CN107814789B8 - Method for synthesizing daclatasvir starting material - Google Patents
Method for synthesizing daclatasvir starting material Download PDFInfo
- Publication number
- CN107814789B8 CN107814789B8 CN201711207599.6A CN201711207599A CN107814789B8 CN 107814789 B8 CN107814789 B8 CN 107814789B8 CN 201711207599 A CN201711207599 A CN 201711207599A CN 107814789 B8 CN107814789 B8 CN 107814789B8
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- CN
- China
- Prior art keywords
- daclatasvir
- starting material
- formula
- synthesizing
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011462952.7A CN112480084B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material with simple reaction route |
CN202011464085.0A CN112409336B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material suitable for industrial production |
CN201711207599.6A CN107814789B8 (en) | 2017-11-27 | 2017-11-27 | Method for synthesizing daclatasvir starting material |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711207599.6A CN107814789B8 (en) | 2017-11-27 | 2017-11-27 | Method for synthesizing daclatasvir starting material |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011464085.0A Division CN112409336B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material suitable for industrial production |
CN202011462952.7A Division CN112480084B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material with simple reaction route |
Publications (3)
Publication Number | Publication Date |
---|---|
CN107814789A CN107814789A (en) | 2018-03-20 |
CN107814789B CN107814789B (en) | 2020-12-15 |
CN107814789B8 true CN107814789B8 (en) | 2021-01-01 |
Family
ID=61610455
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011462952.7A Active CN112480084B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material with simple reaction route |
CN202011464085.0A Active CN112409336B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material suitable for industrial production |
CN201711207599.6A Active CN107814789B8 (en) | 2017-11-27 | 2017-11-27 | Method for synthesizing daclatasvir starting material |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011462952.7A Active CN112480084B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material with simple reaction route |
CN202011464085.0A Active CN112409336B (en) | 2017-11-27 | 2017-11-27 | Synthetic method of daclatasvir starting material suitable for industrial production |
Country Status (1)
Country | Link |
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CN (3) | CN112480084B (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010094977A1 (en) * | 2009-02-23 | 2010-08-26 | Arrow Therapeutics Limited | Novel biphenyl compounds useful for the treatment of hepatitis c |
CN103189371A (en) * | 2010-11-04 | 2013-07-03 | 施万制药 | Novel inhibitors of hepatitis C virus |
WO2015017382A1 (en) * | 2013-07-29 | 2015-02-05 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
WO2015124063A1 (en) * | 2014-02-21 | 2015-08-27 | 常州寅盛药业有限公司 | Hepatitis c virus inhibitors and uses thereof in preparation of drugs |
CN106256825A (en) * | 2016-07-04 | 2016-12-28 | 四川同晟生物医药有限公司 | The synthetic method of his Wei of Dacca |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8221737B2 (en) * | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
CN102791687B (en) * | 2009-12-18 | 2015-02-11 | 北京凯因科技股份有限公司 | Novel inhibitors of hepatitis C virus replication |
WO2012048421A1 (en) * | 2010-10-14 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
SI2850075T1 (en) * | 2012-04-25 | 2017-06-30 | Theravance Biopharma R&D Ip, Llc | Piperazine-piperidine compounds as hepatitis c virus inhibitors |
-
2017
- 2017-11-27 CN CN202011462952.7A patent/CN112480084B/en active Active
- 2017-11-27 CN CN202011464085.0A patent/CN112409336B/en active Active
- 2017-11-27 CN CN201711207599.6A patent/CN107814789B8/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010094977A1 (en) * | 2009-02-23 | 2010-08-26 | Arrow Therapeutics Limited | Novel biphenyl compounds useful for the treatment of hepatitis c |
CN103189371A (en) * | 2010-11-04 | 2013-07-03 | 施万制药 | Novel inhibitors of hepatitis C virus |
WO2015017382A1 (en) * | 2013-07-29 | 2015-02-05 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
WO2015124063A1 (en) * | 2014-02-21 | 2015-08-27 | 常州寅盛药业有限公司 | Hepatitis c virus inhibitors and uses thereof in preparation of drugs |
CN106256825A (en) * | 2016-07-04 | 2016-12-28 | 四川同晟生物医药有限公司 | The synthetic method of his Wei of Dacca |
Non-Patent Citations (1)
Title |
---|
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect;Min Gao等;《Nature》;20100506;第465卷;第96-100页 * |
Also Published As
Publication number | Publication date |
---|---|
CN112480084B (en) | 2021-09-21 |
CN112409336B (en) | 2021-09-14 |
CN107814789B (en) | 2020-12-15 |
CN107814789A (en) | 2018-03-20 |
CN112409336A (en) | 2021-02-26 |
CN112480084A (en) | 2021-03-12 |
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Legal Events
Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information |
Inventor after: You Xinyu Inventor after: Tao Xin Inventor after: Han Jiaqi Inventor after: Shi Hefeng Inventor after: Ji Xiang Inventor after: Luo Anmao Inventor before: Tao Xin Inventor before: Han Jiaqi Inventor before: Shi Hefeng Inventor before: Ji Xiang Inventor before: Luo Anmao |
|
CB03 | Change of inventor or designer information | ||
CI03 | Correction of invention patent |
Correction item: Inventor Correct: You Xinyu|Tao Xin|Han Jiaqi|Shi Hefeng|Ji Xiang|Luo Anmao False: Tao Xin|Han Jiaqi|Shi Hefeng|Ji Xiang|Luo Anmao Number: 51-01 Page: The title page Volume: 36 Correction item: Inventor False: Tao Xin|Han Jiaqi|Shi Hefeng|Ji Xiang|Luo Anmao Number: 51-01 Volume: 36 |
|
CI03 | Correction of invention patent |