CN108042704A - 一种保肾的宣木瓜茶 - Google Patents

一种保肾的宣木瓜茶 Download PDF

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CN108042704A
CN108042704A CN201711412692.0A CN201711412692A CN108042704A CN 108042704 A CN108042704 A CN 108042704A CN 201711412692 A CN201711412692 A CN 201711412692A CN 108042704 A CN108042704 A CN 108042704A
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陈家胜
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XUANCHENG HUAKE XUANMUGUA BIOTECHNOLOGY CO., LTD.
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Abstract

本发明属于保健品领域，具体提供了一种保肾的宣木瓜茶，由下列重量份的原料制备而成：宣木瓜20‑35份、桔梗20‑30份、菊花10‑20份、苦丁茶5‑15份、牛蒡根10‑30份、蒲公英10‑20份、余甘子10‑15份、黄芥子10‑35份、黄精10‑15份，能治疗肾纤维化，具有保肾作用。

Description

一种保肾的宣木瓜茶
技术领域
本发明属于保健品领域，具体涉及一种保肾的宣木瓜茶。
背景技术
肾脏纤维化是一种病理生理改变，是肾脏的功能由健康到损伤，再到损坏，直至功能丧失的渐进过程。肾脏由于受到创伤、感染、炎症、血循环障碍，以及免疫反应等多种致病因素刺激，其固有细胞受损，发展到后期出现大量胶原沉积和积聚，造成肾实质逐渐硬化，形成瘢痕，直至肾脏完全丧失脏器功能。肾脏内固有细胞纤维化、硬化的过程也就是肾脏纤维化的过程。肾脏纤维化是以细胞外基质(ECM)的异常沉积为特征的。
发明内容
本发明的目的在于提供了一种治疗肾脏纤维化，具有保肾的宣木瓜茶。
技术方案：一种保肾的宣木瓜茶，由下列重量份的原料制备而成：宣木瓜20-35份、桔梗20-30份、菊花10-20份、苦丁茶5-15份、牛蒡根10-30份、蒲公英10-20份、余甘子10-15份、黄芥子10-35份、黄精10-15份。
所述保肾的宣木瓜茶，由下列重量份的原料制备而成：宣木瓜28份、桔梗25份、菊花15份、苦丁茶10份、牛蒡根20份、蒲公英15份、余甘子12份、黄芥子25份、黄精12份。
所述保肾的宣木瓜茶，制备方法为：取宣木瓜、桔梗、菊花、苦丁茶、牛蒡根、蒲公英、余甘子、黄芥子、黄精粉碎，过20目筛，即得宣木瓜茶。
所述保肾的宣木瓜茶在制备保肾保健品中的应用。
宣木瓜含有十九种氨基酸、十八种矿物微量元素，以及大量维生素C，同时还含有皂甙、黄酮、苹果酸、齐墩果酸、枸橼酸、柠檬酸、酒石酸、抗坏血酸、反丁烯二酸、鞣质等，含有过氧化氢酶、酚氧化酶、氧化酶，特别富含超氧化物岐化酶(SOD)和齐墩果酸。其SOD的含量是世界上所有水果中无与伦比的，一克宣木瓜鲜果SOD的含量高达3227国际单位。SOD是现代美容养颜产品的核心物质，可以有效消除体内过剩自由基，增进肌体细胞更新。齐墩果酸具有广谱抗菌作用，具有护肝降酶、促免疫、抗炎、降血脂血糖等作用。功能:平肝舒筋，和胃化湿。主治:用于湿痹拘挛，腰膝关节酸重疼痛，吐泻转筋，脚气水肿。小茴香用于寒疝腹痛，睾丸偏坠，痛经，少腹冷痛，脘腹胀痛，食少吐泻。盐小茴香用于寒疝腹痛，睾丸偏坠，经寒腹痛。本发明经试验证明能治疗肾纤维化，具有保肾作用。
具体实施方式
以下通过实施例对本发明作进一步详细的说明，但本发明的保护范围不受具体实施例的任何限制，而是由权利要求加以限定。
实施例1：取宣木瓜20份、桔梗30份、菊花10份、苦丁茶15份、牛蒡根10份、蒲公英20份、余甘子10份、黄芥子35份、黄精10份粉碎，过20目筛，即得宣木瓜茶。
实施例2：取宣木瓜35份、桔梗20份、菊花20份、苦丁茶5份、牛蒡根30份、蒲公英10份、余甘子15份、黄芥子10份、黄精15份粉碎，过20目筛，即得宣木瓜茶。
实施例3：取宣木瓜28份、桔梗25份、菊花15份、苦丁茶10份、牛蒡根20份、蒲公英15份、余甘子12份、黄芥子25份、黄精12份粉碎，过20目筛，即得宣木瓜茶。
实施例4：本发明对单侧输尿管结扎大鼠肾间质纤维化的影响
1.1材料：贝那普利，北京诺华制药有限公司生产；羟脯氨酸(HYP)试剂盒，南京建成生物公司；纤维连结蛋白(FN)试剂盒购自上海生物制品所。取上述实施例1中的制备得到的宣木瓜茶进行试验。实验动物：普通级Wistar大鼠，雄性，体重150-200g，南京医科大学实验动物中心。
1.2试验方法与结果：大鼠60只，随机分6组，即假手术组、模型组、贝那普利灌胃10mg/kg组、本发明灌胃5g/kg组、本发明灌胃10g/kg组、本发明灌胃50g/kg组，动物喂养1周，各大鼠以10％水合氯醛3.0mL/kg腹腔注射麻醉后，将大鼠右侧卧位固定与手术台上，剪毛后用碘酒、75％酒精消毒手术区，行左侧腹切口，逐层切开皮肤、肌肉及腹壁各层，暴露并分离左侧输尿管，假手术组仅切开腹腔并游离左侧输尿管，但不结扎和剪断，其他各组大鼠用4-0丝线结扎两道，上一道结扎点位于左肾下极水平，然后在两道结扎点剪断输尿管，逐层缝合，术后10天10％水合氯醛麻醉后处死各组动物，取血，按纤维连结蛋白测定说明测定说明纤维联接蛋白(FN)。生理盐水反复灌洗后留取左侧肾脏，肾组织经4％的多聚甲醛缓冲液固定。切取适量肾组织，按羟脯氨酸试剂盒测定说明测定羟脯氨酸。
常规病理学检查①肉眼观察：假手术组肾脏颜色鲜红，表明光滑，包膜光泽，无粘连。其他各组肾脏体积增大，颜色苍白，表明呈颗粒状，类似人体大白肾，少数区域肾包膜粘连。②光镜检查：假手术组肾单位结果清晰，肾小球囊无扩张或炎细胞浸润。模型对照组大片肾小管坏死，肾间质纤维细胞增生，肾小管扩张，内有大量棕黄色遮光物质或坏死脱落的上皮细胞，肾小球数目减少，部分肾小球纤维化并与包曼氏囊壁粘连，囊腔消失。给药各组病变与模型对照组类似，但均有不同程度的形态学改善，尤以香兰素灌胃大剂量各组显著，与模型对照组比较有明显差异。
表1本发明对单侧输尿管结扎大鼠肾间质纤维化的影响
*p<0.05，**p<0.01，与模型组相比较
对各组FN、HYP进行T检验。结果见表，本发明灌胃10g/kg组、香兰素灌胃50g/kg组降低FN、HYPP水平(与模型对照组比较，P<0.05或0.01)。
结论：本发明能够显著降低肾间质纤维化FN、HYPP水平的升高，抑制肾间质纤维化，具有保肾作用。

Claims (4)

1.一种保肾的宣木瓜茶，其特征在于，由下列重量份的原料制备而成：宣木瓜20-35份、桔梗20-30份、菊花10-20份、苦丁茶5-15份、牛蒡根10-30份、蒲公英10-20份、余甘子10-15份、黄芥子10-35份、黄精10-15份。
2.如权利要求1所述保肾的宣木瓜茶，其特征在于，由下列重量份的原料制备而成：宣木瓜28份、桔梗25份、菊花15份、苦丁茶10份、牛蒡根20份、蒲公英15份、余甘子12份、黄芥子25份、黄精12份。
3.如权利要求1所述保肾的宣木瓜茶，其特征在于，制备方法为：取宣木瓜、桔梗、菊花、苦丁茶、牛蒡根、蒲公英、余甘子、黄芥子、黄精粉碎，过20目筛，即得宣木瓜茶。
4.如权利要求1所述保肾的宣木瓜茶在制备保肾保健品中的应用。
CN201711412692.0A 2017-12-24 2017-12-24 一种保肾的宣木瓜茶 Withdrawn CN108042704A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463714A (zh) * 2002-06-04 2003-12-31 刘日成 主治***的中药配方
CN104606440A (zh) * 2015-02-16 2015-05-13 成都利旧新生健康咨询有限公司 治疗***的中药
CN105267745A (zh) * 2015-10-29 2016-01-27 张相才 一种医治***的中药组合物及制法
CN107029132A (zh) * 2017-04-05 2017-08-11 黄凤玲 治疗***的药物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463714A (zh) * 2002-06-04 2003-12-31 刘日成 主治***的中药配方
CN104606440A (zh) * 2015-02-16 2015-05-13 成都利旧新生健康咨询有限公司 治疗***的中药
CN105267745A (zh) * 2015-10-29 2016-01-27 张相才 一种医治***的中药组合物及制法
CN107029132A (zh) * 2017-04-05 2017-08-11 黄凤玲 治疗***的药物

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