CN108014264A - It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof - Google Patents

It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof Download PDF

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CN108014264A
CN108014264A CN201711474206.8A CN201711474206A CN108014264A CN 108014264 A CN108014264 A CN 108014264A CN 201711474206 A CN201711474206 A CN 201711474206A CN 108014264 A CN108014264 A CN 108014264A
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silicosis
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缪荣明
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The present invention provides a kind of oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals includes：Cordyceps sinensis, the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, campanulaceae, bulb of thunberg fritillary, the root bark of tree peony, radix glycyrrhizae, the tuber of pinellia, dried orange peel, Poria cocos.For the Chinese medicine preparation of the present invention for silicosis, carrying out treatment especially for I phase of silicosis has good effect.The Chinese medicine preparation of the present invention, the cause of disease and pathogenesis for silicosis carry out verification medication, has effects that good supplementing qi and nourishing yin, promoting blood circulation and removing blood stasis, relieving cough and reducing sputum, can mitigate clinical symptoms, delay aggravation to be in progress.

Description

It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to it is a kind of be used for treat silicosis oral traditional Chinese medicine preparation and its Preparation method.
Background technology
Silicosis be suck silica dust caused by the systemic disease based on pulmonary interstitial fibrosis, body caused by it Body endangers and economic loss depends on 3 factors by extensive concern, the order of severity of silicosis：Dust concentration, powder in air The content of free silicon dioxide and time of contact in dirt, in addition, safeguard procedures and individual factors such as personal habits (smoking), upper, Lower respiratory illness etc. has certain influence in silicosis occurrence and development.Silicosis and its complication are how prevented, improves silicosis and suffers from Person's quality of life, it is the major issue for being badly in need of solving to reduce occupational disease hazards.
The content of the invention
The object of the present invention is to provide a kind of oral traditional Chinese medicine preparation for being used to treat silicosis and preparation method thereof, particularly pin I phase of silicosis is treated.
A kind of oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals include in parts by weight：1-4 parts of cordyceps sinensis, 8-14 parts of the dried rhizome of rehmannia, 8-12 parts of radix scrophulariae, ophiopogon 8-12 part, 10-30 parts of campanulaceae, 7-13 parts of bulb of thunberg fritillary, 9-15 parts of the root bark of tree peony, radix glycyrrhizae 5-7 Part, 4-8 parts of the tuber of pinellia, 5-7 parts of dried orange peel, 10-15 parts of Poria cocos.
Further, the oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals include in parts by weight：The worm summer in winter 2 parts of grass, 12 parts of the dried rhizome of rehmannia, 10 parts of radix scrophulariae, 10 parts of ophiopogon, 20 parts of campanulaceae, 10 parts of bulb of thunberg fritillary, 12 parts of the root bark of tree peony, 6 parts of radix glycyrrhizae, 6 parts of the tuber of pinellia, 6 parts of dried orange peel, 12 parts of Poria cocos.
Further, the oral traditional Chinese medicine preparation is that above-mentioned raw materials medicine addition pharmaceutic adjuvant is made tablet, granule, glue Wafer or oral liquid.
Further, the oral traditional Chinese medicine preparation is granule.
Heretofore described " part " can be any mass units such as gram, kilogram, and equal proportion zooms in or out at this Within the protection domain of invention.
The preparation method of the above-mentioned oral traditional Chinese medicine preparation for being used to treat silicosis, comprises the following steps：
Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, Add in the ethanol solution of 8-10 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain medicine leaching Cream, crushes after vacuum drying, obtains mixed-powder；
Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, adds pharmaceutic adjuvant, mouth is made Take traditional Chinese medicine preparation.
Further, the concentration of ethanol solution is 70-80% in step 2.
The preparation method of the above-mentioned oral traditional Chinese medicine preparation for being used to treat silicosis, comprises the following steps：
Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, Add in the ethanol solution of 8-10 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain medicine leaching Cream, crushes after vacuum drying, obtains mixed-powder；
Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, the dextrin of 3-5 times of weight of addition, The stevioside of 0.05-0.1 times of weight, granulation, dry, whole grain, is made Chinese herbal granules.
Cordyceps sinensis has the function that expansion bronchus, relievings asthma, eliminating the phlegm, prevents pulmonary emphysema；Ophiopogon supports the moon of lung stomach, heat symptoms caused by an exopathgen Promote the production of body fluid, resolving sputum preventing or arresting vomiting；The effect of fritillaria thunbergii clearing heat and eliminating phlegm, powder detoxifcation, its sharp phlegm that detoxifies, open the inhibited lung-energy, is notable；Dried rhizome of rehmannia yin-nourishing Heat-clearing, is apt to the moon of filling liver kidney, lung kidney is mutual generation between metal and water, and the moon of kidney tonifying can support the moon of lung；Poria cocos strengthening the spleen and replenishing qi, dampness removing help fortune, tool There is the effect of strengthening the spleen and replenishing qi, reinforcing earth to generate metal；Radix glycyrrhizae is clearing heat and detoxicating, invigorates the spleen and benefits qi, while can be with coordinating the drug actions of a prescription.
The Chinese medicine preparation of the present invention, verifies medication for this sick etiology and pathogenesis, has good supplementing qi and nourishing yin, promoting blood circulationization The stasis of blood, relieving cough and reducing sputum effect, can mitigate clinical symptoms, delay disease progression.
Embodiment
Technical scheme is described further with reference to specific embodiment.
Embodiment 1
A kind of oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals include in parts by weight：1 part of cordyceps sinensis, it is raw 8 parts of ground, 8 parts of radix scrophulariae, 8 parts of ophiopogon, 10 parts of campanulaceae, 7 parts of bulb of thunberg fritillary, 9 parts of the root bark of tree peony, 5 parts of radix glycyrrhizae, 4 parts of the tuber of pinellia, 5 parts of dried orange peel, Poria cocos 10 Part.
The preparation method of the above-mentioned oral traditional Chinese medicine preparation for being used to treat silicosis, comprises the following steps：
Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, Add in 80% ethanol solution of 8 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain medicine leaching Cream, crushes after vacuum drying, obtains mixed-powder；
Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, the dextrin of 3-5 times of weight of addition, The stevioside of 0.05-0.1 times of weight, granulation, dry, whole grain, is made Chinese herbal granules.
Embodiment 2
A kind of oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals include in parts by weight：3 parts of cordyceps sinensis, it is raw 10 parts of ground, 9 parts of radix scrophulariae, 11 parts of ophiopogon, 15 parts of campanulaceae, 8 parts of bulb of thunberg fritillary, 12 parts of the root bark of tree peony, 5 parts of radix glycyrrhizae, 7 parts of the tuber of pinellia, 7 parts of dried orange peel, Fu 14 parts of Siberian cocklebur.
The preparation method of the above-mentioned oral traditional Chinese medicine preparation for being used to treat silicosis, comprises the following steps：
Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, Add in 80% ethanol solution of 8 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain medicine leaching Cream, crushes after vacuum drying, obtains mixed-powder；
Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, the dextrin of 3-5 times of weight of addition, The stevioside of 0.05-0.1 times of weight, granulation, dry, whole grain, is made Chinese herbal granules.
Embodiment 3
A kind of oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals include in parts by weight：2 parts of cordyceps sinensis, it is raw 12 parts of ground, 10 parts of radix scrophulariae, 10 parts of ophiopogon, 20 parts of campanulaceae, 10 parts of bulb of thunberg fritillary, 12 parts of the root bark of tree peony, 6 parts of radix glycyrrhizae, 6 parts of the tuber of pinellia, 6 parts of dried orange peel, 12 parts of Poria cocos.
The preparation method of the above-mentioned oral traditional Chinese medicine preparation for being used to treat silicosis, comprises the following steps：
Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, Add in 80% ethanol solution of 8 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain medicine leaching Cream, crushes after vacuum drying, obtains mixed-powder；
Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, the dextrin of 3-5 times of weight of addition, The stevioside of 0.05-0.1 times of weight, granulation, dry, whole grain, is made Chinese herbal granules.
Embodiment 4
A kind of oral traditional Chinese medicine preparation for being used to treat silicosis, its bulk pharmaceutical chemicals include in parts by weight：4 parts of cordyceps sinensis, it is raw 14 parts of ground, 12 parts of radix scrophulariae, 12 parts of ophiopogon, 30 parts of campanulaceae, 13 parts of bulb of thunberg fritillary, 15 parts of the root bark of tree peony, 7 parts of radix glycyrrhizae, 8 parts of the tuber of pinellia, 7 parts of dried orange peel, 15 parts of Poria cocos.
The preparation method of the above-mentioned oral traditional Chinese medicine preparation for being used to treat silicosis, comprises the following steps：
Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, Add in 80% ethanol solution of 8 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain medicine leaching Cream, crushes after vacuum drying, obtains mixed-powder；
Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, the dextrin of 3-5 times of weight of addition, The stevioside of 0.05-0.1 times of weight, granulation, dry, whole grain, is made Chinese herbal granules.
It is used to treat I phase of silicosis case using Chinese herbal granules made from the embodiment of the present invention, all cases totally 200, It is pneumoconiosis section outpatient, is randomly divided into treatment group and control group, two groups of ratios 1: 1.In treatment group 100, man 86, female 14：It is age 25-60 Sui, 40.52 ± 10.15 years old, course of disease 2-25 average, 21.52 ± 13.17 years average, control group 100 In, man 83, female 17：It is age 25-60 Sui, 39.65 ± 12.34 years old, course of disease 2-27 average, average 22.35 ± 12.63 Year.Not statistically significant (the P of basic data comparing difference such as two groups of genders, age, courses of disease>0.05), it is comparable.
Using rat as subjects, the Chinese herbal granules made from above-described embodiment carry out acute toxicity test and long-term poison Property experiment, without produce toxic reaction.
Treatment group gives the granule of the preparation of the embodiment of the present invention 1,50mg/ times, 2 times/day, takes orally, morning and evening one after each meal, 1 month as a treatment course.
Control group：Pseudoephedrine hydrochloride solution takes orally, 10mL/ times, 3 times/day, and 1 month as a treatment course.
The results show that taking in the patient of Chinese herbal granules of the present invention, cough in the daytime and nocturnal cough disappear or disappear substantially Mistake person is 33 big, do not have clear improvement person up to 32, alleviator up to 32, without change or add severe one be 2, total effective rate For 98%；
In the patient for taking pseudoephedrine hydrochloride solution, cough in the daytime and nocturnal cough disappear or mostly disappear person are 21 big, equal The person of having clear improvement up to 24, alleviator up to 34, without change or add severe one be 21, total effective rate 79%.

Claims (6)

  1. A kind of 1. oral traditional Chinese medicine preparation for being used to treat silicosis, it is characterised in that：Its bulk pharmaceutical chemicals includes in parts by weight：The worm summer in winter 1-4 parts careless, 8-14 parts of the dried rhizome of rehmannia, 8-12 parts of radix scrophulariae, ophiopogon 8-12 part, 10-30 parts of campanulaceae, 7-13 parts of bulb of thunberg fritillary, 9-15 parts of the root bark of tree peony is sweet It is 5-7 parts careless, 4-8 parts of the tuber of pinellia, 5-7 parts of dried orange peel, 10-15 parts of Poria cocos.
  2. 2. the oral traditional Chinese medicine preparation according to claim 1 for being used to treat silicosis, it is characterised in that：Its bulk pharmaceutical chemicals is with weight Part meter includes：2 parts of cordyceps sinensis, 12 parts of the dried rhizome of rehmannia, 10 parts of radix scrophulariae, 10 parts of ophiopogon, 20 parts of campanulaceae, 10 parts of bulb of thunberg fritillary, 12 parts of the root bark of tree peony are sweet 6 parts of grass, 6 parts of the tuber of pinellia, 6 parts of dried orange peel, 12 parts of Poria cocos.
  3. 3. the oral traditional Chinese medicine preparation according to claim 1 for being used to treat silicosis, it is characterised in that：The oral traditional Chinese medicine system Agent is that above-mentioned raw materials medicine addition pharmaceutic adjuvant is made tablet, granule, capsule or oral liquid.
  4. 4. the oral traditional Chinese medicine preparation according to claim 1 for being used to treat silicosis, it is characterised in that：The oral traditional Chinese medicine system Agent is granule.
  5. 5. Claims 1-4 any one of them is used for the preparation method for treating the oral traditional Chinese medicine preparation of silicosis, its feature exists In：Comprise the following steps：
    Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
    Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, add to In the ethanol solution of 8-10 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain drug extract, very Empty crushed after being dried, obtains mixed-powder；
    Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, adds pharmaceutic adjuvant, be made in taking orally Medicine preparation,
    Wherein, the concentration of ethanol solution is 70-80% in step 2.
  6. 6. the preparation method for being used to treat the oral traditional Chinese medicine preparation of silicosis described in claim 5, it is characterised in that：Including following Step：
    Step 1, cordyceps sinensis is taken, 60 mesh sieves is crushed, it is spare to obtain Cordyceps sinensis powder；
    Step 2, by the dried rhizome of rehmannia, radix scrophulariae, ophiopogon, bulb of thunberg fritillary, the tuber of pinellia, dried orange peel, Poria cocos, campanulaceae, the root bark of tree peony, radix glycyrrhizae, mixing, crush, add to In the ethanol solution of 8-10 times of weight, refluxing extraction 3 times, filtering, mixing filtrate obtain filtrate, are concentrated in vacuo to obtain drug extract, very Empty crushed after being dried, obtains mixed-powder；
    Step 3, the mixed-powder of the Cordyceps sinensis powder of step 1 and step 2 is mixed, the dextrin of 3-5 times of weight of addition, The stevioside of 0.05-0.1 times of weight, granulation, dry, whole grain, is made Chinese herbal granules.
CN201711474206.8A 2017-12-29 2017-12-29 It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof Pending CN108014264A (en)

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CN111249388A (en) * 2020-03-26 2020-06-09 王芬 A Chinese medicinal composition for treating chronic cough, and its preparation method

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CN105343498A (en) * 2014-12-26 2016-02-24 杭州美誉医药有限公司 Traditional Chinese medicine preparation for moistening lungs and preparation method and uses thereof
CN105535738A (en) * 2016-01-22 2016-05-04 杨甫进 Traditional Chinese medicine preparation for treating chronic cough and preparing method thereof
CN105998725A (en) * 2016-05-19 2016-10-12 青岛市中心医院 Traditional Chinese medicine preparation for treating silicosis

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CN105343498A (en) * 2014-12-26 2016-02-24 杭州美誉医药有限公司 Traditional Chinese medicine preparation for moistening lungs and preparation method and uses thereof
CN105535738A (en) * 2016-01-22 2016-05-04 杨甫进 Traditional Chinese medicine preparation for treating chronic cough and preparing method thereof
CN105998725A (en) * 2016-05-19 2016-10-12 青岛市中心医院 Traditional Chinese medicine preparation for treating silicosis

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* Cited by examiner, † Cited by third party
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CN111249388A (en) * 2020-03-26 2020-06-09 王芬 A Chinese medicinal composition for treating chronic cough, and its preparation method

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Application publication date: 20180511