CN109646705B - Composite sponge and preparation method thereof, negative pressure drainage dressing, device and medical equipment - Google Patents
Composite sponge and preparation method thereof, negative pressure drainage dressing, device and medical equipment Download PDFInfo
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- CN109646705B CN109646705B CN201910090948.3A CN201910090948A CN109646705B CN 109646705 B CN109646705 B CN 109646705B CN 201910090948 A CN201910090948 A CN 201910090948A CN 109646705 B CN109646705 B CN 109646705B
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- alginate
- composite sponge
- sponge
- polyvinyl alcohol
- negative pressure
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- 239000002131 composite material Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 38
- 229920000615 alginic acid Polymers 0.000 claims abstract description 38
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 33
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 33
- 229940072056 alginate Drugs 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 238000002156 mixing Methods 0.000 claims abstract description 21
- 238000001816 cooling Methods 0.000 claims abstract description 20
- -1 alginic acid ester Chemical class 0.000 claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 8
- 238000004132 cross linking Methods 0.000 claims abstract description 7
- 239000003377 acid catalyst Substances 0.000 claims abstract description 6
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 6
- 239000004088 foaming agent Substances 0.000 claims abstract description 6
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims description 12
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims description 6
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims description 6
- 230000032050 esterification Effects 0.000 claims description 5
- 238000005886 esterification reaction Methods 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 238000006136 alcoholysis reaction Methods 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 41
- 238000000034 method Methods 0.000 abstract description 15
- 230000008569 process Effects 0.000 abstract description 8
- 239000000783 alginic acid Substances 0.000 abstract description 6
- 229960001126 alginic acid Drugs 0.000 abstract description 6
- 238000004140 cleaning Methods 0.000 abstract description 6
- 238000007906 compression Methods 0.000 abstract description 4
- 230000006835 compression Effects 0.000 abstract description 4
- 230000008859 change Effects 0.000 abstract description 3
- 239000002253 acid Substances 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract description 2
- 238000001556 precipitation Methods 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 19
- 208000027418 Wounds and injury Diseases 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 16
- 239000000243 solution Substances 0.000 description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229940015043 glyoxal Drugs 0.000 description 3
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003519 biomedical and dental material Substances 0.000 description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01042—Absorbency
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Abstract
The invention discloses a composite sponge with good water-retaining property, a preparation method thereof, a negative pressure drainage dressing, a negative pressure drainage device and medical equipment. The composite sponge comprises the following components: alginate, polyvinyl alcohol, a foaming agent, a surfactant, a cross-linking agent, an acid catalyst and deionized water. The preparation method of the composite sponge comprises the following steps: stirring alginic acid ester, polyvinyl alcohol and deionized water; sequentially adding a foaming agent, a surfactant, a cross-linking agent and an acid catalyst, mixing, cooling, stirring, pouring into a mold, carrying out cross-linking reaction, cooling, demolding and cleaning. The alginic acid ester adopted by the invention does not generate precipitation in an acid solution, can promote the sponge to furthest improve the water retention performance of the sponge, reduce the water volatilization of the composite sponge in the using process, change the hardness of the dry composite sponge, reduce the compression force of the dry sponge on a wound, relieve the pain of a patient and accelerate the healing process of the wound surface of the patient.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to a composite sponge, a preparation method thereof, a negative pressure drainage dressing, a negative pressure drainage device and medical equipment.
Background
The negative pressure drainage wound treatment technology is a new technology for treating wounds developed in recent years, and is widely used for treating various acute wounds, skin and soft tissue defects, burn wounds, chronic refractory wounds and other wounds. The main principle is that the dressing with drainage tube inside covers or fills the wound surface with skin and soft tissue defect, and then the dressing is sealed by using a biological semipermeable membrane to form a closed space, and finally the drainage tube is connected with a negative pressure source to intermittently or continuously generate negative pressure on the wound surface to stimulate the growth of granulation tissue and promote the healing of the wound surface.
The biomedical material is used as a novel hemostatic material, has the advantages of high efficiency, economy and the like, and is a conventional dressing in the negative pressure drainage wound treatment technology. A relatively common biomedical material is polyvinyl alcohol sponge, and although polyvinyl alcohol has a very strong water absorption property, the sponge made of polyvinyl alcohol is easy to dry and harden under the action of negative pressure, and the use of the sponge is affected by pressing the wound surface, so researchers try to adopt other materials to compound the sponge with the sponge to improve the performance, and the materials include alginate, chitosan and the like. Wherein, alginate is used as the main composite material. However, in the actual operation process, the alginate-polyvinyl alcohol composite sponge material is still easy to dehydrate and harden in the negative pressure drainage process, and the theoretically expected water retention effect cannot be achieved. Therefore, there is a need for a sponge material that retains water and does not become dry or hard.
Disclosure of Invention
The invention aims to provide a composite sponge with good water retention, a preparation method thereof, a negative pressure drainage dressing, a negative pressure drainage device and medical equipment.
According to a first aspect of the invention, the invention provides a composite sponge, which comprises the following components in percentage by mass according to an embodiment of the invention:
in addition, according to the embodiment of the invention, the composite sponge can also have the following additional technical characteristics:
in some embodiments of the invention, the alginate is at least one of polyethylene glycol alginate, lauryl alginate, octyl alginate, propylene glycol alginate, and cetyl alginate.
In some embodiments of the invention, the alginate ester has a degree of esterification of 10 to 25%.
In some embodiments of the invention, the degree of alcoholysis of the polyvinyl alcohol is from 85 to 99%.
In some embodiments of the invention, the polyvinyl alcohol has an average molecular weight of 110000-200000.
In some embodiments of the invention, the foaming agent is at least one of potassium bicarbonate, ammonium bicarbonate, sodium bicarbonate, calcium bicarbonate.
In some embodiments of the present invention, the surfactant is at least one of alkylphenol ethoxylates, sodium dodecyl sulfate, and sodium dodecyl benzene sulfonate.
In some embodiments of the invention, the crosslinking agent is at least one of glutaraldehyde, formaldehyde, glyoxal.
In some embodiments of the invention, the acid catalyst is at least one of phosphoric acid, hydrochloric acid, sulfuric acid, nitric acid.
According to a second aspect of the invention, the invention provides a preparation method of the composite sponge. According to an embodiment of the invention, the method comprises the steps of:
s1: mixing alginate, polyvinyl alcohol and deionized water at 70-100 ℃ to obtain a system A;
s2: adding a foaming agent and a surfactant into the system A, and mixing to obtain a system B;
s3: cooling the system B to 45-55 ℃, adding a cross-linking agent, and mixing to obtain a system C;
s4: cooling the system C to 35-45 ℃, adding an acid catalyst, and mixing to obtain a system D;
s5: and pouring the system D into a mold, carrying out crosslinking reaction for 5-10h at 40-90 ℃, cooling, demolding and cleaning to obtain the product.
In some embodiments of the present invention, step S1 specifically includes: uniformly stirring the alginate, the polyvinyl alcohol and the deionized water, heating to 70-100 ℃, and continuously stirring to completely dissolve the alginate and the polyvinyl alcohol to obtain a system A.
In some embodiments of the present invention, step S1 specifically includes: mixing alginate and deionized water, heating to 70-100 ℃ to obtain a first solution, mixing polyvinyl alcohol and deionized water, heating to 70-100 ℃ to obtain a second solution, and mixing the first solution and the second solution to obtain a system A; the deionized water in the first solution and the deionized water in the second solution are respectively a part of the total amount of the deionized water in step S1, and specifically, the deionized water in the first solution and the deionized water in the second solution may respectively have at least an amount that can completely dissolve the alginic acid ester in the first solution and the polyvinyl alcohol in the second solution.
According to a third aspect of the invention, the invention proposes a negative pressure drainage dressing, which according to an embodiment of the invention comprises the above-mentioned composite sponge; for example, the negative pressure drainage dressing can specifically comprise the composite sponge and a drainage tube embedded in the composite sponge.
According to a fourth aspect of the invention, the invention provides a negative pressure drainage device, which according to an embodiment of the invention comprises the composite sponge; the negative pressure drainage device comprises the negative pressure drainage dressing; for example, the negative pressure drainage device may specifically include a drainage machine host, a negative pressure drainage kit, a drug administration lavage device, and the like, and the negative pressure drainage kit may include a negative pressure suction cup, a drainage tube, a composite sponge, and the like.
According to a fifth aspect of the invention, a medical device is proposed, which according to an embodiment of the invention comprises the above-mentioned composite sponge, in particular a medical device comprising the above-mentioned composite sponge alone or comprising the above-mentioned negative pressure drainage dressing or comprising any of the above-mentioned negative pressure drainage devices, which can implement the negative pressure drainage technique alone or in combination with other techniques for more complex operations and treatment procedures.
The invention has the beneficial effects that:
the inventor finds that the reason that the expected water retention performance of the sodium alginate-polyvinyl alcohol composite sponge cannot be achieved is that although sodium alginate contains a large amount of hydroxyl groups on a molecular chain to ensure the hydrophilicity, alginic acid gel is easy to form at a pH value lower than 6 to precipitate, so that the pore diameter of the prepared sponge is uneven, and in addition, certain loss of the water retention performance of the sponge product is caused, and the sponge product is easy to dehydrate and harden in the using process. The alginic acid ester used in the present invention is generally prepared by the reaction between alginic acid and alcohol molecules, and has excellent emulsifiability, thickening property and acid resistance, and forms gel in an acidic solution having a pH of 3 to 4, but does not precipitate therefrom. The alginate esters can promote the stabilization of the bubbles during the foaming of the sponge during the preparation. The prepared sponge can also improve the water retention performance to the greatest extent, reduce the water volatilization of the composite sponge in the using process, change the hardness of the dry composite sponge, reduce the compression force of the dry sponge on the wound and relieve the pain of a patient.
In addition, due to the emulsifying property and the thickening property of the alginate, micro bubble holes in the composite sponge obtained after the alginate is added are uniformly communicated, so that the discharge of seepage in the clinical use process is facilitated, and the recovery process of a patient is accelerated.
The negative pressure drainage dressing, the negative pressure drainage device and the medical equipment which adopt the composite sponge can better promote the treatment of the wound surface of a patient.
Drawings
FIG. 1 is a scanning electron micrograph of a sponge prepared according to the method of comparative example 1 in a comparative experiment according to one embodiment of the present invention.
FIG. 2 is a scanning electron micrograph of a sponge prepared according to the method of example 1 in a comparative experiment according to one embodiment of the present invention.
FIG. 3 is a graph showing the results of comparing the water retention properties of the sponges produced in comparative example 1 and example 1 in a comparative experiment according to an example of the present invention.
FIG. 4 is a graph showing the results of comparing the mechanical properties of the sponges produced in comparative example 1 and example 1 in a comparative experiment according to an embodiment of the present invention.
Detailed Description
The conception, the specific structure, and the technical effects produced by the present invention will be clearly and completely described in conjunction with the embodiments below, so that the objects, the features, and the effects of the present invention can be fully understood. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.
Example 1
The composite sponge comprises the following components in percentage by mass:
the esterification degree of the propylene glycol alginate is 25 percent, the average molecular weight of the polyvinyl alcohol is 110000, and the alcoholysis degree is 85-99 percent.
The specific preparation method of the composite sponge comprises the following steps:
step 1: uniformly stirring and mixing propylene glycol alginate, polyvinyl alcohol and deionized water, heating to 90 ℃, and continuously stirring to completely dissolve the propylene glycol alginate and the polyvinyl alcohol to obtain a system A;
step 2: adding sodium bicarbonate and sodium dodecyl sulfate into the system A, stirring for 30min at the stirring speed of 1300rpm to obtain a system B;
and step 3: cooling the system B to 50 ℃, adding glyoxal, stirring for 15min at the stirring speed of 1500rpm, and preparing a system C;
and 4, step 4: cooling the system C to 40 ℃, adding hydrochloric acid, stirring for 8min at the stirring speed of 1500rpm, and obtaining a system D;
and 5: and (3) after uniformly stirring, pouring the system D into a mould, carrying out crosslinking reaction for 5 hours at 70 ℃, cooling, demoulding and cleaning to obtain the composite sponge.
Example 2
The composite sponge comprises the following components in percentage by mass:
the specific preparation method of the composite sponge comprises the following steps:
Step 1: stirring and mixing propylene glycol alginate with a proper amount of deionized water uniformly, heating to 80 ℃ to prepare a first solution, stirring and mixing polyvinyl alcohol and the rest of deionized water uniformly, heating to 90 ℃ to prepare a second solution, and continuously stirring to uniformly mix the first solution and the second solution to prepare a system A;
step 2: adding sodium bicarbonate, calcium bicarbonate and sodium dodecyl benzene sulfonate into the system A, stirring for 15min at the stirring speed of 1400rpm to obtain a system B;
and step 3: cooling the system B to 50 ℃, adding glutaraldehyde, stirring for 20min at the stirring speed of 1600rpm, and obtaining a system C;
and 4, step 4: cooling the system C to 40 ℃, adding sulfuric acid, stirring for 5min at the stirring speed of 1600rpm, and obtaining a system D;
and 5: and uniformly stirring the system D, pouring the mixture into a mold, carrying out crosslinking reaction for 4.5 hours at the temperature of 80 ℃, cooling, demolding and cleaning to obtain the composite sponge.
Example 3
The composite sponge comprises the following components in percentage by mass:
the specific preparation method of the composite sponge comprises the following steps:
step 1: stirring and mixing polyethylene glycol alginate, polyvinyl alcohol and deionized water uniformly, heating to 90 ℃, and continuously stirring to completely dissolve the polyethylene glycol alginate and the polyvinyl alcohol to obtain a system A;
Step 2: adding ammonium bicarbonate and alkylphenol ethoxylates into the system A, stirring for 45min at a stirring speed of 1400rpm to obtain a system B;
and step 3: cooling the system B to 50 ℃, adding formaldehyde, stirring for 20min at the stirring speed of 1100rpm, and preparing a system C;
and 4, step 4: cooling the system C to 40 ℃, adding phosphoric acid, stirring for 15min at the stirring speed of 1100rpm, and obtaining a system D;
and 5: and uniformly stirring the system D, pouring the system D into a mold, carrying out crosslinking reaction for 7 hours at the temperature of 60 ℃, cooling, demolding and cleaning to obtain the composite sponge.
Example 4
Comparative test of Performance
Comparative example 1: the sponge is prepared by the following method, wherein the percentage represents the mass of each component in percentage of the total mass:
step 1: uniformly stirring and mixing 13% of polyvinyl alcohol and 73.2% of deionized water, heating to 90 ℃, and continuously stirring to completely dissolve the polyvinyl alcohol to obtain a polyvinyl alcohol solution;
step 2: adding 0.3% of sodium bicarbonate and 0.5% of sodium dodecyl sulfate into the polyvinyl alcohol solution, stirring for 30min at the stirring speed of 1300rpm to obtain a system B;
and 3, step 3: cooling the system B to 50 ℃, adding 7% glyoxal, stirring for 15min at the stirring speed of 1500rpm to obtain a system C;
And 4, step 4: cooling the system C to 40 ℃, adding 6% hydrochloric acid, stirring for 8min at a stirring speed of 1500rpm to obtain a system D;
and 5: and uniformly stirring the system D, pouring the system D into a mold, carrying out crosslinking reaction for 5 hours at 70 ℃, cooling, demolding and cleaning to obtain the product.
The polyvinyl alcohol used has an average molecular weight of 110000 and a degree of alcoholysis of 85 to 99%.
1. Topography observation
The sponges obtained in comparative example 1 and example 1 were freeze-dried in a freeze dryer, fixed on a sample table, sprayed with gold on the surface, placed in an electron microscope chamber, and observed for surface morphology. FIG. 1 is a scanning electron microscope image of the sponge obtained in comparative example 1, and as shown in FIG. 1, the microcells in the vicinity of the macrocellular cells of the sponge obtained in comparative example 1 have a flat structure, and the microcells in different layers are individually layered and isolated from each other to form a two-dimensional sheet. Fig. 2 is a scanning electron microscope image of the sponge prepared in example 1, and as shown in fig. 2, the micro-bubble pore structures at different levels in the composite sponge prepared in example 1 are communicated with each other and have uniform pore diameters, so that a complex porous structure communicated with each other in a three-dimensional space is formed, and the porous structure with three-dimensional communication has a very large number of open pore structures, and can promote the discharge of wound exudate in the using process, and accelerate the treatment and recovery of wound wounds of patients.
2. Comparison of Water Retention Performance
The sponges prepared in comparative example 1 and example 1 were cut into 15X 1cm sizes, weighed and recorded as 0h of sponge weight, and then placed in an oven at 37 ℃ to measure the weight of the sponges per hour and record the change in weight of the sponges over time, the resulting curve being shown in FIG. 3, where the round dots represent the weight of example 1 and the square dots represent the weight of comparative example 1. As can be seen from the figure: the sponge of example 1 decreased less weight per unit time, i.e., the sponge of example 1 volatilized less water per unit time, i.e., the sponge of example 1 had better water retention than comparative example 1.
3. Mechanical property test (compression deformation resistance):
A50X 50mm sample of each of the sponges prepared in comparative example 1 and example 1 was tested according to ASTM D3574-2011Test C, and the compression force of the sponge at 50% relative deformation was measured. Fig. 4 is a graph showing the comparison result of the mechanical properties of the sponge according to one embodiment of the present invention, as shown in fig. 4, under the condition of 50% relative deformation, a relatively much larger compressive force needs to be applied to the sponge according to embodiment 1, that is, under the same negative pressure condition, the sponge according to embodiment 1 will deform less, which can further ensure that the drainage tube embedded in the sponge during the negative pressure drainage process is less likely to be blocked, and is beneficial to the drainage of the exudate from the wound.
Example 5
A composite sponge, differing from example 1 in that the alginate used is lauryl alginate, the degree of esterification being from 10 to 15%. The prepared composite sponge has good water retention property.
Example 6
A composite sponge differing from example 1 in that the alginate used was cetyl alginate having a degree of esterification of 15 to 18% and the polyvinyl alcohol had an average molecular weight of 180000. The prepared composite sponge has good water retention property.
A negative pressure drainage dressing comprises the composite sponge and at least one drainage catheter, wherein one end of the drainage catheter is inserted into the composite sponge, and the other end of the drainage catheter is connected with a negative pressure source.
The utility model provides a negative pressure drainage device, includes drainage machine host computer, negative pressure drainage external member and lavage device of dosing, this negative pressure drainage external member includes negative sucker, foretell compound sponge and is used for detecting the sensor of surface of a wound parameter, and the sensor is located on negative sucker and/or the compound sponge. The negative pressure drainage kit receives the wound parameters and sends the parameters to the main machine of the drainage machine for processing, and the main machine of the drainage machine sends out a lavage signal to the administration lavage device after processing.
A medical device comprising the negative pressure drainage device and a tissue engineering skin construction kit as described above, for example, see patent CN 206103015U.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (9)
1. The composite sponge is characterized by being prepared from the following raw materials in parts by mass:
1-3% of alginate ester, wherein the esterification degree of the alginate ester is 10-25%;
10-20% of polyvinyl alcohol;
0.3 to 0.5 percent of foaming agent;
0.5 to 1.0 percent of surfactant;
13-18% of a cross-linking agent;
6-10% of an acid catalyst;
47.5 to 69.2 percent of deionized water.
2. The composite sponge according to claim 1, wherein the alginate is at least one of polyethylene glycol alginate, lauryl alginate, octyl alginate, propylene glycol alginate, cetyl alginate.
3. The composite sponge according to claim 1, wherein the degree of alcoholysis of the polyvinyl alcohol is from 85 to 99%.
4. The composite sponge as claimed in claim 1, wherein the polyvinyl alcohol has an average molecular weight of 110000-.
5. A method of making a composite sponge according to any one of claims 1 to 4, comprising the steps of:
s1: taking alginate, polyvinyl alcohol and deionized water, heating to 70-100 ℃, and mixing to obtain a system A;
s2: adding a foaming agent and a surfactant into the system A, and mixing to obtain a system B;
s3: cooling the system B to 45-55 ℃, adding a cross-linking agent, and mixing to obtain a system C;
s4: cooling the system C to 35-45 ℃, adding an acid catalyst, and mixing to obtain a system D;
s5: and (3) carrying out crosslinking reaction on the system D at the temperature of 40-90 ℃ for 5-10h, and cooling.
6. The preparation method of the composite sponge as claimed in claim 5, wherein S1 is specifically:
uniformly mixing the alginate, the polyvinyl alcohol and the deionized water, and heating to 70-100 ℃ to completely dissolve the alginate and the polyvinyl alcohol to obtain a system A;
or
Mixing the alginate and the deionized water, heating to 70-100 ℃ to obtain a first solution, mixing the polyvinyl alcohol and the deionized water, heating to 70-100 ℃ to obtain a second solution, and mixing the first solution and the second solution to obtain a system A;
Any one of the above.
7. A negative pressure drainage dressing comprising the composite sponge of any one of claims 1 to 4.
8. A negative pressure drainage device comprising the composite sponge according to any one of claims 1 to 4.
9. A medical device comprising the composite sponge of any one of claims 1 to 4.
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| JP3097247B2 (en) * | 1991-12-18 | 2000-10-10 | 堺化学工業株式会社 | Alginate / thrombin immobilized product, its production method and hemostatic agent |
| CN101445636A (en) * | 2009-01-04 | 2009-06-03 | 武汉理工大学 | A sodium alginate and polyvinyl alcohol compound sponges material and preparation method thereof |
| CN102093657B (en) * | 2010-12-13 | 2013-10-16 | 谭明宁 | Cellulose ether modified polyvinyl formal sponge and preparation method thereof |
| US8557270B2 (en) * | 2011-01-12 | 2013-10-15 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Interconnected porous non-degradable poly(vinyl) alcohol implant and method of manufacture |
| US9381269B2 (en) * | 2011-04-13 | 2016-07-05 | Avent, Inc. | Biosorbable wound treatment device, process for making, and method of using the same |
| CN103130912B (en) * | 2011-12-02 | 2015-08-12 | 江南大学 | Single stage method prepares covalent cross-linking and hydrophobically modified Sodium Alginate Hydrogel Films |
| CN102828285A (en) * | 2012-09-13 | 2012-12-19 | 青岛明月生物医用材料有限公司 | Alginate fiber as well as preparation method and application thereof |
| CN103012859B (en) * | 2012-12-19 | 2015-04-15 | 青岛明月生物医用材料有限公司 | Chitosan and propylene glycol alginate blending material as well as preparation method and application thereof |
| CN103627010A (en) * | 2013-11-18 | 2014-03-12 | 戴建英 | Preparation method of amide alginate medical dressing |
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