promoting is applicable to that throat rots, aphtha of the mouth and tongue, ulcer do not close up suitable external for a long time." book on Chinese herbal medicine converges and says ": relieving palpitation, decide will, the peace soul, the poison that unhitches is changed malignant boil, receives the internal ulceration junk.
Retinervus Luffae Fructus: dredge the meridian passage is arranged, the effect of removing toxic substances and promoting subsidence of swelling.Cure mainly pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture cough, carbuncle future sore, his carbuncle." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, go into meridians, separate pathogenic heat.Evanescence of heat then wind goes, and the unlikely combination of body fluid in the network and be expectorant becomes all diseases of toxic swelling, the ear so cloud detoxifies.
Flos Rosae Rugosae sweet in the mouth, little hardship, gas is fragrant.Warm in nature.Go into liver, stomach warp.Supplementary Amplifications of the Compendium of Materia Medica carries: " gas perfume (or spice) is warm in nature, and sweet and slightly bitter taste is gone into spleen, Liver Channel, regulating and activating blood circulation." " property of medicine is examined " cloud: " Flos Rosae Rugosae is warm in nature, the promoting the circulation of blood removing mass." " book on Chinese herbal medicine is new again " meaning: " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing." so the hot fragrant row of Flos Rosae Rugosae looses the effect of performance promoting QI circulation for relieving depression and blood dissipating blood stasis speckle removing.
Radix Urenae Lobatae is for Malvaceae Herba urenae procumbentis platymiscium Urena lobata Linn Urena lobata L., with root and all herbal medicine.Excavate autumn, and clean chopping is dried.Radix Urenae Lobatae property is sweet, and is light, puts down into the heart, lung meridian.The effect expelling wind and removing dampness, heat-clearing and toxic substances removing.Cure mainly cold, fever, rheumatic arthralgia, dysentery, edema, leucorrhea is spitted blood, carbuncle, traumatic hemorrhage, venom, acute infantile convulsion, tetanus, asthma, stomachache puerperal exposure to wind." Luchuan book on Chinese herbal medicine " carries: removing mass, poison looses.Control traumatic injury, carbuncle sore is the good medicine of treatment gynecological.
Oral capsule method for preparing of the present invention:
Get Radix Angelicae Dahuricae 2000g, Semen Persicae 2000g, Rhizoma Atractylodis Macrocephalae 2000g, Semen Coicis 2000g, Radix Angelicae Sinensis 2000g, Rhizoma Chuanxiong 2000g, Radix Dipsaci 2000g, Herba Sarcandrae 2000g, Radix Achyranthis Bidentatae 2000g, 2000g dragon, Eupolyphaga Seu Steleophaga 2000g, Radix Codonopsis 2000g, Rhizoma Drynariae 2000g, Ramulus Sambuci Williamsii 2000g and Radix Paeoniae Alba 2000g; Said crude drug is put into pulverizer pulverizing back cross 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects through the raw material fine powder of 120 mesh sieves subsequent use; The remaining particulate matter in back that will sieve is again put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5～7 times of amounts, each 1～2 hour, 2 extracting solution is merged leave standstill; Among the said step c, it is 5～7 times of water gaging heating and refluxing extraction 2 times that the medicinal residues that above-mentioned ethanol extraction is crossed add the weight portion rate, each 1～2 hour, 2 extracting solution is merged leave standstill; Above-mentioned two kinds of extracting solution are merged; 1.38 o'clock filtrating when the concentrating under reduced pressure relative density is 50 ℃～60 ℃ is reclaimed ethanol, with gained filtrating adjustment proportion to 1.06; Feed spray dryer and carry out spray drying; The compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m 2, and the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
The method for preparing of oral pills of the present invention:
Get Radix Angelicae Dahuricae 1000g, Semen Persicae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Semen Coicis 1000g, Radix Angelicae Sinensis 1000g, Rhizoma Chuanxiong 1000g, Radix Dipsaci 1000g, Herba Sarcandrae 1000g, Radix Achyranthis Bidentatae 1000g, 1000g dragon, Eupolyphaga Seu Steleophaga 1000g, Radix Codonopsis 1000g, Rhizoma Drynariae 1000g, Ramulus Sambuci Williamsii 1000g and Radix Paeoniae Alba 1000g; Earlier said crude drug is ground into coarse powder, further pulverizes, cross 120 mesh sieves, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, and the fine powder of collecting through 120 mesh sieves gets fine powder a; Can not drop into multi-function extractor through the coarse powder of 120 mesh sieves again and extract twice, and add 8-10 times of water gaging for the first time and decocted 1-2 hour, and add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, and cross and filter filtrating; Heating is concentrated into pasty state, puts into 80 ℃ in baking oven oven dry postcooling, grinds to form fine-powdered b, with a with call in Mel after b mixes and process the sweet pill that refines.
The manufacturing process of external pulvis of the present invention is: get Sanguis Draxonis 2000g, Myrrha 2000g, Flos Carthami 2000g, Radix Angelicae Sinensis 2000g, Caulis Spatholobi 2000g, Radix Urenae Lobatae 2000g, Radix Notoginseng 2000g, Radix Dipsaci 2000g, Herba Hedyotidis Diffusae 2000g, Olibanum 2000g, Radix Angelicae Dahuricae 2000g, Radix Salviae Miltiorrhizae 2000g, Ramulus Sambuci Williamsii 2000g, Retinervus Luffae Fructus 2000g, Flos Rosae Rugosae 2000g and Cortex Moutan 2000g; The raw medicinal material of getting above-mentioned ratio of weight and number soaked 1 hour, placed multi-function extractor then, decocted amount of water for the first time and be 10 times of medical material; Decoct; When being heated to 100 ℃, pick up counting, after little the boiling 2 hours; Emit medicinal liquid from the feed opening filtration, put in the fluid reservoir; Decoct for the second time, amount of water is 10 times of amounts of medical material, is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 75 ℃, and being concentrated into relative density is 1.20, the extractum of temperature to 65 ℃; Put into baking oven, be controlled at 75 ℃, the oven dry postcooling is pulverized the back with Margarita 2000g and is added in the aforementioned medicated powder that obtains, and processes powder.
The method for preparing of externally-applied soft ointment of the present invention comprises:
Get Sanguis Draxonis 1000g, Myrrha 1000g, Flos Carthami 1000g, Radix Angelicae Sinensis 1000g, Caulis Spatholobi 1000g, Radix Urenae Lobatae 1000g, Radix Notoginseng 1000g, Radix Dipsaci 1000g, Herba Hedyotidis Diffusae 1000g, Olibanum 1000g, Radix Angelicae Dahuricae 1000g, Radix Salviae Miltiorrhizae 1000g, Ramulus Sambuci Williamsii 1000g, Retinervus Luffae Fructus 1000g, Flos Rosae Rugosae 1000g and Cortex Moutan 1000g; Crude drug was soaked 1-2 hour, place multi-function extractor then, the 5-10 that decocts for the first time amount of water and be medical material doubly; Decoct; When being heated to 100 ℃, pick up counting, after little the boiling 2 hours; Emit medicinal liquid from the feed opening filtration, put in the fluid reservoir; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, cooling; Margarita 1000g is pulverized in the adding extractum tinning behind the ultraviolet radiation sterilizing.
The manufacturing process of external pulvis of the present invention is:
To get Sanguis Draxonis 1000g, Myrrha 1000g, Flos Carthami 1000g, Radix Angelicae Sinensis 1000g, Caulis Spatholobi 1000g, Radix Urenae Lobatae 1000g, Radix Notoginseng 1000g, Radix Dipsaci 1000g, Herba Hedyotidis Diffusae 1000g, Olibanum 1000g, Radix Angelicae Dahuricae 1000g, Radix Salviae Miltiorrhizae 1000g, Ramulus Sambuci Williamsii 1000g, Retinervus Luffae Fructus 1000g, Flos Rosae Rugosae 1000g and Cortex Moutan 1000g mixes; Chopping is soaked.Just soaked crude drug heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging.The medicinal residues of more above-mentioned water extraction being crossed add 5～8 times of amount 60～70% alcohol heating reflux and extract 2 times, each 1～2 hour, 2 extracting solution merging are left standstill.Above-mentioned two kinds of extracting solution are merged, and the concentrating under reduced pressure relative density is the filtrating of 1.35 (80 ℃), reclaims ethanol, with gained filtrating adjustment proportion to 1.06, reduce pressure extractum, put into oven drying, add the Margarita of pulverizing and become powder.
The method for preparing of external-use tincture of the present invention comprises:
Get Sanguis Draxonis 1000g, Myrrha 1000g, Flos Carthami 1000g, Radix Angelicae Sinensis 1000g, Caulis Spatholobi 1000g, Radix Urenae Lobatae 1000g, Radix Notoginseng 1000g, Radix Dipsaci 1000g, Herba Hedyotidis Diffusae 1000g, Olibanum 1000g, Radix Angelicae Dahuricae 1000g, Radix Salviae Miltiorrhizae 1000g, Ramulus Sambuci Williamsii 1000g, Retinervus Luffae Fructus 1000g, Flos Rosae Rugosae 1000g and Cortex Moutan 1000g; Mix by proportioning; Put into the acid and alkali-resistance infusion kettle; At normal temperatures and pressures, flooded 10～15 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter; Get filtrating after the separation, can directly be applied in patient part after the filtrating concentration extraction.Also can be condensed into and mix vaseline behind the powder or Cera Flava is processed liniment.Can directly be applied in patient part.
Cera Flava is the excretory wax of Apis, has astringent therapy, holds back skin ulcer, granulation promoting, analgesic function, is used for ulcer being unable to heal, ecthyma erosion, wound, burn and scald etc. outward, suppresses the local organization inflammation, promotes the histiocyte growth, quickens the healing of ulcer skin.Pharmacological testing proof Cera Flava extracting solution has parallel antibacterial action to bacillus larvae, honeycomb bacillus.The Cera Flava substrate of making the excipient and the external-use ointment of Chinese patent medicine commonly used.Cera Flava is used as medicine as the substrate of ointment can regulate soft durometer, improves the release and the absorption of medicine.In Chinese medicine ointment of the present invention, Cera Flava also serves as the effect of substrate in performance convergence, granulation promoting pain relieving drug effect.
The present invention is guidance with modern medicine, pharmacology, Chinese medical theory; Having screened medicines such as dredging the meridian, the QI and blood regulating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence, absorption convergence, putrefaction-removing granulation-promoting forms; Be used treatment through oral administration and externally, given full play to plaster granulation promoting dispel scar, antibiotic, pain relieving, the outstanding advantage of repercussive, also embodied the speciality of detoxicating, relieving inflammation for oral administration, absorption convergence, external putrefaction-removing granulation-promoting more; Bring into play both and treated the advantage of cicatrix, remedied mutual shortcoming.Being used of oral administration and externally is applicable to the external treatment of cicatrix to have the cure rate height, characteristics such as pain relieving is rapid, does not stay cicatrix, is not treated environmental limitations, and convenient in application has no side effect, and is simple for production, and cost is low.Therefore, the present invention has low, the nonirritant of treatment cost, effect is obvious, treatment speed is fast, can eliminate comedo, skin care, slow down aging fully, makes the skin pale advantage of exquisiteness that becomes.Removing the scar product and can only making moderate progress to the cicatrix connective tissue of existing market do not reach and recovers original function of organization and original appearance fully.And the present invention has the when injected organism tissue of inducing organ original position reproduction; The organizational structure that sets back and the effect that recovers original function of organization; Therefore, utilize pure Chinese medicinal preparation of the present invention can realize removing that scar is seamless, the non-pigmented effect in the flat hole of anti-acne, its infiltration, molten, the reparation of disappearing, reductive effect; Directly dissolve the connective tissue of cicatrix; For the regenerative cell of potential creates the spatial material conditions of regeneration, supply with the material of original position histoorgan original position reproduction, reach, anti-acne flat hole non-pigmented effect seamless except that scar.
Pharmacology's toxicity test
The acute oral toxicity test report
One, experiment purpose: oral pills of the present invention is to acute oral toxicity effect and the intensity of mice
Two, material and method:
1. tried thing: oral pills of the present invention; Character: pitchy paste
2. sample pre-treatments: take by weighing 15 duplicate samples, add the 500ml boiled water, soaked 2 hours, as stock solution.
3. experimental animal: one grade of Kunming mouse, 20, female, male half and half, body weight 18-22 gram; Provide by Shandong medical college Experimental Animal Center;
Three, test method: (a time maximum limit is mensuration)
Select 20 of healthy adult mices, body weight 18-22 gram, female, hero half and half, the dosage design is female to be 6000m part/k part BW, male is 6000m part/k part BW, irritates stomach by 0.1ml/10 part BW per os and is tried thing.Irritate the preceding animal fasting of stomach 12 hours, freely drink water.Give normal diet after irritating stomach, observed for two weeks, record poisoning symptom and death condition.
Four, result of the test:
In 14 day observation period, the no abnormal reaction of animal subject does not have death, the postmortem no abnormality seen.Female, male mice acute oral LD 50 is greater than 5000m part/k part/BW.
Five, conclusion:
Judge the nontoxic level in the true border of oral pills agent of the present invention according to acute toxicity grading criteria in " disinfection technology standard " (1999).
The cumulative toxicity test report
One, test method: (dosage escalation cumulative coefficient method)
Experiment material: the same, be kunming mice.Select 20 healthy mices for use; Female, male each 10; Dosage designs per 4 days and is first phase; Each issue dosage is respectively 0.10LD 50,0.15LD 50,0.22LD 50,0.34LD 50,0.50LD 50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Weighed once in per 4 days, the adjustment dosage is pressed 0.1ml/10 part BW per os and is irritated stomach.After 20 days, animal does not have death condition takes place, and cumulative coefficient is calculated in off-test.
Two, result of the test:
To being tried 20 days handss of thing, female, buck does not all have death condition and takes place by ascending-dose.Calculate cumulative coefficient greater than 5.
Three, brief summary:
Judge that according to cumulative toxicity grade scale in " disinfection technology standard " (1999) unguentum of the present invention belongs to weak cumulative toxicity to the mice cumulative toxicity.
The acute skin irritation test report
One, experiment purpose: detect stimulation/corrosiveness and the intensity of ointment to laboratory animal skin
Two, material and method:
1. tried thing: title: ointment of the present invention
2. laboratory animal: one grade big ear white race rabbit, 4, female, body weight 2.1-2.3k part; Provide by Shandong medical college biology department Experimental Animal Center;
3. test method:
Select for use the intact healthy family of skin to exempt from 4, its spinal column both sides, back were cut left and right each the about 3cm * 3cm of QUMAO area by hair in preceding 24 hours in test.Get during test and tried to be applied to side skin of unhairing surface on two layers of gauze that thing 0.2ml is applied to 2.5cm * 2.5cm, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Seal after 4 hours, dismantle, and with the residual thing that tried of warm water cleaning and removing, 1,24 and 48 h observation after removal is tried thing are smeared the position dermoreaction, and scoring.
Three, experimental result: any erythema does not appear in laboratory animal skin, redness, inflammation phenomenon.
Four, brief summary: judge that according to skin irritation reaction standards of grading in " disinfection technology standard " (1999) ointment of the present invention belongs to nonirritant to the animal skin stimulus intensity.、
Repeatedly skin irritation test testing result of the present invention is following:
(1), material and method
1, experimental animal feeding environment room temperature is 22 ℃ ± 2 ℃, relative humidity: 60%-70%.
2, experimental animal: Japan large ear rabbit; Animal rank: regular grade; 4, male; Body weight 2kg-3kg.
3, animal origin: Shandong medical college biology laboratory provides
(2), method 1, test basis: Ministry of Public Health " cosmetics health standard " (version in 2002) " skin irritation/corrosion test " the 6.4th " repeatedly skin irritation test ".2, sample treatment: direct as being tried thing with submitted sample.3, test procedure: 24h before the test, remove the hair of back part of animal spinal column both sides with child's hair cutter, remove scope 3cm * 3cm.Get and tried thing 0.5mL, spread upon on the animal one side skin of unhairing, opposite side is as contrast, application area 2.5cm * 2.5cm; Smear every day once, smear 14d continuously.Smear cropping at every turn, remove the residual thing that tried.Observed result behind the 1h is with reference to the scoring of " cosmetics health standard " (version in 2002) " skin irritation/corrosion test " skin irritation reaction standards of grading.
(3), result
All animals were smeared in the process at 14 days, were tried skin and erythema and edema phenomenon did not occur.Animal subject repeatedly skin irritation reacts average every day every animal integral mean value for " 0 ".
Other test result: under 20-21 ℃ of water bath condition; Show through three repeated trials results; Tincture 1.50% solution effects 20min of the present invention; To Candida albicans (ATCC10231) killing rate is that 99.90%, 3.00% solution effects 10min killing rate is 99.94%, 1.5% solution effects 15min, and escherichia coli (8099), staphylococcus aureus (ATCC6538) killing rate are 99.94%.
Medicine of the present invention is scalded test to rabbit, and concrete condition and result of the test are following:
One, the granulation promoting test of scald property rabbit
(1) material,
1, medication preparation: get external powder 3 grams of the present invention, transfer to 10ml with distilled water and be coated with wound outward.
2, contrast medicine: 1 20g of commercially available medicine JINGWANHONG MEBO.
3, depilatory: 8% sodium sulfide solution:
4, animal: white rabbit medical college experimental animal center provides 10.
(2), method and result
Get 10 of rabbits, body weight 1.75-1.9 kilogram, male and female dual-purpose, cropping under the buttocks of every rabbit and left and right sides rib; Slough hair with depilatory, finish position and area, and at the position of finishing with scalpel standardized " # " font wound; Size is 3 * 2cm, and the degree of depth is for scratching skin corium, till oozing of blood; Inject medical ethanol with cotton balls then, place " # " to light 1.5min, area 3 * 3cm.3 positions of every rabbit burn, 1 position is coated with MEIBAO SHIRUN SHAOSHANG GAO, and a position is coated with medicine of the present invention, and what is not coated with the harmony of accomplishing to test for position, and burn divides the position of each medicine coating to arrange by the Latin mode.
Divide into groups: drug group of the present invention, matched group, blank control group (what is not coated with).Three groups of nine per three one components of rabbit, one group of rabbit is an I degree burn, and one group of rabbit is an II degree burn, and also having one group of rabbit is III degree burn, and the wound situation is observed in burn back medication 15 days every day, (suppurate, the situation of downright bad, fur growth etc.).Wound is cleaned in behind the last coating second day, observes the wound growing state.Carry out result's statistics with scoring method.Long new skin is 40 minutes, and endysising is 20 minutes, and not having incrustation is 20 minutes, and not having suppuration is 20 minutes.Observed result finds that medicine of the present invention burn position wound heals fully, and the wound diameter that is coated with MEIBAO SHIRUN SHAOSHANG GAO obviously dwindles, and the wound of blank group have fester, suppuration, downright bad phenomenon.See table 1.
Table 1 medicine of the present invention is to the influence of scald property rabbit (X ± S)
Group Number of animals (only) Wound healing after the medication (%)
Blank control group 9 35.05±29.72
JINGWANHONG MEBO group 9 75.52±22.16
Drug powder group of the present invention 9 91.32±12.47
Visible from result of the test, healing has positive effect to medicine of the present invention to the rabbit burn wound, has remarkable meaning.
Two. the influence of rat paw edema due to the on Carrageenan
Get 30 of healthy rats, body weight 180-220g is divided into blank group, Herba Sarcandrae positive controls, oral pills group of the present invention at random.Every group 10, male and female half and half, sub-cage rearing.Positive controls and drug group of the present invention be gastric infusion 8g/kg respectively; The normal saline that the blank group deturs talis dosis; Successive administration 3 days; After the last administration 30 minutes; Only cause inflammation at the right back sufficient plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ of rat respectively, respectively at cause scorching before with cause scorching back and surveyed the girth of the right back sufficient sole of the foot of rat in 15,30,60,120,240 minutes, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth * 100%]; The result sees table 2.
The influence of rat paw edema due to table 2 on Carrageenan (X ± SD)
Figure BSA00000442694400161
Figure BSA00000442694400171
Annotate: compare with matched group: * * P＜0.01; Compare with positive controls: #P＜0.05; Can find out that by last table experimental result drug group of the present invention has better pharmacological action.
Three. mouse tail vein is infected the effect of bacillus pyocyaneus
Get 30 of healthy mices, be divided into 3 groups at random, be i.e. blank group, Herba Sarcandrae positive controls, drug group of the present invention; Every group 10, male and female half and half adopt clinical isolating bacillus pyocyaneus; With every mouse tail vein injection 0.2ml of 1 * 10-1 concentration, the mouse infection bacillus pyocyaneus is irritated stomach simultaneously and gives positive controls and drug group of the present invention (5g crude drug/kg), successive administration 3 days after the prerun; Observed and recorded 7 days, the blank group was irritated stomach 1%CMC-Na solution 0.8ml totally 3 days every day, write down 7 days; The result sees table 3.
Table 3 pair mouse tail vein infects the effect of bacillus pyocyaneus
Figure BSA00000442694400172
Annotate: compare with matched group: * * P＜0.01; Compare with positive controls: #P＜0.05;-expression zero; Can find out that by last table experimental result drug group of the present invention has better pharmacological action.
Four. to the clinical trial of rat edema wound: get 40 of healthy Wistar rats, be divided into 4 groups at random, be i.e. vaseline matched group, oral pills group of the present invention, externally-applied soft ointment group, JINGWANHONG group, 10 every group.Rat is anaesthetized with pentobarbital sodium, and ventral decubitus is fixed, and the back depilation is with being melted to 150 ℃ of paraffin drops to the position of losing hair or feathers; Cause III ° of scald, scald each group of back and smear institute's reagent thing immediately, dosage is with table one; Every Mus jugular vein is injected 0.5% azovan blue 0.5ml/100g after 3 hours, cleans medicine after 35 minutes, cuts scald place indigo plant and dyes skin graft; And cut the normal skin graft of homalographic in offside, and weigh up left and right sides skin graft weight difference, be edema and ooze out the weightening finish value; To scald the side skin graft then and shred, (acetone: normal saline=7: 3) 5 milliliters of solution soaked 24 hours, and soak by centrifugal 12 minutes of 3000 rev/mins speed, is left standstill, and got supernatant with 722 its transmitances of type spectrophotometric determination with the acetone normal saline; The result sees table 4.
Figure BSA00000442694400173
The present invention significantly alleviates than vaseline matched group wound surface skin graft edema weightening finish value; Its leachate transmitance significantly improves than vaseline matched group; Show that the present invention can significantly reduce capillary permeability, reduce and ooze out, alleviate edema, its exudation effect highly significant.For oral administration combine with external, effect is stronger.
Pharmacodynamic experiment
One, data and method
1.1 clinical data:
(1) hospital outpatient is accepted for medical treatment in burn patient 60 examples, male 32 examples, women 28 examples; 43 examples of being grown up, child's 17 examples.
(2) stadium and position: 1 month～6 months 8 examples, 6 months～8 months 12 examples, 8 months～12 months 6 examples, 1 year～2 years 4 examples; Cicatrix mainly is distributed in face and extremity position, area between 1%～4%TBSA, wherein facial 20 examples, both hands are carried on the back 10 examples, forearm 9 examples, calf 8 examples, huckle 13 examples.
(3) medical history and symptom: due to 60 examples were behind the burn-healing, all patients all showed as local scratchy discomfort, evening and overcast and rainy increasing the weight of.
1.2 Therapeutic Method: all case is divided 3 groups, and every group 20 people uses gentle externally-applied soft ointment of the present invention of MEIBAO cicatrix and vaseline matched group respectively.Clean a wound, wash the back and smear gentle unguentum of the present invention of MEIBAO cicatrix and vaseline, every day 2 times by explanation.And massaged gently 10 minutes, so treated the variation of observed in detail scar tissue 3 months.
Two, effect
2.1 criterion of therapeutical effect: the degree of improving according to symptom, Signs is divided into produce effects, effective and invalid three types: 1. produce effects: the cicatrix pain transference cure of itching, and cicatrix is softening, and is the same with normal skin basically flat, observes no change after 1 month continuously; 2. effective: cicatrix is protuberance slightly, thickens slightly, little pain of itching, and color is thin out, and quality is softer, and surperficial fold is obvious, and it is stable to observe after 1 month symptom continuously; 3. invalid: the cicatrix quality is soft slightly, and cicatrix flattens slightly, and the pain of itching symptom alleviates to some extent, but after stopping to treat 7 days, symptom is restored.
Three, discuss
The formation of cicatrix is main relevant with some inherited genetic factors with body constitution, inflammation, infection, can produce the pain symptom of significantly itching, and easy diabrosis, forms the ulcer that is difficult to heal, and hinders attractive in appearancely, and often the psychology to the patient causes harmful effect.Though Therapeutic Method is many, as ion penetrate, ultrasound wave, partial closure etc., effect is all not ideal enough.Facts have proved: the present invention itches pain symptom effect certainly to hypertrophic cicatrix occurred, and can make that cicatrix flattens, deliquescing, and granulation promoting rapidly; Can make the effect of flat antipruritic, the pain relieving of cicatrix, inhibition proliferation of fibrous tissue.In addition, external preparation of the present invention is made up of the Chinese medicine of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, and it can improve blood capillary and the anoxic conditions of the peripheral termination of nerve in the scar tissue, helps suppressing scar hyperplasia, impels the cicatrix deliquescing, flattens.
3.1 influence to wound healing time
The normal wound surface group of model control group wound healing time obviously prolongs (P＜0.01); Compare with model control group, unguentum group healing time of the present invention shortens (P＜0.01).See table 5.
Table 15 is respectively formed face healing time relatively (d ,-x ± s)
Group n Wound healing time (D) The average healing (D)
General wound surface group 8 ?15-20 28.28±1.67
Unguentum of the present invention 8 ?18-25 16.27±2.15**
Vaseline group group 8 ?17-22 24.37±2.32
The flat group of MEIBAO cicatrix 8 ?18-24 20.89±2.46
Compare * * P＜0.01 with general wound surface group; Compare △ △ P＜0.01 with model control group.
Four, conclusion: ointment of the present invention is through a large amount of clinical verifications, and behind wound healing, cicatrix does not form preceding or the cicatrization initial stage uses; Evident in efficacy; Can play softening, inhibition cicatrix, reduce the effect of pigmentation, prevent scar contracture and reduce odd-shaped generation.Ointment of the present invention is applied in skin surface, makes medicine quick penetration skin surface get into skin corium, forms the connective tissue of cicatrix before decomposing; Reparation broken fiber tissue; Recover the collagen structure of skin basal layer, make its proper alignment, keep level and smooth and gloss, elasticity and the toughness of skin; Treat various types of burn scar, and the various cicatrixs that form of operation, wound later stage.Has following function: the function of blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, removing toxic substances and promoting subsidence of swelling, software eliminating stagnation, inhibition scar hyperplasia, alleviation cicatrix pruritus, softening cicatrix.The clinical therapeutic efficacy of ointment of the present invention is in particular in: this product is through a large amount of clinical verifications, and is safe in utilization, without any side effects; The early stage use of cicatrix can be played softening cicatrix, alleviates the uncomfortable sensations such as sufferings of cicatrix; To the cicatrix that has formed, can protect cicatrix skin effectively, improve partial microcirculation, the tight bundle sense behind the alleviation cicatrix, the reparation of vesicle behind the promotion cicatrix, the hypertrophy rate of reduction cicatrix, raising cicatrix patient's quality of life.
Specific embodiment 1: Chen, the man, 23 years old, because of adolescence face a large amount of comedos that get up, scratch rear face with hands and stay big and small pothole, and the pigment marking, have a strong impact on attractive in appearance.Come the court to seek medical advice, Radix Angelicae Dahuricae 10g for oral administration, Semen Persicae 15g, Rhizoma Atractylodis Macrocephalae 10g, Semen Coicis 15g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Radix Dipsaci 15g, Herba Sarcandrae 10g, Radix Achyranthis Bidentatae 10g, Pheretima 10g, Eupolyphaga Seu Steleophaga 10g, Radix Codonopsis 15g, Rhizoma Drynariae 15g, Ramulus Sambuci Williamsii 10g, Radix Paeoniae Alba 15g; Process pill, every day three times; External: Sanguis Draxonis 20g, Myrrha 15g, Flos Carthami 15g, Radix Angelicae Sinensis 15g, Caulis Spatholobi 20g, Radix Urenae Lobatae 15g, Radix Notoginseng 20g, Radix Dipsaci 20g, Herba Hedyotidis Diffusae 15g, Olibanum 15g, Radix Angelicae Dahuricae 15g, Margarita 15g, Radix Salviae Miltiorrhizae 20g, Ramulus Sambuci Williamsii 15g, Retinervus Luffae Fructus 15g, Flos Rosae Rugosae 15g; Cortex Moutan 20g processes unguentum; Smear every day, changes dressings once, changes into after one month and change dressings 2 times weekly; Three months wide open beginnings of recurve diminished, and had not seen Chu's pothole cicatrix after 1 year.Patient's self-confidence improves greatly.
Specific embodiment 2: Zhang: the man, 33 years old, fall down to cause and fracture left legs because of riding motor; Right lower limb swelling, left side, facial brow ridge position scratches wide 3 centimetres, long 5 centimetres big openning; It is improper to nurse; Infect, become hypertrophic cicatrix, have a strong impact on attractive in appearance; Come the court to seek medical advice, Radix Angelicae Dahuricae 15g for oral administration, Semen Persicae 15g, Rhizoma Atractylodis Macrocephalae 10g, Semen Coicis 10g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Radix Dipsaci 15g, Herba Sarcandrae 10g, Radix Achyranthis Bidentatae 10g, Pheretima 10g, Eupolyphaga Seu Steleophaga 15g, Radix Codonopsis 10g, Rhizoma Drynariae 15g, Ramulus Sambuci Williamsii 10g, Radix Paeoniae Alba 15g; Process pill, every day three times; External: Sanguis Draxonis 20g, Myrrha 20g, Flos Carthami 15g, Radix Angelicae Sinensis 20g, Caulis Spatholobi 20g, Radix Urenae Lobatae 15g, Radix Notoginseng 20g, Radix Dipsaci 20g, Herba Hedyotidis Diffusae 15g, Olibanum 20g, Radix Angelicae Dahuricae 15g, Margarita 20g, Radix Salviae Miltiorrhizae 20g, Ramulus Sambuci Williamsii 20g, Retinervus Luffae Fructus 15g, Flos Rosae Rugosae 15g; Cortex Moutan 20g processes unguentum; Smear every day, changes dressings once, and the first quarter moon wound surface is clean; Change into and change dressings 2 times weekly, use facial muscle of the present invention to regenerate again.The hypertrophic cicatrix recovery from illness.
Specific embodiment 3: sweet certain, the man, 32 years old, drunk back evening in May, 2009, hindering area was 15cm * 15cm by position in the electric brake fire burn left hand of the high-tension electricity palm, hindering disease is the dark type burn of three degree disease.The back nursing is improper, and wound festers repeatedly, and inflammation is suppurated.Pain unbearably.The court's treatment afterwards, Radix Angelicae Dahuricae 15g for oral administration, Semen Persicae 15g, Rhizoma Atractylodis Macrocephalae 10g, Semen Coicis 10g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 15g, Radix Dipsaci 15g, Herba Sarcandrae 10g, Radix Achyranthis Bidentatae 10g, Pheretima 10g, Eupolyphaga Seu Steleophaga 15g, Radix Codonopsis 10g, Rhizoma Drynariae 15g, Ramulus Sambuci Williamsii 10g, Radix Paeoniae Alba 15g; Process pill, every day three times; External: Sanguis Draxonis 20g, Myrrha 20g, Flos Carthami 15g, Radix Angelicae Sinensis 20g, Caulis Spatholobi 20g, Radix Urenae Lobatae 20g, Radix Notoginseng 20g, Radix Dipsaci 20g, Herba Hedyotidis Diffusae 15g, Olibanum 20g, Radix Angelicae Dahuricae 15g, Margarita 20g, Radix Salviae Miltiorrhizae 15g, Ramulus Sambuci Williamsii 20g, Retinervus Luffae Fructus 15g, Flos Rosae Rugosae 15g, Cortex Moutan 15g processes unguentum, and smear every day; Change dressings once, the first quarter moon wound surface is clean, and the pain of hindering disease is also alleviated significantly; After change at interval that property is coated with 10 hours into, pain has just been eliminated basically, and is continuous and carry out the medication treatment of property and observation property at interval; Ulcer begins slowly to heal after 10 days; Cross that just to reach granulation promoting behind the wheat harvesting period intact, palmar hand is hindered disease and is almost recovered, does not have obvious cicatrix.
Specific embodiment 4: Feng, woman, 5 years old; To certain hospital outpatient treatment commentaries on classics of not getting better in 4 days, changeed my institute's inspection: right thigh by boiling water burn right lower extremity, left thigh and perineal position in August, 2009; Shank, instep are dark II degree, the III degree is scalded, the existing infection of slight inflammatory reaction.Left thigh and perineal position are depth II degree and scald.Handle: sterilization, debridement, the crust of dispelling, removing beancurd sheet slough, Radix Angelicae Dahuricae 10g, Semen Persicae 15g, Rhizoma Atractylodis Macrocephalae 10g, Semen Coicis 15g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Radix Dipsaci 15g, Herba Sarcandrae 10g, Radix Achyranthis Bidentatae 10g, Pheretima 10g, Eupolyphaga Seu Steleophaga 10g, Radix Codonopsis 15g, Rhizoma Drynariae 15g, Ramulus Sambuci Williamsii 10g, Radix Paeoniae Alba 15g; Process pill, every day three times; External: Sanguis Draxonis 20g, Myrrha 15g, Flos Carthami 15g, Radix Angelicae Sinensis 15g, Caulis Spatholobi 20g, Radix Urenae Lobatae 15g, Radix Notoginseng 20g, Radix Dipsaci 20g, Herba Hedyotidis Diffusae 15g, Olibanum 15g, Radix Angelicae Dahuricae 15g, Margarita 15g, Radix Salviae Miltiorrhizae 20g, Ramulus Sambuci Williamsii 15g, Retinervus Luffae Fructus 15g, Flos Rosae Rugosae 15g; Cortex Moutan 20g processes the unguentum honey refining pill of processing for oral administration; Every days two ball; Gauze was wrapped up after unguentum was smeared in external, and change dressings once every day.The wound surface of changing dressings was clean on 8th, and adhesion is prone to hemorrhage, and inflammation is controlled, child's spirit appetite is normal, continues to change dressings once every day.Changed dressings in 15th and heal basically.Recovery from illness after one month.It is normal to follow up a case by regular visits to the back skin color, does not produce cicatrix.

Claims (10)

1. the Chinese medicine composition of a dispeling scar is characterized in that, said compositions is made up of endo-medicine and external used medicine,
Various crude drug and ratio of weight and number thereof are in the said endo-medicine: 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts in Semen Persicae, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Semen Coicis, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis, 10～20 parts of Herba Sarcandraes, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Pheretimas, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Radix Codonopsis, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of the Radix Paeoniae Albas;
Various crude drug and ratio of weight and number thereof are in the said external used medicine: 10～30 parts of Sanguis Draxonis, 10～30 parts of Myrrhas, 10～30 parts on Flos Carthami, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Caulis Spatholobis, 10～30 parts of Radix Urenae Lobataes, 10～30 parts of Radix Notoginseng, 10～30 parts of Radix Dipsacis, 10～30 parts of Herba Hedyotidis Diffusaes, 10～30 parts of Olibanums, 10～30 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Margaritas, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Ramulus Sambuci Williamsii, 10～30 parts of Retinervus Luffae Fructuss, 10～30 parts of Flos Rosae Rugosaes, 10～30 parts of Cortex Moutans.
2. according to the Chinese medicine composition of the said dispeling scar of claim 1, it is characterized in that,
The ratio of weight and number of various crude drug is in the said endo-medicine: 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts in Semen Persicae, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Semen Coicis, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis, 10～15 parts of Herba Sarcandraes, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Pheretimas, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Radix Codonopsis, 10～15 parts of Rhizoma Drynariae, 10～15 parts of Ramulus Sambuci Williamsii, 10～15 parts of the Radix Paeoniae Albas;
The ratio of weight and number of various crude drug is in the external used medicine: 10～30 parts of Sanguis Draxonis, 10～30 parts of Myrrhas, 10～30 parts on Flos Carthami, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Caulis Spatholobis, 10～30 parts of Radix Urenae Lobataes, 10～30 parts of Radix Notoginseng, 10～30 parts of Radix Dipsacis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Olibanums, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Margaritas, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Flos Rosae Rugosaes, 10～20 parts of Cortex Moutans.
3. according to the Chinese medicine composition of the said dispeling scar of claim 1, it is characterized in that,
The ratio of weight and number of various crude drug is in the said endo-medicine: 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts in Semen Persicae, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Semen Coicis, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Dipsacis, 10～20 parts of Herba Sarcandraes, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Pheretimas, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Radix Codonopsis, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of the Radix Paeoniae Albas;
The ratio of weight and number of various crude drug is in the external used medicine: 10～20 parts of Sanguis Draxonis, 10～20 parts of Myrrhas, 10～20 parts on Flos Carthami, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Radix Urenae Lobataes, 10～20 parts of Radix Notoginseng, 10～20 parts of Radix Dipsacis, 10～30 parts of Herba Hedyotidis Diffusaes, 10～30 parts of Olibanums, 10～30 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Margaritas, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Ramulus Sambuci Williamsii, 10～30 parts of Retinervus Luffae Fructuss, 10～30 parts of Flos Rosae Rugosaes, 10～30 parts of Cortex Moutans.
4. according to the Chinese medicine composition medicine of each said dispeling scar in the claim 1～3; It is characterized in that the dosage form of said endo-medicine is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, granule, pill, powder, sublimed preparation or solution; The dosage form of said external used medicine is: tincture, liniment, loose powder agent, plaster or ointment.
5. the method for preparing like the Chinese medicine composition of each said dispeling scar in the claim 1～4 is characterized in that, the dosage form of said external used medicine is an ointment; Its preparation method comprises: the crude drug of getting the said ratio of weight and number except that Margarita soaked 1-2 hour, placed multi-function extractor then, and the 5-10 that decocts amount of water for the first time and be medical material doubly; Decoct, when being heated to 100 ℃, pick up counting; After little the boiling 2 hours, emit medicinal liquid, put in the fluid reservoir from the feed opening filtration; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, cooling; Crushing pearl is added in the extractum tinning behind the ultraviolet radiation sterilizing.
6. the method for preparing like the Chinese medicine composition of each said dispeling scar in the claim 1～3 is characterized in that, the dosage form of said oral preparations is a capsule, and its preparation method comprises:
A. said crude drug is put into the pulverizer grinding and sieving,
B. the remaining particulate matter in back that will sieve is put into the ethanol heating and refluxing extraction 2 times;
C. get the medicinal residues behind the above-mentioned ethanol extraction again, add the water heating and refluxing extraction 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
7. according to the method for preparing of the capsule of the said dispeling scar of claim 6; It is characterized in that; Among the said step a; Said crude drug is put into pulverizer pulverizing back cross 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects through the raw material fine powder of 120 mesh sieves subsequent use.
8. according to the method for preparing of the capsule of claim 6 or 7 said dispeling scars; It is characterized in that, among the said step b, the remaining particulate matter in back that sieves is put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5～7 times of amounts; Each 1～2 hour, 2 extracting solution merging are left standstill; Among the said step c, it is 5～7 times of water gaging heating and refluxing extraction 2 times that the medicinal residues that above-mentioned ethanol extraction is crossed add the weight portion rate, each 1～2 hour, 2 extracting solution is merged leave standstill.
9. according to the method for preparing of the capsule of claim 6 or 7 said dispeling scars; It is characterized in that, in the said steps d above-mentioned two kinds of extracting solution are merged 1.38 o'clock filtrating when the concentrating under reduced pressure relative density is 50 ℃～60 ℃; Reclaim ethanol; With gained filtrating adjustment proportion to 1.06, feed spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m 2, the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
10. the method for preparing of the capsule of said dispeling scar according to Claim 8; It is characterized in that, in the said steps d above-mentioned two kinds of extracting solution are merged 1.38 o'clock filtrating when the concentrating under reduced pressure relative density is 50 ℃～60 ℃; Reclaim ethanol; With gained filtrating adjustment proportion to 1.06, feed spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m 2, the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
CN2011100502697A 2011-03-03 2011-03-03 Chinese medicinal composition for dispelling scars and preparation method thereof Expired - Fee Related CN102091258B (en)

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