CN107802711A - 一种纳米促眠贴及其制备方法 - Google Patents
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Abstract
本发明涉及一种纳米促眠贴及其制备方法,该纳米促眠贴的药物部分包括中药混合物和纳米远红外陶瓷粉两部分组成,所述的中药混合物与纳米远红外陶瓷粉的重量比为20‑25:1‑4。本发明的优点是:纳米远红外陶瓷粉(纳米级的远红外陶瓷粉)本身具有激活生物大分子的活性、促进和改善血液循环、促进药物吸收的作用,另外添加川芎挥发油作为中药透皮技术的天然促透剂,可以显著加强对有镇静、安眠作用的豆腐果苷的吸收;本发明中添加了少许纯天然提取物豆腐果苷,促眠作用显著。具有的对各种睡眠状况的入睡困难、多梦、夜尿、早醒等状况具有明显改善的作用;具有市场开发前景;制备方法简单易行。
Description
技术领域
本发明涉及一种纳米促眠贴及其制备方法,属于生物活性材料结合的保健品技术领域。
背景技术
随着社会竞争日渐激烈及生活节奏的加快,越来越多的人出现睡眠障碍或者和睡眠相关的疾病。睡眠障碍是指睡眠量的异常及睡眠质的异常或在睡眠时发生某些临床症状,如睡眠减少或睡眠过多,睡行症等,其中以失眠症最为常见。据调查显示,成年人出现睡眠障碍的比例高达35%。 60岁以上的老年人57%会出现睡眠障碍,一些城市中2~6岁儿童中发生睡眠障碍的占27%-50%。此外,孕妇在妊娠末期睡眠障碍的发生率可达75%,而一些脑卒中、帕金森病、糖尿病以及精神病患者也会出现不同程度的睡眠障碍。睡眠障碍者中有55.5%的患者存在不同程度的社会功能障碍。目前对于睡眠障碍的治疗包含苯二氮卓类、阿普唑伦、艾思唑伦等西药、中成药、汤药。市场上外用贴相对比较少,疗效不肯定。
发明内容
为克服现有技术的缺陷,本发明提供一种纳米促眠贴及其制备方法,本发明的技术方案是:
一种纳米促眠贴,该纳米促眠贴的药物部分包括中药混合物和纳米远红外陶瓷粉两部分组成,所述的中药混合物与纳米远红外陶瓷粉的重量比为20-25:1-4。
所述的中药混合物包括以下重量份的各组分:党参0.1-0.4克、炒白术0.1-0.4克、炙黄芪0.1-0.4克、炙甘草0.1-0.4克、茯苓0.1-0.4克、制远志0.1-0.4克、炒酸枣仁0.1-0.4克、龙眼肉0.1-0.4克、当归0.1-0.4克、木香0.1-0.4克、去核大枣0.1-0.4克、五味子0.5-2克、石菖蒲各0.5-2克,黄连0.5-2克、肉桂0.5-2克、丹参0.5-2克,朱砂0.5-2克,豆腐果苷0.1-0.2克。
党参 0.27克、炒白术 0.27克、炙黄芪 0.27克、炙甘草 0.27克、茯苓 0.27克、制远志 0.27克、炒酸枣仁 0.27克、龙眼肉 0.27克、当归 0.27克、木香 0.27克、去核大枣0.27克、五味子1克、石菖蒲各1克,黄连1克、肉桂1克、丹参1克,朱砂1克,豆腐果苷0.1克。
制备纳米促眠贴的方法,包括以下步骤:
(1)按照配比称取中药混合物的各组分以及纳米远红外陶瓷粉;
(2)将中药混合物的各组分混合烘干后粉碎成细粉末,在细粉末加川芎挥发油5ml进行搅拌,形成糊状;然后加入纳米远红外陶瓷粉混合均匀,形成膏药;
(3)将膏药分成数份,每份5-6克,每份分别均匀的涂在直径为3-3.5厘米、厚度1.5-2毫米的胶布上,然后将胶布再黏在不透水的纸上,包装即得。
本发明的优点是:纳米远红外陶瓷粉(纳米级的远红外陶瓷粉)本身具有激活生物大分子的活性、促进和改善血液循环、促进药物吸收的作用,另外添加川芎挥发油作为中药透皮技术的天然促透剂,可以显著加强对有镇静、安眠作用的豆腐果苷的吸收;本发明中添加了少许纯天然提取物豆腐果苷,促眠作用显著。具有的对各种睡眠状况的入睡困难、多梦、夜尿、早醒等状况具有明显改善的作用;具有市场开发前景;制备方法简单易行。
具体实施方式
下面结合具体实施例来进一步描述本发明,本发明的优点和特点将会随着描述而更为清楚。但这些实施例仅是范例性的,并不对本发明的范围构成任何限制。本领域技术人员应该理解的是,在不偏离本发明的精神和范围下可以对本发明技术方案的细节和形式进行修改或替换,但这些修改和替换均落入本发明的保护范围内。
实施例1:本发明涉及一种纳米促眠贴,该纳米促眠贴的药物部分包括中药混合物和纳米远红外陶瓷粉(即纳米级的远红外陶瓷粉)两部分组成,所述的中药混合物与纳米远红外陶瓷粉的重量比为20:1。
所述的中药混合物包括以下重量份的各组分:党参0.1克、炒白术0.1克、炙黄芪0.1克、炙甘草0.1克、茯苓0.1克、制远志0.1克、炒酸枣仁0.1克、龙眼肉0.1克、当归0.1克、木香0.1克、去核大枣0.1克、五味子0.5克、石菖蒲各0.5克,黄连0.5克、肉桂0.5克、丹参0.5克,朱砂0.5克,豆腐果苷0.1克。
一种制备纳米促眠贴的方法,包括以下步骤:
(1)按照配比称取中药混合物的各组分以及纳米远红外陶瓷粉;
(2)将中药混合物的各组分混合烘干后粉碎成细粉末,在细粉末加入川芎挥发油5ml进行搅拌,形成糊状;然后加入纳米远红外陶瓷粉混合均匀,形成膏药;
(3)将膏药分成数份,每份5克,每份分别均匀的涂在直径为3-3.5厘米、厚度1.5-2毫米的胶布上,然后将胶布再黏在不透水的纸上,包装即得。
实施例2:一种纳米促眠贴,该纳米促眠贴的药物部分包括中药混合物和纳米远红外陶瓷粉两部分组成,所述的中药混合物与纳米远红外陶瓷材料的重量比为22:3。所述的中药混合物包括以下重量份的各组分,党参 0.27克、炒白术 0.27克、炙黄芪 0.27克、炙甘草 0.27克、茯苓 0.27克、制远志 0.27克、炒酸枣仁 0.27克、龙眼肉 0.27克、当归 0.27克、木香 0.27克、去核大枣 0.27克、五味子1克、石菖蒲各1克,黄连1克、肉桂1克、丹参1克,朱砂1克,豆腐果苷0.2克。
一种制备纳米促眠贴的方法,包括以下步骤:
(1)按照配比称取中药混合物的各组分以及纳米远红外陶瓷粉;
(2)将中药混合物的各组分混合烘干后粉碎成细粉末,在细粉末加入川芎挥发油5ml进行搅拌,形成糊状;然后加入纳米远红外陶瓷粉混合均匀,形成膏药;
(3)将膏药分成数份,每份6克,每份分别均匀的涂在直径为3-3.5厘米、厚度1.5-2毫米的胶布上,然后将胶布再黏在不透水的纸上,包装即得。
实施例3:一种纳米促眠贴,该纳米促眠贴的药物部分包括中药混合物和纳米远红外陶瓷粉两部分组成,所述的中药混合物与纳米远红外陶瓷材料的重量比为25:4。所述的中药混合物包括以下重量份的各组分,党参 0.4克、炒白术 0.4克、炙黄芪 0.4克、炙甘草0.4克、茯苓 0.4克、制远志 0.4克、炒酸枣仁 0.4克、龙眼肉 0.4克、当归 0.4克、木香 0.4克、去核大枣 0.4克、五味子2克、石菖蒲各2克,黄连2克、肉桂2克、丹参2克,朱砂2克,豆腐果苷0.1克。
一种制备纳米促眠贴的方法,包括以下步骤:
(1)按照配比称取中药混合物的各组分以及纳米远红外陶瓷粉;
(2)将中药混合物的各组分混合烘干后粉碎成细粉末,在细粉末加川芎挥发油5ml进行搅拌,形成糊状;然后加入纳米远红外陶瓷粉混合均匀,形成膏药;
(3)将膏药分成数份,每份6克,每份分别均匀的涂在直径为3-3.5厘米、厚度1.5-2毫米的胶布上,然后将胶布再黏在不透水的纸上,包装即得。
临床资料
选取2017年07月至2017年11月,收集了经诊治的10例各种不同程度的睡眠障碍的患者为研究对象,其中男性4 例,女性 6 例,年龄 30-65岁,平均年龄47.5±17岁;失眠时间3个月至20年,每晚口服艾司*** 1-2mg。
纳入标准:①几乎以失眠为唯一的症状,包括难以入睡、睡眠不深、多梦、早醒、醒后不易再睡、醒后不适感、疲乏、或白天困倦等。②每周发生3次,或1个月以上。③所有患者对治疗均知情同意。排除标准:①危急重症患者。②精神障碍症状导致的继发性失眠。③皮肤病及糖尿病足。④足部有新或未愈合的伤口。
治疗方案:用本申请实施例制备的促眠贴贴于神阙穴、膻中穴、内关穴、涌泉穴,10次为 1 疗程。贴敷过程中观察患者局部皮肤有无红肿、水泡、瘙痒,睡眠情况,同时进行心理疏导,使患者身心放松,避免紧张和焦虑,做好交班和“匹茨堡睡眠质量指数量表”记录。
疗效评价:采用匹茨堡睡眠质量指数中的 3 项因子作为评定睡眠质量工具对患者进行评价:①入睡预备期=入睡时间-就寝时间。②夜间实际睡眠时间=入睡后-间断醒来时间的累积睡眠时间。③睡眠效率=睡眠总时间/床上时间×100%。治疗后评估以上指标,同时观察贴敷过程中有无不良反应发生。
统计学处理:采用 SPSS 统计软件进行分析,治疗前后数据以x±s 表示,采用 t检验进行比较。
表1 促眠贴对失眠症睡眠质量影响(x±s)
Claims (4)
1.一种纳米促眠贴,其特征在于,该纳米促眠贴的药物部分包括中药混合物和纳米远红外陶瓷粉两部分组成,所述的中药混合物与纳米远红外陶瓷粉的重量比为20-25:1-4。
2.根据权利要求1所述的纳米促眠贴,其特征在于,所述的中药混合物包括以下重量份的各组分:党参0.1-0.4克、炒白术0.1-0.4克、炙黄芪0.1-0.4克、炙甘草0.1-0.4克、茯苓0.1-0.4克、制远志0.1-0.4克、炒酸枣仁0.1-0.4克、龙眼肉0.1-0.4克、当归0.1-0.4克、木香0.1-0.4克、去核大枣0.1-0.4克、五味子0.5-2克、石菖蒲各0.5-2克,黄连0.5-2克、肉桂0.5-2克、丹参0.5-2克,朱砂0.5-2克,豆腐果苷0.1-0.2克。
3.根据权利要求2所述的纳米促眠贴,其特征在于,党参 0.27克、炒白术 0.27克、炙黄芪 0.27克、炙甘草 0.27克、茯苓 0.27克、制远志 0.27克、炒酸枣仁 0.27克、龙眼肉 0.27克、当归 0.27克、木香 0.27克、去核大枣 0.27克、五味子1克、石菖蒲各1克,黄连1克、肉桂1克、丹参1克,朱砂1克,豆腐果苷0.1克。
4.一种制备权利要求2或3所述的纳米促眠贴的方法,其特征在于,包括以下步骤:
(1)按照配比称取中药混合物的各组分以及纳米远红外陶瓷粉;
(2)将中药混合物的各组分混合烘干后粉碎成细粉末,在细粉末加川芎挥发油5ml进行搅拌,形成糊状;然后加入纳米远红外陶瓷粉混合均匀,形成膏药;
(3)将膏药分成数份,每份5-6克,每份分别均匀的涂在直径为3-3.5厘米、厚度1.5-2毫米的胶布上,然后将胶布再黏在不透水的纸上,包装即得。
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