CN108042771A - 一种治疗乳腺增生的药茶 - Google Patents

一种治疗乳腺增生的药茶 Download PDF

Info

Publication number
CN108042771A
CN108042771A CN201711312099.9A CN201711312099A CN108042771A CN 108042771 A CN108042771 A CN 108042771A CN 201711312099 A CN201711312099 A CN 201711312099A CN 108042771 A CN108042771 A CN 108042771A
Authority
CN
China
Prior art keywords
parts
radix
mammary gland
rhizoma atractylodis
proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711312099.9A
Other languages
English (en)
Inventor
郭景龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shaanxi Clean Dust Yangyuan Hall Health Management Co Ltd
Original Assignee
Shaanxi Clean Dust Yangyuan Hall Health Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shaanxi Clean Dust Yangyuan Hall Health Management Co Ltd filed Critical Shaanxi Clean Dust Yangyuan Hall Health Management Co Ltd
Priority to CN201711312099.9A priority Critical patent/CN108042771A/zh
Publication of CN108042771A publication Critical patent/CN108042771A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/06—Treating tea before extraction; Preparations produced thereby
    • A23F3/14—Tea preparations, e.g. using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明提供一种治疗乳腺增生的药茶，由以下重量份数的原料制成：当归10‑15份、赤芍10‑15份、柴胡10‑15份、茯苓10‑12份、炒白术10‑12份、苍术12‑15份、生姜6‑8份、木香10‑12份、浙贝母10‑12份、天花粉13‑15份、丝瓜络12‑15份、郁金10‑15份、红花8‑10份、丹参15‑18份、元胡10‑12份、生甘草10‑12份、龙井茶叶10‑15份，具有活血化瘀，通经达络，消淤解散，使增生得到康复，使女性乳腺得到保健和治疗，治疗效果好，食用方便。

Description

一种治疗乳腺增生的药茶
技术领域
本发明涉及医疗保健领域，具体地涉及一种治疗乳腺增生的药茶。
背景技术
乳腺增生病是女性乳腺病中的常见病、多发病，尤以中青年多见，临床上以无痛性***肿块为主要症状，很少伴有***疼痛及***溢液者。***相对或绝对升高可引起本病，所以乳腺增生的发生与内分泌激素失调有关。
目前市场上治疗乳腺增生的药物主要有乳宁颗粒、桂枝获冬胶囊、平消胶囊等中成药，这些中成药针对性不强，多为治疗妇科多种疾病甚或***的药物，兼治乳腺增生，或者只针对乳腺增生病的某一症状或某一病理环节，且价格昂贵。
发明内容
本发明的目的是提供一种治疗乳腺增生的药茶，具有活血化瘀，通经达络，消淤解散，使增生得到康复，使女性乳腺得到保健和治疗，治疗效果好，食用方便。
为了解决上述问题采用以下技术方案：
本发明的治疗乳腺增生的药茶，其特殊之处在于：由以下重量份数的原料制成：当归10-15份、赤芍10-15份、柴胡10-15份、茯苓10-12份、炒白术10-12份、苍术12-15份、生姜6-8份、木香10-12份、浙贝母10-12份、天花粉13-15份、丝瓜络12-15份、郁金 10-15份、红花8-10份、丹参15-18份、元胡10-12份、生甘草10-12份、龙井茶叶10-15份。
在一种优选的方案中，由以下重量份数的原料制成：当归10份、赤芍10份、柴胡10份、茯苓10份、炒白术10份、苍术15份、生姜6份、木香10份、浙贝母10份、天花粉 15份、丝瓜络15份、郁金 10份、 红花8份、丹参15份、元胡10份、生甘草10份、龙井茶叶10份。
制备方法：将所有原料混合，并以紫外线灯对其进行杀菌处理，然后，放入烤箱对药物干燥，用粉碎机将药物粉碎，然后研成粉面，搅拌均匀装入一次性茶包袋，每袋装8g。
用法用量：每天1包药茶，开水冲泡，开水浸泡半小时最佳。
本发明提供的一种治疗乳腺增生的药茶，各中药物相互配伍，具有舒肝解郁、软坚散结、通络祛癖、活血调经的功效；对于治疗乳腺增生，子宫肌瘤，***，***和痛经等疾病具有明显效果，且无毒无副作用，疗程短，见效快。
本发明创造之处在于，当归、赤芍、柴胡、茯苓、炒白术、苍术、生姜此配方来源于黑龙江中医药大学妇科协定的调经祛痰方，加入木香、浙贝母、天花粉、红花、丹参、元胡、生甘草此方为千金要方中妇科病证奇效方之一，具有舒肝解郁、软坚散结、通络祛癖、活血调经的作用，最后加入丝瓜络、郁金抗炎，与龙井茶叶一起制备成药茶。
具体实施方式
实施例1
本发明的治疗乳腺增生的药茶由以下重量份数的原料制成：当归10-15份、赤芍10-15份、柴胡10-15份、茯苓10-12份、炒白术10-12份、苍术12-15份、生姜6-8份、木香10-12份、浙贝母10-12份、天花粉13-15份、丝瓜络12-15份、郁金 10-15份、红花8-10份、丹参15-18份、元胡10-12份、生甘草10-12份、龙井茶叶10-15份。
制备方法：将所有原料混合，并以紫外线灯对其进行杀菌处理，然后，放入烤箱对药物干燥，用粉碎机将药物粉碎，然后研成粉面，搅拌均匀装入一次性茶包袋，每袋装8g。
用法用量：每天1包药茶，开水冲泡，开水浸泡半小时最佳。
实施例2
本发明的治疗乳腺增生的药茶由以下重量份数的原料制成：当归10份、赤芍10份、柴胡10份、茯苓10份、炒白术10份、苍术15份、生姜6份、木香10份、浙贝母10份、天花粉 15份、丝瓜络15份、郁金 10份、 红花8份、丹参15份、元胡10份、生甘草10份、龙井茶叶10份。
其余与实施1相同。
病例1，黄某，女，28岁，新疆人。患者双乳肿块伴疼痛2月余，经前尤甚，伴双乳经前疼痛，检查：双乳外上下方可触及块状腺体，质韧，边界不清，压痛，两腋下淋巴；B超检查：右乳下方0.4cm囊性暗区，双乳囊性增生。诊断：乳腺囊性增生。经服用本发明药茶治疗两个疗程（一个月）后，疼痛消失，肿块消失，B超检查：右乳下囊肿消失。
病例2，王某，女，40岁，湖南人。患者左乳疼痛5年余，经前尤甚，月经量少，色暗，睡眠不安，不易入眠，多梦，性情忧郁，诊断：乳腺囊性增生。采用该种治疗乳腺增生的中药治疗三个疗程（一个半月）后，:左乳疼痛消失，左乳肿块变小，基本消失；B超检查囊肿少见。

Claims (2)

1.一种治疗乳腺增生的药茶，其特征在于，由以下重量份数的原料制成：当归10-15份、赤芍10-15份、柴胡10-15份、茯苓10-12份、炒白术10-12份、苍术12-15份、生姜6-8份、木香10-12份、浙贝母10-12份、天花粉13-15份、丝瓜络12-15份、郁金 10-15份、红花8-10份、丹参15-18份、元胡10-12份、生甘草10-12份、龙井茶叶10-15份。
2.根据权利要求1所述的治疗乳腺增生的药茶，其特征是由以下优选重量份原料制成：当归10份、赤芍10份、柴胡10份、茯苓10份、炒白术10份、苍术15份、生姜6份、木香10份、浙贝母10份、天花粉 15份、丝瓜络15份、郁金 10份、 红花8份、丹参15份、元胡10份、生甘草10份、龙井茶叶10份。
CN201711312099.9A 2017-12-12 2017-12-12 一种治疗乳腺增生的药茶 Pending CN108042771A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711312099.9A CN108042771A (zh) 2017-12-12 2017-12-12 一种治疗乳腺增生的药茶

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711312099.9A CN108042771A (zh) 2017-12-12 2017-12-12 一种治疗乳腺增生的药茶

Publications (1)

Publication Number Publication Date
CN108042771A true CN108042771A (zh) 2018-05-18

Family

ID=62124127

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711312099.9A Pending CN108042771A (zh) 2017-12-12 2017-12-12 一种治疗乳腺增生的药茶

Country Status (1)

Country Link
CN (1) CN108042771A (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101401914A (zh) * 2008-11-07 2009-04-08 吴翠霞 一种治疗乳腺增生的药物
CN105213628A (zh) * 2015-11-12 2016-01-06 佛山市朗达信息科技有限公司 治疗乳腺增生的组合物及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101401914A (zh) * 2008-11-07 2009-04-08 吴翠霞 一种治疗乳腺增生的药物
CN105213628A (zh) * 2015-11-12 2016-01-06 佛山市朗达信息科技有限公司 治疗乳腺增生的组合物及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
何祥午: "自拟乳腺病方治疗乳腺病1440例", 《HTTP://WWW.39KF.COM/COOPERATE/QK/JOURNAL/0401/04/2005-05-11-62532.SHTML》 *
卢秀德: "逍遥散在临床上应用点滴", 《福建中医药》 *

Similar Documents

Publication Publication Date Title
CN104043049A (zh) 一种治疗乳腺增生的中药组合物
CN103784887A (zh) 一种治疗肾虚腰痛的中药组合物
CN104758587A (zh) 一种心律失常的中药组合物
CN102988889B (zh) 一种治疗乳腺增生的中药组合物
CN103736018A (zh) 一种治疗胆结石的药物及其制备方法
CN101926882A (zh) 治疗癌症的药物组合物及其制备方法
CN104383495A (zh) 一种治疗化疗所致神经损伤的药物及其制备方法
CN104524159A (zh) 一种治疗乳腺增生的药物组合物
CN105126045A (zh) 一种治疗更年期综合征的中药组合物
CN103816497A (zh) 一种治疗肝郁气滞证的中药组合物
CN103656462A (zh) 一种治疗神经衰弱的中药
CN102552690B (zh) 一种治疗乳腺增生的中草药组合物
CN101897860A (zh) 一种***的中成药内服丸剂
CN103705870A (zh) 一种治疗乳腺炎的中药组合物
CN101259214B (zh) 一种治疗乳腺增生的药物
CN103705900A (zh) 一种治疗高血压的中药组合物
CN103550674A (zh) 一种祛瘀活血药液
CN108042771A (zh) 一种治疗乳腺增生的药茶
CN103041335B (zh) 一种治疗胃痛的中药组合物
CN106266972A (zh) 一种治疗肺癌的中药配方
CN102846911A (zh) 一种用于治疗冠心病的药物
CN104173933A (zh) 一种治疗抑郁症的中药组合物
CN103028063B (zh) 一种治疗肾病的中药组合物
CN103536835A (zh) 一种健脾消食药物的制备方法
CN103356962B (zh) 一种治疗更年期综合症的中药组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180518

RJ01 Rejection of invention patent application after publication