CN107788438A - A kind of Antialcoholic liver-protecting turmeric multifunctional food and preparation method thereof - Google Patents
A kind of Antialcoholic liver-protecting turmeric multifunctional food and preparation method thereof Download PDFInfo
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- CN107788438A CN107788438A CN201710889228.4A CN201710889228A CN107788438A CN 107788438 A CN107788438 A CN 107788438A CN 201710889228 A CN201710889228 A CN 201710889228A CN 107788438 A CN107788438 A CN 107788438A
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Abstract
The invention discloses a kind of Antialcoholic liver-protecting turmeric multifunctional food and preparation method thereof, it is made up of the raw material of following components by weight percent：5 35 parts of curcuma powder, 20 70 parts of corn oligopeptide powder, 5 25 parts of eclipta.Curcuma powder, corn oligopeptide powder and eclipta are crushed and mixed preparing, obtain Antialcoholic liver-protecting functional activity composition.Turmeric multifunctional food made from inventive formulation has removing toxic substances, liver protection, protect liver, invigorating the spleen, the effect of promoting the production of body fluid, it cannot be only used for Antialcoholic liver-protecting, the symptom of mouth parched and tongue scorched after drinking can also be alleviated, assist to improve sleep, may further be used to prevent and treat the disease of the privileged sites such as spleen, channels and collaterals.
Description
Technical field
The present invention relates to a kind of Antialcoholic liver-protecting turmeric multifunctional food and preparation method thereof, and in particular to one kind is by turmeric
Powder, corn peptide (maize oligopeptide), eclipta are the Antialcoholic liver-protecting turmeric multifunctional food that raw material is formulated, and belong to health care food
Product field.
Background technology
Turmeric (Turmeric, Curcuma longa L.) is also known as India turmeric or India's safron, is Zingiber turmeric
Belong to herbaceos perennial, be commonly used for food additives.The invigorant and purification blood of stomach are used as in India, can be controlled
Treating disease of skin can cicatrize a wound.Turmeric powder is the most strong natural antibiotics found so far, and it can also promote tumour thin
Born of the same parents are dead, prevent the generation of angiocardiopathy.Experimental study shows that turmeric powder has weight in medicine, nutrition and health care etc.
The application value wanted, it has the effect of anti-oxidant, anticancer, anti-inflammatory and antibacterial.
Curcumin is the primary bioactivity component in Turmeric, and Modern medical experiment shows that curcumin has a variety of lifes
Thing activity and pharmacological action, there are prevention and treatment to a variety of diseases such as high fat of blood, hepatic injury, tumour, senile dementia, diabetes
Effect, curcumin use in food, medicine and cosmetics frequently as natural pigment and antioxidant, and in food seasoning
Main component.
Existing widely used curcumin and the health product of turmeric correlation originate from the U.S., Germany and Japan more, main production
Product have turmeric powder capsule, tablet, granule, tea and drinks etc., mainly there is the work(such as Antialcoholic liver-protecting, antibacterial, anti-inflammatory and analgesia
Effect.But due to the shortcomings of curcumin dissolubility is poor, stability is bad in curcuma powder, it is greatly limited in functional food health products
In application.Therefore based on turmeric, turmeric series functional foods of the exploitation with independent intellectual property right are with very big hair
Open up space.
Corn peptide (maize oligopeptide) powder (Corn oligopeptides powde), it is using corn protein powder as original
Material, through sizing mixing, protease hydrolyzed, separation, filtering, the technique productions such as spray drying form.On October 21st, 2010, China defended
Life portion approval corn oligopeptide powder be new resource food, can be applied to protect liver, promotion alcohol metabolism, anti-oxidant, hypotensive,
Enhancing is immune, strengthens locomitivity, strengthen immunity etc..
Corn peptide can promote liver detoxification function, reduce toxic and harmful substance to hepar damnification, Modern medical experiment
Prove that corn peptide is respectively provided with significantly to the hepatic injury as caused by a variety of chemical substances such as alcohol, carbon tetrachloride, thioacetamide
Protective effect.Pathological research shows that corn peptide can substantially mitigate the denaturation of liver cell fat, improves liver tissue injury degree,
Corn peptide has important protection effect to liver.
Eclipta also known as Eclipta prostrata, Herba Ecliptae, it is medical and edible dual purpose plant；For the herb of feverfew Eclipta prostrata, annual summer, autumn
Extract herb two seasons, remove silt, drying or drying in the shade to be used as medicine.Eclipta primary bioactivity molecule have wedelolactone,
Demethylwedelolactone, demethylwedelolactone -7- glucosides etc., there is kidney tonifying, beneficial liver, black hair benefit is cloudy, health
It is anti-ageing, cool blood, hemostasis and other effects.
A kind of curcumin of Antialcoholic liver-protecting-dendrobium candidum compound and preparation method thereof (Chinese patent CN
102727759A) report uses curcumin and dendrobium candidum to prepare alcoholism-relieving liver-protecting product for raw material.One kind contains curcumin composition
Health care granule and its prepare (Chinese patent CN 104000213A) report carried using turmeric powder, curcuma powder and Kiwi berry
Thing etc. is taken to prepare the relieving alcoholism and protecting livers health care granule containing curcumin composition for raw material.A kind of curcumin combination of Antialcoholic liver-protecting
Thing (Chinese patent CN106266026A) report using curcumin, sweet osmanthus flower distillate, vinegar woods, east wind dish, tell fireworks, neohesperidin two
Hydrogen chalcone etc. is that composition prepared by raw material has the effect of removing toxic substances, soothing the liver, invigorating the spleen, promote the production of body fluid.New application (the China of eclipta
Patent CN102357110A) report the medicine for being used for preparation prevention and treatment hyperlipidemia and NASH with eclipta
Thing；Eclipta has the function that obvious reducing blood lipid and liver protecting.So far there are no by turmeric, corn oligopeptide powder and eclipta
The report of the turmeric multifunctional food of the Antialcoholic liver-protecting effect being formulated for raw material and application.
The content of the invention
Purpose：To solve the deficiencies in the prior art, the present invention provides a kind of Antialcoholic liver-protecting turmeric multifunctional food and its system
Preparation Method, the Overall View discussed using differential diagnosis in tcm, by the health active in curcuma powder, corn peptide (maize oligopeptide), eclipta
Molecule be developed into containing curcuma powder, corn peptide (maize oligopeptide), eclipta Antialcoholic liver-protecting turmeric multifunctional food, in health care work(
Make it in effect with more science, validity, targeting；For the health-care efficacy of the combination in addition to respective efficacy exertion, it is special
It is fixed with when production technology, to it is drunk caused by Ethanol intake excess, be still drank after a night, alcoholism, alcoholic liver etc. carry out preventing and treating effect
Fruit, it can also prevent the functions such as oxyhepatitis caused by liver disfunction；Edible safety is effective, nontoxic.
Technical scheme：In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of Antialcoholic liver-protecting turmeric multifunctional food, it is characterised in that be made up of the raw material of following components by weight percent：Curcuma powder
5-35 parts, corn oligopeptide powder 20-70 parts, eclipta 5-25 parts.
Described Antialcoholic liver-protecting turmeric multifunctional food, it is characterised in that the processing method of raw material is：Above-mentioned raw materials are pressed
It is respectively processed according to ratio, curcuma powder, corn oligopeptide powder and eclipta are crushed and mixed preparing, produces Antialcoholic liver-protecting
Functional activity composition.
Described Antialcoholic liver-protecting turmeric multifunctional food, it is characterised in that：The Antialcoholic liver-protecting turmeric multifunctional food
Formulation is tablet, granule or capsule.
Described Antialcoholic liver-protecting turmeric multifunctional food, the preparation method of tablet are as follows：
Antialcoholic liver-protecting functional activity composition 25-60 parts, add Celluloasun Microcrystallisatum 20-40 parts, carboxymethyl cellulose 5-10
Part, xylitol 0.2-2.5 parts, ascorbic acid 0.1-1.5 parts input mixer interior mixing 20-40 minutes, ethanol is added as wet
Moisten agent, mix 10-20 minutes, mixed material is pelletized with 10-20 mesh sieves, is put into drying equipment and is dried, and adds 1-5 parts
Magnesium stearate, whole grain, tabletting, packaging, produce.
Described Antialcoholic liver-protecting turmeric multifunctional food, the preparation method of granule are as follows：Antialcoholic liver-protecting functional activity group
Compound 30-70 parts, starch 10-25 parts are added, Celluloasun Microcrystallisatum 10-30 parts, white granulated sugar 5-10 parts, input mixer is interior to be mixed
20-40 minutes, ethanol is added as wetting agent, mixes 10-20 minutes, mixed material is pelletized with 10-20 mesh sieves, is put into dry
Dried in dry equipment, dry particle is sieved with 20-60 eye mesh screens, is removed coarse granule and fine powder, packaging, is produced.
Described Antialcoholic liver-protecting turmeric multifunctional food, the preparation method of capsule are as follows：Antialcoholic liver-protecting functional activity combines
Thing 10-50 parts, Celluloasun Microcrystallisatum 40-70 parts, dextrin 5-10 parts, input mixer interior mixing 20-30 minutes, add ethanol conduct
Wetting agent, 10-20 minutes being mixed, mixed material is pelletized with 10-20 mesh sieves, the hard fatty acids magnesium of addition 1-5 parts, whole grain,
Capsule charge, packaging, is produced.
Beneficial effect：A kind of Antialcoholic liver-protecting turmeric multifunctional food provided by the invention and preparation method thereof, using the traditional Chinese medical science
The Overall View of dialectical opinion, Antialcoholic liver-protecting effect bioactive molecule in curcuma powder, corn peptide and eclipta is developed into Antialcoholic liver-protecting
Turmeric multifunctional food, it is made on health-care efficacy with more science, validity, targeting；The health-care efficacy of the combination removes
Outside with respective efficacy exertion, its is specific with when production technology, in terms of strengthen immunity, to excessively causing because of Ethanol intake
It is drunk, be still drank after a night, alcoholism, alcoholic liver etc. carry out prevention effect, can also prevent the phases such as hepatitis caused by liver disfunction
Related disorders etc. have the function that uniqueness.Containing abundant curcuma powder in Turmeric, have strong anti-oxidative activity etc. a variety of
Biological effect, curcuma powder can promote choleresis, reduce blood cholesterol level, increase plasmin activity, prevent artery
The generation of hardening, it is rapid decomposable internal, suppress the effect such as inflammatory reaction, anti-oxidant, resisting rheumatoid disease.In American-European and Japan's solution
Bartender's liver product scope is in widespread attention.The protein that corn peptide is extracted from natural food corn, then by orientation digestion
And the micromolecule polypeptide material that specific small peptide isolation technics obtains.Chain amino acid content is high in corn peptide, is a kind of high F value peptide
(Fischer ratio).Research shows that branched-chain amino acid (leucine, isoleucine, valine) can when lesion occurs for liver
By eubolism, and other amino acid metabolisms are obstructed, and F values in blood plasma is changed, and become abnormal, destroy internal body balance
Thus cause a disease.Corn peptide can improve liver function, and alleviating blood aromatic amino acid excessive concentration causes hepatic coma and other effects.Country
The Ministry of Industry and Information Technology issued on July 9th, 2014《Corn oligopeptide powder professional standard》(QB/T 4707-2014).Black drought
Lotus is feverfew Eclipta prostrata (Eclipta prostrata) dry aerial parts.For《Chinese Pharmacopoeia) version received cultivation product 2015 years
Kind, have nourishing liver and kidney, the effect of cooling blood and hemostasis, its chemical composition mainly has wedelolactone, demethyl wedelolactone, different gone
The alkaloids such as first wedelolactone.Modern pharmacological research proves that eclipta also has anti-inflammatory and antalgic, liver protection, immunological regulation, anti-lured
Become, activate the effect such as tyrosinase, anti-aging, anti anoxia and antimicrobial antiphlogistic.Curcuma powder, corn Gly-His-Lys 10-40 parts and ink
Non-irrigated lotus improves functional activity molecular biosciences availability by bio-nanotechnology, and it is more to be prepared into Antialcoholic liver-protecting turmeric by finishing
Functional food.Edible safety of the present invention is effective, nontoxic.To it is drunk caused by Ethanol intake excess, be still drank after a night, in alcohol
Poison, alcoholic liver etc. carry out prevention effect, can also prevent the functions such as oxyhepatitis caused by liver disfunction.
Embodiment
The present invention is illustrated with reference to example：
Embodiment 1：A kind of Antialcoholic liver-protecting turmeric multifunctional food, including traditional Chinese medicinal components, by the raw material of following components by weight percent
It is made：Curcuma powder 5-35 parts, corn oligopeptide powder 20-70 parts, eclipta 5-25 parts.
Above-mentioned raw materials are proportionally respectively processed, curcuma powder, corn oligopeptide powder and eclipta crushed and
Mixed preparing, produce Antialcoholic liver-protecting functional activity composition.
The formulation of the Antialcoholic liver-protecting turmeric multifunctional food is tablet, granule or hard capsule.
Embodiment 1 (being parts by weight below)
Curcuma powder, corn oligopeptide powder, eclipta parts by weight are：5 parts of curcuma powder, 70 parts of corn oligopeptide powder, ink drought
25 parts of lotus, crush, Antialcoholic liver-protecting functional activity composition 1 is obtained after being well mixed.
Embodiment 2
Curcuma powder, corn oligopeptide powder, eclipta parts by weight are：25 parts of curcuma powder, 60 parts of corn oligopeptide powder, ink drought
15 parts of lotus, crush, Antialcoholic liver-protecting functional activity composition 2 is obtained after being well mixed.
Embodiment 3
Curcuma powder, corn oligopeptide powder, eclipta parts by weight are：25 parts of curcuma powder, 70 parts of corn oligopeptide powder, ink drought
5 parts of lotus, crush, Antialcoholic liver-protecting functional activity composition 3 is obtained after being well mixed.
Embodiment 4
Curcuma powder, corn oligopeptide powder, eclipta parts by weight are：20 parts of curcuma powder, 60 parts of corn oligopeptide powder, ink drought
20 parts of lotus, crush, Antialcoholic liver-protecting functional activity composition 4 is obtained after being well mixed.
Embodiment 2 is to embodiment 4：
The Antialcoholic liver-protecting function into embodiment 4 of EXPERIMENTAL EXAMPLE 2 is carried out by the Feedstock Component content specified in table 1 below to live
The preparation method of property composition, the Antialcoholic liver-protecting functional activity composition 2 of different component content is respectively obtained to Antialcoholic liver-protecting work(
Can active compound 4.
Table 1
Embodiment 5
The preparation of Antialcoholic liver-protecting turmeric multifunctional food tablet：60 parts of Antialcoholic liver-protecting functional activity compositions 2, it is brilliant to add dimension
35 parts of cellulose, 5 parts of carboxymethyl cellulose, 1 part of xylitol, 0.5 part of ascorbic acid, input mixer interior mixing 20-40 minutes,
Ethanol is added as wetting agent, mixes 10-20 minutes, mixed material is pelletized with 10-20 mesh sieves, is put into drying equipment and is done
It is dry, 1 part of magnesium stearate is added, whole grain, tabletting, packaging, that is, tablet of the invention is made.
Embodiment 6
The preparation of Antialcoholic liver-protecting turmeric multifunctional food tablet：20 parts of Antialcoholic liver-protecting functional activity compositions 3, it is brilliant to add dimension
50 parts of cellulose, 15 parts of carboxymethyl cellulose, 15 parts of dextrin, 1.4 parts of xylitol, 0.5 part of ascorbic acid, the same example of following steps
4。
Embodiment 7
The preparation of Antialcoholic liver-protecting turmeric multifunctional food hard capsule：Antialcoholic liver-protecting functional activity composition 4 in 50 parts, dimension
40 parts of crystalline cellulose, 5 parts of carboxymethyl cellulose, 5 parts of dextrin, 2 parts of xylitol, 1.5 parts of ascorbic acid, input mixer is interior to be mixed
20-40 minutes, ethanol is added as wetting agent, mixes 10-20 minutes, mixed material is pelletized with 10-20 mesh sieves, adds 1
The hard fatty acids magnesium of part, whole grain, capsule charge, packaging, that is, hard capsule of the invention is made.
Embodiment 8
The preparation of Antialcoholic liver-protecting turmeric multifunctional food hard capsule：
15 parts of Antialcoholic liver-protecting functional activity compositions 2,75 parts of Celluloasun Microcrystallisatum, 10 parts of dextrin, following steps are the same as example 7.
Embodiment 9 is relieved the effect of alcohol experiment
The gained Antialcoholic liver-protecting turmeric multifunctional food of 2g embodiments 1~8 and curcuma powder are added separately to 100mL 50%
In alcohol and the alcohol of 100mL 30%, the ethanol mass concentration in two parts of alcohol is detected every 1h, the results are shown in Table 1.
Table 1 relieves the effect of alcohol result of the test
From table 1, compared with using curcuma powder merely, the Antialcoholic liver-protecting turmeric multifunctional food prepared by the present invention can
The obvious concentration of alcohol reduced in alcohol, you can the effect of Dealcoholic sobering-up is played, wherein it is best with the dispelling effects of alcohol of embodiment 2, its
Secondary is embodiment 5.
The liver protection of embodiment 10 is tested
Take same age in days SPF level Wistar rats 110, male and female half and half, 220 ± 20g of body weight, after adaptability is raised 20 days,
Rat is randomly divided into 11 groups：
1st~8 group is test group, and it carries out modeling with 50% alcohol gavage 2 times a week, each 50mL, continues 6 weeks, its
The remaining time carries out gavage with 10% alcohol, 1 time a day；Wherein, since the 3rd week, embodiment 1 was contained with 1.2mg/mL every 1 day
10% alcohol of~8 gained Antialcoholic liver-protecting turmeric multifunctional food samples carries out gavage；9th group is positive controls, and it weekly 2
It is secondary to carry out modeling with 50% alcohol gavage, each 50mL, continue 6 weeks, remaining time carries out gavage with 10% alcohol, 1 time a day；
Wherein, since the 3rd week, every 1 day, with 1.2mg/mL, 10% alcohol containing curcuma powder carried out gavage；10th group is model comparison
Group, it carries out modeling with 50% alcohol gavage 2 times a week, each 50mL, continues 6 weeks, and remaining time carries out gavage with distilled water,
1 time a day；11st group is blank control group, and it 1 time a day, each 50mL, continues 6 weeks with distilled water gavage.
After processing terminates, triglycerides (TG) kit, serum alanine aminotransferase (ALT) reagent is respectively adopted
Box, serum winter histidine amino group transferase (AST) kit and MDA (MDA) kit carry out indices detection, and it is detected
It the results are shown in Table 2.
The liver protection result of the test of table 2
From table 2, compared with blank control group (the 11st group), ALT in model control group (the 10th group) rat blood serum,
MDA contents significantly raise in AST, TG content and hepatic tissue；And compared with model control group (the 10th group), positive controls
(the 9th group) has dropped with MDA contents in ALT, AST, TG content in test group (the 1st~8 group) rat blood serum and hepatic tissue
It is low, wherein, with test group positive effect, illustrate that the present composition has good liver protection, repairs the effect of hepatic injury.
Proved by above-mentioned experiment, the turmeric compound powder that the present invention is prepared by material matching has the Antialcoholic liver-protecting of collaboration
Effect, wherein best with the resultant effect of embodiment 5.
The present invention is disclosed with preferred embodiment above, so it is not intended to limiting the invention, all to use equivalent substitution
Or the technical scheme that equivalent transformation mode is obtained, it is within the scope of the present invention.
Claims (6)
1. a kind of Antialcoholic liver-protecting turmeric multifunctional food, it is characterised in that be made up of the raw material of following components by weight percent：Curcuma powder 5-
35 parts, corn oligopeptide powder 20-70 parts, eclipta 5-25 parts.
2. Antialcoholic liver-protecting turmeric multifunctional food according to claim 1, it is characterised in that the processing method of raw material is：
Above-mentioned raw materials are proportionally respectively processed, curcuma powder, corn oligopeptide powder and eclipta are crushed and mixed preparing,
Produce Antialcoholic liver-protecting functional activity composition.
3. Antialcoholic liver-protecting turmeric multifunctional food according to claim 2, it is characterised in that：The Antialcoholic liver-protecting turmeric is more
The formulation of functional food is tablet, granule or capsule.
4. Antialcoholic liver-protecting turmeric multifunctional food according to claim 3, the preparation method of tablet are as follows：
Antialcoholic liver-protecting functional activity composition 25-60 parts, add Celluloasun Microcrystallisatum 20-40 parts, carboxymethyl cellulose 5-10 parts, wood
Mixing 20-40 minutes in sugar alcohol 0.2-2.5 parts, ascorbic acid 0.1-1.5 parts input mixer, ethanol is added as wetting agent,
10-20 minutes are mixed, mixed material is pelletized with 10-20 mesh sieves, is put into drying equipment and is dried, and adds the tristearin of 1-5 parts
Sour magnesium, whole grain, tabletting, packaging, produce.
5. Antialcoholic liver-protecting turmeric multifunctional food according to claim 3, the preparation method of granule are as follows：Antialcoholic liver-protecting
Functional activity composition 30-70 parts, add starch 10-25 parts, Celluloasun Microcrystallisatum 10-30 parts, white granulated sugar 5-10 parts, input mixing
Mixing 20-40 minutes in machine, ethanol is added as wetting agent, mixes 10-20 minutes, mixed material 10-20 mesh sieve series
Grain, it is put into drying equipment and dries, dry particle is sieved with 20-60 eye mesh screens, is removed coarse granule and fine powder, packaging, is produced.
6. Antialcoholic liver-protecting turmeric multifunctional food according to claim 3, the preparation method of capsule are as follows：Antialcoholic liver-protecting work(
Energy active compound 10-50 parts, Celluloasun Microcrystallisatum 40-70 parts, dextrin 5-10 parts, input mixer interior mixing 20-30 minutes, add
Enter ethanol as wetting agent, mix 10-20 minutes, mixed material is pelletized with 10-20 mesh sieves, adds the tallow of 1-5 parts
Sour magnesium, whole grain, capsule charge, packaging, produce.
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Effective date of registration: 20210108 Address after: 318000 No. 218-1 Waisha Road, Jiaojiang District, Taizhou City, Zhejiang Province Applicant after: Taizhou Yunong Biotechnology Co.,Ltd. Address before: No.305, No.66, Lingjiao City, Qinhuai District, Nanjing City, Jiangsu Province, 210004 Applicant before: NANJING HOPE-PHARM Co.,Ltd. |
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Application publication date: 20180313 |
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