CN107987309B - Medical sponge and preparation method thereof - Google Patents
Medical sponge and preparation method thereof Download PDFInfo
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- CN107987309B CN107987309B CN201711072847.0A CN201711072847A CN107987309B CN 107987309 B CN107987309 B CN 107987309B CN 201711072847 A CN201711072847 A CN 201711072847A CN 107987309 B CN107987309 B CN 107987309B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000000017 hydrogel Substances 0.000 claims abstract description 53
- 239000002002 slurry Substances 0.000 claims abstract description 30
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 22
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 20
- 238000007710 freezing Methods 0.000 claims abstract description 18
- 230000008014 freezing Effects 0.000 claims abstract description 18
- 238000004108 freeze drying Methods 0.000 claims abstract description 17
- 238000010146 3D printing Methods 0.000 claims abstract description 15
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 14
- 239000000661 sodium alginate Substances 0.000 claims abstract description 14
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 14
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 11
- 239000001110 calcium chloride Substances 0.000 claims abstract description 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 11
- 239000000499 gel Substances 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 238000007639 printing Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 8
- 239000011148 porous material Substances 0.000 claims description 7
- 238000006136 alcoholysis reaction Methods 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 abstract description 10
- 238000010521 absorption reaction Methods 0.000 abstract description 7
- 238000012545 processing Methods 0.000 abstract description 6
- 238000001035 drying Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 230000002439 hemostatic effect Effects 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000013499 data model Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012890 simulated body fluid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
- C08J2201/0484—Elimination of a frozen liquid phase the liquid phase being aqueous
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/04—Alginic acid; Derivatives thereof
Abstract
The invention discloses a preparation method of a medical sponge, which comprises the following steps of: mixing polyvinyl alcohol, sodium alginate and calcium chloride according to the proportion of 1 (0.2-1): (0.1-0.6) making into gel to obtain hydrogel slurry; preparing a hydrogel profile by 3D printing; a freezing pretreatment step and a freezing drying step. The invention also provides the medical sponge obtained by the method. The method is characterized in that hydrogel slurry is prepared first, and then medical sponge with small aperture and high porosity is obtained through 3D printing and freeze-drying. The polyvinyl alcohol and the sodium alginate used in the method have good biocompatibility and liquid absorption, and good wet elasticity after absorbing liquid, and have good prospect in medical application. In the production process of the medical sponge, the external shape of the medical sponge is accurate and controllable, and the problems of chipping and the like are avoided in the processing process.
Description
Technical Field
The invention belongs to material processing, and relates to a medical sponge and a preparation method thereof.
Background
The medical sponge has super strong liquid absorption capacity due to the unique foaming structure, and the liquid absorption capacity can reach several times to dozens of times of the self weight. In addition, the hemostatic material has high liquid absorption rate, good elasticity and high drying rate, so that the hemostatic material is widely applied to the medical field, and compared with the traditional hemostatic materials such as gelatin, cotton and gauze, the hemostatic material has obvious advantages of hemostasis, expansion, tensile shrinkage and the like and has a good development prospect.
However, due to the limitation of the structure of the medical sponge, the following problems exist in the processing of the medical sponge: 1) chip falling is easy to occur; 2) because of its good elasticity, it is difficult to perform precision machining.
In recent years, 3d printing technology has attracted much attention as an additive molding technology, both in industrial applications and in the field of scientific and technological research. The 3d printing technology is characterized in that materials such as liquid, powder, sheets and the like are processed and overlapped layer by layer under the condition of not needing an additional die by combining a computer data model with a rapid automatic forming system, and finally the materials are printed into the required shape. 3d printing technology has been successfully used in clinical fields including neurosurgery, orthopedics, stomatology, etc. over the last decades. Currently, the main applications of 3d printing are shown in auxiliary medical treatment, such as 3d printing of a patient model, 3d printing of a personalized surgical guide and other medical tools.
However, at present, the 3D printing technology is applied to the preparation of medical sponges, and has the following problems: due to the randomness and complexity of the sponge porous structure, the pore size of the printed sponge is large, or a lot of time and cost are consumed to improve the precision of 3D printing. Therefore, a preparation and processing technology of medical sponge with controllable surface shape is developed to solve the defects of the prior art, and becomes a problem to be solved by the technical personnel in the field.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a preparation method of a medical sponge. The method combines 3D printing and freeze drying, so that the medical sponge with higher porosity is prepared under the condition of lower 3D printing precision.
The second purpose of the invention is to provide the medical sponge prepared by the method.
One of the purposes of the invention is realized by adopting the following technical scheme:
a preparation method of a medical sponge comprises the following steps:
the preparation steps of the hydrogel slurry are as follows: mixing polyvinyl alcohol, sodium alginate and calcium chloride according to the proportion of 1 (0.2-1): (0.1-0.6) making into gel to obtain hydrogel slurry;
the preparation method of the hydrogel profile comprises the following steps: 3D printing the hydrogel slurry to obtain a hydrogel section; the temperature of a charging barrel for 3D printing is 40-50 ℃; the temperature of the printing platform is 20-30 ℃;
a freezing pretreatment step: freezing and pretreating the hydrogel to obtain a frozen section;
and (3) freeze drying: freeze drying the frozen section for 6-12h at-30 deg.C to-40 deg.C under vacuum degree of 30-50Pa to obtain medical sponge.
Further, in the preparation step of the hydrogel slurry, polyvinyl alcohol, sodium alginate and calcium chloride are respectively dissolved to obtain solutions, and the obtained solutions are stirred and mixed to carry out gel conversion.
Further, the mixture was stirred at 40 to 50 ℃.
Further, in the preparation step of the hydrogel slurry, the alcoholysis degree of polyvinyl alcohol is 70-90%, and the average polymerization degree is 1000-2000-one.
Further, in the preparation step of the hydrogel slurry, the weight ratio of the polyvinyl alcohol, the sodium alginate and the calcium chloride is 1 (0.2-0.4): (0.05-0.2).
Further, in the step of preparing the hydrogel slurry, the water content of the hydrogel slurry is 86-88%.
Further, in the preparation step of the hydrogel profile, the printing speed is 1-3mm 3/s.
Further, in the freezing pretreatment, the treatment temperature is-20 to-40 ℃.
Further, in the step of freezing pretreatment, the mixture is frozen and dried until the water content is less than or equal to 2 percent.
The second purpose of the invention is realized by adopting the following technical scheme:
the medical sponge obtained by the method.
Compared with the prior art, the invention has the beneficial effects that:
the preparation method of the medical sponge provided by the invention comprises the steps of preparing hydrogel slurry, obtaining a hydrogel section through 3D printing, and drying water in the section in a freeze-drying mode, so that the medical sponge with small aperture and high porosity is obtained. The polyvinyl alcohol and the sodium alginate used in the method have good biocompatibility and liquid absorption, and good wet elasticity after absorbing liquid, and have good prospect in medical application. In the production process of the medical sponge, the external shape of the medical sponge is accurate and controllable, and the problems of chipping and the like are avoided in the processing process.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
The invention provides a preparation method of a medical sponge, which comprises the following steps:
the preparation steps of the hydrogel slurry are as follows: mixing polyvinyl alcohol, sodium alginate and calcium chloride according to the proportion of 1 (0.2-1): (0.1-0.6) making into gel to obtain hydrogel slurry;
the preparation method of the hydrogel profile comprises the following steps: 3D printing the hydrogel slurry to obtain a hydrogel section; the temperature of a charging barrel for 3D printing is 40-50 ℃; the temperature of the printing platform is 20-30 ℃;
a freezing pretreatment step: freezing and pretreating the hydrogel to obtain a frozen section;
and (3) freeze drying: freeze drying the frozen section for 6-12h at-30 deg.C to-40 deg.C under vacuum degree of 30-50Pa to obtain medical sponge.
The method comprises the steps of preparing hydrogel slurry, obtaining a hydrogel section through 3D printing, and drying water in the section in a freeze-drying mode to obtain the medical sponge with small aperture and high porosity. The polyvinyl alcohol and the sodium alginate used in the method have good biocompatibility and liquid absorption, and good wet elasticity after absorbing liquid, and have good prospect in medical application. In the production process of the medical sponge, the external shape of the medical sponge is accurate and controllable, and the problems of chipping and the like are avoided in the processing process.
The medical sponge has the water content of 84-94% in the hydrogel slurry. During freezing, a loose cellular structure can be produced.
Example 1:
a medical sponge and a preparation method thereof comprise the following steps:
the preparation steps of the hydrogel slurry are as follows:
adding 5g of polyvinyl alcohol with alcoholysis degree of 80% and average polymerization degree of 1800 into 20g of purified water, stirring at 85 +/-2 ℃ for 2-3h until the polyvinyl alcohol is completely dissolved, and standing to room temperature to obtain the polyvinyl alcohol solution. 1.5g of sodium alginate was dissolved in 15g of purified water. 0.5g of calcium chloride was dissolved in 8g of purified aqueous solution. Slowly stirring and mixing the 3 solutions at the temperature of 45 +/-2 ℃ for gel conversion for 2-3h to obtain hydrogel slurry;
the preparation method of the hydrogel profile comprises the following steps:
the temperature of the charging barrel is adjusted to be 45 ℃, the temperature of the printing platform is adjusted to be 25 ℃, and the printing speed is set to be 1mm3A cubic hydrogel profile was printed and measured to have a length of ×, a width of × and a height of 20.00 × 20.00.00 20.00 × 20.00.00 mm.
A freezing pretreatment step: pre-freezing the hydrogel section at-20 ℃ for 3-4h to obtain a frozen section;
and (3) freeze drying: freeze-drying the frozen section for 8h at-30 deg.C under vacuum degree of 40 Pa. Obtaining the porous medical sponge.
The medical sponge obtained in this example had a porosity of 87.38% and an average pore diameter of 1.14 mm.
Example 2:
a medical sponge and a preparation method thereof comprise the following steps:
the preparation steps of the hydrogel slurry are as follows:
adding 4g of polyvinyl alcohol with alcoholysis degree of 85% and average polymerization degree of 1500 into 20g of purified water, stirring at 85 +/-2 ℃ for 2-3h until the polyvinyl alcohol is completely dissolved, and standing to room temperature to obtain the polyvinyl alcohol solution. 1.8g of sodium alginate was dissolved in 15g of purified water. 0.6g of calcium chloride was dissolved in 8.6g of purified aqueous solution. Slowly stirring and mixing the 3 solutions at the temperature of 45 +/-2 ℃ for carrying out gel conversion for 2-3h to obtain hydrogel slurry;
the preparation method of the hydrogel profile comprises the following steps:
the temperature of the charging barrel is adjusted to be 40 ℃, the temperature of the printing platform is adjusted to be 25 ℃, and the printing speed is set to be 2mm3A cubic hydrogel profile was printed and measured to have a length of ×, a width of × and a height of 20.00 × 20.00.00 20.00 × 20.00.00 mm.
A freezing pretreatment step: pre-freezing the hydrogel section at-20 ℃ for 3-4h to obtain a frozen section;
and (3) freeze drying: freeze-drying the frozen section for 8h at-30 ℃ and a vacuum degree of 40 Pa; obtaining the medical sponge.
The medical sponge obtained in this example had a porosity of 81.75% and an average pore diameter of 1.32 mm.
Example 3:
a medical sponge and a preparation method thereof comprise the following steps:
the preparation steps of the hydrogel slurry are as follows:
adding 3g of polyvinyl alcohol with alcoholysis degree of 90% and average polymerization degree of 1500 into 20g of purified water, stirring at 85 +/-2 ℃ for 2-3h until the polyvinyl alcohol is completely dissolved, and standing to room temperature to obtain the polyvinyl alcohol solution. 2.5g of sodium alginate are dissolved in 15g of purified water. Dissolving 0.8g of calcium chloride in 8.7g of purified aqueous solution; slowly stirring and mixing the 3 solutions at the temperature of 45 +/-2 ℃ for gel conversion for 2-3h to obtain hydrogel slurry;
the preparation method of the hydrogel profile comprises the following steps:
the temperature of the charging barrel is adjusted to be 40 ℃, the temperature of the printing platform is adjusted to be 25 ℃, and the printing speed is set to be 3mm3A cubic hydrogel profile was printed and measured to have a length of ×, a width of × and a height of 20.00 × 20.00.00 20.00 × 20.00.00 mm.
A freezing pretreatment step: pre-freezing the hydrogel section at-30 ℃ for 3-4h to obtain a frozen section;
and (3) freeze drying: freeze-drying the frozen section for 6h at-40 deg.C under vacuum degree of 40 Pa; obtaining the medical sponge.
The medical sponge obtained in this example had a porosity of 82.43% and an average pore diameter of 1.26 mm.
The medical sponges obtained in examples 1 to 3 all had a porosity of 80% or more and an average pore diameter of 1.1 to 1.4 mm. Has better internal pore structure.
Performance detection and Effect evaluation
1. Water absorption macroscopic size detection
10 samples of each of the medical sponges obtained in examples 1 to 3 were sufficiently immersed in a simulated body fluid, the dimensions were measured, and the standard deviation was calculated, and the results are shown in the following table:
as can be seen from the table above, the medical sponge obtained by the invention has the size close to that of the 3D printing section bar after absorbing water. Namely, the macroscopic dimension precision is ideal.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. A preparation method of a medical sponge comprises the following steps:
the preparation steps of the hydrogel slurry are as follows: mixing polyvinyl alcohol, sodium alginate and calcium chloride according to the proportion of 1 (0.2-1): (0.1-0.6) making into gel to obtain hydrogel slurry;
the preparation method of the hydrogel profile comprises the following steps: 3D printing the hydrogel slurry to obtain a hydrogel section; the temperature of a charging barrel for 3D printing is 40-50 ℃; the temperature of the printing platform is 20-30 ℃;
a freezing pretreatment step: freezing and pretreating the hydrogel to obtain a frozen section;
and (3) freeze drying: freeze-drying the frozen section for 6-12h at-30 deg.C to-40 deg.C under vacuum degree of 30-50Pa to obtain medical sponge; the medical sponge has a porosity of more than 80% and an average pore diameter of 1.1-1.4 mm.
2. The method according to claim 1, wherein the hydrogel slurry is prepared by dissolving polyvinyl alcohol, sodium alginate and calcium chloride in water to obtain solutions, and mixing the solutions under stirring to perform gel conversion.
3. The method of claim 2, wherein the mixing is carried out with stirring at 40-50 ℃.
4. The method according to claim 1, wherein in the step of preparing the hydrogel slurry, the degree of alcoholysis of the polyvinyl alcohol is 70 to 90% and the average degree of polymerization is 1000-2000.
5. The preparation method according to claim 1, wherein in the preparation step of the hydrogel slurry, the weight ratio of the polyvinyl alcohol to the sodium alginate to the calcium chloride is 1 (0.2-0.4): (0.05-0.2).
6. The method of claim 5, wherein the hydrogel slurry is prepared in such a manner that the hydrogel slurry has a water content of 86 to 88%.
7. The method of claim 1, wherein the hydrogel profile is prepared at a printing speed of 1-3mm3/s。
8. The method according to claim 1, wherein the temperature in the freezing pretreatment is-20 to-40 ℃.
9. The method of claim 1, wherein in the step of freeze-drying, the water content is freeze-dried to 2% or less.
10. A medical sponge obtained by the process according to any one of claims 1 to 9.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030407A1 (en) * | 1999-10-27 | 2001-05-03 | Department Of Atomic Energy | A process for manufacture of hydrogels for burn and injury treatment |
| CN105749354A (en) * | 2014-12-19 | 2016-07-13 | 深圳先进技术研究院 | Normal forming method for sodium alginate containing three-dimensional scaffold |
| CN106178106A (en) * | 2016-07-19 | 2016-12-07 | 湖北工业大学 | 3D prints the method that sodium alginate/polyvinyl alcohol is physical crosslinking double-network hydrogel support entirely |
-
2017
- 2017-11-03 CN CN201711072847.0A patent/CN107987309B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030407A1 (en) * | 1999-10-27 | 2001-05-03 | Department Of Atomic Energy | A process for manufacture of hydrogels for burn and injury treatment |
| CN105749354A (en) * | 2014-12-19 | 2016-07-13 | 深圳先进技术研究院 | Normal forming method for sodium alginate containing three-dimensional scaffold |
| CN106178106A (en) * | 2016-07-19 | 2016-12-07 | 湖北工业大学 | 3D prints the method that sodium alginate/polyvinyl alcohol is physical crosslinking double-network hydrogel support entirely |
Non-Patent Citations (1)
| Title |
|---|
| "Development of a novel alginate-polyvinyl alcohol-hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds";Stephanie T. Bendtsen et al.;《Society For Biomaterials》;20170531;第105卷(第5期);第1457-1468页 * |
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