CN112986598A - Automatic slide loading and unloading mechanism capable of continuously loading slide boxes and slides - Google Patents
Automatic slide loading and unloading mechanism capable of continuously loading slide boxes and slides Download PDFInfo
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- CN112986598A CN112986598A CN202110171513.9A CN202110171513A CN112986598A CN 112986598 A CN112986598 A CN 112986598A CN 202110171513 A CN202110171513 A CN 202110171513A CN 112986598 A CN112986598 A CN 112986598A
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- 230000007246 mechanism Effects 0.000 title claims abstract description 100
- 238000011084 recovery Methods 0.000 claims abstract description 37
- 230000005540 biological transmission Effects 0.000 claims abstract description 4
- 239000011521 glass Substances 0.000 claims description 15
- 238000001514 detection method Methods 0.000 description 10
- 230000009471 action Effects 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
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Abstract
The invention relates to an automatic slide loading and unloading mechanism capable of continuously loading a slide box and slides, which comprises a slide box loading module and a slide box moving module; the cassette loading module includes a cassette conveyor; the slide box moving module comprises a multifunctional pushing mechanism which moves horizontally and a vertical moving mechanism which moves up and down; the multifunctional pushing mechanism comprises a slide box pushing plate, a slide resetting push plate and a slide box recovering push plate; the slide boxes on the slide box transmission belt are sequentially pushed into a vertical moving mechanism device by a slide box pushing plate, the slides in the vertical moving mechanism are sequentially pushed into a scanning device by the slide pushing plate, and the scanned slides are pushed back into the slide boxes by a slide resetting pushing plate; the slide box recovery push plate pushes out the slide box in the vertical moving mechanism. The slide box can be continuously loaded, and the slide can be quickly loaded and unloaded, so that the slide scanning efficiency is improved.
Description
Technical Field
The invention relates to the technical field of slide scanning detection, in particular to an automatic slide loading and unloading mechanism capable of continuously loading a slide box and slides.
Background
Slide scanning detection is the indispensable work in medical research, and cell sample is through the film-making, dyeing back, and the staff carries out scanning detection on scanning microscope, and cell sample is through the film-making, dyeing back, generally deposits in slide glass box earlier, then presss from both sides the slide from slide glass box when needing to examine and gets out. Some automatic scanning detection devices are available in the market, but the one-time detection amount of a slide sample is limited, and the requirement of continuous scanning work cannot be met, for example, a full-automatic mycobacterium tuberculosis micro-scanning analyzer disclosed in the invention patent with the publication number of CN111272659A can load 120 slides at one time, and after the detection is finished, a slide box needs to be replaced again, so that the slide detection cannot be continuously carried out. In the automatic scanning detection equipment, the slide transfer process of placing a slide under a microscope for scanning has the problems of slow action, complex mechanism and low slide transfer efficiency, for example, a manipulator device which can freely grab the slide is disclosed in the invention patent of publication No. CN110587585A, the slide is clamped and transferred by adopting a plurality of groups of lead screw nut mechanisms and electric clamping jaws, the structure is complex, the slide transfer efficiency is low, the plurality of groups of lead screw nut mechanisms occupy the equipment space, and more vibration can be generated in the operation engineering to influence the detection result of the slide.
Disclosure of Invention
The invention aims to provide an automatic slide loading and unloading mechanism capable of continuously loading slide boxes and slides, which is used for solving the problems that continuous scanning cannot be realized in the conventional automatic slide scanning and detecting process and the slide transfer efficiency is low.
In order to achieve the purpose, the invention adopts the following technical scheme:
an automatic transfer mechanism and an automatic slide loading and unloading mechanism for continuously loading slide boxes, which comprises a slide box loading module and a slide box moving module; the cassette loading module includes a cassette conveyor; the slide box moving module comprises a multifunctional pushing mechanism which moves horizontally and a vertical moving mechanism which moves up and down; the multifunctional pushing mechanism comprises a slide box pushing plate, a slide resetting push plate and a slide box recovering push plate; the slide boxes on the slide box transmission belt are sequentially pushed into the vertical moving mechanism by the slide box pushing plate, the slides in the vertical moving mechanism are sequentially pushed into the scanning device by the slide pushing plate, and the slides in the scanning device are pushed back into the slide boxes by the slide resetting push plate; the slide box recovery push plate pushes out the slide box in the vertical moving mechanism.
Further preferably, a cassette limiting plate is disposed on the right side of the cassette conveyor and is used to limit the cassette when it moves.
Further preferably, the slide pushing plate is horizontally mounted on the slide cassette pushing plate.
Further preferably, the slide pushing plate and the slide resetting pushing plate are arranged at the same height.
Preferably, a slide box recovery slot is arranged below the slide box loading module, and the slide box recovery push plate pushes the slide box into the slide box recovery slot.
Preferably, the slide rail is arranged at the bottom of the slide box recovery slot.
Further preferably, the cassette recycling slot is disposed directly below the cassette conveyor.
Further preferably, the upper side surface of the glass box fixing frame is provided with a notch.
Further preferably, the vertical movement mechanism comprises a cassette stop disposed on the vertical movement mechanism for limiting the cassette when the slide push plate is actuated.
The invention has the beneficial effects that:
the automatic transfer mechanism and the automatic slide loading and unloading mechanism can continuously load and install the slide boxes, and the package comprises a slide box loading module and a slide box moving module; the cassette loading module includes a cassette conveyor; the slide box moving module comprises a multifunctional pushing mechanism which moves horizontally and a vertical moving mechanism which moves up and down; the multifunctional pushing mechanism comprises a slide box pushing plate, a slide resetting push plate and a slide box recovering push plate; the slide boxes on the slide box transmission belt are sequentially pushed into a vertical moving mechanism device by a slide box pushing plate, the slides in the vertical moving mechanism are sequentially pushed into a scanning device by the slide pushing plate, and the scanned slides are pushed back into the slide boxes by a slide resetting pushing plate; the slide box recovery push plate pushes out the slide box in the vertical moving mechanism. The automatic transfer mechanism and the automatic slide loading and unloading mechanism can continuously load the slide boxes and realize the quick automatic loading and unloading of the slides, have high automation degree, can continuously scan the slides in a large scale, and greatly improve the working efficiency of the slide scanner.
Drawings
FIG. 1 is a schematic structural view of an automatic slide loading and unloading mechanism of the present invention for continuously loading cassettes and slides;
FIG. 2 is a side view of FIG. 1;
FIG. 3 is a schematic view from another angle of FIG. 1;
FIG. 4 is a schematic view of the multi-functional pusher plate configuration of FIG. 3;
FIG. 5 is a schematic view showing the structure of a vertical moving mechanism in an automatic slide loading and unloading mechanism for continuously loading cassettes and slides according to the present invention;
FIG. 6 is a schematic structural view of the plectrum fixing frame in FIG. 5;
FIG. 7 is a schematic view of the configuration of the cassette of FIG. 1;
figure 8 is a schematic view of a cassette mated to a cassette holding frame;
fig. 9 is a schematic structural view of a cassette recovery module in an automatic loading and unloading mechanism for continuously loading cassettes and slides according to the present invention.
Names corresponding to the marks in the figure:
1. a cassette loading module, 11, a cassette conveyor, 12, a cassette limiting plate, 13, a cassette slot, 14, a cassette support plate, 15, a limiting plate screw nut mechanism, 151, a first screw, 152, a first servo motor, 153, a first screw retaining plate, 2, a cassette movement module, 21, a first horizontal chute, 22, a multi-function pusher mechanism, 221, a cassette moving plate, 222, a slide pusher plate, 223, a slide reset push plate, 224, a cassette recovery push plate, 23, a pusher plate screw nut mechanism, 231, a second screw, 232, a second servo motor, 24, a vertical movement mechanism, 241, a cassette, a retaining frame, 2411, a rib plate, 242, a retaining frame screw nut mechanism, 2421, a third screw, 2422, a third servo motor, 2423, a third screw retaining plate, 25, a cassette retaining plate, 3, a cassette recovery module, 31, a slide cassette retaining plate, a slide retaining, A slide box recovery slot 32, a second horizontal chute 33, a slide box guide mechanism 331, a guide screw nut mechanism 332, a guide plate 3311, a fourth screw, 3312, a fourth servo motor, 4, and a slide box.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
Example 1 of the invention:
an automatic slide loading and unloading mechanism capable of continuously loading slide boxes and slides comprises a slide box loading module 1, a slide box moving module 2 and a slide box recovery module 3.
As shown in fig. 1, the cassette loading module includes a cassette conveyor 11, a cassette limiting plate 12, and a cassette slot 13.
The slide cassette slot 13 is for holding a slide cassette, the width of the slide cassette slot 13 is slightly greater than the width of the slide cassette, the slide cassette 4 can move left and right in the slide cassette slot 13, the slide cassette slot 13 is longer in length direction for holding more slide cassettes 4, the height of the slide cassette slot 13 is less than the height of the slide cassette 4, and the slide cassette 4 can be smoothly placed by an operator.
As shown in fig. 7, a cassette conveyor 11 is disposed at the bottom of the cassette slot 13, the cassette conveyor 11 is used to move the cassette 4, a cassette support plate 14 is disposed below the conveyor, and the cassette support plate 14 is used to support the cassette 4 to prevent the cassette conveyor 11 from deforming, so that the cassette 4 is always conveyed on a horizontal plane.
A glass box limiting plate 12 is arranged at the right end of the glass box clamping groove 13, the glass box limiting plate 12 is arranged in the vertical direction and can be lifted, the glass box limiting plate 12 is driven by a screw-nut mechanism, the screw-nut mechanism is recorded as a limiting plate screw-nut mechanism 15 and comprises a screw rod which is recorded as a first screw rod 151, a first servo motor 152 is used for driving the first screw rod 151, and the limiting plate screw-nut mechanism 15 is arranged on a first screw rod fixing plate 153.
The cassette conveyor 11 drives the cassettes 4 to move right in sequence, and after the first cassette 4 enters the rightmost end of the cassette slot 13, the cassette limiting plate 12 moves down to block the rear cassette 4, the right end of the cassette slot 13 is connected with the cassette moving module 2, and the first cassette 4 enters the cassette moving module 2.
As shown in fig. 2-3, the cassette moving module 2 includes a first horizontal slide slot 21 for moving the cassette in a horizontal direction, a vertical moving mechanism 24 for moving the cassette in a vertical direction, and a multi-function pushing mechanism 22.
A first horizontal slide slot 21 is provided at the right end of the slide slot 13 and extends forwardly at the right end of the cassette slot 13, with the cassette moving forwardly in a horizontal direction along the first horizontal slide slot 21.
As shown in fig. 4, the multifunctional pushing mechanism 22 is a T-shaped plate structure, the multifunctional pushing mechanism 22 includes a slide cassette moving plate 221, a slide pushing plate 222, a slide resetting pushing plate 223 and a slide cassette recovery pushing plate 224, the slide cassette moving plate 221 is disposed at the rear end of the multifunctional pushing mechanism body, the slide resetting pushing plate 223 is disposed at the front end of the slide cassette moving mechanism body and extends backward, the slide pushing plate 222 is disposed on the slide cassette moving plate 221 and extends forward, the slide pushing plate 222 and the slide resetting pushing plate 223 are disposed at the same height level, and the slide cassette recovery pushing plate 224 is disposed at the lower end of the slide cassette moving mechanism.
The multifunctional pushing mechanism 22 is driven by a lead screw nut mechanism, the lead screw nut mechanism is marked as a pushing plate lead screw nut mechanism 23, the multifunctional pushing mechanism comprises a lead screw, marked as a second lead screw 231, and a second servo motor 232 drives the second lead screw 231.
The bottom of the first horizontal slide channel 21 is at the same level as the bottom of the cassette slot 13, and the cassette moving plate 221 on the multi-function pushing mechanism 22 is located at the rear side of the cassette 4 when the cassette 4 enters the first horizontal slide channel.
After the cassette 4 enters the first horizontal slide slot 21, the multi-function pusher mechanism 22 moves forward, and the cassette moving plate 221 pushes the cassette to slide forward along the first horizontal slide slot 21, so that the cassette 4 enters the vertical moving mechanism 24.
As shown in fig. 5, the vertical moving mechanism 24 includes a cassette fixing frame 241, the cassette fixing frame 241 is movable up and down, the cassette fixing frame 241 is driven by a lead screw nut mechanism, which is denoted as a fixing frame lead screw nut mechanism 242, includes a lead screw, which is denoted as a third lead screw 2421, and a third servo motor 2422 which drives the third lead screw 2421, and the third lead screw is mounted on a third lead screw fixing plate 2423.
As shown in fig. 6-8, the cassette holder 241 has a square structure, the cassette holder 241 is fitted to the cassette 4, the upper side of the cassette holder 241 is provided with a notch, the rear end of the cassette 4 is higher than the cassette holder 241, the notch forms a limit for the cassette 4 to limit the movement of the cassette 4 in the cassette holder and prevent the cassette 4 from sliding out of the cassette holder.
The right side of the upper side of the cassette holder 241 has a rib 2411 extending downward, the right side of the lower side has a rib extending upward, a gap is formed between the two ribs 2411, the rib 2411 is used to limit the slide cassette 4 from moving left to right in the cassette holder 241, and the gap is used to avoid interference when the slide cassette recovery pusher 224 pushes the slide cassette 4.
After the cassette 4 enters the cassette holder 241, the multi-function pusher mechanism 22 is reset.
When the cassette 4 enters the cassette fixing frame 241, the cassette fixing frame 241 is linearly raised along the third lead screw 2421, and the cassette fixing frame 241 is raised to a certain distance. A plurality of slides coated with samples are inserted in the upper and lower rows in the slide cassette 4, wherein the slide located at the uppermost layer in the slide cassette 4 is located at the same level as the bottom of the slide positioning groove on the slide table according to a setting, and then the multi-function pushing mechanism 22 moves forward along the second lead screw 231, and the slide pushing plate 222 provided on the multi-function pushing mechanism 22 moves forward to push one slide at the uppermost layer of the slide cassette 4, which is pushed forward by the slide pushing plate 222, into the slide positioning groove.
After the slide enters the slide positioning groove, the scanning microscope performs operations such as scanning and recording on the slide, after the operations are completed, the slide positioning groove is reset, the slide resetting push plate arranged on the multifunctional pushing mechanism pushes the slide backwards, and the scanned slide is pushed back into the slide box 4.
In order to avoid driving the slide box to move backwards when the slide resetting push plate 223 pushes the slide backwards, the third screw rod fixing plate 2423 is provided with a slide box baffle 25, after the slide box 4 rises to a specified position, the slide baffle 25 is clamped at the rear end of the slide box to limit the movement of the slide box 4, and the position of the slide box is ensured not to change when the slide resetting push plate 223 pushes the slide.
After one of the slides is scanned and detected, the slide box fixing frame 241 is lifted for a certain distance, the slide pushing plate 222 and the slide resetting push plate 223 continue to repeat the actions, and the slides of each layer are scanned and detected in sequence, so that the scanning and the detection of the slides in the whole slide box are completed.
After the scanning of the slides in the entire cassette 4 is completed, the cassette holding frame 241 is linearly lowered to a specified position along the third lead screw 2421.
As shown in fig. 7, the cassette recovery module 3 is disposed below the slide scanning module 2, and the cassette recovery module 3 includes a cassette recovery slot 31, a second horizontal chute 32, and a cassette guide mechanism 33.
A cassette recovery slot 31 is provided in the bottom panel of the housing below the cassette slot 13, and the left side of the cassette recovery slot 31 is closed to limit the cassette and ensure that the cassette 4 does not push out of the cassette recovery slot 31 to the left. A slide rail arranged along the front-back direction is arranged below the slide box recovery clamping groove 31, a slide block combined with the slide rail is arranged at the bottom of the slide box recovery clamping groove 31, and the slide box recovery clamping groove can be drawn out, so that a worker can take out the slide box conveniently.
The second horizontal slide groove 32 is arranged in the front-rear direction, the second horizontal slide groove 32 is arranged on the right side of the cassette recovery slot 31, and the bottom surface of the second horizontal slide groove 32 is slightly higher than the bottom surface of the cassette recovery slot 31, so that the slide cassette 4 can smoothly slide into the cassette recovery slot 31.
A cassette guide mechanism 33 is provided above the second horizontal chute 32, and the cassette guide mechanism 33 includes a guide screw nut mechanism 331 and a guide plate 332 for guiding the cassette. The lead screw in the lead screw nut mechanism is denoted as a fourth lead screw 3311, and the fourth lead screw 3311 is driven by a fourth servo motor 3312. The guide plate 332 is movable left and right on the fourth lead screw 3311.
After the cassette holder 241 is lowered to the designated position, the bottom surface of the cassette holder 241 is at the same height as the bottom surface of the second horizontal sliding chute 32, and the cassette recovery push plate 224 provided at the lower end of the multifunctional push mechanism 22 moves backward to push the cassette into the second horizontal sliding chute 32.
The cassette 4 enters the second horizontal chute 32 and the guide plate 332 pushes the cassette to move to the left, where it eventually enters the cassette recovery chute 31.
The movement of one of the cassette 4 is completed, after scanning and recovery, the cassette limiting plate 12 is opened upwards, the next cassette 4 enters the cassette moving module 2 through the cassette belt 11, and then the above actions are repeated to complete scanning and recovery.
The automatic slide loading and unloading mechanism capable of continuously loading the slide boxes and the slides has the following characteristics:
firstly, intelligentizing, providing one-stop operation of moving and recovering a slide box; need not artifical on duty, reduce artifical intensity, degree of automation is high, raises the efficiency.
The multifunctional pushing mechanism has the advantages that the structure is compact, the multifunctional pushing mechanism simultaneously provides four functions of moving the glass sheet box, pushing the glass sheet, resetting the glass sheet and recovering the glass sheet box, the structure is simple and compact, internal parts of the scanner are greatly reduced, the vibration of the working state of the equipment is effectively reduced, and the scanning quality is improved.
And thirdly, the slide can be continuously loaded, tens of slide boxes can be loaded at one time in the slide box clamping groove, the slide scanning can be rapidly completed, and the slide boxes can be continuously loaded in the slide clamping groove, so that the slide scanning efficiency is obviously improved.
Claims (10)
1. The utility model provides a can install slide box and slide's automatic mechanism of going up of slide additional in succession which characterized in that: comprises a slide box loading module and a slide box moving module; the cassette loading module includes a cassette conveyor; the slide box moving module comprises a multifunctional pushing mechanism which moves horizontally and a vertical moving mechanism which moves up and down; the multifunctional pushing mechanism comprises a slide box pushing plate, a slide resetting push plate and a slide box recovering push plate; the slide boxes on the slide box transmission belt are sequentially pushed into the vertical moving mechanism by the slide box pushing plate, the slides in the vertical moving mechanism are sequentially pushed into the scanning device by the slide pushing plate, and the slides in the scanning device are pushed back into the slide boxes by the slide resetting push plate; the slide box recovery push plate pushes out the slide box in the vertical moving mechanism.
2. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 1, wherein: a slide box limiting plate is arranged on the right side of the slide box conveyor belt and used for limiting the slide box when the slide box moves.
3. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 1, wherein: the slide pushing plate is horizontally mounted on the slide cassette pushing plate.
4. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 1, wherein: the slide pushing plate and the slide resetting push plate are arranged at the same height.
5. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 1, wherein: a slide box recovery slot is arranged below the slide box loading module, and a slide box recovery push plate pushes the slide box into the slide box recovery slot.
6. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 5, wherein: the bottom of the glass box recovery clamping groove is provided with a sliding rail.
7. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 6, wherein: the slide box recovery slot is arranged right below the slide box conveyor belt.
8. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 1, wherein: the vertical moving mechanism comprises a glass box fixing frame, and a notch is formed in the right side face of the glass box fixing frame.
9. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 8, wherein: the upper side surface of the glass box fixing frame is provided with a notch.
10. An automated slide loading and unloading mechanism for serially loading cassettes and slides as recited in claim 1, wherein: the vertical moving mechanism comprises a slide box baffle plate which is arranged on the vertical moving mechanism and used for limiting the slide box when the slide pushing plate acts.
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CN202110171513.9A CN112986598B (en) | 2021-02-08 | 2021-02-08 | Automatic slide loading and unloading mechanism capable of continuously loading slide boxes and slides |
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CN202110171513.9A CN112986598B (en) | 2021-02-08 | 2021-02-08 | Automatic slide loading and unloading mechanism capable of continuously loading slide boxes and slides |
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CN112986598B CN112986598B (en) | 2024-06-21 |
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CN114383915A (en) * | 2021-11-25 | 2022-04-22 | 山东省农业科学院作物研究所 | Portable field corn pollen collecting and dyeing device |
CN114878464A (en) * | 2022-02-28 | 2022-08-09 | 北京毅能博科技有限公司 | Double-slide double-push-slide loading and unloading mechanism for automatic cytomorphology microscopic scanner |
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CN114383915A (en) * | 2021-11-25 | 2022-04-22 | 山东省农业科学院作物研究所 | Portable field corn pollen collecting and dyeing device |
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CN114878464A (en) * | 2022-02-28 | 2022-08-09 | 北京毅能博科技有限公司 | Double-slide double-push-slide loading and unloading mechanism for automatic cytomorphology microscopic scanner |
CN114878464B (en) * | 2022-02-28 | 2024-04-16 | 北京毅能博科技有限公司 | Double-piece double-push slide loading and unloading mechanism for automatic microscopic scanner of cell morphology |
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CN112986598B (en) | 2024-06-21 |
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