CN107802619A - 一种用于眼部健康的浓缩物 - Google Patents
一种用于眼部健康的浓缩物 Download PDFInfo
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- CN107802619A CN107802619A CN201711279921.6A CN201711279921A CN107802619A CN 107802619 A CN107802619 A CN 107802619A CN 201711279921 A CN201711279921 A CN 201711279921A CN 107802619 A CN107802619 A CN 107802619A
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- vitamin
- concentrate
- luteole
- lutein
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Abstract
本发明涉及一种用于眼部健康的浓缩物，该浓缩物配方中包含叶黄素、玉米黄素、以及内消旋玉米黄质，然后通过添加维生素、微量元素及其它物质，构成浓缩物，其是一种视觉特异性医疗食品，该浓缩物对于保护黄斑色素对抗自由基、游离氧起到关键作用。
Description
技术领域
本申请涉及医疗食品技术领域，尤其涉及一种用于眼部健康的浓缩物。
背景技术
黄斑是位于灵长类动物视网膜后极部的一个色素性区域，黄斑中心凹是视网膜上对视觉最敏锐的部位。目前，黄斑色素对视网膜的保护机制有两种假说，一是“保护假说”，认为类胡萝卜素作为抗氧化剂，清除自由基和游离氧，从而限制由于新陈代谢和光线所致的氧张力，起到保护视网膜的作用，二是“光学滤过假说”，认为黄斑色素可以选择性吸收短波长光，从而保护光感受器与视网膜色素上皮细胞，并提高视力。而年龄相关性视黄斑衰退症(AMD)是一种主要的人类致盲疾病，发病时往往导致中央视力下降，严重时使人失明。视黄斑衰退症发病率与人的年龄相关，年龄越大，此病越容易发生。调查发现，仅在北美就有1500万50岁以上的人患此疾病，其中120万人病情严重。在美国75岁以上的人口中，30％患有某种程度的视黄斑衰退症，另外有23％的人口会在随后的五年中会患上此种疾病。有些调查表明，在55-64岁，65-74岁及75岁以上年龄段人群中，视黄斑衰退症的发病率分别为16.8％，25.6％和42％。
如上所述，AMD是一种会导致失明的眼科疾病，其往往是由于眼中脂质氧化形成一种荧光性脂褐质而导致玻璃疣、玻璃膜、脉络膜新生血管的生成。一般认为，眼睛长期暴露于高能量的蓝光中会加速这种脂褐质的形成。目前AMD形成的确切机理不是很清楚，也没有明确的治疗和预防方法，但多项研究表明，AMD的形成与发展和人眼中类胡萝卜素特别是叶黄素和玉米黄素的含量息息相关，多量的叶黄素和玉米黄素能延缓AMD的发生和形成，另外，体内的抗氧化剂如维生素E、维生素A、硒、锌、谷胱甘肽也能对AMD的发展起到抑制作用。
叶黄素和玉米黄素独特的生理功能，已经引起了人们越来越大的兴趣。目前国外出现了大量含以上两种天然色素的健康食品和强化食品。
基于对叶黄素和玉米黄素眼健康功能的认识和法律法规的完善，越来越多的人从事这方面的研究，市场上也出现了许多叶黄素和玉米黄素治疗和预防眼底黄斑变性(AMD)疾病方面的产品。在这些研究或产品中，往往集中于叶黄素的功能，有关玉米黄素的功能也有所涉及，但对玉米黄素和叶黄素的复合使用，则未见报道。
发明内容
针对上述提出问题，本发明旨在提供一种用于眼部健康的浓缩物，以解决上述提出问题。
本发明的实施例中提供了一种用于眼部健康的浓缩物，该浓缩物中包含叶黄素和玉米黄素，其能够被血液快速吸收，进而补充黄斑色素。
该浓缩物包括叶黄素、玉米黄素、以及内消旋玉米黄质，所述叶黄素和玉米黄素的重量比为3～8:1。
优选地，所述叶黄素和玉米黄素的重量比为5:1。
优选地，所述叶黄素和玉米黄素的含量分别为15mg、3mg，所述内消旋玉米黄质的含量为10mg。
其中，所述玉米黄素为按常规方法从植物中提取或者是通过化学合成得到的(3R，3’R)-玉米黄素或以叶黄素为原料通过异构化转位得到的(3R，3’S)-玉米黄素。所述叶黄素和玉米黄素为游离晶体形式或脂肪酸酯形式。
优选地，所述浓缩物中还包括维生素和微量元素；
其中，所述维生素选自维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B12、维生素C、维生素D3、维生素E中的一种或多种；
上述所述维生素的含量分别为：1.5mg、1.7mg、20mg、10mg、10mg、1000mcg、500mg、2000iu、200iu。
所述微量元素选自钙、镁、锌、硒、铜、锰、铬、钼中的一种或多种；
上述所述微量元素的含量分别为：250mg、100mg、25mg、70mcg、2mg、2mg、120mcg、75mcg。
优选地，所述浓缩物中还包括叶酸、蛋白生物素、乙酰半胱氨酸、乙酰左旋肉碱、牛磺酸、槲皮素、泛醌10、虾青素、番茄红素；
其中，叶酸、蛋白生物素、乙酰半胱氨酸、乙酰左旋肉碱、牛磺酸、槲皮素、泛醌10、虾青素、番茄红素的含量分别为800mcg、100mcg、500mg、500mg、500mg、100mg、50mg、1000mcg、500mcg。
本申请的实施例提供的技术方案可以包括以下有益效果：
本发明的浓缩物配方中包含叶黄素、玉米黄素、以及内消旋玉米黄质，然后通过添加维生素、微量元素及其它物质，构成浓缩物，其是一种视觉特异性医疗食品，该浓缩物对于保护黄斑色素对抗自由基、游离氧起到关键作用。
具体实施方式
以下将结合实施例对本发明做进一步说明，本发明的实施例仅用于说明本发明的技术方案，并非限定本发明。
本发明的实施例中提供了一种用于眼部健康的浓缩物，该浓缩物中包含叶黄素和玉米黄素，其能够被血液快速吸收，进而补充黄斑色素。
该浓缩物包括叶黄素、玉米黄素、以及内消旋玉米黄质，所述叶黄素和玉米黄素的重量比为3～8:1。
优选地，所述叶黄素和玉米黄素的重量比为5:1。
优选地，所述叶黄素和玉米黄素的含量分别为15mg、3mg，所述内消旋玉米黄质的含量为10mg。
其中，所述玉米黄素为按常规方法从植物中提取或者是通过化学合成得到的(3R，3’R)-玉米黄素或以叶黄素为原料通过异构化转位得到的(3R，3’S)-玉米黄素。所述叶黄素和玉米黄素为游离晶体形式或脂肪酸酯形式。
玉米黄素在眼睛中主要有两种形态，分别是(3R，3’R)和(3R，3’S)两种异构体，(3S，3’S)构型只是在视黄斑中央有微量存在。在前两种异构体中，(3R，3’R)是从外界摄入并经血液吸收后转移到视黄斑中，(3R，3’S)则是在视网膜中在某种酶的作用下由叶黄素异构化转位得到。所以根据目前的研究认为，单纯补充玉米黄素，只能保证血液或视黄斑中玉米黄素的含量，而不能保证体内叶黄素的供应，而且体内玉米黄素的异构体构型与摄入的玉米黄素的构型一致；如单纯补充叶黄素，在视网膜中部分叶黄素可以转化为内消旋玉米黄素((3R，3’S，meso)-玉米黄素)，但这种转化会受到个体中转化酶的水平限制，有可能使眼睛视黄斑最中央的内消旋玉米黄素的量不够，从而影响到视黄斑功能的发挥。因此，为了达到眼健康目的，人体最好同时补充叶黄素和玉米黄素。
优选地，所述浓缩物中还包括维生素和微量元素；
其中，所述维生素选自维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B12、维生素C、维生素D3、维生素E中的一种或多种；
上述所述维生素的含量分别为：1.5mg、1.7mg、20mg、10mg、10mg、1000mcg、500mg、2000iu、200iu。
所述微量元素选自钙、镁、锌、硒、铜、锰、铬、钼中的一种或多种；
上述所述微量元素的含量分别为：250mg、100mg、25mg、70mcg、2mg、2mg、120mcg、75mcg。
优选地，所述浓缩物中还包括叶酸、蛋白生物素、乙酰半胱氨酸、乙酰左旋肉碱、牛磺酸、槲皮素、泛醌10、虾青素、番茄红素；
其中，叶酸、蛋白生物素、乙酰半胱氨酸、乙酰左旋肉碱、牛磺酸、槲皮素、泛醌10、虾青素、番茄红素的含量分别为800mcg、100mcg、500mg、500mg、500mg、100mg、50mg、1000mcg、500mcg。
在食用时，将本发明的浓缩物取一汤匙，并将其与适量的水、果汁、牛奶等混合均匀即可食用。
以上所述仅为本申请的较佳方式，并不用以限制本申请，凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。
Claims (8)
1.一种用于眼部健康的浓缩物，其特征在于，所述浓缩物包括叶黄素、玉米黄素、以及内消旋玉米黄质，所述叶黄素和玉米黄素的重量比为3～8:1。
2.根据权利要求1所述的浓缩物，其特征在于，所述叶黄素和玉米黄素的重量比为5:1。
3.根据权利要求2所述的浓缩物，其特征在于，所述叶黄素和玉米黄素的含量分别为15mg、3mg，所述内消旋玉米黄质的含量为10mg。
4.根据权利要求1所述的浓缩物，其特征在于，所述浓缩物中还包括维生素和微量元素；其中，所述维生素选自维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B12、维生素C、维生素D3、维生素E中的一种或多种；所述微量元素选自钙、镁、锌、硒、铜、锰、铬、钼中的一种或多种。
5.根据权利要求4所述的浓缩物，其特征在于，所述维生素的含量分别为：1.5mg、1.7mg、20mg、10mg、10mg、1000mcg、500mg、2000iu、200iu。
6.根据权利要求4所述的浓缩物，其特征在于，所述微量元素的含量分别为：250mg、100mg、25mg、70mcg、2mg、2mg、120mcg、75mcg。
7.根据权利要求1所述的浓缩物，其特征在于，所述浓缩物中还包括叶酸、蛋白生物素、乙酰半胱氨酸、乙酰左旋肉碱、牛磺酸、槲皮素、泛醌10、虾青素、番茄红素。
8.根据权利要求7所述的浓缩物，其特征在于，所述叶酸、蛋白生物素、乙酰半胱氨酸、乙酰左旋肉碱、牛磺酸、槲皮素、泛醌10、虾青素、番茄红素的含量分别为800mcg、100mcg、500mg、500mg、500mg、100mg、50mg、1000mcg、500mcg。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992544A (zh) * | 2018-09-12 | 2018-12-14 | 西安力邦制药有限公司 | 一种防治眼病的中药组合物 |
| CN109222093A (zh) * | 2018-08-29 | 2019-01-18 | 华南理工大学 | 一种具有眼保健功能的水溶性多重营养添加剂及制备与应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102481011A (zh) * | 2009-09-02 | 2012-05-30 | 奥米尼埃克蒂夫健康科技有限公司 | 含有黄斑色素的叶黄素组合物及其制备方法 |
| CN103796717A (zh) * | 2011-07-07 | 2014-05-14 | 霍华德基金会控股有限公司 | 视觉功效和/或黄斑色素沉着的改善或与之相关的改善 |
| CN105146539A (zh) * | 2015-09-22 | 2015-12-16 | 哈尔滨宝德生物技术股份有限公司 | 含有叶黄素和玉米黄质的营养食品添加剂及制备方法 |
| CN106692187A (zh) * | 2015-11-16 | 2017-05-24 | 浙江医药股份有限公司新昌制药厂 | 一种用于改善明视持久度、保护眼睛健康的组合物 |
| CN106692259A (zh) * | 2015-11-16 | 2017-05-24 | 浙江医药股份有限公司新昌制药厂 | 一种用于改善眩光刺激的组合物 |
-
2017
- 2017-12-06 CN CN201711279921.6A patent/CN107802619A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102481011A (zh) * | 2009-09-02 | 2012-05-30 | 奥米尼埃克蒂夫健康科技有限公司 | 含有黄斑色素的叶黄素组合物及其制备方法 |
| CN103796717A (zh) * | 2011-07-07 | 2014-05-14 | 霍华德基金会控股有限公司 | 视觉功效和/或黄斑色素沉着的改善或与之相关的改善 |
| CN105146539A (zh) * | 2015-09-22 | 2015-12-16 | 哈尔滨宝德生物技术股份有限公司 | 含有叶黄素和玉米黄质的营养食品添加剂及制备方法 |
| CN106692187A (zh) * | 2015-11-16 | 2017-05-24 | 浙江医药股份有限公司新昌制药厂 | 一种用于改善明视持久度、保护眼睛健康的组合物 |
| CN106692259A (zh) * | 2015-11-16 | 2017-05-24 | 浙江医药股份有限公司新昌制药厂 | 一种用于改善眩光刺激的组合物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109222093A (zh) * | 2018-08-29 | 2019-01-18 | 华南理工大学 | 一种具有眼保健功能的水溶性多重营养添加剂及制备与应用 |
| CN108992544A (zh) * | 2018-09-12 | 2018-12-14 | 西安力邦制药有限公司 | 一种防治眼病的中药组合物 |
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