CN107982331A - A kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland - Google Patents
A kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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Abstract
The present invention relates to the Chinese medicine preparation essential oil of the external curing proliferation of mammary gland, can effectively solve the problems, such as the treatment medication of the proliferation of mammary gland, its technical solution solved is, by weight ratio meter：The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=（2.5‑3.5）︰（2.5‑3.5）︰（1.8‑2.2）︰（0.8‑1.2）Mixing is made, abundant raw material of the present invention, prepared by easily production, easy to use, effect is good, can be effectively used for the treatment proliferation of mammary gland, it is the innovation treated on proliferation of mammary gland medicine, it is notable has opened up radix glycyrrhizae, peach blossom, safflower, the medical value of Mentholum and economic value, economic and social benefit.
Description
Technical field
The present invention relates to medicine, the particularly a kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland (also known as pink grass essence
Oil).
Background technology
Cyclomastopathy is that the proliferation of mammary gland refers to breast epithelium and proliferation of fibrous tissue, and breast tissue conduit and newborn leaflet exist
The growth of retrogression pathological changes and progressive connective tissue in structure, its pathogenic factor are lacked of proper care mainly due to endocrine hormone.
Cyclomastopathy is the most common breast disease of women, its incidence accounts for the first place of mammary gland disease.The disease incidence in recent years
In the trend risen year by year, the age also increasingly becomes younger.There are about according to investigations 70%~80% women have it is different degrees of
The proliferation of mammary gland, is more common in the women of 25~45 years old.
Clinical manifestation is, has a different characteristics in age groups, unmarried female, it is married do not educate, the women of not yet lactation, its
Cardinal symptom is distending pain of the breast, can involve bilateral at the same time, but laid particular stress on more with side.Distending pain of the breast is obvious before menstruation, after menstruation
To see and mitigate and taper off, pain occurs once again before next menstruation comes, and whole breast has diffusivity tubercle sense, and with tactile
Bitterly.Women's cardinal symptom is breast lump after 35 years old, and breast pain and tenderness are lighter and unrelated with the menstrual cycle.Breast is touched with hand
Room can touch differ in size, oblate or irregular shape, quality flexible tubercle, obscure boundary Chu, with skin and deep tissue
Without adhesion, can be promoted.The single or multiple Cystic lesions being dispersed in often are shown as after 45 years old, clear border, more with blunt pain,
Distending pain or burn feeling.Postmenopausal women's mammary gland atrophy, cystic lesion are more prominent.The order of severity and tubercle of breast pain
The presence or absence of and scope non-correlation, pain can be diffused to oxter, shoulder back.Small number of patients can occur together nipple discharge.Due to the cause of disease
From body endocrine dysfunction, therefore at the same time it may also occur that menstruation irregularis, has a bad temper in addition to the symptom in terms of breast, love
Worry the symptoms such as love is angry, love is perspired.Though the existing multi-medicament for having the treatment proliferation of mammary gland, for various reasons, it is using simultaneously
Unsatisfactory, therefore, the improvement and innovation on treatment proliferation of mammary gland medicine are imperative.
The content of the invention
For the above situation, to overcome the defect of the prior art, the purpose of the present invention is just to provide a kind of external curing breast
The Chinese medicine preparation essential oil of gland hyperplasia, can effectively solve the problems, such as the treatment medication of the proliferation of mammary gland.
The technical solution that the present invention solves is that a kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland, is by weight ratio
Meter：The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=(2.5-3.5) ︰ (2.5-3.5) ︰ (1.8-2.2) ︰ (0.8-
1.2) mix and be made, wherein：
The radix glycyrrhizae essential oil is that radix glycyrrhizae was ground into the coarse powder of 10~20 mesh sieves, is measured for 0.5-1.5 times in medicinal material weight
Ethanol, any one or two or more in the mixed solvents infiltration 2min~4min in ethyl acetate or hexamethylene, take profit
Wet medicinal material, supercritical CO2Fluid extraction (SFE), 42~50 DEG C, 20~25MPa of extracting pressure of extraction temperature, separation temperature 50
~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time, obtains radix glycyrrhizae essential oil；
The peach blossom essential oil is that peach blossom crushed to the coarse powder of 10~20 mesh sieves, is measured in 0.5-1.5 times of medicinal material weight
Any one in ethanol, ethyl acetate or hexamethylene or two or more in the mixed solvents infiltration 2min~4min, take wetting
Medicinal material, supercritical CO2Fluid extraction (SFE), 42~50 DEG C, 20~25MPa of extracting pressure of extraction temperature, separation temperature 50~
60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time, obtains peach blossom essential oil；
The safflower essential oil is that safflower crushed to the coarse powder of 10~20 mesh sieves, is measured in 0.5-1.5 times of medicinal material weight
Any one in ethanol, ethyl acetate or hexamethylene or two or more in the mixed solvents infiltration 2min~4min, take wetting
Medicinal material, supercritical CO2Fluid extraction (SFE), 42~50 DEG C, 20~25MPa of extracting pressure of extraction temperature, separation temperature 50~
60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time, obtains safflower essential oil.
Prepared by abundant raw material of the present invention, easily production, easy to use, effect is good, can be effectively used for the treatment proliferation of mammary gland, is to control
Treat the innovation on proliferation of mammary gland medicine, opened up radix glycyrrhizae, peach blossom, safflower, the medical value of Mentholum and economic value, it is economical and
Social benefit is notable.
Embodiment
Elaborate with reference to embodiments to the embodiment of the present invention.
The present invention can be provided by following embodiments in specific implementation.
Embodiment 1
In specific implementation, a kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland, is by weight ratio meter to the present invention：
The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=3 ︰, 3 ︰, 2 ︰ 1 are mixed and are made.
The radix glycyrrhizae essential oil, peach blossom essential oil, the same content of the invention of safflower essential oil, it is the same below.
Embodiment 2
In specific implementation, a kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland, is by weight ratio meter to the present invention：
The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=2.6 ︰, 3.4 ︰, 1.9 ︰ 1.1 are mixed and are made.
Embodiment 3
In specific implementation, a kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland, is by weight ratio meter to the present invention：
The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=3.4 ︰, 2.6 ︰, 2.1 ︰ 0.9 are mixed and are made.
Organic cooperation between instant component, mutually support, effective for treat the proliferation of mammary gland, and through experiment achieve it is non-
Often satisfied advantageous effects, related testing data are as follows：
First, influence of the pink careless essential oil of the present invention to proliferation of mammary gland mouse model
1. experiment material
1.1 medication medication
Essential oil (also known as pink careless essential oil) of the present invention；Estradiol benzoate injection, the production of Hangzhou animal drug factory；Olive
Oil, Euro-China Natural Food Co., Ltd.'s production.
1.2 experimental animal
18-22g female mices, KM, SPF, Shandong Province's Experimental Animal Center provide, the certification of fitness
NO.37009200006989。
2. experimental method
2.1 modelings and experimental method
20-22g female mices are taken, normal raising, after adapting to environment, takes 10 mouse as blank group not modeling at random,
Separately take mouse to make hyperplasia of mammary gland model, dilute (1 with olive oil:9) estradiol benzoate injection (0.5mg/kg), abdominal cavity note
Penetrate, 1 time every other day, until experiment terminates.Modeling the 4th day, selects existing nipple blush, the mouse 30 of protuberance, is randomly divided into 3 groups,
Respectively model group, (small dose group is diluted the pink careless essential oil group of large and small dosage for heavy dose of pink careless essential oil with atoleine
One).Pink careless essential oil group morning and evening each coating 1 time daily of large and small dosage, dosage is about at 0.03ml/, and model group is given with dosage
Atoleine, continuous 30d.
2.2 detection project
(1) detection of mouse weight：After modeling and medication are intervened, the weekly weight for weighing each group mouse.
(2) detection of mouse mammary appearance：Medication uses weekly each mouse second of vernier caliper measurement to breast after intervening
Papilla diameter, observes breast color and size.
(3) in after the last administration, eye socket takes blood, places 30min, 4 000rmin-1 centrifugation 5min, take serum, by examination
The level of agent box specification method serum measured by radioimmunoassay E2, P.
(4) the 2nd pair of complete breast is removed again, is fixed with 10% formalin, conventional film-making, HE dyeing, Microscopic observation point
Analyse the breast tissue situations such as leaflet acinus, Epithelial hyperplasia.
2.3 statistical method
Experimental data carries out statistical procedures with SPSS21.0 statistical softwares, and statistical method is variance analysis, data withRepresent, comparison among groups is examined using t, and P ＜ 0.01 have significant difference, and P ＜ 0.05 have notable difference.
1 proliferation of mammary gland lesion ranking criterion of table
3 experimental results
Influence of the 3.1 pink careless essential oils to hyperplasia of mammary gland model mouse weight
Influence of the pink careless essential oil of table 2 to proliferation of mammary gland mouse weight
Note：The * * P compared with model group<0.01, * P<0.05
After mouse injection oestradiol benzoate, weight gain, with blank group ratio, model group mouse weight substantially increases (P<
0.05)；With model group ratio, pink grass essential oil heavy dose group can make mouse weight significantly reduce (P<0.01), pink careless essential oil is big
Dosage group can make mouse weight substantially reduce (P<0.01).
Influence of the 4.2 pink careless essential oils to hyperplasia of mammary gland model mouse papilla diameter and height of nipples
Influence of the pink careless essential oil of table 3 to mammary gland of mouse model of hyperplasia papilla diameter
Note：The * * P compared with model group<0.01
With blank group ratio, after model group injects oestradiol benzoate, papilla diameter and highly significant increase, increase (P<
0.01).With model group ratio, the pink grass large and small dosage group of essential oil can be substantially reduced model mice papilla diameter and height of nipples
(P<0.01)。
Influence of the 4.3 pink careless essential oils to hyperplasia of mammary gland model mice serum estradiol, progesterone level
The pink careless essential oil of table 4 is to hyperplasia of mammary gland model mice serum E2, P levels influence
Note：The * * P compared with model group<0.01
With blank group ratio, estradiol level conspicuousness rise (P in model group mice serum<0.01), progesterone level is notable
Property reduce (P<0.01), illustrate that model is successfully prepared；With model group ratio, the pink grass large and small dosage group of essential oil can significantly reduce
Proliferation of mammary gland mice serum E2Level (P<0.01) blood-serum P level (P, is dramatically increased<0.01).
Influence of the 4.4 pink careless essential oils to hyperplasia of mammary gland model mammary gland of mouse tissue morphology
Influence of the pink careless essential oil of table 5 to hyperplasia of mammary gland model mammary gland of mouse tissue
Note：The * * P compared with model group<0.01
With blank group ratio, model group mammary gland of mouse hyperplasia integration significantly rise (P<0.01), illustrate that model is successfully prepared；With
Model group ratio, the pink grass large and small dosage group of essential oil can significantly reduce mammary gland of mouse hyperplasia integration (P<0.01).
Each group breast tissue form：Blank group is resting mammary gland, and no proliferative lesion, acinus is few, and acinar epithelia is in single
Layer cube, lumen of gland have no lymphocytic infiltration phenomenon without expansion, no epithelial hyperplasia, conduit without secretion；Model group gland
The obvious expansion of bubble, acinus luminal sectetion increase and have exuviation, relatively have significant difference with blank group；Pink grass essential oil
Heavy dose group acinus is slightly expanded, and secretion is less, simple cuboidal epithelium, and fibrous connective tissue is without obvious hyperplasia, accidental lymph
Cell；Pink grass essential oil low dose alveolar lumen is slightly expanded, and intracavitary has a little secretion, leaflet showed increased, hyperplasia unobvious,
There are secretion, accidental lymphocyte.
The result shows that the pink careless essential oil external application of the present invention, the therapeutic effect having had to mammary gland of mouse model of hyperplasia.
The present invention through testing repeatedly, achieve it is same or like as a result, show that curative effect of medication is reliable and stable, and pass through
Clinical trial has obtained further proof.
2nd, pink careless essential oil 58 proliferation of mammary gland clinical observations of external curing
1. general information：58 are out-patient, and no Pregnant Patients, are married；Age is 26 years old minimum, maximum 44
In year, be more with 28 years old~35 years old；The course of disease is most 2 months short, most 3 years long, is more with 1~2 year；Bilateral breast hyperplasia 44, it is unilateral
The proliferation of mammary gland 8.It is swollen breasts, and is radiated to oxter, no redness, and it is more related with menstruation or feelings will；Lump is in mostly
Oval tubercle is streak, removable.Wherein treatment group 30, control group 28.Two groups of ages, the state of an illness are without obvious poor
It is different.
2. diagnostic criteria：1. mammary gland side or bilateral pain or distending pain, pain often aggravates before menstruation in the moon.2. there is bar in mammary gland
Strand, nodositas lump, are often increasing, are being hardened, softening after before menstruation.3. exclude tumour and inflammatory lesion.
3. therapeutic scheme
Treatment group is applied with pink careless essential oil outside proliferation of mammary gland part, each dosage about 0.05mL/cm2, it is outer 3 times a day
With auxiliary part massage.It is 1 course for the treatment of that 14d, which is used in conjunction,.The 2nd course of therapy is carried out again in the 14th~28 day menstrual cycle next time.2
The course for the treatment of terminates evaluation result.
Control group anti-inflammatory analgesic cream, the production of Guangzhou Sanitary Materials Factory, external application, sticks 12h, is aided in after removing applicator
Part massage, it is 1 course for the treatment of that 14d, which is used in conjunction,.The second course of therapy is carried out again in the 14th~28 day menstrual cycle next time.
Criterion of therapeutical effect：Learn second of mammary gland disease Society view standard determination with reference to traditional Chinese medical science Quan Ke.Cure:Mammary gland pain
Disappear with lump, stop treatment 3 months without recurrence；It is effective：Breast lump reduces more than 1/2, and pain substantially mitigates；Effectively：Breast
Gland mass reduction 1/3, pain relief；It is invalid：After 3 course for the treatment of symptoms, signs for the treatment of are unchanged, or pain is slightly alleviated and recur.
4. treatment results
Treatment group 30, healing 10, effective 15, effective 3, invalid 2, cure rate 33.3%, total effective rate
93.3%.
Control group 28, effective 2, effective 19, invalid 8, cure rate 0%, total effective rate 71.4%.
In above-mentioned experiment, any toxic side effect and adverse reaction are found no, shows drug safety, curative effect is stablized can
Lean on.
Clearly shown by above-mentioned data, abundant raw material of the present invention, prepared by easily production, easy to use, has very to the proliferation of mammary gland
Good therapeutic effect, and high efficiency up to more than 93%, do not expect, not only solves by the original of getting well of its effect by clinic application
The medication problem for the treatment proliferation of mammary gland of having determined, and opened up radix glycyrrhizae, peach blossom, safflower, the medical value of Mentholum and economic valency
Value, is the innovation treated on proliferation of mammary gland medicine, and economic and social benefit is notable.
Claims (5)
1. a kind of Chinese medicine preparation essential oil of the external curing proliferation of mammary gland, it is characterised in that by weight ratio meter：Licorice You ︰ peaches
The red flower essential oil ︰ Mentholums of anthosin oil ︰=（2.5-3.5）︰（2.5-3.5）︰（1.8-2.2）︰（0.8-1.2）Mixing is made, wherein：
The radix glycyrrhizae essential oil is that radix glycyrrhizae was ground into the coarse powder of 10~20 mesh sieves, in 0.5-1.5 times of second measured of medicinal material weight
Any one in alcohol, ethyl acetate or hexamethylene or two or more in the mixed solvents infiltration 2min~4min, take wetting
Medicinal material, supercritical CO2Fluid extraction, 42~50 DEG C, 20~25MPa of extracting pressure of extraction temperature, 50~60 DEG C of separation temperature,
4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time, obtains radix glycyrrhizae essential oil；
The peach blossom essential oil is that peach blossom crushed to the coarse powder of 10~20 mesh sieves, in 0.5-1.5 times of second measured of medicinal material weight
Any one in alcohol, ethyl acetate or hexamethylene or two or more in the mixed solvents infiltration 2min~4min, take wetting
Medicinal material, supercritical CO2Fluid extraction, 42~50 DEG C, 20~25MPa of extracting pressure of extraction temperature, 50~60 DEG C of separation temperature,
4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time, obtains peach blossom essential oil；
The safflower essential oil is that safflower crushed to the coarse powder of 10~20 mesh sieves, in 0.5-1.5 times of second measured of medicinal material weight
Any one in alcohol, ethyl acetate or hexamethylene or two or more in the mixed solvents infiltration 2min~4min, take wetting
Medicinal material, supercritical CO2Fluid extraction, 42~50 DEG C, 20~25MPa of extracting pressure of extraction temperature, 50~60 DEG C of separation temperature,
4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time, obtains safflower essential oil.
2. the Chinese medicine preparation essential oil of the external curing proliferation of mammary gland according to claim 1, it is characterised in that by the weight
Than meter：The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=3 ︰, 3 ︰, 2 ︰ 1 are mixed and are made.
3. the Chinese medicine preparation essential oil of the external curing proliferation of mammary gland according to claim 1, it is characterised in that by the weight
Than meter：The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=2.6 ︰, 3.4 ︰, 1.9 ︰ 1.1 are mixed and are made.
4. the Chinese medicine preparation essential oil of the external curing proliferation of mammary gland according to claim 1, it is characterised in that by the weight
Than meter：The red flower essential oil ︰ Mentholums of licorice oil ︰ peach flower essential oils ︰=3.4 ︰, 2.6 ︰, 2.1 ︰ 0.9 are mixed and are made.
5. Chinese medicine preparation essential oil prepared by any one of claim 1 or 2-4 the method is in treatment proliferation of mammary gland medicine is prepared
Application.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010781A (en) * | 2018-10-17 | 2018-12-18 | 韦水秀 | A kind of activating microcirculation and removing stasis medicinal plants herb essential oil and preparation method thereof |
| CN109864932A (en) * | 2019-03-28 | 2019-06-11 | 江西登云健康美业互联有限公司 | A kind of frost with the effect of releiving |
| CN114432187A (en) * | 2020-11-03 | 2022-05-06 | 北京东方淼森生物科技有限公司 | Preparation method of peach blossom oil and application of peach blossom oil in cosmetics |
-
2017
- 2017-12-25 CN CN201711421783.0A patent/CN107982331B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010781A (en) * | 2018-10-17 | 2018-12-18 | 韦水秀 | A kind of activating microcirculation and removing stasis medicinal plants herb essential oil and preparation method thereof |
| CN109864932A (en) * | 2019-03-28 | 2019-06-11 | 江西登云健康美业互联有限公司 | A kind of frost with the effect of releiving |
| CN114432187A (en) * | 2020-11-03 | 2022-05-06 | 北京东方淼森生物科技有限公司 | Preparation method of peach blossom oil and application of peach blossom oil in cosmetics |
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|---|---|
| CN107982331B (en) | 2020-09-04 |
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