CN108031975B - Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping - Google Patents
Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping Download PDFInfo
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- CN108031975B CN108031975B CN201711003709.7A CN201711003709A CN108031975B CN 108031975 B CN108031975 B CN 108031975B CN 201711003709 A CN201711003709 A CN 201711003709A CN 108031975 B CN108031975 B CN 108031975B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
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Abstract
The invention discloses a continuous multilayer droplet-wrapped laser-induced implantation preparation method, which comprises the following steps: s1: preparing various media; s2: the method comprises the following steps that a pulse laser beam (1) is vertically incident from a glass substrate (3), the laser beam (1) penetrates through the glass substrate (3) and is focused on one surface of a first dielectric layer (4), when the energy of the laser beam (1) is larger than the breakdown threshold value of the first dielectric layer (4), high-temperature and high-pressure plasma (2) is generated, and the plasma (2) externally radiates shock waves; s3: the plasma (2) radiates shock waves outwards to push the first dielectric layer (4) to form molten liquid drops (5), and the molten liquid drops (5) are embedded into the second dielectric layer (6) and the third dielectric layer (7) below to form a plurality of layers of liquid drop embedding bodies (8). According to the invention, two or more layers of liquid drops which are uniform and controllable in size and can be accurately controlled for a single liquid drop are wrapped by a laser-induced forward transfer technology.
Description
Technical Field
The invention relates to a laser-induced implantation preparation method, in particular to a laser-induced implantation preparation method with continuous multilayer liquid drop wrapping.
Background
The micro-volume droplet packing technology has great application significance in the fields of biomedical detection, molecular biology, chemical chemistry, food science, cosmetic application, engineering application and the like. The liquid drops with micro-volume can be used as a micro-reactor for chemical reaction, medical drug package transportation and release, packaged single cell for biological detection and analysis, digital PCR (polymerase chain reaction) based on liquid drops, tissue engineering, diagnostic imaging and other engineering applications [1 ]. At present, the micro-fluidic chip generates liquid drops which are a main liquid drop generating mode, the liquid drops are used as a new fluid motion mode appearing on the micro-fluidic chip in recent years, and each liquid drop can be regarded as an independent micro-reactor to research micro-size reaction and a micro-size process. The method is applied to the application fields, and can control the chemical reagents, cells, proteins and other macromolecules, microparticles and other substances on the basis of liquid drops, more accurately control the experimental conditions of each reaction, more flexibly control the actual dosage of each component participating in the reaction, and shorten the reaction time.
The specific liquid drop generation principle is as follows: in the micro-fluidic chip, two mutually insoluble liquids are used for generating liquid drops, one of the liquids is used as a continuous phase,the other liquid is used as a dispersed phase, and the continuous phase can shear the dispersed phase into uniform micro volume units to be dispersed in the continuous phase by virtue of the channel structure of the chip and external force operation, so that liquid drops are formed. The generated liquid drops have uniform size, stable property and uniform composition by controlling the flow velocity of two phases on the microfluidic chip. The droplet generation method is mainly a multiphase flow method, the speed change gradient of the disperse phase fluid is generated at the local part of a channel through the design of a fluid channel structure, and droplets are generated by utilizing the interaction of shearing force, viscous force and surface tension between two phases. The multiphase flow method can generate liquid drops in batches, is easy to integrally control the liquid drops in batches, and has the defect of accurately regulating and controlling the shell thickness or the internal cavity structure, components and the like of a single liquid drop[2]. According to the geometrical structure difference of the PDMS-based microfluidic device and the flow direction difference of the liquid phase fluid, the generation of micro-droplets can be divided into the following 5 basic forms: (1) a two-dimensional extruded structure; (2) a T-shaped microchannel; (3) a flow focusing microchannel; (4) a confocal micro-channel; (5) y-shaped microchannels (as shown in FIGS. 3 a-h). The microfluidic device built by the capillary glass tube can be divided into a single-emulsion drop structure and a multiple-emulsion drop structure according to the diversity of nested structures (as shown in figures 3 i-k)[3]。
When multiple layer wrapping of droplets is desired, the droplet formation is cascaded to achieve multiple layer droplet wrapping, as shown in fig. 4.
The prior art has the following disadvantages: the existing micro-fluidic chip controls the size of liquid drops by controlling the speed of a dispersed phase, the uniformity of the liquid drops is low, and the liquid drops need to be sorted; the shell thickness or the internal cavity structure, the components and the like of a single liquid drop are difficult to be accurately regulated and controlled; one microfluidic chip corresponds to only one size of droplet.
Disclosure of Invention
The invention aims to provide a laser-induced implantation preparation method for continuous multilayer droplet wrapping, which is used for obtaining two-layer or multilayer droplet wrapping with uniform and controllable size, controllable wrapping layer number and thickness and optional wrapping substances capable of accurately controlling a single droplet by a laser-induced forward transfer technology.
The technical scheme adopted by the invention is as follows: a preparation method of continuous multilayer droplet-wrapped laser-induced implantation comprises the following steps:
s1: preparation of various media: specifically, a first medium layer (4) is coated on a glass substrate, a containing device is arranged below the first medium layer (4), and a second medium layer (6), a third medium layer (7) and a fourth medium layer (10) are sequentially arranged on the containing device from top to bottom;
s2: the method comprises the following steps that a pulse laser beam (1) is vertically incident from a glass substrate (3), the laser beam (1) penetrates through the glass substrate (3) and is focused on one surface of a first dielectric layer (4), when the energy of the laser beam (1) is larger than the breakdown threshold value of the first dielectric layer (4), high-temperature and high-pressure plasma (2) is generated, and the plasma (2) externally radiates shock waves;
s3: the plasma (2) radiates shock waves outwards to push the first dielectric layer (4) to form molten liquid drops (5), and the molten liquid drops (5) are embedded into the second dielectric layer (6) and the third dielectric layer (7) below to form a plurality of layers of liquid drop embedding bodies (8); the formed multilayer liquid drop embedding (8) is further forwards sprayed into a fourth medium layer (10), a multilayer liquid drop package (9) is formed due to the action of the viscous force and the surface tension of the fourth medium layer (10), the driving force of the multilayer liquid drop package (9) is reduced under the resistance of the fourth medium layer (10), and complete liquid drops are finally formed;
s4: driving the glass substrate (3) to move according to a preset direction, and repeating the steps S2 and S3; the preparation of the multilayer droplets is completed.
Preferably, the first medium layer (4) is a liquid, a suspension containing fine powder, or a solid film.
Preferably, the second medium layer (6), the third medium layer (7) and the fourth medium layer (10) are liquids with different densities.
Preferably, in step S4, the driving the glass substrate (3) to move in the preset direction includes: and driving the glass substrate (3) to move along the circumferential direction by taking a preset straight line parallel to the direction of the laser beam (1) as a central axis.
Preferably, the density of the second dielectric layer (6) is less than that of the third dielectric layer (7), and the density of the third dielectric layer (7) is less than that of the fourth dielectric layer (10).
Preferably, the laser beam (1) is fixed above the glass substrate (3).
Compared with the prior art, the invention has the beneficial effects that: (1) the laser beam (1) induces to generate plasma (2) to push a first medium layer (4) coated on a glass substrate to penetrate through layer liquid in a containing device to generate multilayer liquid drop packages, and the multilayer liquid drop packages which are different in size, number of layers and package thickness and can accurately control single liquid drop are obtained by adjusting and changing laser energy, focal spot diameter and the number of layers, thickness and material of sample preparation; (2) the method can continuously generate multilayer liquid drop packages; the liquid drop package with multiple thicknesses and sizes can be realized by adjusting laser parameters and sample preparation; (3) the size of the liquid drops generated by the method is uniform; (4) the method can accurately control a single liquid drop, avoids the difficulty of liquid spin coating, and simplifies the process of multilayer liquid preparation spin coating; (5) the method is not limited to the wrapping of liquid and liquid, can realize the wrapping of the liquid and the solid by replacing the liquid on the glass substrate with the solid target, and has the advantages of high flux, high generation efficiency, low generation cost and the like.
Drawings
FIG. 1 is a schematic diagram of a method for preparing a continuous multilayer droplet encapsulated laser-induced implant according to the present invention.
FIG. 2 is a schematic diagram of the preparation of the present invention for automatically generating a multilayer liquid.
Fig. 3 is a schematic diagram of a droplet generator in the prior art.
Figure 4 is a schematic diagram of the serial formation of multiple layer droplet packs formed by droplets.
Detailed Description
The technical scheme of the invention is further explained by combining specific examples.
As shown in fig. 1-2, a method for preparing a continuous multilayer droplet-encapsulated laser-induced implant includes the following steps:
s1: preparation of various media: specifically, a first medium layer (4) is coated on a glass substrate, a containing device is arranged below the first medium layer (4), and a second medium layer (6), a third medium layer (7) and a fourth medium layer (10) are sequentially arranged on the containing device from top to bottom;
s2: the method comprises the following steps that a pulse laser beam (1) is vertically incident from a glass substrate (3), the laser beam (1) penetrates through the glass substrate (3) and is focused on one surface of a first dielectric layer (4), when the energy of the laser beam (1) is larger than the breakdown threshold value of the first dielectric layer (4), high-temperature and high-pressure plasma (2) is generated, and the plasma (2) externally radiates shock waves;
s3: the plasma (2) radiates shock waves outwards to push the first dielectric layer (4) to form molten liquid drops (5), and the molten liquid drops (5) are embedded into the second dielectric layer (6) and the third dielectric layer (7) below to form a plurality of layers of liquid drop embedding bodies (8); the formed multilayer liquid drop embedding (8) is further forwards sprayed into a fourth medium layer (10), a multilayer liquid drop package (9) is formed due to the action of the viscous force and the surface tension of the fourth medium layer (10), the driving force of the multilayer liquid drop package (9) is reduced under the resistance of the fourth medium layer (10), and complete liquid drops are finally formed;
s4: driving the glass substrate (3) to move according to a preset direction, and repeating the steps S2 and S3; the preparation of the multilayer droplets is completed.
In the specific technical scheme of the invention, the first medium layer (4) is a liquid, a suspension containing fine powder or a solid film; the second medium layer (6), the third medium layer (7) and the fourth medium layer (10) are liquids with different densities; the density of the second dielectric layer (6) is smaller than that of the third dielectric layer (7), and the density of the third dielectric layer (7) is smaller than that of the fourth dielectric layer (10). The types and the number of the first dielectric layers (4) can be selected according to actual needs, and are usually at least two; the second medium layer (6), the third medium layer (7) and the fourth medium layer (10) are liquid, and uniform layering is generated in the containing device by utilizing physical action or chemical action between the liquid and the liquid.
Further, in step S4, the driving the glass substrate (3) to move in the preset direction specifically includes: the glass substrate (3) is driven to move in the circumferential direction by taking a preset straight line parallel to the direction of the laser beam (1) as a central axis, and the laser beam (1) is fixed above the glass substrate (3).
The method is characterized in that a pulse laser beam (1) is vertically incident from a glass substrate (3), the laser (1) penetrates through the glass substrate (3) and is focused on one surface coated with a first dielectric layer (4), when the laser energy is greater than the breakdown threshold of the first dielectric layer (4), high-temperature and high-pressure plasma (2) is generated, and the plasma (2) externally radiates shock waves; the instantaneous high energy of the laser beam (1) pushes the first medium layer (4) to form molten liquid drops (5) to be embedded into the second medium layer (6) and the third medium layer (7) below, and a plurality of layers of liquid drop embedding bodies (8) are formed; the formed multilayer drop embedding (8) is further sprayed forwards into a fourth medium layer (10) to form a multilayer drop package (9) due to the action of liquid viscosity and surface tension.
Preparation principle for automatically generating multilayer liquid: as shown in figure 2, in order to avoid the difficulty in preparing the liquid target, the second medium layer (6) and the third medium layer (7) are uniformly generated in the container by utilizing the physical action or the chemical action between the liquid and the liquid, and when the molten liquid drop (5) passes through the second medium layer (6) and the third medium layer (7), the uniform laminar liquid can be automatically formed due to the liquidity of the liquid, so that the preparation of automatically generating the multilayer uniform laminar liquid can be realized by circulation, and the process of preparing the multilayer liquid coating is simplified.
Continuous multilayer droplet wrapping implementation: as shown in fig. 2, a pulse laser beam (1) is fixed, the glass substrate (3) coated with the first dielectric layer (4) is rotated in a manner that the glass substrate (3) is used as a turntable and the rotating direction (a) rotates periodically, and steps S2-S4 are performed, so that the laser beam acts on different positions of the first dielectric layer (4) to form molten droplets (5) embedded into the second dielectric layer (6), the third dielectric layer (7) and the fourth dielectric layer (10), thereby realizing the wrapping for continuously preparing multilayer droplets and improving the preparation efficiency of multilayer droplet wrapping.
Various other changes and modifications to the above-described embodiments and concepts will become apparent to those skilled in the art from the above description, and all such changes and modifications are intended to be included within the scope of the present invention as defined in the appended claims.
Claims (6)
1. A continuous multilayer liquid drop wrapped laser-induced implantation preparation method is characterized by comprising the following steps: the method comprises the following steps:
s1: preparation of various media: specifically, a first medium layer (4) is coated on a glass substrate, a containing device is arranged below the first medium layer (4), and a second medium layer (6), a third medium layer (7) and a fourth medium layer (10) are sequentially arranged on the containing device from top to bottom;
s2: the method comprises the following steps that a pulse laser beam (1) is vertically incident from a glass substrate (3), the laser beam (1) penetrates through the glass substrate (3) and is focused on one surface of a first dielectric layer (4), when the energy of the laser beam (1) is larger than the breakdown threshold value of the first dielectric layer (4), high-temperature and high-pressure plasma (2) is generated, and the plasma (2) externally radiates shock waves;
s3: the plasma (2) radiates shock waves outwards to push the first dielectric layer (4) to form molten liquid drops (5), and the molten liquid drops (5) are embedded into the second dielectric layer (6) and the third dielectric layer (7) below to form a plurality of layers of liquid drop embedding bodies (8); the formed multilayer liquid drop embedding (8) is further forwards sprayed into a fourth medium layer (10), a multilayer liquid drop package (9) is formed due to the action of the viscous force and the surface tension of the fourth medium layer (10), the driving force of the multilayer liquid drop package (9) is reduced under the resistance of the fourth medium layer (10), and finally, complete liquid drops are formed.
2. The method for preparing continuous multilayer droplet-encapsulated laser-induced implantation according to claim 1, wherein: further comprising S4: driving the glass substrate (3) to move according to a preset direction, and repeating the steps S2 and S3; the preparation of the multilayer droplets is completed.
3. The method for preparing continuous multilayer droplet-encapsulated laser-induced implantation according to claim 1, wherein: the second medium layer (6), the third medium layer (7) and the fourth medium layer (10) are liquids with different densities.
4. The method for preparing continuous multilayer droplet-encapsulated laser-induced implantation according to claim 2, wherein: step S4, driving the glass substrate (3) to move in a predetermined direction, specifically: and driving the glass substrate (3) to move along the circumferential direction by taking a preset straight line parallel to the direction of the laser beam (1) as a central axis.
5. The method for preparing continuous multilayer droplet-encapsulated laser-induced implantation according to claim 1, wherein: the density of the second dielectric layer (6) is smaller than that of the third dielectric layer (7), and the density of the third dielectric layer (7) is smaller than that of the fourth dielectric layer (10).
6. The method for preparing continuous multilayer droplet-encapsulated laser-induced implantation according to claim 1, wherein: the laser beam (1) is fixed above the glass substrate (3).
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