CN107951036A - A kind of polypeptide product - Google Patents
A kind of polypeptide product Download PDFInfo
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- CN107951036A CN107951036A CN201711111099.2A CN201711111099A CN107951036A CN 107951036 A CN107951036 A CN 107951036A CN 201711111099 A CN201711111099 A CN 201711111099A CN 107951036 A CN107951036 A CN 107951036A
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- 229920001184 polypeptide Polymers 0.000 title claims abstract description 73
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- 210000000582 semen Anatomy 0.000 claims abstract description 21
- 241000202807 Glycyrrhiza Species 0.000 claims abstract description 18
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 18
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- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 18
- 229940010454 licorice Drugs 0.000 claims abstract description 18
- 235000020717 hawthorn extract Nutrition 0.000 claims abstract description 16
- 241001415306 Cryptobranchidae Species 0.000 claims description 20
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- 241001465754 Metazoa Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
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- 239000004480 active ingredient Substances 0.000 description 2
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- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
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- 102000002322 Egg Proteins Human genes 0.000 description 1
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- 229910021529 ammonia Inorganic materials 0.000 description 1
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- 210000000969 egg white Anatomy 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
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- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- 230000003285 pharmacodynamic effect Effects 0.000 description 1
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- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
A kind of polypeptide product of the present invention, it is characterised in that the polypeptide product includes Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, haw thorn extract, Semen Phaseoli extract, Fructus lycii P.E and licorice, and the percentage by weight of each component is：Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide 20%~80%, haw thorn extract 5%~20%, Semen Phaseoli extract 5%~20%, Fructus lycii P.E 5%~20%, licorice 5%~20%.The present invention have chosen the polypeptide of small-molecular-weight, be more conducive to the absorption of human body.Polypeptide reasonable mixture ratio, after haw thorn extract, Semen Phaseoli extract, Fructus lycii P.E and licorice being added in Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, each component obvious synergy, can play strengthen immunity, the effect to slow down aging, have significant immunological enhancement；And it is this polypeptide color and luster, in good taste, it is normal edible to bring harm and toxic side effect to body；While formulation product production technology is safe and simple, strong operability.
Description
Technical field
The present invention relates to heath-function field of food, more particularly to a kind of production that polypeptide is extracted from Megalobatrachus japonicus daoidianuas(Blanchard)
Product.
Background technology
It is well known that giant salamander has very abundant nutritive value, contain protein, lipid, amino acid, trace element etc.
Nutritional ingredient and metallothionein, collagen, epidermis activity bleach the multiple functions factor such as the factor and poly glycopeptide.It is rich in meat
Containing zinc, ω -3 and ω -6 type polyunsaturated fatty acids, the protein and amino acid classes of meat are various and abundant, and total amount reaches
91.92%, nutritive value is high.According to《Western pool addendum》Record, the meat of giant salamander can also improve breathes hard, to alleviate body tired
Labor.As it can be seen that the nutritive value of giant salamander is high, pharmacodynamic feature is unique, can alleviate physical fatigue, improve the function and health of body
It is horizontal.
Megalobatrachus japonicus daoidianuas(Blanchard) protein peptide powder is prepared by using biological enzymolysis technology, it contains the ammonia that a variety of human bodies can not synthesize
Base acid, is the raw material of histocyte reparation, and often appropriate supplement giant salamander protein peptide powder, helps to strengthen each tissue organ function,
Body immunity, repair cell and organelle film are lifted, adjusts neuroendocrine, improves organismic internal environment, boosts metabolism
Deng, it is widely used in anti-osteoporosis, improves articulation health, medical treatment rheumatism, rheumatoid, ankylosing spondylitis, smoothing wrinkle removes acne scar,
Skin moisture-keeping protects elasticity, and fat-reducing body-building, improves the immunity of the human body, and repairs metabolic impairment, adjusts the decompression of blood fat hypoglycemic and anti-ageing guarantor
It is good for.It is a discovery of the invention that although the processing to giant salamander and study of active components have certain report now, not yet find to utilize
Product is made as active ingredient in giant salamander polypeptide and other traditional Chinese medicine ingredients such as hawthorn, rde bean, the fruit of Chinese wolfberry, radix glycyrrhizae etc.
Report, is especially made health food jointly by above-mentioned active ingredient, for strengthen immunity, the research to slow down aging report.
The content of the invention
To solve the above-mentioned problems, the technical problems to be solved by the invention are to provide a kind of with immunological enhancement
Polypeptide product, relies on medicinal animal specific to China --- giant salamander, the two thing thinking formulas based on " animal+plant "
Design concept, by combining integration of drinking and medicinal herbs Chinese medicine, designs a set of new compositions that can alleviate physiologic fatigability, for delaying
Solve the symptom of physiologic fatigability and its adjoint hypoimmunity.Pass through the weight to polypeptide and several integration of drinking and medicinal herbs kinds
New proportioning, not only improves the strengthen immunity effect of polypeptide, while improves human body environment, improves each component in human body
Absorptivity, so as to reach anti-aging, the effect for keeping fit and healthy, building up resistance.
To achieve these goals, the present invention provides a kind of polypeptide product, it is characterised in that the polypeptide
Product includes Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, haw thorn extract, Semen Phaseoli extract, Fructus lycii P.E and licorice, described
The percentage by weight of each component is：Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide 20%~80%, haw thorn extract 5%~20%, rde bean extraction
Thing 5%~20%, Fructus lycii P.E 5%~20%, licorice 5%~20%.
Further, the average molecular weight of the polypeptide product is 800~4000Da.
Further, the polypeptide product can also include jujube, Semen sesami nigrum, chrysanthemum, oyster, mulberries, peach kernel,
One or more in coix seed, Chinese yam.
Further, giant salamander polypeptide source used is the one or more in Megalobatrachus japonicus daoidianuas(Blanchard), giant salamander skin, Giant salamander bone.
Further, the polypeptide product includes the Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide of percentage by weight 60%, weight percent
The Semen Phaseoli extract of haw thorn extract, percentage by weight 10% than 10%, the Fructus lycii P.E of percentage by weight 10%,
The licorice of percentage by weight 10%.
Further, the polypeptide product includes the Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide of percentage by weight 80%, weight percent
The Semen Phaseoli extract of haw thorn extract, percentage by weight 5% than 5%, the Fructus lycii P.E of percentage by weight 5%, again
Measure the licorice of percentage 5%.
Further, the polypeptide product is solid pharmaceutical preparation form.
Further, the polypeptide product is solid beverage, pressed candy or capsule form.
Further, the polypeptide product is conventional liquid preparation form.
Further, the polypeptide product is beverage or oral liquid form.
The present invention has the following advantages relative to the prior art：
The polypeptide of small-molecular-weight is have chosen, is more conducive to the absorption of human body.Polypeptide reasonable mixture ratio, in giant salamander
After haw thorn extract, Semen Phaseoli extract, Fructus lycii P.E and licorice being added in meat albumen polypeptide, and to each component
Rational proportion, each component obvious synergy, can play strengthen immunity, the effect to slow down aging, have significant
Immunological enhancement；And it is this polypeptide color and luster, in good taste, it is normal edible to bring harm and toxic side effect to body；Together
When formulation product production technology is safe and simple, strong operability, can not only obtain good economic benefit, but also with significant
Social benefit.
Embodiment
Below by way of specific embodiment further illustrate the present invention, but following embodiments be merely to illustrate the present invention rather than
For limiting the present invention.Experimental method in following embodiments, is conventional method unless otherwise specified.It is used in embodiment
Raw material, reagent material etc., unless otherwise specified, be commercially available products.
Polypeptide product disclosed by the invention with immunological enhancement, mainly comprising Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, mountain
Short, bristly hair or beard extract, Semen Phaseoli extract, Fructus lycii P.E and licorice, the percentage by weight of each component are：Megalobatrachus japonicus daoidianuas(Blanchard) egg
White polypeptide 20%~80%, haw thorn extract 5%~20%, Semen Phaseoli extract 5%~20%, Fructus lycii P.E 5%~
20%th, licorice 5%~20%.
The average molecular weight of the polypeptide product is 800~4000Da.The polypeptide product can also include
One or more in jujube, Semen sesami nigrum, chrysanthemum, oyster, mulberries, peach kernel, coix seed, Chinese yam.
Giant salamander polypeptide source used can be the one or more in Megalobatrachus japonicus daoidianuas(Blanchard), giant salamander skin, Giant salamander bone.
The polypeptide product can be any type in conventional solid pharmaceutical preparation form, such as solid beverage, pressed candy
Fruit, capsule；But also any type in Common liquid formulations form, such as beverage, oral liquid.
Embodiment one：Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide (Protein Peptide Powder of giant Salamander
Meat, PPPSM) strengthen immunity experiment
Experimental method
1. packet is weighed
Healthy KM mouse 60,20 ± 2g of weight, half male and half female, is divided into two big group.Each big group is divided into blank control
Group, positive controls, PPPSM various dose groups, each dosage group six, each 3 of male and female, separately raising, record of weighing.
2. dosage selects
Positive control group selection soybean separation protein white powder (Isolated Soy Protein Powder, ISPP)：(according to
Knowable to the composition situation analysis that physiologic fatigability and the protide health food of strengthen immunity can be alleviated, soybean protein isolate
Powder is often the primary raw material in such product compatibility, and the performance for such effect plays the role of more important.Therefore, may be used
Itself and Megalobatrachus japonicus daoidianuas(Blanchard) protein peptide powder are compared into efficacy assessments), it is 10g that general human body recommends dose daily.It is daily according to human body
5,10 and 15 times of setting 1g/kgd, 2g/kgd and 3g/kgd tri- dosage groups of PPPSM of taking dose.
3. gastric infusion
Tri- dosage groups of PPPSM, are administered according to setting dosage respectively, positive controls according to 3g/kgd gavage ISPP,
According to mouse weight gavage 0.2ml/20g, blank control group gavage physiological saline, once a day, continuous 30 days.
Carbonic clearance is tested
Before last dose, the mouse organized greatly to first carries out secondary weighing record, afterwards last dose.1h after administration, tail
The carbon black ink (0.05ml/10g) of intravenous injection 20%.2,12 minutes eye sockets take 20 μ L of blood respectively, are added to containing 2mL 0.1%
Shaken up in Na2CO3 solution E P pipes.Mouse is put to death, it is sterile to take spleen, thymus gland, liver, weigh, calculate body increasing, organ index.With
Spectrophotometer (λ=680nm) measure absorbance (OD2 and OD12), calculates carbonic clearance index K and phagocytic index α.
K=(lgOD2-lgOD12)/(t2-t1)
4. result
Table 1PPPSM to the influence analysis of results table of mouse carbonic clearance index and phagocytic index (N=6)
| Packet | Carbonic clearance index K | Phagocytic index α |
| Blank group | 0.0055±0.0008 | 3.7400±0.0361 |
| ISPP groups | 0.0074±0.0013 | 3.7480±0.0317 |
| 1g/kgd PPPSM groups | 0.0068±0.0009 | 3.7360±0.0292 |
| 2g/kgd PPPSM groups | 0.0071±0.0020 | 3.8940±0.0439* |
| 3g/kgd PPPSM groups | 0.0164±0.0031** | 4.4540±0.1678** |
*P<0.05,**P<0.01VS blank groups
As shown in Table 1, compared with blank group, the carbonic clearance index of 3g/kgd PPPSM groups significantly raises (P<0.05),
Mouse carbonic clearance index can significantly be raised by illustrating the PPPSM of 3g/kgd.As shown in Table 1, compared with blank group, 2g/kgd
(P is significantly raised with the phagocytic index of 3g/kgdPPPSM groups<0.05), illustrate that the PPPSM of 2g/kgd and 3g/kgd are equal
Mouse phagocytic index can be significantly raised, significantly increases nonspecific immunity of mice.Prompting Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide has
The effect of obvious enhancing immunity of organisms.
Embodiment two：The screening experiment of integration of drinking and medicinal herbs Chinese medicine strengthen immunity kind-dimethyl diaminophenazine chloride phagocytosis experiment
According to experimental result, acted on reference to pharmacology of Chinese materia medica, cell Proliferation can be obviously promoted and have potential by selecting 12 kinds
Chinese medicine (rde bean, jujube, radix glycyrrhizae, matrimony vine, Semen sesami nigrum, chrysanthemum, oyster, mulberries, peach kernel, hawthorn, the Job's tears of immunoloregulation function
Benevolence, Chinese yam), detect this influence of 12 kinds of integration of drinking and medicinal herbs Chinese medicines to RAW264.7 cell phagocytic activity.
2 integration of drinking and medicinal herbs Chinese medicine of table is to RAW264.7 cell dimethyl diaminophenazine chloride phagocytic rate analysis of results table
*P<0.05,**P<0.01,***P<0.001VS blank groups
As shown in Table 2, compared with blank group, rde bean group, radix glycyrrhizae group, matrimony vine group, Semen sesami nigrum group, oyster group, mulberries group,
The dimethyl diaminophenazine chloride phagocytic rate of hawthorn group, coix seed group and Chinese yam group RAW264.7 cells significantly raises (P<0.05), illustrate red small
Beans, radix glycyrrhizae, matrimony vine, Semen sesami nigrum, oyster, mulberries, hawthorn, coix seed and Chinese yam can improve the neutrality of RAW264.7 cells
Red phagocytic rate, has the effect for significantly increasing RAW264.7 cell phagocytic activity, it was demonstrated that has enhancing immunity of organisms effect.
Embodiment three
A kind of polypeptide product with immunological enhancement of the present embodiment is by weight percentage by 60% Megalobatrachus japonicus daoidianuas(Blanchard)
Polypeptide, 10% haw thorn extract, 10% Semen Phaseoli extract, 10% Fructus lycii P.E, 10% licorice composition.
Preparation method：By the Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide of formula ratio, haw thorn extract, Semen Phaseoli extract, fruit of Chinese wolfberry extraction
Thing, licorice, are mixed evenly, dispense to every bag of 10g, up to strengthen immunity solid beverage.
Example IV
A kind of polypeptide product with immunological enhancement of the present embodiment is by weight percentage by 80% Megalobatrachus japonicus daoidianuas(Blanchard)
Polypeptide, 5% haw thorn extract, 5% Semen Phaseoli extract, 5% Fructus lycii P.E, 5% licorice composition.
Preparation method：By the Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide of formula ratio, haw thorn extract, Semen Phaseoli extract, fruit of Chinese wolfberry extraction
Thing, licorice, are dosed in appropriate pure water and dissolve respectively, stir (time >=20min), with 200 mesh screens, it is filling,
Sterilizing (108 DEG C of insulation 30min), be distributed into every bottle of 10ml, up to strengthen immunity oral liquid.
The foregoing is only a preferred embodiment of the present invention, the numerical value and number mentioned in the description of description above
Value scope is not intended to limit the invention, and is simply provided preferred embodiment for the present invention, is not intended to limit the invention, right
For those skilled in the art, the invention may be variously modified and varied.Within the spirit and principles of the invention,
Any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of polypeptide product, it is characterised in that the polypeptide product includes Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, hawthorn is extracted
Thing, Semen Phaseoli extract, Fructus lycii P.E and licorice, the percentage by weight of each component are：Giant salamander meat albumen
Polypeptide 20%~80%, haw thorn extract 5%~20%, Semen Phaseoli extract 5%~20%, Fructus lycii P.E 5%~
20%th, licorice 5%~20%.
2. polypeptide product according to claim 1, it is characterised in that the average molecular weight of the polypeptide product
For 800~4000Da.
3. polypeptide product according to claim 1 or 2, it is characterised in that the polypeptide product can also wrap
Include the one or more in jujube, Semen sesami nigrum, chrysanthemum, oyster, mulberries, peach kernel, coix seed, Chinese yam.
4. polypeptide product according to claim 1, it is characterised in that giant salamander polypeptide source used is giant salamander
One or more in meat, giant salamander skin, Giant salamander bone.
5. polypeptide product according to claim 1, it is characterised in that the polypeptide product includes weight percent
The rde bean extraction of the haw thorn extract, percentage by weight 10% of Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, percentage by weight 10% than 60%
Thing, the Fructus lycii P.E of percentage by weight 10%, the licorice of percentage by weight 10%.
6. polypeptide product according to claim 1, it is characterised in that the polypeptide product includes weight percent
The haw thorn extract of Megalobatrachus japonicus daoidianuas(Blanchard) polypeptide, percentage by weight 5% than 80%, the Semen Phaseoli extract of percentage by weight 5%,
Fructus lycii P.E, the licorice of percentage by weight 5% of percentage by weight 5%.
7. polypeptide product according to claim 1, it is characterised in that the polypeptide product is solid pharmaceutical preparation shape
State.
8. polypeptide product according to claim 7, it is characterised in that the polypeptide product be solid beverage,
Pressed candy or capsule form.
9. polypeptide product according to claim 1, it is characterised in that the polypeptide product is conventional liquid
Dosage form.
10. polypeptide product according to claim 9, it is characterised in that the polypeptide product is beverage or mouth
Take liquid form.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381366A (en) * | 2018-11-12 | 2019-02-26 | 汉中市汉鲵食品加工有限公司 | Edible face pack and preparation method thereof |
| CN109997944A (en) * | 2019-04-19 | 2019-07-12 | 吉林省东鳌鹿业科技开发有限公司 | A kind of deer tire polypeptide pressed candy and preparation method thereof |
| CN110432498A (en) * | 2019-09-03 | 2019-11-12 | 湖北世厚耀榜纪田农业发展有限公司 | A kind of giant salamander protein peptides health-preserving capsule and preparation method thereof |
| CN113925172A (en) * | 2021-11-16 | 2022-01-14 | 陕西语泽生物医药有限公司 | Giant salamander peptide nutritional composition suitable for children |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101720933A (en) * | 2009-12-14 | 2010-06-09 | 张家界金鲵生物科技有限公司 | Giant salamander functional food with immune regulation action and preparation method thereof |
| CN105018555A (en) * | 2015-08-06 | 2015-11-04 | 重庆馗丰食品有限公司 | Preparation method of giant salamander skin collagen peptide |
| CN106047968A (en) * | 2016-05-13 | 2016-10-26 | 张家界（中国）金驰大鲵生物科技有限公司 | Giant salamander active peptide and application |
| CN106107397A (en) * | 2016-06-27 | 2016-11-16 | 张博 | A kind of Andrias davidianus Blanchard protein peptide powder solid beverage formula and preparation method thereof |
| CN106562413A (en) * | 2016-10-17 | 2017-04-19 | 武汉龙族药号生物医药科技有限公司 | Oral thick paste for immunity enhancement and preparation method thereof |
-
2017
- 2017-11-13 CN CN201711111099.2A patent/CN107951036A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101720933A (en) * | 2009-12-14 | 2010-06-09 | 张家界金鲵生物科技有限公司 | Giant salamander functional food with immune regulation action and preparation method thereof |
| CN105018555A (en) * | 2015-08-06 | 2015-11-04 | 重庆馗丰食品有限公司 | Preparation method of giant salamander skin collagen peptide |
| CN106047968A (en) * | 2016-05-13 | 2016-10-26 | 张家界（中国）金驰大鲵生物科技有限公司 | Giant salamander active peptide and application |
| CN106107397A (en) * | 2016-06-27 | 2016-11-16 | 张博 | A kind of Andrias davidianus Blanchard protein peptide powder solid beverage formula and preparation method thereof |
| CN106562413A (en) * | 2016-10-17 | 2017-04-19 | 武汉龙族药号生物医药科技有限公司 | Oral thick paste for immunity enhancement and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381366A (en) * | 2018-11-12 | 2019-02-26 | 汉中市汉鲵食品加工有限公司 | Edible face pack and preparation method thereof |
| CN109997944A (en) * | 2019-04-19 | 2019-07-12 | 吉林省东鳌鹿业科技开发有限公司 | A kind of deer tire polypeptide pressed candy and preparation method thereof |
| CN110432498A (en) * | 2019-09-03 | 2019-11-12 | 湖北世厚耀榜纪田农业发展有限公司 | A kind of giant salamander protein peptides health-preserving capsule and preparation method thereof |
| CN113925172A (en) * | 2021-11-16 | 2022-01-14 | 陕西语泽生物医药有限公司 | Giant salamander peptide nutritional composition suitable for children |
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