CN108066244A - A kind of composition containing brown algae polyphenols - Google Patents
A kind of composition containing brown algae polyphenols Download PDFInfo
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- CN108066244A CN108066244A CN201810108083.4A CN201810108083A CN108066244A CN 108066244 A CN108066244 A CN 108066244A CN 201810108083 A CN201810108083 A CN 201810108083A CN 108066244 A CN108066244 A CN 108066244A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The present invention relates to a kind of compositions containing brown algae polyphenols, and by weight, the composition containing brown algae polyphenols includes following components：35 45 parts of brown algae polyphenols, 5 15 parts of dendrobium loddigesii Rolfe extracts and 18 parts of Roselle flower extracts.Brown algae polyphenols are extracted using following techniques：To clean, crush after brown alga add in 70% 80% ethanol water extraction concentration, again plus distillation aqueous suspension, macroporous resin column is crossed with petroleum ether, ethyl acetate, water-saturated n-butanol successively to extract, then with distillation 13 column volumes of water elution to remove polar impurity, eluent is collected, is concentrated to give brown algae polyphenols.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of composition containing brown algae polyphenols.
Background technology
Lipstick has become the common cosmetics of China's modern female.But existing lip balm product, which is mostly common beauty, to be repaiied
Decorations only play profit lip, and raw material used is mostly mineral grease, Synthetic Oil and wax, such as atoleine, vaseline, wool
Fat, ceresine, paraffin, microwax, polyethylene wax, Brazil wax, candelila wax etc..Atoleine therein and vaseline,
Wax, paraffin, microwax are all the oil components extracted in oil, if Long Term Contact can make skin have some bad works
With, and moistening effect is bad；Lanolin can cause allergic dermatitis to some people.
At present, the most widely used for algae in marine natural product.Seaweed growth is in high salt, high pressure, low temperature, low battalion
It supports, in the Seawater that no light and chemical constituent are extremely complex, ecological environment, metabolite and metabolic characteristic and land are planted
Object has larger difference, embodies a concentrated reflection of in body containing structure special biological active matter and metabolite.Wherein, contain in brown alga
There are abundant carbohydrate, protein, lipid, trace element, minerals, vitamin etc., this kind of biological active matter can be applied
In new type functional cosmetics, there is larger potentiality to be exploited, but be currently based on brown alga extract as moisturizing, anti-aging should
With having not been reported.
The content of the invention
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of anti-aging, the composition containing brown algae polyphenols of moisturizing.
A kind of composition containing brown algae polyphenols, by weight, including following components：
35-45 parts of brown algae polyphenols；
5-15 parts of dendrobium loddigesii Rolfe extracts；
And 1-8 parts of Roselle flower extracts；
Wherein, the brown algae polyphenols are extracted using following techniques：
Will clean, crush after brown alga add in 70%-80% ethanol water extraction concentration, then add distillation aqueous suspension, according to
It is secondary to cross macroporous resin column extraction with petroleum ether, ethyl acetate, water-saturated n-butanol, then with distillation 1-3 column volume of water elution
To remove polar impurity, eluent is collected, is concentrated to give brown algae polyphenols.
Present inventor is by said extracted object and brown algae polyphenols compatibility, and side, is aided with ring grass stone based on brown algae polyphenols
Dry measure used in former times extract and Roselle flower extract, each ingredient of composition play an important role of synergy, experiment proves that, moisturizing and anti-ageing
Old effect is good.
In a preferred embodiment, by the ethanol water of the brown alga and 70%-80% according to mass ratio 1:(5-8)
It is mixed.
In a preferred embodiment, the dendrobium loddigesii Rolfe extract is extracted using following techniques：
Dendrobium loddigesii Rolfe after crushing is impregnated in 40-60v/v% aqueous acetone solutions, and assisting ultrasonic is extracted.By gained
Acetone-water extract concentrates, with macroporous absorption column extracting, then with water, 70%, 80%, 90%, 100% methanol or ethyl alcohol successively
Elution, each gradient solvent dosage are 1-5 column volume, collect 70%-90% methanol or ethanol elution part, obtain dendrobium loddigesii Rolfe
Extract.
In a preferred embodiment, the Roselle flower extract is extracted using following techniques：
After Roselle flower is smashed to pieces, impregnate, filter in the ethanol water for the 70%-80% for adding in 3-5 times of parts by weight
To filtrate, then the filtrate is transferred in high-pressure extracting tank, 200MPa-300MPa, pressurize 10- are forced under room temperature
20min, then release obtain Roselle flower extract.
In a preferred embodiment, the brown algae polyphenols include undaria pinnitafida polyphenol, bladder-wrack polyphenol, kelp polyphenol, sheep
It dwells the mixing of any one or more in dish polyphenol.
In a preferred embodiment, by weight, the brown algae polyphenols are 40 parts, and 40 parts of brown algae polyphenols are 10
Part undaria pinnitafida polyphenol, 15 parts of sargassum fusifome polyphenol and 15 parts of kelp polyphenol.
In a preferred embodiment, by weight, the brown algae polyphenols are 40 parts, and 40 parts of brown algae polyphenols are 20
Part undaria pinnitafida polyphenol, 20 parts of sargassum fusifome polyphenol.
In a preferred embodiment, the composition containing brown algae polyphenols further includes the grease of 30-40 parts by weight.
In a preferred embodiment, the grease is selected from least one of walnut oil, champaca flower oil or sunflower oil.
In a preferred embodiment, the composition containing brown algae polyphenols further includes the grease of 32 parts by weight.
The present invention also provides a kind of lipsticks.
A kind of lipstick by weight, including the composition of the present invention containing brown algae polyphenols, 10 parts of emulsifier, is gone
5 parts and 7 parts 10 parts of ionized water, 5 parts of butanediol, beeswax auxiliary materials.
Above-mentioned lipstick has effects that anti-aging, moisturizing.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with specific embodiment
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are only used to explain the present invention,
It is not intended to limit the present invention.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The normally understood meaning of technical staff is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein " and/or " include one or more
The arbitrary and all combination of relevant Listed Items.
A kind of composition containing brown algae polyphenols by weight, is formed including following components：35-45 parts of brown algae polyphenols, 5-
15 parts of dendrobium loddigesii Rolfe extracts and 1-8 parts of Roselle flower extracts.
Brown algae polyphenols are extracted using following techniques：
Will clean, crush after brown alga add in 70%-80% ethanol water extraction concentration, then add distillation aqueous suspension, according to
It is secondary to cross macroporous resin column extraction with petroleum ether, ethyl acetate, water-saturated n-butanol, then with distillation 1-3 column volume of water elution
To remove polar impurity, eluent is collected, is concentrated to give brown algae polyphenols.
Macroporous resin column extraction is crossed with petroleum ether, ethyl acetate, water-saturated n-butanol use ethanol water compared to single successively
For solution extraction, after measured, when brown alga raw material selects sargassum fusifome, the extraction yield of brown algae polyphenols can improve 8%.
Brown alga (Phaeophyta) be higher algae, about 1,500 kinds, be distributed continent bank cold water water body, fresh water
In it is rare.Its color depends on the ratio of what brown pigment (fucoxanthin) and marennin (chlorophyll), from dun to olive green.It fills
The air bag of gas makes thallophytic photosynthetic part swim or close to water meter.Contain abundant carbohydrate, protein, fat in brown alga
Matter, trace element, minerals, vitamin, polyphenol etc., this kind of biological active matter can be applied in new type functional cosmetics, have
Larger potentiality to be exploited.
In particular, it should be pointed out that brown algae polyphenols are a kind of phenolic compounds extracted from brown alga, it is phloroglucin
Derivative.Research shows that brown algae polyphenols have such as anti-oxidant (anti-aging), antibacterial, antiviral activity, antitumor, anti-angiocarpy
The extensive bioactivity such as disease, anti-diabetic syndrome, protection liver and inhibition hyaluronidase lysyl oxidase.
In a preferred embodiment, the mass ratio of the ethanol water of brown alga raw material and 70%-80% is 1：5-8.
It so can fully extract brown algae polyphenols.If solid-liquid ratio is too low, it is impossible to fully brown algae polyphenols contained in extraction brown alga, feed liquid
Than excessively high, alcohol dissolubility impurity leaching rate increases, unfavorable to subsequent purification, while causes the waste of alcohol solvent, under the conditions of being somebody's turn to do
Solid-liquid ratio can fully extract in brown alga contained brown algae polyphenols, and alcohol dissolubility impurity is few in polyphenol crude product solution.
In a preferred embodiment, the ethanol water of 70%-80% is selected to extract concentration, the ethyl alcohol in the range of this
Extraction with aqueous solution efficiency is more preferable, is more advantageous to the dissolution of brown algae polyphenols.Preferably, the ethanol water of 75%-80% is selected to carry
Take concentration.
In a preferred embodiment, brown algae polyphenols are dwelt including undaria pinnitafida polyphenol, bladder-wrack polyphenol, kelp polyphenol, sheep
The mixing of any one or more in dish polyphenol.Undaria pinnitafida polyphenol, bladder-wrack polyphenol, kelp polyphenol, sargassum fusifome are more in the present invention
Phenol individually can be applied directly, can be mutually combined application.Such as：The combination of undaria pinnitafida polyphenol and bladder-wrack polyphenol, undaria pinnitafida
The combination of polyphenol, bladder-wrack polyphenol, kelp polyphenol.
In a preferred embodiment, by weight, brown algae polyphenols are 40 parts, more including 10 parts of undaria pinnitafidas
Phenol, 15 parts of sargassum fusifome polyphenol, 15 parts of kelp polyphenol.
In a preferred embodiment, by weight, brown algae polyphenols are 40 parts, more including 20 parts of undaria pinnitafidas
Phenol, 20 parts of sargassum fusifome polyphenol.
Wherein, the following technique extractions of the use of dendrobium loddigesii Rolfe extract：
Dendrobium loddigesii Rolfe after crushing is impregnated in 40-60v/v% aqueous acetone solutions, and assisting ultrasonic is extracted.By gained
Acetone-water extract concentrates, with macroporous absorption column extracting, then with water, 70%, 80%, 90%, 100% methanol or ethyl alcohol successively
Elution, each gradient solvent dosage are 1-5 column volume, collect 70%-90% methanol or ethanol elution part, obtain dendrobium loddigesii Rolfe
Extract.
" v/v% " shown in this article refers to percent by volume, such as：Dendrobium loddigesii Rolfe is in 40-60v/v% aqueous acetone solutions
In, refer to that the volume parts that dendrobium loddigesii Rolfe accounts for aqueous acetone solution are 40%-60%.
Dendrobium loddigesii Rolfe, also cry Dendrobium loddigesii, it is lofty or bottomless must, small ring is careless, small yellow grass, be the stem of orchid dendrobium loddigesii Rolfe.Ring
The careless stem of noble dendrobium is grown nonparasitically upon another plant in tree above or on hayashishita rock, and nature and flavor are sweet, are slightly cold, and can promote the production of body fluid beneficial stomach；Nourishing Yin and clearing heat；Moistening lung kidney-nourishing；Improving eyesight is strong
The effect of waist.Research shows in dendrobium loddigesii Rolfe that containing relatively rich glucide pharmacological research shows with antitumor activity,
Play an important role of to inhibit tumor cell viability that there is significant prevention and auxiliary therapeutic action to tumour.
In a preferred embodiment, the dendrobium loddigesii Rolfe after crushing is impregnated in 40-60v/v% aqueous acetone solutions,
Dendrobium loddigesii Rolfe extraction efficiency more, especially wherein polysaccharose substance dissolution rate higher, such as：40%th, 50%, 60% acetone
Aqueous solution.
In a preferred embodiment, 70%-90% methanol or ethanol elution part are collected, through compared with other sections
It measures, in the range of the section, dendrobium loddigesii Rolfe extract recovery rate higher and impurity is minimum.
Wherein, Roselle flower extract is extracted using following techniques：
After Roselle flower is smashed to pieces, impregnate, filter in the ethanol water for the 70%-80% for adding in 3-5 times of parts by weight
To filtrate, then the filtrate is transferred in high-pressure extracting tank, 200MPa-300MPa, pressurize 10- are forced under room temperature
20min, then release obtain Roselle flower extract.
Roselle flower, slightly in coniform or irregular shape, calyx aubergine to atropurpureus, 5 split, sliver lanceolar, lower part
It can be seen that the squamella with calyx healing, about 10 split, lanceolar, and base portion has the cavity left after removal fruit.Corolla yellowish-brown,
There are wire striped, inner surface base portion yellowish-brown, accidental sparse coarse wool in outer surface.Body is light, and matter is crisp.The micro- faint scent of gas, it is sour.Research
Show that Roselle flower has effects that releive well decompression, moisturizing.
In a preferred embodiment, the ethanol water of 70%-80% is selected to impregnate, the ethyl alcohol in the range of this is water-soluble
Liquid extraction efficiency is more preferable, is more advantageous to the dissolution of Roselle flower extract.Preferably, the ethanol water of 75%-80% is selected
It impregnates.
In a preferred embodiment, the composition containing brown algae polyphenols further includes the grease of 30-40 parts by weight.Wherein,
The main function of grease is to make the composition dispersiveness containing brown algae polyphenols more preferable.Preferably, grease is selected from walnut oil, champaca flower oil
Or at least one of sunflower oil.In a preferred embodiment, the composition containing brown algae polyphenols further includes 32 weight
The grease of part.For example, a kind of composition containing brown algae polyphenols, by weight, including following components：35-45 portions of brown algas are more
Phenol；5-15 parts of dendrobium loddigesii Rolfe extracts；The grease of 30-40 parts by weight；And 1-8 parts of Roselle flower extracts；Wherein, it is described brown
Algae polyphenol is extracted using following techniques：It will clean, the ethanol water extraction concentration that brown alga adds in 70%-80% after crushing, then
Add distillation aqueous suspension, crossing macroporous resin column with petroleum ether, ethyl acetate, water-saturated n-butanol successively extracts, and then uses distilled water
1-3 column volume of elution collects eluent, is concentrated to give brown algae polyphenols to remove polar impurity.
The inventors of the present application found that compared with prior art, the dendrobium loddigesii Rolfe in the technical solution provided in the present invention
Extract has a variety of dendrobium loddigesii Rolfe carbohydrate gums, dendrobium loddigesii Rolfe polysaccharide and mannitol, has very strong hydrability, can firmly lock water
Point, it is possible to provide other polysaccharide components and fibrous proteins in efficient moisture-retention, with skin collectively constitute the born of the same parents containing large quantity of moisture
Outer gelatinised matrix provides moisture for skin；Also one layer of uniform film can be formed in skin surface simultaneously, to reduce skin surface
Moisture evaporation makes moisture permeate into cuticula from substrate microstructure, the further aquation of cuticula is induced, so as to preserve moisture of skin.
Protein, trace element, minerals and vitamins provide good nutrition to skin.
In addition, the brown algae polyphenols in the present invention have antioxidation, skin photoage is prevented, removes free radical, is reduced
The generation of wrinkle, while also there is anti-inflammatory, the breeding of energy strong inhibition inflammatory mediator, skin of releiving.In the present invention
Roselle flower extract contains abundant organic acid (pyruvic acid, 2-ketoacid etc.), promotes the update of cell, improves moisturizing rate, contains
A large amount of colloids, irritation are very low；Organic acid is by reducing update of the cutin cohesive force come active cell, the guarantor for improving epidermal cell
Wet ability.Therefore there is moisturizing, skin lightening, Exfoliating Scrub, cleaning, anti-aging.
Further, the composition containing brown algae polyphenols further includes 12~15 parts of bladder-wrack extract.For example, described contain
The composition of brown algae polyphenols further include bladder-wrack extract 12,13,14 or 15 parts.Contain fucosan sulphur in bladder-wrack extract
Acid esters (Fucoidan) and fucosterol (Fucosterol), have preferable repair.For example, the bladder-wrack extract
In fucoidan mass ratio be not less than 1.2%.Fucoidan is a kind of chemical substance, mainly by containing
Sulfate fucose (Fucose) forms, and molecular formula is (C6H10O7S)n.Fucoidan is consolidated as algae such as bladder-wracks
Some iuntercellular polysaccharide are present in alga cells wall matrix, are the substances of bioactivity specific to algae, mainly effectively into
Part is α-L-fucose -4- sulfuric esters.Fucoidan be it is a kind of have to macrophage, T cell directly act on it is immune
Conditioning agent；Pharmacological activity with apparent anticoagulation and rush fibrinolytic；It can be lured comprising the fucose of sulfate or its degradation product
Cancer cell-apoptosis is led, can be used as inducer of apoptosis and anticarcinogen；The generation of Porcine HGF can be induced, it is various thin so as to promote
Intracellular growth, reparation is damaged or hypothyroid organ and tissue；Since it is with anticoagulant effect, so being glued suitable for blood
High patient is spent, it can be as the drug or health products of antithrombotic；It also has good reducing blood lipid, hypoglycemic, drop courage
The effect of sterol, can overcome some side effects of fat-reducing medicament；Chronic kidney hypofunction can be treated, centering early stage renal failure significant effect is special
It is other to improve renal function, improve kidney it is especially pronounced to creatinine clearance rate effect；It can be inhaled as the bonding agent of metal ion and resistance
Agent can such as make human body reduce more than 70% to the absorption of lead.And/or in one of the embodiments, the bladder-wrack extract
In fucosterol mass ratio be not less than 1%.Fucosterol is one isolated and purified from the extract of bladder-wrack
Kind of component some researches show that fucosterol has antitumor action, acts on cardio-cerebralvascular diseases more notable, affects
The function of cell ion channel, fucosterol also have very strong antioxidation, can act on cell ion channel, influence
The transhipment of intracellular matter and energy influences the form and function of cell.One example is the rock in the bladder-wrack extract
The mass ratio of algae glycan sulfuric ester and fucosterol is (1~2):1, for another example, the fucosan in the bladder-wrack extract
The mass ratio of sulfuric ester and fucosterol is (1~1.5):1, a preferable example is, in the bladder-wrack extract
The mass ratio of fucoidan not less than 1.2% and the fucosterol in the bladder-wrack extract mass ratio not
Less than 1%；For example, the mass ratio of the fucoidan in the bladder-wrack extract is not less than 1.2% and the ink
The mass ratio of fucosterol in the algae extract of angle is not less than 1%, also, the quality of fucoidan and fucosterol
Ratio is (1~2):1；For another example, the mass ratio of the fucoidan in the bladder-wrack extract not less than 1.5% and
The mass ratio of fucosterol in the bladder-wrack extract is not less than 1.2%；For another example, the rock in the bladder-wrack extract
The mass ratio of algae glycan sulfuric ester is not less than 1.5% and the mass ratio of the fucosterol in the bladder-wrack extract is not low
In 1.2%, also, the mass ratio of fucoidan and fucosterol is (1~1.5):1, when the group containing brown algae polyphenols
It closes the fucoidan in object and fucosterol reaches a certain concentration and the quality of fucoidan and fucosterol
When ratio is close or slightly more, preferably anti-oxidant and anti-aging synergistic effect can be formed to a certain extent so that contain
The composition of brown algae polyphenols has preferable moisturizing and the effect to slow down aging.
Present inventor is by said extracted object and brown algae polyphenols compatibility, and side, is aided with ring grass stone based on brown algae polyphenols
Dry measure used in former times extract and Roselle flower extract, each ingredient of composition play an important role of synergy, experiment proves that, moisturizing and anti-ageing
Old effect is good.
The present invention also provides a kind of lipsticks.For example, a kind of lipstick, by weight, including any embodiment of the present invention
The composition containing brown algae polyphenols.
For example, a kind of lipstick, by weight, including the combination containing brown algae polyphenols described in any embodiment of the present invention
5 parts and 7 parts object, 10 parts of emulsifier, 10 parts of deionized water, 5 parts of butanediol, beeswax auxiliary materials.
In a preferred embodiment, emulsifier is ABIL WE10 type emulsifiers.
Above-mentioned lipstick has effects that anti-aging, moisturizing.
Below in conjunction with specific embodiment, the invention will be further elaborated.
Embodiment 1
A kind of composition containing brown algae polyphenols, by weight including following components：
Table 1
| Component | Content (is converted into g calculating) |
| Undaria pinnitafida polyphenol | 35 |
| Dendrobium loddigesii Rolfe extract | 5 |
| Roselle flower extract | 1 |
Brown algae polyphenols are extracted using following techniques：
3kg undaria pinnitafidas add in 70% ethanol water that quality is 5 times and extract concentration after cleaning, crush, then add and steam
Distilled water suspends, and crossing macroporous resin column with petroleum ether, ethyl acetate, water-saturated n-butanol successively extracts, then with distillation water elution
1.5 column volumes collect eluent, are concentrated to give brown algae polyphenols to remove polar impurity.
Dendrobium loddigesii Rolfe extract is extracted using following techniques：
Dendrobium loddigesii Rolfe 2kg after crushing is impregnated in 40v/v% aqueous acetone solutions, and assisting ultrasonic is extracted.By gained
Acetone-water extract concentrates, and is eluted successively with macroporous absorption column extracting, then with water, 70%, 80%, 90%, 100% ethyl alcohol, often
A gradient solvent dosage is 2 column volumes, collects 70%-90% ethanol elutions part, obtains dendrobium loddigesii Rolfe extract.
Roselle flower extract is extracted using following techniques：
The Roselle flower that 3kg is smashed to pieces is taken, adds in 70% ethanol water of 3 times of parts by weight and impregnates, filter is obtained by filtration
Then filtrate is transferred in high-pressure extracting tank by liquid, 200MPa, pressurize 10min are forced under room temperature, and then release obtains rose
Rare nightshade extract.
Composition in table 1 and this field are prepared after other general substances of lipstick mix in mass ratio, according to GB/T
Lipstick is made in 26513-2011 standards.Wherein, by weight, emulsifier is selected from 10 parts of ABIL WE10 types emulsifier, deionization
5 parts and 7 parts 10 parts of water, 5 parts of butanediol, beeswax auxiliary materials.Lipstick obtained is denoted as A1.
Embodiment 2
A kind of composition containing brown algae polyphenols, by weight including following components：
Table 2
| Component | Content (is converted into g calculating) |
| Undaria pinnitafida polyphenol | 40 |
| Dendrobium loddigesii Rolfe extract | 10 |
| Roselle flower extract | 4 |
Brown algae polyphenols are extracted using following techniques：
3kg undaria pinnitafidas add in 75% ethanol water that quality is 7 times and extract concentration after cleaning, crush, then add and steam
Distilled water suspends, and crossing macroporous resin column with petroleum ether, ethyl acetate, water-saturated n-butanol successively extracts, then with distillation water elution 2
A column volume collects eluent, is concentrated to give brown algae polyphenols to remove polar impurity.
Dendrobium loddigesii Rolfe extract is extracted using following techniques：
Dendrobium loddigesii Rolfe 2kg after crushing is impregnated in 50v/v% aqueous acetone solutions, and assisting ultrasonic is extracted.By gained
Acetone-water extract concentrates, and is eluted successively with macroporous absorption column extracting, then with water, 70%, 80%, 90%, 100% ethyl alcohol, often
A gradient solvent dosage is 4 column volumes, collects 70%-90% ethanol elutions part, obtains dendrobium loddigesii Rolfe extract.
Roselle flower extract is extracted using following techniques：
The Roselle flower that 3kg is smashed to pieces is taken, adds in 75% ethanol water of 4 times of parts by weight and impregnates, filter is obtained by filtration
Then filtrate is transferred in high-pressure extracting tank by liquid, 250MPa, pressurize 15min are forced under room temperature, and then release obtains rose
Rare nightshade extract.
Composition in table 2 and this field are prepared after other general substances of lipstick mix in mass ratio, according to GB/T
Lipstick is made in 26513-2011 standards.Wherein, by weight, emulsifier is selected from 10 parts of ABIL WE10 types emulsifier, deionization
5 parts and 7 parts 10 parts of water, 5 parts of butanediol, beeswax auxiliary materials.Lipstick obtained is denoted as A2.
Embodiment 3
A kind of composition containing brown algae polyphenols, by weight including following components：
Table 3
| Component | Content (is converted into g calculating) |
| Sargassum fusifome polyphenol | 45 |
| Dendrobium loddigesii Rolfe extract | 15 |
| Roselle flower extract | 8 |
Brown algae polyphenols are extracted using following techniques：
3kg sargassum fusifomes add in 80% ethanol water that quality is 8 times and extract concentration after cleaning, crush, then add and steam
Distilled water suspends, and crossing macroporous resin column with petroleum ether, ethyl acetate, water-saturated n-butanol successively extracts, then with distillation water elution 3
A column volume collects eluent, is concentrated to give brown algae polyphenols to remove polar impurity.
Dendrobium loddigesii Rolfe extract is extracted using following techniques：
Dendrobium loddigesii Rolfe 2kg after crushing is impregnated in 60v/v% aqueous acetone solutions, and assisting ultrasonic is extracted.By gained
Acetone-water extract concentrates, and is eluted successively with macroporous absorption column extracting, then with water, 70%, 80%, 90%, 100% ethyl alcohol, often
A gradient solvent dosage is 4 column volumes, collects 70%-90% ethanol elutions part, obtains dendrobium loddigesii Rolfe extract.
Roselle flower extract is extracted using following techniques：
The Roselle flower that 3kg is smashed to pieces is taken, adds in 80% ethanol water of 5 times of parts by weight and impregnates, filter is obtained by filtration
Then filtrate is transferred in high-pressure extracting tank by liquid, 300MPa, pressurize 20min are forced under room temperature, and then release obtains rose
Rare nightshade extract.
Composition in table 3 and this field are prepared after other general substances of lipstick mix in mass ratio, according to GB/T
Lipstick is made in 26513-2011 standards.Wherein, by weight, emulsifier is selected from 10 parts of ABIL WE10 types emulsifier, deionization
5 parts and 7 parts 10 parts of water, 5 parts of butanediol, beeswax auxiliary materials.Lipstick obtained is denoted as A3.
Embodiment 4
A kind of composition containing brown algae polyphenols, by weight including following components：
Table 4
| Component | Content (is converted into g calculating) |
| Sargassum fusifome polyphenol | 20 |
| Undaria pinnitafida polyphenol | 20 |
| Dendrobium loddigesii Rolfe extract | 10 |
| Roselle flower extract | 4 |
Brown algae polyphenols are extracted using following techniques：
1.5kg undaria pinnitafidas and 1.5kg sargassum fusifomes add in 75% ethanol water that quality is 7 times after cleaning, crush
Extraction concentration, then add distillation aqueous suspension, crossing macroporous resin column with petroleum ether, ethyl acetate, water-saturated n-butanol successively extracts, so
Eluent is collected, is concentrated to give brown algae polyphenols to be removed polar impurity with distillation 2 column volumes of water elution afterwards.
Dendrobium loddigesii Rolfe extract is extracted using the technique of embodiment 2.
Roselle flower extract is extracted using the technique of embodiment 2.
Composition in table 4 and this field are prepared after other general substances of lipstick mix in mass ratio, according to GB/T
Lipstick is made in 26513-2011 standards.Wherein, by weight, emulsifier is selected from 10 parts of ABIL WE10 types emulsifier, deionization
5 parts and 7 parts 10 parts of water, 5 parts of butanediol, beeswax auxiliary materials.Lipstick obtained is denoted as A4.
Comparative example 1
By weight, including following components：
Table 5
| Component | Content (is converted into g calculating) |
| Dendrobium loddigesii Rolfe extract | 10 |
| Roselle flower extract | 4 |
Dendrobium loddigesii Rolfe extract is extracted using the technique of embodiment 2.
Roselle flower extract is extracted using the technique of embodiment 2.
Composition in table 5 and this field are prepared after other general substances of lipstick mix in mass ratio, according to GB/T
Lipstick is made in 26513-2011 standards.Wherein, by weight, emulsifier is selected from 10 parts of ABIL WE10 types emulsifier, deionization
5 parts and 7 parts 10 parts of water, 5 parts of butanediol, beeswax auxiliary materials.Lipstick obtained is denoted as B1.
Comparative example 2
Include following components by weight：
Table 6
| Component | Content (is converted into g calculating) |
| Undaria pinnitafida polyphenol | 40 |
| Roselle flower extract | 4 |
Dendrobium loddigesii Rolfe extract is extracted using the technique of embodiment 2.
Roselle flower extract is extracted using the technique of embodiment 2.
Composition in table 6 and this field are prepared after other general substances of lipstick mix in mass ratio, according to GB/T
Lipstick is made in 26513-2011 standards.Wherein, by weight, emulsifier is selected from 10 parts of ABIL WE10 types emulsifier, deionization
5 parts and 7 parts 10 parts of water, 5 parts of butanediol, beeswax auxiliary materials.Lipstick obtained is denoted as B2.
Performance test：
Moistening effect is tested
1st, material and instrument
The present embodiment 1-4, comparative example 1-2 lipsticks and certain commercially available brand lipstick (are denoted as：B3).
Moisture of skin analyzer Corneometer CM825.
2nd, test method
The healthy volunteer of dry skin is chosen, age 30-45 Sui, 40 years old average, no serious systemic disease, immune deficiency
Or autoimmune disease, to cosmetics without allergy, facial no acute inflammation, be not used hormone medicine or immunosuppressor,
Other clinical tests are not participated in, do not smear external preparation.7 groups are randomly divided into, every group 10, is coated in will using test specimen respectively
On the forearm of hope person, index of the transdermal percentage of water loss as evaluation skin moisture-keeping, transdermal percentage of water loss is smaller, and moistening effect is better.
Measure experimental condition be room temperature, relative humidity 40%.
Transdermal percentage of water loss=(moisture when original water content -4 is small)/original water content.
3rd, measurement result
Table 7
| Test specimen | Original water content | 4 it is small when moisture | Transdermal percentage of water loss |
| A1 | 30.8 | 23.6 | 23.38% |
| A2 | 33.6 | 24.8 | 26.19% |
| A3 | 32.9 | 23.3 | 29.18% |
| A4 | 31.4 | 24.9 | 20.70% |
| B1 | 32.3 | 20.1 | 37.77% |
| B2 | 31.8 | 19.9 | 37.42% |
| B3 | 33.7 | 23.7 | 29.67% |
As shown in Table 7, the transdermal percentages of water loss of test group A1-A4 are respectively less than the transdermal percentage of water loss of control group B1-B3, moistening effect
Better than control group.Wherein, the transdermal percentage of water loss of test group A4 is minimum, reaches 20.70%, moistening effect is best.
Control group B1 (being free of brown algae polyphenols) and B2 (being free of dendrobium loddigesii Rolfe extract) lacks active ingredient, moistening effect
It is worst.So as to further prove the mutual compatibility of each composition of the invention, synergistic effect is formed.
Anti-aging is tested
1 material and reagent
SD rats 50, it is SPF grades, 200 ± 20g of weight, male female fifty-fifty.
It chooses embodiment 1-4 and comparative example 1-2 lipsticks and certain commercially available brand lipstick (is denoted as：B3).Total superoxide dismutase
Enzyme (SOD) assay kit, malonaldehyde (MDA) testing cassete, glutathione peroxidase (GSH-PX) assay kit (colorimetric
Method) by Nanjing build up Bioengineering Research Institute provide.
2 zooperies
2.1 animal packet
7 groups are randomly divided into, every group of 10 rats.
2.2 animal models are built
Skin aging model uses D- gal Aging models.
D- gal Aging models
In addition to negative (blank) control group, remaining each group rat skin lower injection 80mg/ (kg.d) D- galactolipins, continuous seven
Week.Back hits exactly skin depilatory, the skin of exposure 2cm*2cm.Experimental group gives the lipstick (3%w/ smeared in embodiment 1-4
W), control group, which is given, smears B1-B3 lipsticks (3%w/w), and positive controls, which are given, smears vitamin E (3%w/w), negative control
Group gives smearing distilled water.All experimental animals are once a day, continuous seven weeks, and with the measured value of SOD, MDA, GSH-PX
Evaluation index as long-term aging test.
2.3 detection
After 8th week last day smeared, animal orbital venous plexus venous blood sampling, according to SOD, MDA, GSH-PX kit
Illustrate to operate.
3 test results
Table 8
| Group | SOD(U/mL) | MDA(nmol/mL) | GSH-PX(U.ml/min) |
| Negative (blank) control | 120.2±3.6 | 11.23±0.23 | 15.69±2.12 |
| Positive control | 147.3±5.3** | 9.53±0.86* | 16.17±2.93 |
| A1 | 157.4±3.2** | 8.03±0.44** | 16.13±3.48** |
| A2 | 162.1±3.3** | 8.64±0.32** | 16.12±2.11* |
| A3 | 160.2±1.9** | 8.21±0.63** | 17.02±1.33** |
| A4 | 169.3±6.9** | 8.02±0.82** | 17.93±3.39** |
| B1 | 130.4±5.3 | 9.01±0.34 | 16.21±2.33* |
| B2 | 120.5±8.3 | 10.21±0.34 | 15.61±3.21 |
| B3 | 160.2±1.9** | 8.21±0.63** | 17.02±1.33** |
Note：* P ＜ 0.05 are compared with feminine gender (blank), * * P are compared with feminine gender (blank)<0.01.
As shown in Table 8, compared with negative control group.Wherein, the horizontal significantly rise (P of SOD in positive controls<0.01 is poor
It is heteropolar notable), and MDA levels significantly reduce, but GSH-PX values are not much different.The composition A1-A4 of the present invention is compared to feminine gender
For control group, skin SOD activity apparent increase (P<0.01), and MDA contents are substantially reduced (P<0.01), GSH-PX is measured
Value rise is apparent (to remove A2 groups P<Outside 0.05,0.01) remaining is respectively less than.B1 groups (being free of brown algae polyphenols) and negative control group ratio
Compared in three indexs in addition to GSH-PX, other differences are not notable.But each finger of B2 (being free of dendrobium loddigesii Rolfe extract) group
For mark compares negative control group, though some indexs have a certain upgrade, difference unobvious.So as to further prove this hair
The mutual compatibility of bright each composition forms synergistic effect.
In addition, by being also seen that A4 groups (polyphenol containing sargassum fusifome and undaria pinnitafida polyphenol combine) are compareed compared with other in table 8
For group and experimental group, anti-aging effects are optimal.Although applicant have further found that all it is brown algae polyphenols, in different materials
Also difference is had between the polyphenol extracted, effectively, the combination anti-aging effects of different brown algae polyphenols are better than single kind
The brown algae polyphenols of class.
It should be noted that the parts by weight in each embodiment, i.e. mass parts, that is, mass fraction, Ke Yili
Xie Weike, milligram, kilogram, jin, kilogram, pound, ton etc..By gram exemplified by, for example, 1 parts by weight is in 0.0001 to 10000 grams
A certain quality；For example, 1 parts by weight can be 0.001g, 0.01g, 0.02g, 0.05g, 0.1g, 0.2g, 0.5g, 1g, 2g, 3g,
4g, 5g, 10g, 15g, 20g, 30g, 50g, 80g, 100g, 500g, 1000g, 5000g, 10000g or 50000g etc., and be not limited to
This, manufactures according to actual production and selects, each embodiment and so on.For example, 1 parts by weight are 1 gram, 0.1 parts by weight are
0.1 gram, and so on.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope that this specification is recorded all is considered to be.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that come for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of composition containing brown algae polyphenols, which is characterized in that by weight, including following components：
35-45 parts of brown algae polyphenols；
5-15 parts of dendrobium loddigesii Rolfe extracts；
And 1-8 parts of Roselle flower extracts；
Wherein, the brown algae polyphenols are extracted using following techniques：
Will clean, crush after brown alga add in 70%-80% ethanol water extraction concentration, then add distillation aqueous suspension, use successively
Petroleum ether, ethyl acetate, water-saturated n-butanol cross macroporous resin column extraction, then with distilling 1-3 column volume of water elution to go
Polar impurity collects eluent, is concentrated to give brown algae polyphenols.
2. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that by the brown alga and 70%-80%
Ethanol water according to mass ratio 1:5 to 1:8 are mixed.
3. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that the dendrobium loddigesii Rolfe extract uses
Following technique extractions：
Dendrobium loddigesii Rolfe after crushing is impregnated in 40-60v/v% aqueous acetone solutions, and assisting ultrasonic is extracted.By gained acetone-
Water extract concentrates, and is eluted successively with macroporous absorption column extracting, then with water, 70%, 80%, 90%, 100% methanol or ethyl alcohol,
Each gradient solvent dosage is 1-5 column volume, collects 70%-90% methanol or ethanol elution part, obtains dendrobium loddigesii Rolfe and carry
Take object.
4. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that the Roselle flower extract uses
Following technique extractions：
After Roselle flower is smashed to pieces, impregnated in the ethanol water for the 70%-80% for adding in 3-5 times of parts by weight, filter is obtained by filtration
Then the filtrate is transferred in high-pressure extracting tank by liquid, 200MPa-300MPa, pressurize 10-20min are forced under room temperature, so
Release afterwards obtains Roselle flower extract.
5. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that the brown algae polyphenols include undaria pinnitafida
The mixing of any one or more in polyphenol, bladder-wrack polyphenol, kelp polyphenol, sargassum fusifome polyphenol.
6. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that by weight, the brown alga is more
Phenol is 40 parts, and 40 parts of brown algae polyphenols are 10 parts of undaria pinnitafida polyphenol, 15 parts of sargassum fusifome polyphenol and 15 parts of kelp polyphenol.
7. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that by weight, the brown alga is more
Phenol is 40 parts, and 40 parts of brown algae polyphenols are 20 parts of undaria pinnitafida polyphenol, 20 parts of sargassum fusifome polyphenol.
8. the composition according to claim 1 containing brown algae polyphenols, which is characterized in that the composition containing brown algae polyphenols
Further include the grease of 30-40 parts by weight.
9. the composition according to claim 8 containing brown algae polyphenols, which is characterized in that the grease is selected from walnut oil, Huang
At least one of orchid oil or sunflower oil.
10. the composition according to claim 8 containing brown algae polyphenols, which is characterized in that the combination containing brown algae polyphenols
Object further includes the grease of 32 parts by weight.
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| CN110227052A (en) * | 2019-06-19 | 2019-09-13 | 杭州悦萱堂化妆品有限公司 | Face cream and preparation method thereof is repaired in a kind of moisturizing |
| CN110507677A (en) * | 2019-07-29 | 2019-11-29 | 广东药科大学 | A kind of extracting method of sargassum fusifome total polyphenols |
| CN113194743A (en) * | 2018-12-05 | 2021-07-30 | 博塔医疗株式会社 | Composition for improving food flavor comprising brown algae polyphenol as effective ingredient |
| CN113350235A (en) * | 2021-06-22 | 2021-09-07 | 科丝美诗(中国)化妆品有限公司 | Lip care composition and preparation and application of cosmetics thereof |
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| CN106822599A (en) * | 2017-01-09 | 2017-06-13 | 中山大学 | A kind of dendrobium loddigesii Rolfe extract and its anti-diabetes use |
| CN107582493A (en) * | 2017-10-25 | 2018-01-16 | 海南宝元堂保健品有限公司 | A kind of dendrobium polysaccharide emulsion containing coconut oil and preparation method thereof |
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| CN106822599A (en) * | 2017-01-09 | 2017-06-13 | 中山大学 | A kind of dendrobium loddigesii Rolfe extract and its anti-diabetes use |
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| CN113194743A (en) * | 2018-12-05 | 2021-07-30 | 博塔医疗株式会社 | Composition for improving food flavor comprising brown algae polyphenol as effective ingredient |
| CN110227052A (en) * | 2019-06-19 | 2019-09-13 | 杭州悦萱堂化妆品有限公司 | Face cream and preparation method thereof is repaired in a kind of moisturizing |
| CN110507677A (en) * | 2019-07-29 | 2019-11-29 | 广东药科大学 | A kind of extracting method of sargassum fusifome total polyphenols |
| CN113350235A (en) * | 2021-06-22 | 2021-09-07 | 科丝美诗(中国)化妆品有限公司 | Lip care composition and preparation and application of cosmetics thereof |
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