CN107814789B8 - 一种达卡他韦起始原料的合成方法 - Google Patents

一种达卡他韦起始原料的合成方法 Download PDF

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Publication number
CN107814789B8
CN107814789B8 CN201711207599.6A CN201711207599A CN107814789B8 CN 107814789 B8 CN107814789 B8 CN 107814789B8 CN 201711207599 A CN201711207599 A CN 201711207599A CN 107814789 B8 CN107814789 B8 CN 107814789B8
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daclatasvir
starting material
formula
synthesizing
reacting
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CN107814789B (zh
CN107814789A (zh
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游新雨
陶鑫
韩加齐
史鹤峰
季翔
罗安贸
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CHANGZHOU YINSHENG PHARMACEUTICAL CO LTD
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CHANGZHOU YINSHENG PHARMACEUTICAL CO LTD
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Priority to CN202011464085.0A priority patent/CN112409336B/zh
Priority to CN202011462952.7A priority patent/CN112480084B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种达卡他韦起始原料的合成方法，如式Ⅰ所示的2，4’-二溴苯乙酮、如式Ⅱ所示的L-BOC-脯氨酸、碳酸钾和甲苯，反应生成如式Ⅲ所示的中间产物，如式Ⅲ所示的中间产物与乙酸铵反应生成如式Ⅳ所示的化合物。本发明的达卡他韦起始原料的合成方法反应路线简单、原料成本较低，适于工业化生产。
CN201711207599.6A 2017-11-27 2017-11-27 一种达卡他韦起始原料的合成方法 Active CN107814789B8 (zh)

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CN201711207599.6A CN107814789B8 (zh) 2017-11-27 2017-11-27 一种达卡他韦起始原料的合成方法
CN202011464085.0A CN112409336B (zh) 2017-11-27 2017-11-27 适于工业化生产的达卡他韦起始原料的合成方法
CN202011462952.7A CN112480084B (zh) 2017-11-27 2017-11-27 反应路线简单的达卡他韦起始原料的合成方法

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CN202011464085.0A Division CN112409336B (zh) 2017-11-27 2017-11-27 适于工业化生产的达卡他韦起始原料的合成方法

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CN202011464085.0A Active CN112409336B (zh) 2017-11-27 2017-11-27 适于工业化生产的达卡他韦起始原料的合成方法

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094977A1 (en) * 2009-02-23 2010-08-26 Arrow Therapeutics Limited Novel biphenyl compounds useful for the treatment of hepatitis c
CN103189371A (zh) * 2010-11-04 2013-07-03 施万制药 新颖丙型肝炎病毒抑制剂
WO2015017382A1 (en) * 2013-07-29 2015-02-05 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
WO2015124063A1 (zh) * 2014-02-21 2015-08-27 常州寅盛药业有限公司 丙肝病毒抑制剂及其制药用途
CN106256825A (zh) * 2016-07-04 2016-12-28 四川同晟生物医药有限公司 达卡他韦的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8221737B2 (en) * 2009-06-16 2012-07-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
CN104530079B (zh) * 2009-12-18 2017-10-20 北京凯因科技股份有限公司 C型肝炎病毒复制的新型抑制剂
WO2012048421A1 (en) * 2010-10-14 2012-04-19 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
US9206159B2 (en) * 2012-04-25 2015-12-08 Theravance Biopharma R&D Ip, Llc Piperazine-piperidine compounds as hepatitis C virus inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094977A1 (en) * 2009-02-23 2010-08-26 Arrow Therapeutics Limited Novel biphenyl compounds useful for the treatment of hepatitis c
CN103189371A (zh) * 2010-11-04 2013-07-03 施万制药 新颖丙型肝炎病毒抑制剂
WO2015017382A1 (en) * 2013-07-29 2015-02-05 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
WO2015124063A1 (zh) * 2014-02-21 2015-08-27 常州寅盛药业有限公司 丙肝病毒抑制剂及其制药用途
CN106256825A (zh) * 2016-07-04 2016-12-28 四川同晟生物医药有限公司 达卡他韦的合成方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect;Min Gao等;《Nature》;20100506;第465卷;第96-100页 *

Also Published As

Publication number Publication date
CN112409336A (zh) 2021-02-26
CN112409336B (zh) 2021-09-14
CN107814789B (zh) 2020-12-15
CN112480084A (zh) 2021-03-12
CN112480084B (zh) 2021-09-21
CN107814789A (zh) 2018-03-20

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Inventor after: You Xinyu

Inventor after: Tao Xin

Inventor after: Han Jiaqi

Inventor after: Shi Hefeng

Inventor after: Ji Xiang

Inventor after: Luo Anmao

Inventor before: Tao Xin

Inventor before: Han Jiaqi

Inventor before: Shi Hefeng

Inventor before: Ji Xiang

Inventor before: Luo Anmao

CB03 Change of inventor or designer information
CI03 Correction of invention patent

Correction item: Inventor

Correct: You Xinyu|Tao Xin|Han Jiaqi|Shi Hefeng|Ji Xiang|Luo Anmao

False: Tao Xin|Han Jiaqi|Shi Hefeng|Ji Xiang|Luo Anmao

Number: 51-01

Page: The title page

Volume: 36

Correction item: Inventor

False: Tao Xin|Han Jiaqi|Shi Hefeng|Ji Xiang|Luo Anmao

Number: 51-01

Volume: 36

CI03 Correction of invention patent