CN104383495A - 一种治疗化疗所致神经损伤的药物及其制备方法 - Google Patents
一种治疗化疗所致神经损伤的药物及其制备方法 Download PDFInfo
- Publication number
- CN104383495A CN104383495A CN201410693397.7A CN201410693397A CN104383495A CN 104383495 A CN104383495 A CN 104383495A CN 201410693397 A CN201410693397 A CN 201410693397A CN 104383495 A CN104383495 A CN 104383495A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- ginseng
- herba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/614—Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗化疗所致神经损伤的药物,包括黄芪、当归、细辛、生晒参、伸筋草、威灵仙、白芍、生姜、红花、全蝎、地龙、人参、川芎、丹参、桃花、瓜蒌、大黄、淫羊藿、银杏叶、鹿茸、葛根、僵蚕、红景天、水蛭、宽筋藤、桑枝、蜈蚣、桂枝、桃仁、鸡血藤、甘草、诃子、草乌、石菖蒲、木香、麝香、珊瑚、珍珠、丁香、肉豆蔻、沉香、禹粮土和磁石,取补中有通、通中有补、填疏相济、静动结合之义,使全身气血调达,络通痹宣,则凉、麻、痛、痿渐缓至消。活血引血下行,对化疗所致神经损伤患者有明显的活血通络作用,同时可以益气补血、强筋止痛的作用,从而提高病人生存质量、延长生命。
Description
技术领域
本发明涉及一种神经损伤的药物,具体地说,涉及一种治疗化疗所致神经损伤的药物及其制备方法,属于中医药技术领域。
背景技术
随着人类生存期的延长及医疗诊断水平的提高,肿瘤目前已成为人类死亡的首位原因。我国每年新发肿瘤病例约为312万例,其中中晚期失去手术机会的患者约为192万例。
临床治疗中晚期肿瘤主要以抗肿瘤化疗药物治疗为主。抗肿瘤化疗药物可引起的神经损害,它几乎存在于所有的化疗药物治疗过程当中。严重的神经毒性反应常常使病人面临减低化疗药物剂量甚至停药的困境,同时对病人的心理、生理、和生活质量都可能产生损害。化疗药物的神经毒性可累及神经***任何部位,引起脑、脊髓、周围神经和肌肉损害,表现为肢端和(或)口周的感觉迟钝或感觉异常、肢体末端或颚部的强直性肌肉收缩、腿痛性痉挛等。
目前,治疗化疗药物所致神经损伤主要方法有钙镁灌注、谷氨酰胺、谷胱甘肽和N-乙酰半胱氨酸、维生素E、神经妥乐平等,以上药物起效慢而且疗效甚微。虽然也有采用中药治疗化疗所致神经损伤的报道,但治疗效果并不明显,复发率高。
发明内容
本发明要解决的技术问题是针对以上不足,提供一种治疗化疗所致神经损伤的药物,克服了现有技术中西药副作用较大,起效较慢,效果不理想,复发率高的缺陷,采用所述药物治疗化疗所致神经损伤效果明显,复发率低。
本发明的另一目的是提供一种治疗化疗所致神经损伤药物的制备方法。
为解决上述技术问题,本发明所采用的技术方案是:一种治疗化疗所致神经损伤的药物,其特征在于,其疗效成分包括以下重量份的原料:
黄芪25-30份、当归5-10份、细辛5-10份、生晒参5-10份、伸筋草30-40份、威灵仙30-40份、白芍20-30份、生姜10-15份、红花5-10份、全蝎10-15份、地龙20-25份、人参(新开河参)15-20份、川芎10-15份、丹参20-25份、桃花20-25份、瓜蒌20-25份、大黄5-10份、淫羊藿20-25份、银杏叶20-25份、鹿茸5-10份、葛根20-25份、僵蚕10-15份、红景天20-25份、水蛭5-10份、宽筋藤20-25份、桑枝20-25份、蜈蚣15-20份、桂枝5-10份、桃仁20-25份、鸡血藤10-15份、甘草20-25份、诃子10-15份、草乌20-25份、石菖蒲20-25份、木香10-15份、麝香5-10份、珊瑚20-25份、珍珠10-15份、丁香20-25份、肉豆蔻10-15份、沉香20-25份、禹粮土5-10份和磁石5-10份。
一种优化方案,所述药物的疗效成分包括以下重量份的原料:黄芪25-28份、当归5-8份、细辛5-8份、生晒参5-8份、伸筋草30-35份、威灵仙30-35份、白芍20-28份、生姜10-12份、红花5-8份、全蝎10-12份、地龙20-22份、人参(新开河参)15-18份、川芎10-12份、丹参20-22份、桃花20-22份、瓜蒌20-22份、大黄5-8份、淫羊藿20-22份、银杏叶20-22份、鹿茸5-8份、葛根20-22份、僵蚕10-12份、红景天20-22份、水蛭5-8份、宽筋藤20-22份、桑枝20-22份、蜈蚣15-18份、桂枝5-8份、桃仁20-22份、鸡血藤10-12份、甘草20-22份、诃子10-12份、草乌20-22份、石菖蒲20-22份、木香10-12份、麝香5-8份、珊瑚20-22份、珍珠10-12份、丁香20-22份、肉豆蔻10-12份、沉香20-22份、禹粮土5-8份和磁石5-8份。
一种优化方案,其疗效成分包括以下重量份的原料:
黄芪28份、当归9份、细辛5份、生晒参8份、伸筋草35份、威灵仙30份、白芍22份、生姜12份、红花10份、全蝎12份、地龙20份、人参(新开河参)16份、川芎15份、丹参25份、桃花24份、瓜蒌22份、大黄6份、淫羊藿24份、银杏叶25份、鹿茸5份、葛根25份、僵蚕14份、红景天24份、水蛭5份、宽筋藤24份、桑枝24份、蜈蚣17份、桂枝6份、桃仁23份、鸡血藤13份、甘草24份、诃子13份、草乌21份、石菖蒲23份、木香13份、麝香6份、珊瑚25份、珍珠15份、丁香24份、肉豆蔻15份、沉香23份、禹粮土7份和磁石6份。
基于以上药物,其制备方法包括以下步骤:
a、按照重量份分别称取各原料;
b、盐、麸制黄芪:取麸皮炒热后,加入黄芪片炒热,筛去麸皮,加盐水喷匀,用微火烘干;
c、酥油制淫羊藿:取酥油,置锅内文火加热熔化,再将上述淫羊藿丝倒入,炒拌均匀,取出,摊开,晾凉;
d、生地麦麸制僵蚕:取生地加水煮沸2小时,将僵蚕放生地水内浸1小时,洗净晒干,再取麦麸炒热,加入僵蚕,炒至淡黄色,筛出麦麸即可;
e、制草乌:取泡过的草乌略晒至半干,用生地、天麻、黑豆同煎得的浓汁浸泡搅拌均匀,蒸4小时使透,至内无自心取出,略晒至半干,另将锅中蒸出液和剩余的生地、天麻、黑豆汁合并浓缩,拌入草乌中,润透使尽,切片晒干;
f、面裹煨肉豆蔻:用面片将肉豆蔻逐个包裹,或如水泛丸包裹面粉3~4层,投入热的滑石粉中翻动,至面皮呈焦黄色时取出,用时剥去面;
g、煨制诃子:用面裹煨法,煨至面皮焦黄为度,剥去面皮,临用时打碎。
h、木瓜汁酒喷制水蛭:水蛭在猪油中炸至焦黄鼓起,趁热喷适量木瓜汁与黄酒,用文火至干燥,加入少量花椒拌匀取出;
j、将当归、细辛、生晒参、伸筋草、威灵仙、白芍、生姜、红花、全蝎、地龙、人参(新开河参)、川芎、丹参、桃花、瓜蒌、大黄、银杏叶、鹿茸、葛根、红景天、宽筋藤、桑枝、蜈蚣、桂枝、桃仁、鸡血藤、甘草、石菖蒲、木香、麝香、珊瑚、珍珠、丁香、沉香、禹粮土和盐、麸制黄芪、酥油制淫羊藿、生地麦麸制僵蚕、制草乌、煨制诃子、木瓜汁酒喷制水蛭、面裹煨肉豆蔻混合,用粉碎机粉碎,过120目筛成为细末;
k、然后将细末用泥罐密封后,埋于地下1米处,两年后取出;
l、分袋密封包装。
治疗化疗所致神经损伤中药的使用方法包括以下步骤:
a、将中药细末与熬炼好的蜂蜜按1∶1.5混匀,搓条、和丸,每粒药丸0.3g。
b、一次30粒,每日三次口服。
c、外用浸泡四肢:煎取药液后的药渣30份+透骨草50份+干蟾皮10份+川乌15份以1300ml水煎取1000ml,每次浸泡30min,每日3次。
中医将肢体麻木不仁、感觉异常、运动障碍等神经病变归于痹证,因此化疗所致神经损伤属于中医“痹证”范畴。其病机为化疗损伤正气,气虚推动乏力,血行不畅,导致筋脉失养,络脉瘀阻。治宜补气活血,化瘀通络。方中制黄芪、当归、人参、生晒参、白芍、银杏叶、面裹煨肉豆蔻具有益气养血之功效;鸡血藤、细辛、生姜、丹参、桃花、葛根、红景天、麝香具有活血之功效;制水蛭、桂枝、川芎、红花、地龙、桃仁、桑枝、全蝎具有破瘀通络之功效;鹿茸、制草乌、制淫羊藿、伸筋草、宽筋藤、制僵蚕和磁石具有强筋健骨之功效;威灵仙、蜈蚣、石菖蒲、木香、禹粮土具有通痹止痛之功效;瓜蒌、大黄、制诃子具有凉血解毒之功效;珊瑚、珍珠、丁香、沉香温中和胃共为使药,综观全方,体现了“以通为补”、“以通为用”的原则,取补中有通、通中有补、填疏相济、静动结合之义,使全身气血调达,络通痹宣,则凉、麻、痛、痿渐缓至消。活血引血下行。
本发明采用以上技术方案,对化疗所致神经损伤患者有明显的活血通络作用,同时可以益气补血、强筋止痛的作用,从而提高病人生存质量、延长生命,经试验,有效率达到87.5%以上。
下面结合具体实施方式对本发明的技术方案进一步的说明。
具体实施方式
实施例1,一种治疗化疗所致神经损伤的药物,其疗效成分包括以下重量份的原料:
黄芪30份、当归10份、细辛10份、生晒参10份、伸筋草40份、威灵仙40份、白芍30份、生姜15份、红花5份、全蝎15份、地龙23份、人参(新开河参)20份、川芎11份、丹参20份、桃花20份、瓜蒌25份、大黄10份、淫羊藿21份、银杏叶20份、鹿茸10份、葛根21份、僵蚕10份、红景天25份、水蛭10份、宽筋藤25份、桑枝20份、蜈蚣20份、桂枝10份、桃仁25份、鸡血藤15份、甘草25份、诃子15份、草乌20份、石菖蒲25份、木香15份、麝香10份、珊瑚20份、珍珠13份、丁香25份、肉豆蔻10份、沉香25份、禹粮土10份和磁石10份。
实施例2,一种治疗化疗所致神经损伤的药物,其疗效成分包括以下重量份的原料:
黄芪29份、当归5份、细辛6份、生晒参5份、伸筋草37份、威灵仙38份、白芍28份、生姜11份、红花7份、全蝎13份、地龙24份、人参(新开河参)19份、川芎12份、丹参24份、桃花23份、瓜蒌24份、大黄7份、淫羊藿22份、银杏叶24份、鹿茸7份、葛根22份、僵蚕13份、红景天22份、水蛭7份、宽筋藤22份、桑枝25份、蜈蚣18份、桂枝10份、桃仁22份、鸡血藤12份、甘草23份、诃子14份、草乌25份、石菖蒲22份、木香11份、麝香8份、珊瑚24份、珍珠12份、丁香20份、肉豆蔻13份、沉香22份、禹粮土9份和磁石8份。
实施例3,一种治疗化疗所致神经损伤的药物,其疗效成分包括以下重量份的原料:
黄芪26份、当归8份、细辛8份、生晒参6份、伸筋草30份、威灵仙35份、白芍20份、生姜10份、红花8份、全蝎10份、地龙22份、人参(新开河参)15份、川芎10份、丹参22份、桃花22份、瓜蒌20份、大黄5份、淫羊藿20份、银杏叶22份、鹿茸8份、葛根20份、僵蚕12份、红景天20份、水蛭8份、宽筋藤20份、桑枝22份、蜈蚣15份、桂枝8份、桃仁22份、鸡血藤10份、甘草22份、诃子10份、草乌22份、石菖蒲20份、木香10份、麝香5份、珊瑚22份、珍珠10份、丁香22份、肉豆蔻12份、沉香20份、禹粮土5份和磁石5份。
实施例4,一种治疗化疗所致神经损伤的药物,其疗效成分包括以下重量份的原料:
黄芪28份、当归9份、细辛5份、生晒参8份、伸筋草35份、威灵仙30份、白芍22份、生姜12份、红花10份、全蝎12份、地龙20份、人参(新开河参)16份、川芎15份、丹参25份、桃花24份、瓜蒌22份、大黄6份、淫羊藿24份、银杏叶25份、鹿茸5份、葛根25份、僵蚕14份、红景天24份、水蛭5份、宽筋藤24份、桑枝24份、蜈蚣17份、桂枝6份、桃仁23份、鸡血藤13份、甘草24份、诃子13份、草乌21份、石菖蒲23份、木香13份、麝香6份、珊瑚25份、珍珠15份、丁香24份、肉豆蔻15份、沉香23份、禹粮土7份和磁石6份。
实施例5,一种治疗化疗所致神经损伤的药物,其疗效成分包括以下重量份的原料:
黄芪25份、当归7份、细辛7份、生晒参7份、伸筋草32份、威灵仙32份、白芍25份、生姜14份、红花9份、全蝎14份、地龙25份、人参(新开河参)18份、川芎13份、丹参23份、桃花25份、瓜蒌21份、大黄8份、淫羊藿25份、银杏叶23份、鹿茸9份、葛根24份、僵蚕15份、红景天21份、水蛭9份、宽筋藤23份、桑枝24份、蜈蚣16份、桂枝9份、桃仁21份、鸡血藤14份、甘草20份、诃子12份、草乌24份、石菖蒲24份、木香12份、麝香7份、珊瑚23份、珍珠14份、丁香23份、肉豆蔻21份、沉香23份、禹粮土8份和磁石7份。
以上五个实施例的药物分别按照以下步骤制备:
a、按照重量份分别称取各原料;
b、盐、麸制黄芪:取麸皮炒热后,加入黄芪片炒热,筛去麸皮,加盐水喷匀,用微火烘干。(每黄芪500g,用食盐186g,水与麸皮适量)
c、酥油制淫羊藿:取酥油,置锅内文火加热熔化,再将上述淫羊藿丝倒入,炒拌均匀,取出,摊开,晾凉。(每淫羊藿100kg,用酥油25kg)
d、生地麦麸制僵蚕:取生地加水煮沸2小时,将僵蚕放生地水内浸1小时,洗净晒干,再取麦麸炒热,加入僵蚕,炒至淡黄色,筛出麦麸即可。(每僵蚕500g,用生地30g,麦麸60g)。
e、制草乌:取泡过的草乌略晒至半干,用生地、天麻、黑豆同煎得的浓汁浸泡搅拌均匀,蒸4小时使透,至内无自心取出,略晒至半干,另将锅中蒸出液和剩余的生地、天麻、黑豆汁合并浓缩,拌入草乌中,润透使尽,切片晒干。(每草乌200kg,用生地10kg,天麻20kg,黑豆10kg)。
f、面裹煨肉豆蔻:用面片将肉豆蔻逐个包裹,或如水泛丸包裹面粉3~4层,投入热的滑石粉中翻动,至面皮呈焦黄色时取出,用时剥去面。(每100斤肉豆蔻,用面粉50斤)。
g、煨制诃子:用面裹煨法,煨至面皮焦黄为度,剥去面皮,临用时打碎。
h、木瓜汁酒喷制水蛭:水蛭在猪油中炸至焦黄鼓起,趁热喷适量木瓜汁与黄酒,用文火至干燥,加入少量花椒拌匀取出。
j、将当归、细辛、生晒参、伸筋草、威灵仙、白芍、生姜、红花、全蝎、地龙、人参(新开河参)、川芎、丹参、桃花、瓜蒌、大黄、银杏叶、鹿茸、葛根、红景天、宽筋藤、桑枝、蜈蚣、桂枝、桃仁、鸡血藤、甘草、石菖蒲、木香、麝香、珊瑚、珍珠、丁香、沉香、禹粮土和盐、麸制黄芪、酥油制淫羊藿、生地麦麸制僵蚕、制草乌、煨制诃子、木瓜汁酒喷制水蛭、面裹煨肉豆蔻混合,用粉碎机粉碎,过120目筛成为细末;
k、然后将细末用泥罐密封后,埋于地下1米处,两年后取出;
l、分袋密封包装。
治疗化疗所致神经损伤中药的使用方法包括以下步骤:
a、将中药细末与熬炼好的蜂蜜按1∶1.5混匀,搓条、和丸,每粒药丸0.3g。
b、一次30粒,每日三次口服。
c、外用浸泡四肢:煎取药液后的药渣30份+透骨草50份+干蟾皮10份+川乌15份以1300ml水煎取1000ml,每次浸泡30min,每日3次。
将以上五个实施例所得药物用于治疗化疗所致神经损伤的试验,使用疗效评定标准为:
痊愈:肢端和(或)口周的感觉异常、肢体末端肌肉痛性痉挛等症状消失。
显效:肢端和(或)口周的感觉异常、肢体末端肌肉痛性痉挛等症状消失,偶有该症状。
有效:肢端和(或)口周的感觉异常、肢体末端肌肉痛性痉挛等症状减轻,时常出现该症状,但次数明显减少。
无效:肢端和(或)口周的感觉异常、肢体末端肌肉痛性痉挛等症状无明显改变。
2010年7月至2014年10月就医的240例化疗所致神经损伤患者,患者病症符合《肿瘤内科学》第3版化疗所致神经损伤诊断标准。240例均有应用抗肿瘤药物史,男91例,女149例,年龄40-80岁,病程1个月至2年。
共设置1个对照组和5个试验组,随机平均分配患者进行治疗。试验组1使用实施例1所得的药物治疗,试验组2使用实施例2所得的药物治疗,试验组3使用实施例3所得的药物治疗,试验组4使用实施例4所得的药物治疗,试验组5使用本发明实施例5所得的药物治疗,对照组采用西医钙镁灌注、谷氨酰胺、维生素E、神经妥乐平的方法治疗。
试验得到的结果如下表:
从以上数据看出,本发明所得治疗化疗所致神经损伤的药物,有效率可达87.5%以上,且复发率低,在以上实施例中,实施例4为最佳方案,痊愈率达到60%,有效率达到95%。
本领域技术人员应该认识到,上述的具体实施方式只是示例性的,是为了使本领域技术人员能够更好的理解本发明内容,不应理解为是对本发明保护范围的限制,只要是根据本发明技术方案所作的改进,并实现与本发明的相同的作用,均落入本发明的保护范围。
Claims (4)
1.一种治疗化疗所致神经损伤的药物,其特征在于,其疗效成分包括以下重量份的原料:
黄芪25-30份、当归5-10份、细辛5-10份、生晒参5-10份、伸筋草30-40份、威灵仙30-40份、白芍20-30份、生姜10-15份、红花5-10份、全蝎10-15份、地龙20-25份、人参(新开河参)15-20份、川芎10-15份、丹参20-25份、桃花20-25份、瓜蒌20-25份、大黄5-10份、淫羊藿20-25份、银杏叶20-25份、鹿茸5-10份、葛根20-25份、僵蚕10-15份、红景天20-25份、水蛭5-10份、宽筋藤20-25份、桑枝20-25份、蜈蚣15-20份、桂枝5-10份、桃仁20-25份、鸡血藤10-15份、甘草20-25份、诃子10-15份、草乌20-25份、石菖蒲20-25份、木香10-15份、麝香5-10份、珊瑚20-25份、珍珠10-15份、丁香20-25份、肉豆蔻10-15份、沉香20-25份、禹粮土5-10份和磁石5-10份。
2.如权利要求1所述的药物,其特征在于,所述药物的疗效成分包括以下重量份的原料:黄芪25-28份、当归5-8份、细辛5-8份、生晒参5-8份、伸筋草30-35份、威灵仙30-35份、白芍20-28份、生姜10-12份、红花5-8份、全蝎10-12份、地龙20-22份、人参(新开河参)15-18份、川芎10-12份、丹参20-22份、桃花20-22份、瓜蒌20-22份、大黄5-8份、淫羊藿20-22份、银杏叶20-22份、鹿茸5-8份、葛根20-22份、僵蚕10-12份、红景天20-22份、水蛭5-8份、宽筋藤20-22份、桑枝20-22份、蜈蚣15-18份、桂枝5-8份、桃仁20-22份、鸡血藤10-12份、甘草20-22份、诃子10-12份、草乌20-22份、石菖蒲20-22份、木香10-12份、麝香5-8份、珊瑚20-22份、珍珠10-12份、丁香20-22份、肉豆蔻10-12份、沉香20-22份、禹粮土5-8份和磁石5-8份。
3.如权利要求1所述的药物,其特征在于,其疗效成分包括以下重量份的原料:
黄芪28份、当归9份、细辛5份、生晒参8份、伸筋草35份、威灵仙30份、白芍22份、生姜12份、红花10份、全蝎12份、地龙20份、人参(新开河参)16份、川芎15份、丹参25份、桃花24份、瓜蒌22份、大黄6份、淫羊藿24份、银杏叶25份、鹿茸5份、葛根25份、僵蚕14份、红景天24份、水蛭5份、宽筋藤24份、桑枝24份、蜈蚣17份、桂枝6份、桃仁23份、鸡血藤13份、甘草24份、诃子13份、草乌21份、石菖蒲23份、木香13份、麝香6份、珊瑚25份、珍珠15份、丁香24份、肉豆蔻15份、沉香23份、禹粮土7份和磁石6份。
4.如权利要求1所述药物的制备方法,其特征在于,包括以下步骤:
a、按照重量份分别称取各原料;
b、盐、麸制黄芪:取麸皮炒热后,加入黄芪片炒热,筛去麸皮,加盐水喷匀,用微火烘干;
c、酥油制淫羊藿:取酥油,置锅内文火加热熔化,再将上述淫羊藿丝倒入,炒拌均匀,取出,摊开,晾凉;
d、生地麦麸制僵蚕:取生地加水煮沸2小时,将僵蚕放生地水内浸1小时,洗净晒干,再取麦麸炒热,加入僵蚕,炒至淡黄色,筛出麦麸即可;
e、制草乌:取泡过的草乌略晒至半干,用生地、天麻、黑豆同煎得的浓汁浸泡搅拌均匀,蒸4小时使透,至内无自心取出,略晒至半干,另将锅中蒸出液和剩余的生地、天麻、黑豆汁合并浓缩,拌入草乌中,润透使尽,切片晒干;
f、面裹煨肉豆蔻:用面片将肉豆蔻逐个包裹,或如水泛丸包裹面粉3~4层,投入热的滑石粉中翻动,至面皮呈焦黄色时取出,用时剥去面;
g、煨制诃子:用面裹煨法,煨至面皮焦黄为度,剥去面皮,临用时打碎。
h、木瓜汁酒喷制水蛭:水蛭在猪油中炸至焦黄鼓起,趁热喷适量木瓜汁与黄酒,用文火至干燥,加入少量花椒拌匀取出;
j、将当归、细辛、生晒参、伸筋草、威灵仙、白芍、生姜、红花、全蝎、地龙、人参(新开河参)、川芎、丹参、桃花、瓜蒌、大黄、银杏叶、鹿茸、葛根、红景天、宽筋藤、桑枝、蜈蚣、桂枝、桃仁、鸡血藤、甘草、石菖蒲、木香、麝香、珊瑚、珍珠、丁香、沉香、禹粮土和盐、麸制黄芪、酥油制淫羊藿、生地麦麸制僵蚕、制草乌、煨制诃子、木瓜汁酒喷制水蛭、面裹煨肉豆蔻混合,用粉碎机粉碎,过120目筛成为细末;
k、然后将细末用泥罐密封后,埋于地下1米处,两年后取出。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410693397.7A CN104383495A (zh) | 2014-11-15 | 2014-11-15 | 一种治疗化疗所致神经损伤的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410693397.7A CN104383495A (zh) | 2014-11-15 | 2014-11-15 | 一种治疗化疗所致神经损伤的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104383495A true CN104383495A (zh) | 2015-03-04 |
Family
ID=52601519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410693397.7A Pending CN104383495A (zh) | 2014-11-15 | 2014-11-15 | 一种治疗化疗所致神经损伤的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104383495A (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107308498A (zh) * | 2017-06-23 | 2017-11-03 | 武汉康华世纪药业有限公司 | 一种复合纳米纤维神经支架的制备方法 |
CN108815194A (zh) * | 2018-09-11 | 2018-11-16 | 四川聚元药业集团有限公司 | 一种麸炒僵蚕的炒制方法 |
CN108853365A (zh) * | 2018-09-17 | 2018-11-23 | 蔺莉 | 一种防治长春新碱所致周围神经毒性的药物 |
CN112691143A (zh) * | 2021-02-07 | 2021-04-23 | 新乡医学院第一附属医院 | 一种用于防治化疗导致周围神经损伤的外用中药熏洗剂及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090036676A (ko) * | 2007-10-10 | 2009-04-15 | 강옥화 | 독활로부터 분리된 추출물을 이용한 만성 염증 질환 치료제 |
CN102973799A (zh) * | 2012-12-31 | 2013-03-20 | 林艳霞 | 一种用于麻醉术后神经损伤的药丸 |
CN103961555A (zh) * | 2014-06-02 | 2014-08-06 | 刘惠平 | 一种治疗周围神经损伤的中药制剂及制备方法 |
-
2014
- 2014-11-15 CN CN201410693397.7A patent/CN104383495A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090036676A (ko) * | 2007-10-10 | 2009-04-15 | 강옥화 | 독활로부터 분리된 추출물을 이용한 만성 염증 질환 치료제 |
CN102973799A (zh) * | 2012-12-31 | 2013-03-20 | 林艳霞 | 一种用于麻醉术后神经损伤的药丸 |
CN103961555A (zh) * | 2014-06-02 | 2014-08-06 | 刘惠平 | 一种治疗周围神经损伤的中药制剂及制备方法 |
Non-Patent Citations (4)
Title |
---|
傅宏义: "《常用药物分册》", 31 December 2005, 中国医药科技出版社 * |
张红杰等: "自拟通络活血方治疗尺神经损伤8例", 《国医论坛》 * |
朱家恺等: "《现代周围神经外科学》", 31 October 2007, 上海科学技术出版社 * |
詹红生等: "《中医筋伤学》", 31 August 2012, 上海科学技术出版社 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107308498A (zh) * | 2017-06-23 | 2017-11-03 | 武汉康华世纪药业有限公司 | 一种复合纳米纤维神经支架的制备方法 |
CN108815194A (zh) * | 2018-09-11 | 2018-11-16 | 四川聚元药业集团有限公司 | 一种麸炒僵蚕的炒制方法 |
CN108853365A (zh) * | 2018-09-17 | 2018-11-23 | 蔺莉 | 一种防治长春新碱所致周围神经毒性的药物 |
CN108853365B (zh) * | 2018-09-17 | 2021-05-04 | 蔺莉 | 一种防治长春新碱所致周围神经毒性的药物 |
CN112691143A (zh) * | 2021-02-07 | 2021-04-23 | 新乡医学院第一附属医院 | 一种用于防治化疗导致周围神经损伤的外用中药熏洗剂及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104383495A (zh) | 一种治疗化疗所致神经损伤的药物及其制备方法 | |
CN104225508A (zh) | 一种治疗颈椎病的中药组合物及其制备方法 | |
CN104043087A (zh) | 一种治疗雷诺氏综合症的中药组合物 | |
CN104225166A (zh) | 一种治疗闭经的中药组合物及其制备方法 | |
CN100420480C (zh) | 乳腺增生、乳腺良性肿瘤、乳腺导管扩张症防治丸 | |
CN105688063A (zh) | 化癌消瘤外用膏 | |
CN104971331A (zh) | 一种内服外用的乳腺增生的中药组合物及制备方法 | |
CN102973758A (zh) | 一种治疗抑郁症的中药组合物 | |
CN104840577A (zh) | 一种治疗产后遍身疼痛的中药 | |
CN105012833A (zh) | 一种多发性神经病的中药 | |
CN102204978B (zh) | 一种治疗癌性疼痛的药物组合物及其制剂 | |
CN104127567A (zh) | 一种治疗糖尿病周围神经病变的中药组合物 | |
CN103977256A (zh) | 一种治疗癌症的药物组合物 | |
CN103191229B (zh) | 一种治疗膝关节肿胀中药 | |
CN106236847A (zh) | 一种治疗颈椎病的中药组合物及其制备方法和使用方法 | |
CN104398975A (zh) | 一种治疗乳腺纤维瘤的中药制剂及其制备方法 | |
CN101721479A (zh) | 治疗风湿痛的中草药制剂 | |
CN104474524A (zh) | 一种治疗病毒性心肌炎的中药组合物 | |
CN104027764A (zh) | 治疗风湿骨病的药物 | |
CN104027430A (zh) | 一种治疗血瘀型子宫肌瘤的中药组合物 | |
CN104547512B (zh) | 一种治疗咽部疾病的药物组合物及其制备方法 | |
CN104547474B (zh) | 一种中药制剂在制备治疗肝癌药物中的用途 | |
CN103055172A (zh) | 一种治疗白癜风的中药组合 | |
CN103623355B (zh) | 一种治疗滑动性斜疝的中药制剂 | |
CN104042730A (zh) | 治疗慢性肝炎的中药制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150304 |