CN107764993B - Automatic solid-phase carrier feeding device and reaction disc system for analyzer - Google Patents
Automatic solid-phase carrier feeding device and reaction disc system for analyzer Download PDFInfo
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- CN107764993B CN107764993B CN201710977061.7A CN201710977061A CN107764993B CN 107764993 B CN107764993 B CN 107764993B CN 201710977061 A CN201710977061 A CN 201710977061A CN 107764993 B CN107764993 B CN 107764993B
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- 239000007790 solid phase Substances 0.000 title claims abstract description 104
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 63
- 230000007246 mechanism Effects 0.000 claims abstract description 91
- 239000007787 solid Substances 0.000 claims abstract description 68
- 239000000969 carrier Substances 0.000 claims abstract description 19
- 230000005540 biological transmission Effects 0.000 claims description 16
- 238000001514 detection method Methods 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract 1
- 238000007599 discharging Methods 0.000 description 42
- 238000005452 bending Methods 0.000 description 34
- 238000000034 method Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 230000009471 action Effects 0.000 description 3
- 239000013566 allergen Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Food Science & Technology (AREA)
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- Biotechnology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses an automatic solid-phase carrier feeding device for an analyzer and a reaction disc system, which can automatically put a solid-phase carrier into a reaction disc, thereby improving the detection efficiency. Solid phase carrier automatic material conveying device includes: a solid support library for storing one or more solid support plates; the feeding piece is provided with a feeding groove which is used for facing the outer side of the reaction position of the reaction disc; a first clamping mechanism movable along the y-axis for moving one of the solid support plates out of the library of solid support plates; the first driving mechanism is used for driving the first clamping mechanism to move; a second clamping mechanism movable along the x-axis for moving one of the solid phase carriers on the removed solid phase carrier plate into the feed bin; the second driving mechanism is used for driving the second clamping mechanism to move; the pushing piece is movably arranged in the feeding groove so as to push the fixed carrier in the feeding groove into the reaction position of the reaction disc; and the pushing driving mechanism is used for driving the pushing piece to move.
Description
Technical Field
The invention relates to the technical field of analysis and detection, in particular to an automatic solid-phase carrier feeding device for an analyzer and a reaction disc system with the same.
Background
When the analyzer is used for biochemical immunity detection, the solid phase carrier needs to be placed in a reaction position of a reaction disk so as to facilitate subsequent sample adding, reaction and the like. For example, in the case of allergen IgE detection, an antibody, which is an IgE antibody that can be captured and bound to an allergen, is pre-coated on a solid carrier to be used; the reaction disc is provided with a plurality of (e.g. 60) reaction sites, and temperature control is realized in the disc; the IgE washing liquid, the IgE buffer solution, the IgE substrate solution and the IgE enzyme-labeled antibody are respectively added through a plurality of fixed needles; the solid phase carriers are stored in a solid phase carrier box, a plurality of solid phase carrier plates which are horizontally arranged and are stacked are arranged in one box, a plurality of slots are formed in each solid phase carrier plate, one solid phase carrier is placed in each slot, and one box of solid phase carrier can support the instrument for uninterrupted use for a certain time.
It can be seen that a plurality of solid carriers are often required to complete a test, each solid carrier needs to be moved out of the hole site of each plate one by one and put into the corresponding reaction site, if an automatic feeding device for pushing the solid carriers into the reaction sites one by one can be designed, the biochemical immunity test is more convenient, and the test efficiency is improved.
Disclosure of Invention
On one hand, the invention provides an automatic solid-phase carrier feeding device for an analyzer, which can automatically put a solid-phase carrier into a reaction disc, so that the detection efficiency is improved; in another aspect, the present invention provides a reaction tray system for an analyzer having an automatic solid support feeding device for automatically placing a solid support into a reaction tray.
In order to achieve the above purpose, the invention adopts a technical scheme that:
A solid phase carrier automatic feed device for an analyzer, comprising:
A solid phase carrier library for storing one or more solid phase carrier plates, the solid phase carrier library having an outlet for removal of the solid phase carrier plates;
the feeding piece is provided with a feeding groove which is used for facing the outer side of the reaction position of the reaction disc;
A first clamping mechanism movable along the y-axis for moving one of the solid support plates out of the library of solid support plates;
the first driving mechanism is used for driving the first clamping mechanism to move;
A second clamping mechanism movable along the x-axis for moving one of the solid phase carriers on the removed solid phase carrier plate into the feed bin;
The second driving mechanism is used for driving the second clamping mechanism to move;
the pushing piece is movably arranged in the feeding groove so as to push the fixed carrier in the feeding groove into the reaction position of the reaction disc; and
And the pushing driving mechanism is used for driving the pushing piece to move.
Preferably, the solid-phase carrier automatic feeding device further comprises a y-direction guide rail extending along a y-axis, and the first clamping mechanism is slidably arranged on the y-direction guide rail along the y-axis.
More preferably, the first clamping mechanism comprises a first sliding block which is driven by the first driving mechanism and is slidably arranged on the y-direction guide rail along the y axis, and at least one pair of first clamping pieces which is driven by the first driving mechanism and is slidably arranged on the first sliding block along the x axis, wherein two first clamping pieces in the pair of first clamping pieces are arranged at intervals so as to synchronously close or open to clamp or release the solid-phase carrier plate.
More preferably, the solid-phase carrier automatic feeding device further comprises a solid-phase carrier frame, the solid-phase carrier warehouse is movably arranged on the solid-phase carrier frame along the z-axis direction, and the solid-phase carrier automatic feeding device further comprises a third driving mechanism for driving the solid-phase carrier warehouse to move.
Further, the solid phase carrier rack is provided with a column extending along the z-axis, and the solid phase carrier warehouse is driven by the third driving mechanism to be slidably arranged on the column along the z-axis.
Preferably, the solid-phase carrier automatic feeding device further comprises an x-direction guide rail extending along an x-axis, and the second clamping mechanism is slidably arranged on the x-direction guide rail along the x-axis.
More preferably, the second clamping mechanism comprises a second slider slidably arranged on the x-direction guide rail along the x-axis by the second driving mechanism, a clamping piece mounting plate slidably arranged on the second slider along the z-axis by the second driving mechanism, and a second clamping piece arranged on the clamping piece mounting plate, and the feeding groove is positioned right below the second clamping piece.
Further, the second clamping members can be rotatably arranged on the clamping member mounting plate around the y-axis direction and are arranged in pairs, the second clamping mechanism further comprises a transmission plate which can be rotatably arranged on the clamping member mounting plate around the y-axis direction and is driven to rotate by the second driving mechanism, the transmission plate is positioned between the two second clamping members which are arranged in pairs, the transmission plate is provided with a pair of protrusions which correspond to the two second clamping members respectively, one of the protrusions is connected with one of the second clamping members respectively, and the other protrusion is connected with the other of the protrusions to drive the two second clamping members to rotate in opposite directions.
Preferably, the feed trough extends along the x-axis.
The invention adopts another technical scheme that:
a reaction disk system for an analyzer comprises the automatic solid-phase carrier feeding device.
Compared with the prior art, the invention has the following advantages:
The first clamping mechanism is driven by the first driving mechanism to move out the solid carrier plates bearing a plurality of solid carriers, then the second clamping mechanism is driven by the second driving mechanism to put the solid carriers on the solid carrier plates into the feeding groove of the feeding piece one by one, and the notch of the feeding groove is opposite to the outer side of the reaction position of the reaction disc, so that the solid carriers can be pushed into the reaction position by driving the pushing piece to slide along the feeding groove by the third driving mechanism, automatic feeding is realized, detection is facilitated, and detection efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions of the present invention, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic perspective view of a reaction disk system according to the present invention;
FIG. 2 is a top view of the reaction disk system shown in FIG. 1;
FIG. 3a is a schematic perspective view of the solid support automatic feeding apparatus of FIG. 1;
FIG. 3b is a top view of the solid support automatic feeding device of FIG. 1;
FIG. 4 is an enlarged view of a portion of FIG. 3a at A;
FIG. 5 is a schematic perspective view of the automatic solid phase carrier discharging device shown in FIG. 1;
FIG. 6 is an exploded schematic view of the automatic solid support discharge apparatus shown in FIG. 5;
FIG. 7 is a partial cross-sectional view of the automatic solid support discharge apparatus shown in FIG. 5, taken from the left side;
Fig. 8 is a cross-sectional view at B-B of fig. 7.
In the above figures of the drawings,
1. A reaction plate; 10. a reaction site;
2. a solid phase carrier automatic feeding device; 21. a solid phase carrier rack; 210. a column; 22. a solid phase carrier library; 220. a solid phase carrier plate; 220a, slot positions; 23. a y-direction guide rail; 24. a first clamping member; 25. an x-direction guide rail; 261a, pulleys; 261b, pulleys; 262. a belt; 271. a second slider; 272. a clamping piece mounting plate; 273. a second clamping member; 273a, clamping jaw; 273b, pivot; 274. a second clamping member; 274a, jaws; 274b, a pivot; 275. a drive plate; 275a, a protrusion; 275b, protrusions; 28. a feeding piece; 280. feeding a trough; 29. a pushing piece;
3. An automatic solid-phase carrier discharging device; 30. a bracket; 301. a discharging guide rail; 31. a discharging hook; 31a, a body; 31b, a rocker; 311. a first bending part; 312. a long hole; 313. a pivot; 314. a first end of the rocker; 315. a second end of the rocker; 32. a baffle; 321. a second bending part; 322. a first stopper; 322a, a first screw; 33. a second stopper; 33a, a second screw; 35a, a pulley; 35b, a pulley; 36. a belt; 37. a discharging slide block; 38. a connecting member; 39. a connecting block; 40. an elastic member.
Detailed Description
Preferred embodiments of the present invention will be described in detail below with reference to the attached drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art. The description of these embodiments is provided to assist understanding of the present invention, but is not intended to limit the present invention. In addition, technical features of the embodiments of the present invention described below may be combined with each other as long as they do not collide with each other.
The present embodiment provides a reaction disk system for use in an automated immunoassay analyzer. Referring to fig. 1-2, the reaction disc system comprises a reaction disc 1, an automatic solid-phase carrier feeding device 2 and an automatic solid-phase carrier discharging device 3, wherein a circle of reaction sites 10 which are arranged at intervals along the circumference are arranged on the outer edge of the reaction disc 1, the reaction sites 10 are specifically grooves formed on the outer edge of the reaction disc 1, and the notch of each groove is upward and the outer sides of the grooves are open, so that the solid-phase carriers can conveniently enter and exit from the outer sides of the reaction sites 10. The solid phase carrier referred to herein refers to an assembly of fibrous membrane, shell and liner, and its specific structure can be found in chinese patent application No. 201720417480.0. The automatic solid-phase carrier feeding device 2 is used for loading the solid-phase carriers into the reaction sites 10 of the reaction tray 1 one by one, and the automatic solid-phase carrier discharging device 3 is used for discharging the solid-phase carriers which are subjected to the test on the reaction sites 10. The automatic feeding device 2 and the automatic discharging device 3 will be described in detail with reference to fig. 3 to 8, respectively.
Referring to FIGS. 3a, 3b and 4, an automatic solid phase carrier feeding apparatus 2 for an analyzer comprises:
a solid support library 22 for holding one or more solid support plates 220, the solid support library 22 having an outlet for removal of the solid support plates 220;
the feeding piece 28 is provided with a feeding groove 280 which is used for facing the outer side of the reaction position 10 of the reaction disc 1;
A first clamping mechanism movable along the y-axis for moving one of the solid support plates 220 out of the solid support library 22;
the first driving mechanism is used for driving the first clamping mechanism to move;
a second clamping mechanism movable along the x-axis for moving one of the solid phase carriers on the removed solid phase carrier plate 220 into the feed slot 280;
The second driving mechanism is used for driving the second clamping mechanism to move;
A pushing member 29 movably disposed in the feed slot 280 to push the fixed carrier in the feed slot 280 into the reaction site 10 of the reaction tray 1; and
And the pushing driving mechanism is used for driving the pushing member 29 to move.
Wherein, the solid phase carrier warehouse 22 is movably arranged on a solid phase carrier frame 21 along the z-axis direction, and the solid phase carrier automatic feeding device 2 further comprises a third driving mechanism for driving the solid phase carrier warehouse 22 to move. In the invention, the z axis extends along the vertical direction, the x axis and the y axis extend along the horizontal direction respectively and are mutually perpendicular, and the x axis, the y axis and the z axis form a space rectangular coordinate system.
The solid carrier rack 21 has a column 210 extending along the z-axis, and the solid carrier magazine 22 is slidably provided on the column 210 along the z-axis by being driven by a third driving mechanism. The third drive mechanism includes a motor M1 that drives the solid phase carrier library 22 up and down through a transmission mechanism known in the art, and will not be described in detail herein. The inner wall of the solid carrier library 22 is provided with a clamping groove matched with the solid carrier plate 220, the solid carrier plate 220 is clamped in the clamping groove, and normally, the solid carrier library 22 is internally provided with a plurality of solid carrier plates 220, and the plurality of solid carrier plates 220 are vertically stacked at intervals. As the library 22 is raised and lowered, each of the solid support plates 220 has a position substantially flush with the second clamping mechanism. A plurality of slots 220a are regularly arranged on each solid phase carrier plate 220, and one solid phase carrier is placed on each slot 220 a.
The first clamping mechanism is slidably disposed along the y-axis on a y-direction rail 23 extending along the y-axis. Specifically, the first clamping mechanism includes a first slider driven by the first driving mechanism to be slidably disposed on the y-direction guide rail 23 along the y-axis, and at least one pair of first clamping members 24 driven by the first driving mechanism to be slidably disposed on the first slider along the x-axis, the first slider and the y-direction guide rail 23 are slidably engaged, the first clamping members 24 and the first slider are slidably engaged, two first clamping members 24 of the pair of first clamping members are disposed at intervals, and can be synchronously closed or opened to clamp or release the solid phase carrier plate 220. A pair of spaced grooves are formed in the side of each solid support plate 220 facing the first clamping member 24, and the ends of the first clamping member 24 have hooks that are insertable into the grooves. The hooks of the two first clamps 24 are opposed to clamp the solid support plate 220. The first driving mechanism specifically comprises a motor M2 for driving the first slider to slide, and a motor M3 for driving the first clamping member 24 to close or open relatively, wherein the motors M2 and M3 respectively drive the first slider and the first clamping member 24 to move through transmission mechanisms known in the prior art.
The second clamping mechanism is slidably disposed along the x-axis on an x-direction rail 25 extending along the x-axis. Specifically, the second clamping mechanism includes a second slider 271 slidably disposed on the x-direction guide rail 25 along the x-axis by the second driving mechanism, a clamp mounting plate 272 slidably disposed on the second slider 271 along the z-axis by the second driving mechanism, and second clamps 273 and 274 disposed on the clamp mounting plate 272, the second slider 271 and the x-direction guide rail 25 are slidably fitted, the clamp mounting plate 272 and the second slider 271 are slidably fitted, and the feed slot 280 is located directly below the second clamps 273 and 274. The second clamping members 273 and 274 are rotatably provided on the clamping member mounting plate 272 about the y-axis direction, respectively, and are provided in pairs, and the second clamping mechanism further includes a transmission plate 275 rotatably provided on the clamping member mounting plate 272 about the y-axis direction, which is driven to rotate by the second driving mechanism, the transmission plate 275 being located between the two second clamping members 273 and 274 provided in pairs, the transmission plate 275 having a pair of protrusions 275a and 275b corresponding to the two second clamping members 273 and 274, respectively, one of the protrusions 275a being connected to one of the second clamping members 273 and the other of the protrusions 275b being connected to the other of the second clamping members 274 to drive the two second clamping members 273 and 274 to rotate in opposite directions. As shown in fig. 4, the upper protrusion 275a is abutted against the left second clamping member 273, the lower protrusion 275b is abutted against the right second clamping member 274, the second clamping members 273 and 274 are respectively rotatably provided on the clamping member mounting plate 272 by means of pivots 273b, 274b extending along the y-axis, the lower Fangbie of the second clamping members 273, 274 has clamping jaws 273a, 274a, the pivot 273b is located between the protrusion 275a and the clamping jaw 274a, and the pivot 274b is located between the protrusion 275b and the clamping jaw 274a, so that when the transmission plate 275 is rotated counterclockwise, the left clamping jaw 273a is rotated rightward, and the right clamping jaw 274a is rotated leftward, thereby being brought together to clamp the solid phase carrier; the second clamping members 273 and 274 slide downwardly in the z-axis after moving over the inlet chute 280 along the x-direction guide 25 until the clamped solid phase carriers fall into the inlet chute 280, and the two clamping jaws 273a, 274a are rotated open in opposite directions to release the solid phase carriers.
The second driving mechanism includes a motor M4 for driving the second slider 271 to slide, a motor M5 for driving the clamping member mounting plate 272 to lift, and a motor M6 for driving the transmission plate 275 to rotate, where the motors M4, M5, and M6 are driven by the transmission mechanism, respectively. The motor M4 drives the second slider 271 to move through the fourth transmission mechanism, the motor M4 is fixedly arranged on the x-directional guide rail 25, the second transmission mechanism comprises a pair of belt pulleys 261a and 261b arranged on the x-directional guide rail 25 and a belt 262 arranged on the pair of belt pulleys 261a and 261b, an output shaft of the motor M4 is connected with the belt pulley 261a, one of the second slider 271 and the belt 262 is fixedly connected, and the second slider 271 can slide along the x-directional guide rail 25 along with the movement of the belt 262.
The feed slot 280 extends along the x-axis, and the pushing member 29 is slidably disposed in the feed slot 280 along the x-axis, and the pushing member 29 and the feeding member 28 are slidably engaged. The pushing drive mechanism comprises a motor M7 for driving the movement of the pushing member 29.
It should be noted that, the motors M1 to M7 may be replaced by power sources such as cylinders, respectively.
The solid-phase carrier automatic feeding device 2 of the present invention generally has the following action processes:
(I) The third drive mechanism drives the solid support magazine 22 to rise and fall along the upright 210 until one of the solid support plates 220 within the solid support magazine 22 reaches a position substantially level with the first clamping mechanism; the first driving mechanism drives the first sliding block y-axis to move towards the solid-phase carrier warehouse 22 until the first sliding block y-axis moves to the outlet of the solid-phase carrier warehouse 22 and the hook part of the first clamping piece 24 is inserted into the groove of the solid-phase carrier plate 220; the first driving mechanism drives the pair of first clamping pieces 24 to move along the x-axis in opposite directions, so that the hook parts are close to clamp the solid phase carrier plate 220; the first driving mechanism drives the first sliding block to reversely move along the y axis, and the solid phase carrier plate 220 clamped by the hook part is pulled out from the solid phase carrier warehouse 22;
(II) the second driving mechanism drives the second clamping members 273 and 274 to move downward until the clamping jaws 273a, 274a reach a position level with the solid phase carrier, and the two clamping jaws 273a, 274a are respectively located on both sides of the same solid phase carrier; the second drive mechanism drives the second clamping members 273 and 274 to rotate in opposite directions so that the two clamping jaws 273a, 274a clamp the solid phase carrier; the second driving mechanism then drives the second clamping parts 273 and 274 to move upwards, and then drives the second clamping parts 273 and 274 to move along the x-axis direction of the feeding part 28 until the second clamping parts 273 and 274 move right above the feeding part 28; then, the second driving mechanism drives the second clamping members 273 and 274 to drop into the feeding trough 280 when moving downwards, and drives the second clamping members 273 and 274 to rotate reversely, the two clamping jaws 273a and 274a are opened relatively, and the solid phase carrier is released and is positioned in the feeding trough 280;
(III) the pushing driving mechanism drives the pushing member 29 to move towards the reaction disc 1 along the x-axis, so that the solid phase carrier is pushed into the reaction site 10 outside the reaction site 10, and the automatic feeding process is completed.
When all the solid carriers on the withdrawn solid carrier plate 220 are used, the two second clamping members 273 and 274 are reset, and the solid carrier plate 220 is removed; and then repeating the step (I), extracting the other solid carrier plate 220 loaded with the solid carrier, and continuing the steps (II) and (III) to ensure the subsequent solid carrier feeding.
Referring to fig. 5 to 8, an automatic solid carrier discharging device 3 for an analyzer comprises:
A bracket 30;
A discharge hook 31 slidably disposed on the bracket 30 in a front-rear direction, wherein a front end portion of the discharge hook 31 has a first bending portion 311 extending to be bent downward;
The baffle 32 is capable of sliding relative to the bracket 30 along the front-rear direction, the baffle 32 is arranged below the discharging hook 31, the front end part of the baffle 32 is provided with a second bending part 321 which is bent and extended downwards, and the second bending part 321 is positioned behind the first bending part 311;
A discharge driving mechanism for driving the discharge hook 31 and the shutter 32 to move;
The automatic solid-phase carrier discharging device 3 has a first state and a second state, wherein in the first state, a first distance is formed between the second bending part 321 and the first bending part 311, and the first distance is larger than the length of the solid-phase carrier, so that the solid-phase carrier is allowed to enter between the second bending part 321 and the first bending part 311 or be released; in the second state, the second bending portion 321 and the first bending portion 311 are spaced apart by a second distance, which is not greater than the length of the solid phase carriers, to clamp and remove the solid phase carriers. In the present invention, the upper part of the solid phase carrier specifically refers to the dimension of the solid phase carrier in the reaction tray 1 in the radial direction of the reaction tray 1, and the azimuth terms "front" and "rear" are defined with reference to the center of the reaction tray 1, and are defined closer to the center of the reaction tray 1, and vice versa.
The first bending part 311 corresponds to the front side surface of the solid phase carrier and is used for driving the solid phase carrier to move backwards; the second bending part 321 corresponds to the rear side of the solid phase carrier and is used for preventing the solid phase carrier from toppling over.
The discharging driving mechanism comprises one or two motors as power sources. In this embodiment, a motor M8 is preferably used to drive the movement of the discharge hook 31 and the shutter 32. Specifically, the motor M8 is mounted on the bracket 30, a pair of pulleys 35a and 35b and a belt 36 provided on the pair of pulleys 35a and 35b are provided on the bracket 30, and an output shaft of the motor M8 is connected to one of the pulleys 35a to thereby drive the belt 36 to move. The support 30 further has a discharge guide 301 extending in the front-rear direction, the discharge guide 301 is slidably engaged with a discharge slider 37, the discharge slider 37 is slidably provided on the discharge guide 301 in the front-rear direction, and the discharge slider 37 is fixedly connected to the belt 36 by a connecting member 38 so as to be slidable forward and backward along with the belt 36.
The discharging hook 31 is fixedly connected with the discharging sliding block 37, and the discharging hook and the discharging sliding block can be directly connected or indirectly connected through a plurality of connecting blocks 39. The shutter 32 is slidably attached to the discharge hook 31 in the front-rear direction, and is slidable in synchronization with the discharge hook 31 and allows the discharge hook 31 to slide forward and backward with respect to the shutter 32. Specifically, the discharge hook 31 is provided with a long hole 312 extending in the front-rear direction, the baffle 32 is provided on the discharge hook 31 by a screw provided in the long hole 312, and the screw is movable back and forth in the long hole 312, thereby allowing the discharge hook 31 to slide back and forth with respect to the baffle 32.
The rear end of the baffle 32 is provided with a first stop block 322 which is bent upwards and extends, and when the automatic solid carrier discharging device 3 is in the first state, the first stop block 322 is positioned behind the discharging hook 31 and is separated by a distance; in the process of sliding the discharging hook 31 backwards, the rear end of the discharging hook 31 gradually approaches to the first stop block 322 and is abutted against the first stop block 322, and after the abutment, the baffle 32 slides backwards along with the discharging hook 31, so that the solid-phase carrier automatic discharging device 3 is converted into the second state; that is, when the solid-phase-carrier automatic discharging device 3 is in the second state, the rear end of the discharging hook 31 abuts against the first stopper 322.
The discharging hook 31 includes a body 31a and a rocker 31b rotatably disposed at a rear end portion of the body 31a, and the body 31a is connected to the discharging slider 37 and the baffle 32 and has the first bending portion 311. The rocker 31b is rotatably disposed on the body 31a, and the rocker 31b has a first end 314 and a second end 315 extending downward from an upper surface of the body 31a, and the first end 314 and the second end 315 of the rocker 31b are disposed on opposite sides of the pivot 313 and behind a rear end of the body 31 a. The rocker has a first position in which the first stop 322 is in particular in abutment with the first end 314 of the rocker 31b and a second position. The rear end of the bracket 30 is provided with a second stop block 33, as the discharging hook 31 continues to slide backwards from the first position, the rocker 31b gradually approaches the second stop block 33 and is abutted against the second stop block 33, the rocker 31b reaches the second position, the discharging hook 31 is motionless, the second end 315 of the rocker 31b is abutted against the second stop block 33, and in the process of approaching the second stop block 33, the rocker 31b rotates clockwise under the blocking action of the second stop block 33, so that the baffle 32 slides backwards relative to the discharging hook 31 along with the pushing of the first stop block 322 by the first end 314 of the rocker 31b, and the distance between the second bending part 321 and the first bending part 311 is increased, thereby releasing the solid-phase carrier. Another function of the second stop 33 is to prevent the discharge hook 31 from being excessively moved back out of the discharge rail 301.
In a preferred embodiment, the first stopper 322 includes a first screw 322a movably penetrating the rear end of the barrier 32, the first screw 322a is rotated, and the first screw 322a is moved forward and backward with respect to the barrier 32 by screw-coupling to adjust the distance between the same and the discharge hook body 31a, and in the first position, the rear end of the body 31a is abutted by the first end 314 of the rocker and the first screw 322 a; the second stopper 33 includes a second screw 33a movably inserted through the rear end of the bracket 30, the second screw 33a is rotated, and the second screw 33a is moved forward and backward with respect to the bracket 30 by screw-coupling so as to adjust a distance between the body 31a of the discharge hook 31, and in the second position, the rear end portion of the body 31a is abutted against the second screw 33a through the second end portion 315 of the rocker.
An elastic member 40 is further disposed between the discharging hook 31 and the baffle 32, and is in a deformed state in the second state, and is configured to provide an elastic force to the baffle 32 to clamp the second bending portion 321 to the solid carrier and to reset the baffle 32 after the solid carrier is released. The elastic member 40 is specifically a tension spring, the front end of which is hung on the discharging hook body 31a, and the rear end of which is hung on the baffle 32.
The bracket 30 is further provided with a front end limiting block, and the front end limiting block is specifically located at the front end part of the discharging guide rail 301 and is used for preventing the discharging hook 31 from excessively moving forward to be separated from the discharging guide rail 301.
The automatic solid-phase carrier discharging device 3 of the present invention generally has the following action processes:
The first bending part 311 is positioned above the reaction tray 1 and at the front side of the reaction site 10, the second bending part 321 is positioned at the outer side of the reaction site 10, and the first bending part and the second bending part are separated by the first distance; when the solid phase carrier rotates to be positioned below the discharging hook 31, the solid phase carrier is positioned between the first bending part 311 and the second bending part 321 of the baffle plate 32; the motor M8 rotates forward, the discharging hook 31 starts to move backward, at this time, under the action of the long hole 312, the baffle 32 cannot move along with the discharging hook 31 yet until the discharging hook 31 reaches the first position, that is, the first stop block 322, the first end 314 of the rocker 31b and the rear end of the body 31a of the discharging hook 31 abut, the baffle 32 can start to move backward along with the discharging hook 31, in this process, the first bending part 311 moves backward, the second bending part 321 keeps still, so that the distance between the first bending part 311 and the second bending part 321 is reduced to the second distance, the elastic piece 40 deforms, and the solid phase carrier is pushed out of the reaction position 10 by the first bending part 311 and is clamped between the first bending part 311 and the second bending part 321, that is, in the second state; subsequently, the baffle 32 moves backward synchronously with the discharge hook 31, and the solid phase carriers are completely moved out of the reaction tray 1; when the second end 315 of the rocker 31b is gradually connected with the second stop 33, after being blocked by the second stop 33, the rocker 31b rotates clockwise until the second stop 33, the second end 315 of the rocker 31b and the rear end of the body 31a abut against each other, the first bending portion 311 stops moving backward, the solid carrier is above the solid carrier recovery opening, and the first end 314 of the rocker 31b pushes the first stop 322 backward in the process of approaching the second stop 33, so that the baffle 32 moves backward relative to the body 31a of the discharge hook 31, that is, the distance of the backward movement of the second bending portion 321 is greater than the distance of the backward movement of the first bending portion 311 in the process, so that the distance between the second stop 33 and the rear end of the body 31a is increased (to the first distance), the solid carrier is released, and then falls into the solid carrier recovery opening.
The above-described embodiments are provided for illustrating the technical concept and features of the present invention, and are intended to be preferred embodiments for those skilled in the art to understand the present invention and implement the same according to the present invention, not to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of the present invention.
Claims (5)
1. A solid phase carrier automatic feed device for an analyzer, comprising:
A solid phase carrier library for storing one or more solid phase carrier plates, the solid phase carrier library having an outlet for removal of the solid phase carrier plates;
the feeding piece is provided with a feeding groove which is used for facing the outer side of the reaction position of the reaction disc;
A first clamping mechanism movable along the y-axis for moving one of the solid support plates out of the library of solid support plates;
the first driving mechanism is used for driving the first clamping mechanism to move;
A second clamping mechanism movable along the x-axis for moving one of the solid phase carriers on the removed solid phase carrier plate into the feed bin;
The second driving mechanism is used for driving the second clamping mechanism to move;
the pushing piece is movably arranged in the feeding groove so as to push the fixed carrier in the feeding groove into the reaction position of the reaction disc; and
The pushing driving mechanism is used for driving the pushing piece to move;
The solid-phase carrier automatic feeding device further comprises a y-direction guide rail extending along a y-axis, and the first clamping mechanism can be arranged on the y-direction guide rail in a sliding manner along the y-axis; the first clamping mechanism comprises a first sliding block which is driven by the first driving mechanism and can be arranged on the y-direction guide rail in a sliding way along the y axis, and at least one pair of first clamping pieces which are driven by the first driving mechanism and can be arranged on the first sliding block in a sliding way along the x axis, wherein two first clamping pieces in the pair of first clamping pieces are arranged at intervals so as to be synchronously closed or opened to clamp or release the solid-phase carrier plate;
the solid-phase carrier automatic feeding device further comprises an x-direction guide rail extending along an x-axis, and the second clamping mechanism can be arranged on the x-direction guide rail in a sliding manner along the x-axis; the second clamping mechanism comprises a second sliding block which is arranged on the x-direction guide rail in a sliding manner along the x-axis by the second driving mechanism, a clamping piece mounting plate which is arranged on the second sliding block in a sliding manner along the z-axis by the second driving mechanism, and a second clamping piece which is arranged on the clamping piece mounting plate, and the feeding groove is positioned right below the second clamping piece; the second clamping pieces can be rotatably arranged on the clamping piece mounting plate around the y-axis direction and are arranged in pairs, the second clamping mechanism further comprises a transmission plate which can be rotatably arranged on the clamping piece mounting plate around the y-axis direction and is driven to rotate by the second driving mechanism, the transmission plate is positioned between the two second clamping pieces which are arranged in pairs, the transmission plate is provided with a pair of bulges which correspond to the two second clamping pieces respectively, one bulge is connected with one second clamping piece respectively, and the other bulge is connected with the other second clamping piece so as to drive the two second clamping pieces to rotate along the opposite directions.
2. The solid support automatic feeding device according to claim 1, further comprising a solid support frame, wherein the solid support magazine is movably disposed on the solid support frame along the z-axis direction, and wherein the solid support automatic feeding device further comprises a third driving mechanism for driving the solid support magazine to move.
3. The automatic solid support feeding device according to claim 2, wherein the solid support frame has a column extending along the z-axis, and the solid support magazine is slidably provided on the column along the z-axis by being driven by the third driving mechanism.
4. The solid support automatic feeding device of claim 1, wherein the feed trough extends along the x-axis.
5. A reaction tray system for an analyzer comprising the solid support automatic feeding device according to any one of claims 1 to 4.
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| CN201710977061.7A CN107764993B (en) | 2017-10-19 | 2017-10-19 | Automatic solid-phase carrier feeding device and reaction disc system for analyzer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710977061.7A CN107764993B (en) | 2017-10-19 | 2017-10-19 | Automatic solid-phase carrier feeding device and reaction disc system for analyzer |
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| CN107764993B true CN107764993B (en) | 2024-05-10 |
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| CN207263760U (en) * | 2017-10-19 | 2018-04-20 | 东方伊诺(苏州)医疗科技有限公司 | The solid phase carrier automatic feeding device and reaction disc system of a kind of analyzer |
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| JPH0589584A (en) * | 1991-09-26 | 1993-04-09 | Sharp Corp | Disk reproducing device |
| WO2016046402A1 (en) * | 2014-09-25 | 2016-03-31 | Altergon Italia S.R.L. | Apparatus for separation, washing and mixing of magnetic particles in a reaction cup, adapted to be used in an immunoanalyzer system |
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| CN107764993A (en) | 2018-03-06 |
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