CN1080627A - Biological active incline ceramic material - Google Patents

Biological active incline ceramic material Download PDF

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Publication number
CN1080627A
CN1080627A CN 92105372 CN92105372A CN1080627A CN 1080627 A CN1080627 A CN 1080627A CN 92105372 CN92105372 CN 92105372 CN 92105372 A CN92105372 A CN 92105372A CN 1080627 A CN1080627 A CN 1080627A
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CN
China
Prior art keywords
incline
ceramic material
feature
biological active
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 92105372
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Chinese (zh)
Inventor
谢建林
许业静
李伟
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Shan Dong Industrial Ceramic Research Inst Of National Building Material Indust
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Shan Dong Industrial Ceramic Research Inst Of National Building Material Indust
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Application filed by Shan Dong Industrial Ceramic Research Inst Of National Building Material Indust filed Critical Shan Dong Industrial Ceramic Research Inst Of National Building Material Indust
Priority to CN 92105372 priority Critical patent/CN1080627A/en
Publication of CN1080627A publication Critical patent/CN1080627A/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
    • C04B41/50—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials
    • C04B41/5076—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials with masses bonded by inorganic cements
    • C04B41/5092—Phosphate cements
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/009—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone characterised by the material treated
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/80—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only ceramics
    • C04B41/81—Coating or impregnation
    • C04B41/85—Coating or impregnation with inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention belongs to inorganic non-metallic materials science, Biofunctional materials field.The invention provides a kind of incline ceramic material of biologically active, this material has the feature of structural ceramics a side, and its composition is stable or PSZ, or aluminum oxide, zirconium white composite alumina; The feature of another side biologically active pottery, its composition are hydroxyapatite (HA), or are made up of TCP, bioactivity glass and mixture thereof.Chemical ingredients and physicochemical property between two sides are continuous variation.This material has 300MPa above bending strength and excellent biological compatibility, can be used as substituting or repair materials of osseous tissue.

Description

Biological active incline ceramic material
The invention belongs to inorganic non-metallic materials science, Biofunctional materials field, the present invention relates to a kind of high-intensity bioceramic material.Because biological ceramics has than metallic substance and the more excellent biocompatibility of macromolecular material, so recent two decades comes, and is developed faster, existing bioceramic material is broadly divided into two big classes, and the first is with pure AI 2O 3Pottery is the high-intensity bio-inert ceramic of representative.Characteristics are nontoxic, non-carcinogenesis, stabilizer pole in vivo, and can keep high physical strength for a long time.In recent years, also have some to be usually used in the technical ceramics (or being called structural ceramics) of structured material, as the report in the applied research of biomedical sector such as zirconium white, silicon nitride, titanium nitride.It two is to be the bioactive ceramics (comprising the bioactivity glass that contains the phosphoric acid salt crystallite) of representative with synthesizing hydroxylapatite (HA), tricalcium phosphate (TCP), be characterized in, has excellent biological compatibility, can produce directly with osseous tissue and combine, be applied in fields such as tooth section and decorative surseries.But all there are some shortcomings in this two classes material, and the former is that the top layer is often held by fibrous tissue after implanting living body, can not directly engage with bone interface, and life-time service can be loosening with the interface generation of osseous tissue at pottery.The latter is because physical strength is lower, and the intensity of bending strength and cortex bone is suitable, uses so be only limited at non-weight bearing area.
Recently, aspect the intensity that improves bioactive ceramics, JP6140884 discloses a kind of with partially stabilized ZrO 2Pottery (PSZ) is a core, and the top layer applies the thick TCP of 50U, has high bending strength (1100MPa).The result of study (Japanese " pottery " 1989 No2, P, 164) that the investigator of Japan AGC company in 1989 has disclosed them adopts silicon nitride crystal whisker that HA is carried out compound enhancing, and its bending strength reaches 400MPa.The Osaka, Japan industrial technology test employing ZrO that reported in 1988 2The result of compound enhancing HA and TCP (Japan " fine ceramics " 88 years No9P.106-111), its bending strength reaches 350-400MPa.
, there is some difference because the coefficient of expansion of bioactive ceramic coating and Young's modulus are with body material, behind the implantable bioartificial body, and under the repeated stress effect, the possibility that has generation to peel off; The compound enhancing with particle dispersion of above-mentioned whisker needs realize that under hot pressing condition its goods and shape will be restricted, and ceramic whisker has certain carcinogenesis.
The purpose of this invention is to provide a kind of biologically active that can under normal pressure-sintered condition, prepare and high-intensity ceramic artificial bone material.
Feature of the present invention is that this material has the feature of structural ceramics a side, and its composition is stable or PSZ; The feature of another side biologically active pottery, its composition are hydroxyapatite or TCP, bioactivity glass, or their mixture.Chemical ingredients and physicochemical property between two sides are continuous variation.The AL that the present invention adopts 2O 3Material purity is more than 99.5%, and particle diameter is in 0.01-50 μ scope; The ZrO that adopts 2Raw material particle size is at 0.01-50 μ scope, ZrO 2Raw material is through CaO, MgO, Y 2O 3, a kind of in the oxide compound such as CeO or one to three kind of oxide compound stablize or partially stabilized, the content of its stablizer is in the 0.01-20% scope, HA raw material and TCP raw material adopt the artificial synthesis preparation, its Ca/P ratio is respectively 1.65-1.69 and 1.40-1.62.After raw material is made respectively and had mobile slip, regulate pressure system through ratio and make green compact, 1200-1650 ℃ of scope in normal pressure-sintered stove preferably burnt till 1450-1600 ℃ of scope, and this material can be made en plaque or tubular body.
This material has 300MPa above bending strength and excellent biological compatibility, this stupalith is owing to realized the continuous variation of chemical composition and physicochemical property, both the biologically active pottery can with the direct bonded performance of osseous tissue, have the good characteristic of structural ceramics strength high toughness again, in giving birth to body, use to keep its biological safety and mechanical stability for a long time.
Embodiment 1
With the AL of particle diameter in 0.01-0.5 μ scope 2O 3Micro mist, Ca/P are made respectively than the HA that is 1.67 has mobile slip, and its water content is the 40-150% scope.Regulate pressure system through ratio, make bulk or tubulose green compact, in normal pressure-sintered stove, preferably burn till 1450-1600 ℃ of scope.Aluminum oxide in its sample is the 98%-0% gradual change from a side to another lateral content distribution; The content distribution of HA is then correspondingly from the 0%-100% gradual change.Its bending strength is 320MPa.
Embodiment 2
With particle diameter in 0.01-0.5 μ scope, by the Y of 3-8mol% 2O 3Stable ZrO 2Particulate and β-TCP(Ca/P=1.50); Yttrium partially stabilized zirconic content distribution is 99.8%-0% to the sample that employing example 1 described method is made from a side to another side, and the content distribution of β-TCP correspondingly gradually changes from 0-100%.Its bending strength is 350Ma.

Claims (5)

1, a kind of biological active incline ceramic material is characterized in that: a side has the feature of structural ceramics (biologically inert), the feature of another side biologically active pottery, and the chemical ingredients between two sides is continuous variation.
2, biological active incline ceramic material according to claim 1 is characterized in that: this material can be made into en plaque or piped goods.
3, according to claim 1 or the described biological active incline ceramic material of claim 2, it is characterized in that: the composition that side has the stupalith of structural ceramics feature is AI 2O 3, or stable ZrO 2, or partially stabilized ZrO 2, or by AI 2O 3With partially stabilized ZrO 2Mix and form, mix ZrO in the composition 2Content can change in 0～100% scope.
4, according to claim 1 or the described biological active incline ceramic material of claim 2, it is characterized in that: the chemical ingredients of the stupalith of a side biologically active pottery feature is HA, β-TCP, α-TCP, bioactivity glass, also can is that they are with the arbitrary proportion composite material mixed.
5, according to claim 1 or the described biological active incline ceramic material of claim 2, it is characterized in that: this stupalith is applicable to medical field, as artificial bone, joint prosthesis, artificial dental root, modified bone clamp plate etc.
CN 92105372 1992-06-29 1992-06-29 Biological active incline ceramic material Pending CN1080627A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 92105372 CN1080627A (en) 1992-06-29 1992-06-29 Biological active incline ceramic material

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 92105372 CN1080627A (en) 1992-06-29 1992-06-29 Biological active incline ceramic material

Publications (1)

Publication Number Publication Date
CN1080627A true CN1080627A (en) 1994-01-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN 92105372 Pending CN1080627A (en) 1992-06-29 1992-06-29 Biological active incline ceramic material

Country Status (1)

Country Link
CN (1) CN1080627A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100336775C (en) * 2005-05-17 2007-09-12 杭州市萧山区中医院 Preparation method of hydroxyapatite/zirconium dioxide biological ceramic composite material and its products
CN100371296C (en) * 2006-03-17 2008-02-27 中国科学院上海硅酸盐研究所 Method increasing bioactivity of ceramic material contg. zirconium oxide
WO2009042110A1 (en) * 2007-09-21 2009-04-02 New York University School Of Medicine Bioactive graded ceramic-based structures
CN101934096A (en) * 2009-06-25 2011-01-05 四川大学 Ca-P biological glass-ceramic compound nano biological ceramic and preparation method thereof
CN101991877A (en) * 2010-11-02 2011-03-30 陕西科技大学 Preparation method of three-phase CaP-glass coating/porous A1203 rack biological composite material
EP2083744A4 (en) * 2006-11-09 2013-08-28 Univ New York Graded glass/zirconia/glass structures for damage resistant ceramic dental and orthopedic prostheses
EP3178464A1 (en) * 2015-12-07 2017-06-14 WDT-Wolz-Dental-Technik GmbH Method for producing an implant blank
CN109153615A (en) * 2016-03-04 2019-01-04 维塔蔡恩法布里克H劳特尔两合公司 For manufacturing the preform of dental prosthesis

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100336775C (en) * 2005-05-17 2007-09-12 杭州市萧山区中医院 Preparation method of hydroxyapatite/zirconium dioxide biological ceramic composite material and its products
CN100371296C (en) * 2006-03-17 2008-02-27 中国科学院上海硅酸盐研究所 Method increasing bioactivity of ceramic material contg. zirconium oxide
EP2083744A4 (en) * 2006-11-09 2013-08-28 Univ New York Graded glass/zirconia/glass structures for damage resistant ceramic dental and orthopedic prostheses
WO2009042110A1 (en) * 2007-09-21 2009-04-02 New York University School Of Medicine Bioactive graded ceramic-based structures
US8703294B2 (en) 2007-09-21 2014-04-22 New York University Bioactive graded zirconia-based structures
CN101934096A (en) * 2009-06-25 2011-01-05 四川大学 Ca-P biological glass-ceramic compound nano biological ceramic and preparation method thereof
CN101991877A (en) * 2010-11-02 2011-03-30 陕西科技大学 Preparation method of three-phase CaP-glass coating/porous A1203 rack biological composite material
CN101991877B (en) * 2010-11-02 2012-07-25 陕西科技大学 Preparation method of three-phase CaP-glass coating/porous A1203 rack biological composite material
EP3178464A1 (en) * 2015-12-07 2017-06-14 WDT-Wolz-Dental-Technik GmbH Method for producing an implant blank
US11147655B2 (en) 2015-12-07 2021-10-19 Wdt-Wolz-Dental-Technik Gmbh Method for producing an implant blank
CN109153615A (en) * 2016-03-04 2019-01-04 维塔蔡恩法布里克H劳特尔两合公司 For manufacturing the preform of dental prosthesis
CN109153615B (en) * 2016-03-04 2022-04-05 维塔蔡恩法布里克H劳特尔两合公司 Preform for manufacturing a dental restoration

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