CN104524341B - A kind of Qingyan Granules and preparation method thereof - Google Patents
A kind of Qingyan Granules and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
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- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of Qingyan Granules, it is made up of the extract and sweetener of following raw material, the raw material is：The parts by weight of balloonflower root 20~30, the parts by weight of the tuber of dwarf lilyturf 15~25, the parts by weight of radix glehniae 18~26, the parts by weight of radix glycyrrhizae 10~20, the parts by weight of peppermint 5~15, the parts by weight of coix seed 5~15 and the parts by weight of cordate houttuynia 10~20；The sweetener is 0~0.3 parts by weight.Rationally, rich in saponin(e, the bioactive substance such as polysaccharide is shown inventive formulation through results of animal:Rat paw edema can substantially be mitigated；Human test results show：Pharyngeal mucous membrane can substantially be mitigated congested, mucosa edema.Illustrate health-care efficacy of the present invention with clearing and persistent, extensively, reliable in quality, price are economical for raw material sources.
Description
Technical field
The present invention relates to a kind of Qingyan Granules and preparation method thereof, belong to field of health care food.
Background technology
In recent years due to the stimulation of air quality decline, pungent diet and tobacco and wine, the pharyngolaryngitis incidence of disease is set substantially to increase,
As the big factor being detrimental to health.Particularly with often under high-temperature dust, excessive pernicious gas environment operation work
People and cause with the more teacher of throat, shop-assistant, performer and malnutrition, with body illness Abwehrkraft des Koepers decline
, often there is throat problem in people.Pharyngolaryngitis not only influences people to carry out Verbal interaction and sleep when falling ill, especially to being engaged in
Teaching and Energy of Vocal Music person directly affect the development of work.And pathological change caused by the active chronic inflammation swallowed, is not only caused
Local dysfunction is swallowed, can also involve neighbouring organ-tissue, other diseases are induced.
Because the harm of pharyngolaryngitis is very big, throat expert advice to the anti-of pharyngolaryngitis and is controlled, and weight is placed on anti-
Point, it is important that enhancing body defenses ability.Clearing health food had both had the nutrition general character of normal food, again there is anti-inflammatory to press down
Bacterium, the cough-relieving that wets one's whistle, eliminate swell and ache, it is clearing heat and detoxicating, recover the special effects such as vocal cords are tired, available for throat health care, prevent throat
Disease.
Clearing health food is mainly what is refined by the herbal raw material with effects of clearing and nourishing throat.Research shows tool
The Chinese herbal medicine for having effects of clearing and nourishing throat has:Green tea, the sterculia seed, honeysuckle, peppermint, Momordica grosvenori, chrysanthemum, Chinese olive, cordate houttuynia, careless coral
Coral, water melon frost, Rabdosia rubescens, radix glycyrrhizae, Exocarpium Citri Rubrum, mast, balloonflower root etc..But the single effect of these above-mentioned materials is paid no attention to
Think.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of Qingyan Granules, overcome in throat-clearing throat-moistening of the prior art
The single effect of medicinal herbs is limited, it is impossible to give full play to the defect of effect of each material.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of Qingyan Granules, by the extract of following raw material
With sweetener composition, the raw material is：The parts by weight of balloonflower root 20~30, the parts by weight of the tuber of dwarf lilyturf 15~25, the parts by weight of radix glehniae 18~26,
The parts by weight of radix glycyrrhizae 10~20, the parts by weight of peppermint 5~15, the parts by weight of coix seed 5~15 and the parts by weight of cordate houttuynia 10~20；The sweet tea
Taste agent is 0~0.3 parts by weight.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
A kind of Qingyan Granules as described above of the invention, further, the raw material is：The parts by weight of balloonflower root 25, the weight of the tuber of dwarf lilyturf 20
Part, the parts by weight of radix glehniae 22, the parts by weight of radix glycyrrhizae 15, the parts by weight of peppermint 10, the parts by weight of coix seed 10 and the parts by weight of cordate houttuynia 15.
A kind of Qingyan Granules as described above of the invention, further, the raw material is：The parts by weight of balloonflower root 24, the weight of the tuber of dwarf lilyturf 18
Part, the parts by weight of radix glehniae 20, the parts by weight of radix glycyrrhizae 16, the parts by weight of peppermint 11, the parts by weight of coix seed 11 and the parts by weight of cordate houttuynia 16.
A kind of Qingyan Granules as described above of the invention, further, the sweetener is mogroside.
The present invention also provides a kind of preparation method of Qingyan Granules, comprises the following steps：
Step (1), peppermint and cordate houttuynia extract volatile oil and prepared：Weigh peppermint and 10~20 weight of 5~15 parts by weight
The cordate houttuynia of part is respectively or mixing is placed in extractor and adds water, heating and refluxing extraction, collects volatile oil standby；
Step (2), balloonflower root, the tuber of dwarf lilyturf, radix glehniae, the preparation of radix glycyrrhizae and Semen Coicis extract powder：Weigh 20~30 weight
The balloonflower root, the tuber of dwarf lilyturf of 15~25 parts by weight, the radix glehniae of 18~26 parts by weight, the radix glycyrrhizae of 10~20 parts by weight and 5~15 weights of part
Measure the coix seed of part respectively or mixing is placed in extractor and adds flooding, concentration and dry；
Step (3), mixing preparation：Balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae and Semen Coicis extract powder prepared by step (2)
The sweetener of end and 0~0.3 parts by weight adds alcohol and does wetting agent softwood, cross 12~20 mesh in high speed wet granulator
The wet granular of sieve series, by wet granular drying to moisture≤3%, obtains dry particl；Mixing preparation is operated in 300,000 grades of dust proof workshops；
The peppermint and cordate houttuynia that step (4) obtains step (1) extract volatile oil and sprayed into the dry particl that step (4) is obtained
Qingyan Granules are made.
A kind of preparation method of Qingyan Granules as described above of the invention, further, step (1) weighs 5~15 parts by weight
Peppermint and the cordate houttuynia of 10~20 parts by weight are respectively or mixing is placed in extractor the water for adding 10 times of amounts, heating and refluxing extraction
2h, collects volatile oil standby.
A kind of preparation method of Qingyan Granules as described above of the invention, further, step (2) adds flooding twice, the
Once plus the water of 10 times of amounts are extracted 2 hours, the filtering of 100 mesh, second plus 8 times of amount water, 1.5h is extracted, the filtering of 100 mesh merges two
Secondary filtrate.
A kind of preparation method of Qingyan Granules as described above of the invention, further, step (2) concentration be pressure for-
0.06--0.08MPa, 70-80 DEG C of temperature is concentrated under reduced pressure into relative density for 1.06-1.1.
A kind of preparation method of Qingyan Granules as described above of the invention, further, step (2) is dried to be spray-dried, and is obtained
To dried powder, dried powder crushed 80 mesh sieves.
A kind of preparation method of Qingyan Granules as described above of the invention, further, obtains step (1) in step (4)
Peppermint and cordate houttuynia extract volatile oil and spray into closed 24h in the dry particl that step (4) is obtained.
The beneficial effects of the invention are as follows：Balloonflower root of the present invention, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae, peppermint, coix seed, based on cordate houttuynia
Want raw material and by the synergy between these materials, be aided with mogroside, clearing heat, relieving sore-throat, nourishing Yin and promoting production of body fluid, a surname can be played
Lung resolving sputum, reaches the health-care efficacy and persistent of clearing, extensively, reliable in quality, price are economical for raw material sources.
This product formula is reasonable, rich in saponin(e, the bioactive substance such as polysaccharide.Shown through results of animal:Can be substantially
Mitigate rat paw edema；Human test results show：Pharyngeal mucous membrane can substantially be mitigated congested, mucosa edema.Illustrate that this product has
There is clearing.
This product technique is easily operated, and no special installation and chemical reagent, production safety, process conditions are basicly stable, without " three
It is useless " process problem, it is suitable for industrialized large-scaled production.
Embodiment
The principle and feature to the present invention are described with the following Examples, and the given examples are served only to explain the present invention,
It is not intended to limit the scope of the present invention.
Embodiment 1
A kind of Qingyan Granules of the present invention, are made up of following raw material：Balloonflower root 20kg, tuber of dwarf lilyturf 18kg, radix glehniae 20kg, radix glycyrrhizae
15kg, peppermint 6.7kg, coix seed 10kg, cordate houttuynia 10kg, mogroside 0.3kg.
Qingyan Granules as described above are prepared to comprise the following steps：
(1) peppermint, cordate houttuynia extract the preparation of volatile oil
Weigh peppermint 6.7kg, cordate houttuynia 10kg and be placed in extractor the water for adding 10 times of amounts, heating and refluxing extraction 4h is received
Collect volatile oil standby.
(2) balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae, the preparation of Semen Coicis extract xeraphium
Balloonflower root 20kg, tuber of dwarf lilyturf 18kg, radix glehniae 20kg, radix glycyrrhizae 15kg, coix seed 10kg is weighed to extract twice using water, the
Once plus the water of 10 times of amounts are extracted 2 hours, the filtering of 100 mesh, second plus 8 times of amount water, 1.5h is extracted, the filtering of 100 mesh merges two
Secondary filtrate, is -0.08MPa in pressure, it is 1.1 that 80 DEG C of temperature, which is concentrated under reduced pressure into relative density,.It is spray-dried to obtain xeraphium
End, dried powder crushed 80 mesh sieves, dry powder was made standby；
(3) mixing granulation is allocated
The dried powder for preparing step (2) in 300,000 grades of dust proof workshops, is well mixed with the mogroside of 80 mesh sieves,
In high speed wet granulator, add 80% alcohol and do wetting agent softwood, cross the granulation of 18 mesh sieves.Wet granular is placed in 60 DEG C
Under state, dry to moisture≤3%, obtain dry particl, dry particl whole grain is standby.
(4) peppermint, cordate houttuynia extract volatile oil
The volatile oil that step (1) is obtained is sprayed into the dry particl that step (3) is obtained, closed 24h.
(5) dispense
Qualified particle will be examined to dispense on request, outsourcing.
(6) product inspection, storage
Every detection is carried out to finished product as requested, meets defined storage.
Embodiment 2
A kind of Qingyan Granules of the present invention, are made up of following raw material：Balloonflower root 25kg, tuber of dwarf lilyturf 15kg, radix glehniae 18kg, radix glycyrrhizae
10kg, peppermint 8kg, coix seed 8.7kg, cordate houttuynia 15kg, mogroside 0.3kg.
Qingyan Granules as described above are prepared to comprise the following steps：
(1) peppermint, cordate houttuynia extract volatile oil
Weigh peppermint 8kg and cordate houttuynia 15kg and be placed in extractor the water for adding 10 times of amounts, heating and refluxing extraction 4h is collected
Volatile oil is standby.
(2) balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae, the preparation of Semen Coicis extract xeraphium
Weigh balloonflower root 25kg, tuber of dwarf lilyturf 15kg, radix glehniae 18kg, radix glycyrrhizae 10kg, coix seed 8.7kg water to extract twice, first
Secondary plus 10 times of amounts water is extracted 2 hours, the filtering of 100 mesh, second plus 8 times of amount water, extracts 1.5h, and the filtering of 100 mesh merges twice
Filtrate, is -0.06MPa in pressure, it is 1.1 that 80 DEG C of temperature, which is concentrated under reduced pressure into relative density, spray-dried to obtain dried powder,
Dried powder crushed 80 mesh sieves, dry powder was made standby；
(3) mixing granulation is allocated
The dried powder for preparing step (2) in 300,000 grades of dust proof workshops, is well mixed with the mogroside of 80 mesh sieves,
In high speed wet granulator, add 80% alcohol and do wetting agent softwood, cross the granulation of 18 mesh sieves.Wet granular is placed in 60 DEG C
Under state, dry to moisture≤3%, obtain dry particl, dry particl whole grain is standby.
(4) volatile oil is sprayed into
The volatile oil that step (1) is obtained is sprayed into the dry particl that step (4) is obtained, closed 24h.
(5) dispense：
Qualified particle will be examined to dispense on request, outsourcing.
(6) product inspection, storage
Every detection is carried out to finished product as requested, meets defined storage.
Embodiment 3
A kind of Qingyan Granules of the present invention, are made up of following raw material：Balloonflower root 30kg, tuber of dwarf lilyturf 16kg, radix glehniae 19kg, radix glycyrrhizae
12kg, peppermint 5kg, coix seed 6kg, cordate houttuynia 11.7kg, mogroside 0.3kg.
Qingyan Granules as described above are prepared to comprise the following steps：
(1) peppermint, cordate houttuynia extract volatile oil
Weigh peppermint 5kg and cordate houttuynia 11.7kg and be placed in extractor the water for adding 10 times of amounts, heating and refluxing extraction 4h is received
Collect volatile oil standby.
(2) balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae, the preparation of Semen Coicis extract xeraphium
Weigh balloonflower root 30kg, tuber of dwarf lilyturf 16kg, radix glehniae 19kg, radix glycyrrhizae 12kg, coix seed 6kg water to extract twice, for the first time
Plus the water of 10 times of amounts is extracted 2 hours, the filtering of 100 mesh, second plus 8 times of amount water extract 1.5h, 100 mesh filtering, merging is filtered twice
Liquid, is -0.08MPa in pressure, it is 1.1 that 80 DEG C of temperature, which is concentrated under reduced pressure into relative density,.It is spray-dried to obtain dried powder, do
Dry powder crushed 80 mesh sieves, dry powder was made standby；
(3) mixing granulation is allocated
The dried powder for preparing step (2) in 300,000 grades of dust proof workshops, is well mixed with the mogroside of 80 mesh sieves,
In high speed wet granulator, add 80% alcohol and do wetting agent softwood, cross the granulation of 18 mesh sieves.Wet granular is placed in 60 DEG C
Under state, dry to moisture≤3%, obtain dry particl, dry particl whole grain is standby.
(4) peppermint, cordate houttuynia extract volatile oil
The volatile oil that step (1) is obtained is sprayed into the dry particl that step (4) is obtained, closed 24h.
(5) dispense
Qualified particle will be examined to dispense on request, outsourcing.
(6) product inspection, storage
Every detection is carried out to finished product as requested, meets defined storage.
Embodiment 4
A kind of Qingyan Granules of the present invention, are made up of following raw material：Balloonflower root 25kg, tuber of dwarf lilyturf 20kg, radix glehniae 22kg, radix glycyrrhizae
15kg, peppermint 10kg, coix seed 10kg, cordate houttuynia 15kg, mogroside 0.3kg.
Qingyan Granules as described above are prepared to comprise the following steps：
(1) peppermint, cordate houttuynia extract volatile oil
Weigh peppermint 10kg and cordate houttuynia 15kg and be placed in extractor the water for adding 10 times of amounts, heating and refluxing extraction 4h is received
Collect volatile oil standby.
(2) balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae, the preparation of Semen Coicis extract xeraphium
Weigh balloonflower root 25kg, tuber of dwarf lilyturf 20kg, radix glehniae 22kg, radix glycyrrhizae 15kg, coix seed 10kg water to extract twice, for the first time
Plus the water of 10 times of amounts is extracted 2 hours, the filtering of 100 mesh, second plus 8 times of amount water extract 1.5h, 100 mesh filtering, merging is filtered twice
Liquid, is -0.08MPa in pressure, it is 1.1 that 80 DEG C of temperature, which is concentrated under reduced pressure into relative density,.It is spray-dried to obtain dried powder, do
Dry powder crushed 80 mesh sieves, dry powder was made standby；
(3) mixing granulation is allocated
The dried powder for preparing step (2) in 300,000 grades of dust proof workshops, is mixed with the mogroside 0.3kg of 80 mesh sieves
Uniformly, in high speed wet granulator, add 80% alcohol and do wetting agent softwood, cross the granulation of 18 mesh sieves.Wet granular is placed in
In the state of 60 DEG C, dry to moisture≤3%, obtain dry particl, dry particl whole grain is standby.
(4) peppermint, cordate houttuynia extract volatile oil
The volatile oil that step (1) is obtained is sprayed into the dry particl that step (4) is obtained, closed 24h.
(5) dispense
Qualified particle will be examined to dispense on request, outsourcing.
(6) product inspection, storage
Every detection is carried out to finished product as requested, meets defined storage.
Function assessment is tested
Function of moistening and cleaning throat
Experimental animal：Male SD rat, 150-220g.
Experimental method and step：Rat is divided into blank control group and 3 given the test agent dosage groups, blank control group by body weight
Give solvent.Experiment terminates the same day again to a given the test agent, is subcutaneously injected into 1% Irish moss after vola pedis after Rat Right within 1 hour
Glue 0.1ml/ only, respectively 1 after extremely inflammation, 3,6 hours, measures each category foot plantar thickness, same position measures 3 times, averaged.
As a result show, 4 right metapedes of test group of animals occur different degrees of red, swollen compared with left foot, and swelling is light enough
There is situations such as irritated, cross mountains foot, right metapedes dare not land in slight fever, animal.Compared with blank control group, middle and high dosage group is equal
The rat paw edema degree caused by carrageenan can substantially be suppressed, rapid-action, lh can reach obvious suppression upon administration
Effect, duration of efficacy is long, can continue until more than 6h, the middle and high dosage group of Qingyan Granules manufactured in the present embodiment is at each
Duan Jun has significant inhibition (P<0.01).
The sample Carrageenan of table 1 causes the influence (x scholar s) of rat paw edema
* is compared with control group, P ＜ 0.01.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (10)
1. a kind of Qingyan Granules, it is characterised in that be made up of the extract and sweetener of following raw material, the raw material is：Balloonflower root
20~30 parts by weight, the parts by weight of the tuber of dwarf lilyturf 15~25, the parts by weight of radix glehniae 18~26, the parts by weight of radix glycyrrhizae 10~20, the weight of peppermint 5~15
Measure part, the parts by weight of coix seed 5~15 and the parts by weight of cordate houttuynia 10~20；The sweetener is 0~0.3 parts by weight.
2. a kind of Qingyan Granules according to claim 1, it is characterised in that the raw material is：The parts by weight of balloonflower root 25, the tuber of dwarf lilyturf 20
Parts by weight, the parts by weight of radix glehniae 22, the parts by weight of radix glycyrrhizae 15, the parts by weight of peppermint 10, the parts by weight of coix seed 10 and the weight of cordate houttuynia 15
Part.
3. a kind of Qingyan Granules according to claim 1, it is characterised in that the raw material is：The parts by weight of balloonflower root 24, the tuber of dwarf lilyturf 18
Parts by weight, the parts by weight of radix glehniae 20, the parts by weight of radix glycyrrhizae 16, the parts by weight of peppermint 11, the parts by weight of coix seed 11 and the weight of cordate houttuynia 16
Part.
4. according to a kind of any one of claims 1 to 3 Qingyan Granules, it is characterised in that the sweetener is sweet Momordica grosvenori
Glycosides.
5. a kind of preparation method of Qingyan Granules, it is characterised in that comprise the following steps：
Step (1), peppermint and cordate houttuynia extract volatile oil and prepared：According to the weight ratio described in any one of claims 1 to 3
Weigh peppermint and cordate houttuynia respectively or mixing is placed in extractor and adds water, heating and refluxing extraction, collect volatile oil；
Step (2), balloonflower root, the tuber of dwarf lilyturf, radix glehniae, the preparation of radix glycyrrhizae and Semen Coicis extract powder：Appoint according to claims 1 to 3
Weight ratio described in one weighs balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae, coix seed respectively or mixing is placed in extractor and added
Enter flooding, concentration and drying and powder is made；
Step (3), mixing preparation：By step (2) prepare balloonflower root, the tuber of dwarf lilyturf, radix glehniae, radix glycyrrhizae and Semen Coicis extract powder and
Sweetener adds alcohol and does wetting agent softwood in high speed wet granulator, crosses 12~20 mesh sieves and wet granular is made, by wet
Grain is dried to moisture≤3%, obtains dry particl；
The peppermint and cordate houttuynia that step (4) obtains step (1) are extracted in the dry particl that volatile oil penetrating step (3) is obtained and are made
Qingyan Granules.
6. according to a kind of preparation method of Qingyan Granules of claim 5, it is characterised in that step (1) is according to claims 1 to 3
Weight ratio described in any one weighs peppermint and cordate houttuynia respectively or mixing is placed in extractor and adds 10 times of raw material total amount
Water, heating and refluxing extraction 2h, collect volatile oil it is standby.
7. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterised in that step (2) adds flooding
Twice, first time adds the water of 10 times of amounts to extract 2 hours, the filtering of 100 mesh, and 8 times of water of raw material total amount are added for the second time, 1.5h, 100 is extracted
Mesh is filtered, and merges filtrate twice.
8. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterised in that step (2) concentration is in pressure
Power is -0.06--0.08MPa, and 70-80 DEG C of temperature is concentrated under reduced pressure into relative density for 1.06-1.1.
9. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterised in that step (2) is dried as spraying
Dry, obtain dried powder, dried powder crushed 80 mesh sieves.
10. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterised in that by step in step (4)
(1) peppermint obtained and cordate houttuynia extract volatile oil and spray into closed 24h in the dry particl that step (3) is obtained.
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| CN110313597A (en) * | 2018-11-13 | 2019-10-11 | 广东一方制药有限公司 | One kind is instant to be exempted to rush throat soothing particle and preparation method thereof |
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|---|---|---|---|---|
| CN101062270A (en) * | 2007-05-30 | 2007-10-31 | 方阳 | Mint glycyrrhiza decoction |
| CN103125629A (en) * | 2011-11-23 | 2013-06-05 | 鲜丹科 | Throat nourishing tea |
| CN103141906A (en) * | 2013-02-28 | 2013-06-12 | 康美药业股份有限公司 | Extract capable of clearing heat and relieving sore throat, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062270A (en) * | 2007-05-30 | 2007-10-31 | 方阳 | Mint glycyrrhiza decoction |
| CN103125629A (en) * | 2011-11-23 | 2013-06-05 | 鲜丹科 | Throat nourishing tea |
| CN103141906A (en) * | 2013-02-28 | 2013-06-12 | 康美药业股份有限公司 | Extract capable of clearing heat and relieving sore throat, and preparation method and application thereof |
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| Title |
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| 简方解除多种家常病;王凤珍;《东方药膳》;20071231(第2期);第36页 * |
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