CN107715076A - 一种治疗痔疮的中药制剂及其制备方法 - Google Patents
一种治疗痔疮的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗痔疮的中药制剂及其制备方法,该中药制剂由以下重量份含量的原料制成:桃仁45‑55份、芒硝45‑55份、莪术45‑55份、白芨45‑55份、蝉衣25‑35份、冰片10‑20份、金银花25‑35份、木鳖子25‑35份、酒精45‑55份、麻油适量。本发明重在化瘀软件,解毒托溃,清热除湿,本发明从中医学角度分析了痔疮病因的致病因素、发病机理和药物治疗要点及组方分析,用纯中药原料粉碎、赋形而成,组方配伍严谨,论治合理,作用直接,效力充分,安全无毒,使用方便,预后良好,是一种方便用药、疗效确切、内吸收性良好的痔疾外治手段。
Description
技术领域
本发明属于中医药技术领域,具体涉及一种治疗痔疮的中药制剂及其制备方法。
背景技术
痔疮是常见而多发的外科疾患,俗有“十人九痔”之说,可见无论男女患病率极高,发病没有年龄限制,一般情况下常与久坐、久站、饮酒、潮湿、便秘、重体力劳动等因素有关,职业以办公室人员、司机、教师多见。其发病机理是直肠下段黏膜下和肛管皮肤下的静脉丛淤血、扩张和屈曲所致的静脉团,当长久坐站或便秘不爽及劳累、饮酒等不良刺激时发作加重,从而影响人们的正常生活和作息。
中医学认为人体感受六淫外邪和机体气血阴阳的失衡均可导致本病的发生,风热、寒湿、湿热、血瘀、气虚等病理状态的存在,是造成疾病的内外因素。《见闻录》说:“纯下清血者,风也……色如烟尘者,湿也……”;《医宗金鉴》说:“***围折纹破裂便结者,火燥也”;《丹溪心法》指出:“痔者皆因脏腑本虚,以致气血下坠,结聚***,宿滞不散,而冲突为痔”;《黄帝内经》则指出:“妇人生育过多,力尽血枯,气虚下陷,及小儿久痢,皆能使***脱出”;可见感于外邪、内伤情志、房劳过度、饮食宜忌等皆为致病因素。临床治疗多采取药物治疗和手术治疗两种。但现有药物治疗效果不明显,服药不方便;手术治疗风险大,患者有较大的心里忧虑。
发明内容
本发明的目的是为了解决现有技术中存在的技术问题,提供一种方便用药、作用直接、疗效确切、安全性高的治疗痔疮的中药制剂。
本发明的另一个目的是为了提供一种治疗痔疮的中药制剂的制备方法。
为了达到上述目的,本发明采用以下技术方案:一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁45-55份、芒硝45-55份、莪术45-55份、白芨45-55份、蝉衣25-35份、冰片10-20份、金银花25-35份、木鳖子25-35份、酒精45-55份、麻油适量。
进一步地,一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁50份、芒硝50份、莪术50份、白芨50份、蝉衣30份、冰片15份、金银花30份、木鳖子30份、酒精50份、麻油适量。
进一步地,所述酒精的浓度为95%。
一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁45-55份、芒硝45-55份、莪术45-55份、白芨45-55份、蝉衣25-35份、冰片10-20份、金银花25-35份、木鳖子25-35份、基质适量。
进一步地,一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁50份、芒硝50份、莪术50份、白芨50份、蝉衣30份、冰片15份、金银花30份、木鳖子30份、基质适量。
进一步地,所述基质为可可豆脂和芝麻油。
一种治疗痔疮的中药制剂的制备方法,该方法包括以下步骤:
A、按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除金银花和木鳖子之外的其他中药原料混合粉碎过千目筛,制得药粉;
B、将栓模洗净、擦干,用润滑剂少许涂布于栓模内部,取可可豆脂入熔器,再在熔器中加入适量芝麻油将其熔融后加入药粉并充分混匀;
C、注入栓模,待其冷却凝固后用刀修理边缘,成鱼雷状,取出既得。
一种治疗痔疮的中药制剂的制备方法,该方法包括以下步骤:
A、按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除冰片、金银花和木鳖子外的其他中药原料混合粉碎过千目筛,制得药粉;
B、取冰片并粉碎过千目筛,将冰片粉末加入药钵中并在药钵中加入酒精,水飞取其细末与药粉混匀,装瓶备用,用时取适量以麻油调和制成膏剂。
本发明相对现有技术具有以下有益效果:本发明治疗痔疮的中药制剂主要由桃仁、芒硝、莪术、白芨、蝉衣、冰片、金银花、木鳖子制成,重在化瘀软件,解毒托溃,清热除湿,方中金银花清热解毒,所含绿原酸、异绿原酸有抗炎、解热、增强免疫作用,对内毒素引起的发热有解热作用,并加速内毒素从血中清除;木鳖子苦温入大肠经,功能消肿解毒,主要成分为脂肪油、皂甙、甾醇和多糖,能促进外周血液循环,消除水肿,《本草纲目》谓其“治疳积痞块利大肠泻痢痔瘤瘰疬”;二者相合,用于入药治疗前外洗,一可解毒消肿,二则清理局部;桃仁活血逐瘀而抗凝,所含脂肪油有缓下作用;芒硝为含水硫酸钠,苦寒泄热,软件消肿,归胃与大肠经,在肠道能形成高渗溶液而促进蠕动及泻下;莪术破瘀消肿,抗炎抗凝,所含倍半萜类是预防癌变的主要成分;白芨收敛止血、消肿生肌,《本草汇言》云“消痈之要药也……封填破损,痈肿可消,溃败可托,死肌可去,脓血可洁,有托旧生新之妙用”,其挥发油、粘液质、淀粉等有缩短凝血时间及抑制纤溶作用,有良好的止血之功,用于痔疮出血难止者甚为合拍;蝉衣宣散风热,富含甲克质、有机酸、酚类及多种微量元素,有镇痛、抗毒、抗过敏、抗肿瘤作用;冰片去腐生肌,抗炎止痛,能显著提高其他药物的生物利用度。同时,本发明可制作成栓剂和膏剂,用药方便,释放、内吸收性好。本发明从中医学角度分析了痔疮病因的致病因素、发病机理和药物治疗要点及组方分析,用纯中药原料粉碎、赋形而成,组方配伍严谨,论治合理,作用直接,效力充分,安全无毒,使用方便,预后良好,是一种方便用药、疗效确切、内吸收性良好的痔疾外治手段。
具体实施方式
下面结合具体实施例对本发明作进一步说明。
实施例1
一种治疗痔疮的中药制剂,它由以下重量含量的原料制成:桃仁45g、芒硝55g、莪术45g、白芨55g、蝉衣25g、冰片20g、金银花25g、木鳖子35g、浓度为95%的酒精45g、麻油适量。
制备上述治疗痔疮的中药制剂时,按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除冰片、金银花和木鳖子外的其他中药原料混合粉碎过千目筛,制得药粉;取冰片并粉碎过千目筛,将冰片粉末加入药钵中并在药钵中加入酒精,水飞取其细末与药粉混匀,装瓶备用,用时取适量以麻油调和制成膏剂。贮存时应在15-30℃避光贮存。
实施例2
一种治疗痔疮的中药制剂,它由以下重量含量的原料制成:桃仁55g、芒硝45g、莪术55g、白芨45g、蝉衣35g、冰片10g、金银花35g、木鳖子25g、浓度为95%的酒精55g、麻油适量。
制备上述治疗痔疮的中药制剂时,按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除冰片、金银花和木鳖子外的其他中药原料混合粉碎过千目筛,制得药粉;取冰片并粉碎过千目筛,将冰片粉末加入药钵中并在药钵中加入酒精,水飞取其细末与药粉混匀,装瓶备用,用时取适量以麻油调和制成膏剂。贮存时应在15-30℃避光贮存。
实施例3
一种治疗痔疮的中药制剂,它由以下重量含量的原料制成:桃仁50g、芒硝50g、莪术50g、白芨50g、蝉衣30g、冰片15g、金银花30g、木鳖子30g、浓度为95%的酒精50g、麻油适量。
制备上述治疗痔疮的中药制剂时,按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除冰片、金银花和木鳖子外的其他中药原料混合粉碎过千目筛,制得药粉;取冰片并粉碎过千目筛,将冰片粉末加入药钵中并在药钵中加入酒精,水飞取其细末与药粉混匀,装瓶备用,用时取适量以麻油调和制成膏剂。贮存时应在15-30℃避光贮存。
实施例4
一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁45g、芒硝55g、莪术45g、白芨55g、蝉衣25g、冰片20g、金银花25g、木鳖子35g、基质适量,基质为可可豆脂和芝麻油。
制备上述治疗痔疮的中药制剂时,按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除金银花和木鳖子之外的其他中药原料混合粉碎过千目筛,制得药粉;将栓模洗净、擦干,用润滑剂少许涂布于栓模内部,取可可豆脂入熔器,再在熔器中加入适量芝麻油将其熔融后加入药粉并充分混匀;注入栓模,待其冷却凝固后用刀修理边缘,成鱼雷状,取出既得栓剂。贮存时应在15-30℃避光贮存。
实施例5
一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁55g、芒硝45g、莪术55g、白芨45g、蝉衣35g、冰片10g、金银花35g、木鳖子25g、基质适量,基质为可可豆脂和芝麻油。
制备上述治疗痔疮的中药制剂时,按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除金银花和木鳖子之外的其他中药原料混合粉碎过千目筛,制得药粉;将栓模洗净、擦干,用润滑剂少许涂布于栓模内部,取可可豆脂入熔器,再在熔器中加入适量芝麻油将其熔融后加入药粉并充分混匀;注入栓模,待其冷却凝固后用刀修理边缘,成鱼雷状,取出既得栓剂。贮存时应在15-30℃避光贮存。
实施例6
一种治疗痔疮的中药制剂,它由以下重量份含量的原料制成:桃仁50g、芒硝50g、莪术50g、白芨50g、蝉衣30g、冰片15g、金银花30g、木鳖子30g、基质适量,基质为可可豆脂和芝麻油。
制备上述治疗痔疮的中药制剂时,按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除金银花和木鳖子之外的其他中药原料混合粉碎过千目筛,制得药粉;将栓模洗净、擦干,用润滑剂少许涂布于栓模内部,取可可豆脂入熔器,再在熔器中加入适量芝麻油将其熔融后加入药粉并充分混匀;注入栓模,待其冷却凝固后用刀修理边缘,成鱼雷状,取出既得栓剂。贮存时应在15-30℃避光贮存。
疗效试验:
1.1中医辩证标准:
符合气血凝滞、湿热下注所致的局部红肿、疼痛、肿物脱出和突起、***潮湿、瘙痒,湿疹,便血等,患者常有便秘、走路、起坐困难,查舌质暗红苔黄腻,脉象滑数或芤。
1.2适用类型:内痔、外痔、混合痔。
1.3病例选取:选取30例,采用随机分组自身对照比较法,观察患者治疗前后的症状、体征和预后情况。
1.4治疗方法:
方法一:患者于每晚睡前充分暴露用药部位,先用金银花和木鳖子煎液晾温后外洗患处20分钟,然后取侧卧位,屈曲双腿,一手戴指套取本发明实施例6制备的栓剂缓缓推入***约3cm,合拢双腿,保持30分钟,并在***口塞少许纸巾,以防基质溶化漏出而污染衣物。7天为一疗程,用药期间注意休息,忌食辛辣刺激、海鲜及饮酒。
方法二:患者于每晚睡前充分暴露用药部位,先用金银花和木鳖子煎液晾温后外洗患处20分钟,然后取侧卧位,屈曲双腿,根据患处面积大小取本发明实施例3制备的膏剂,膏剂性状以手指盛起不自然流落为宜,将膏剂涂敷于病变部位,厚度约为1cm,然后并拢双腿,备用纸巾擦拭外流油迹,保持40分钟,然后用生理盐水洗净即可,7天为一疗程,用药期间注意休息,忌食辛辣刺激、海鲜及饮酒。
1.5疗效观察指标:经2个疗程的治疗,临床症状消失或好转,无其他不适。
1.6疗效判定标准:
显效:痔核消失,肛周无红肿,无其他不适,随访半年无复发;
有效:痔核消去2/3,周围无红肿,需继续治疗;
无效:用药前后症状无明显改变。
1.7治疗结果:见表一。
表一 疗效试验治疗结果
本发明的栓剂和膏剂在临床治疗中未发现任何毒副作用,从表一数据显示,本发明治疗痔疮疾患疗效确切。
典型病例:
病例一:患者巴某某,男,56岁,个体工商户,素有痔疾十余年,每次发作均经***、输液及外用痔疮栓等控制治疗,多持续半月左右才能缓解,十天前在田间劳作,长时间下蹲除草,三天后***部坠胀疼痛,经治疗后不减并有痔核脱出,疼痛难忍,大便时有出血,色鲜红,量不多,在家人扶持下求治,查舌质暗红苔厚腻,脉沉滑。给予本发明栓剂并取金银花和木鳖子,嘱其每晚先用金银花和木鳖子煎液晾温后外洗患处20分钟,然后取侧卧位,屈曲双腿,一手戴指套取栓剂缓缓推入***约3cm,合拢双腿,保持30分钟,一日一次,用药期间注意休息,忌食辛辣刺激、海鲜及饮酒。患者坚持用药,按法治疗,十天后症状大减,疼痛消去大半,继用十天后诸症消失,解便轻松,活动自如,随访一年未复发。
病例二:患者王某,男,45岁,司机,患痔疾两年余,常因过食辛辣刺激及饮酒后出现***周围疼痛,常以马应龙痔疮膏外擦,初期疗效尚可,以后发作则收效不佳,一周前与朋友小聚,饮食不当,翌日晨起出现***部疼痛伴奇痒,自感局部发热肿胀,自己用手触之觉有黄豆大小肿物数个,触痛明显,***及***周围潮湿并有红色丘疹,瘙痒难忍,用药后不减而来检查治疗,查舌质红苔黄腻,脉滑数。给予本发明的膏剂并取金银花和木鳖子治疗,嘱其每晚睡前先用金银花和木鳖子煎液晾温后外洗患处20分钟,然后取侧卧位,屈曲双腿,根据患处面积大小取本发明制备的膏剂,膏剂性状以手指盛起不自然流落为宜,将膏剂涂敷于病变部位,厚度约为1cm,然后并拢双腿,备用纸巾擦拭外流油迹,保持40分钟,然后用生理盐水洗净即可,一日一次,用药期间注意休息,忌食辛辣刺激、海鲜及饮酒。患者积极配合治疗,用药三天后即感疼痛减轻,瘙痒及***周围湿疹大有好转,继续用药7天后诸症消失,无任何不适,嘱其以后注意饮食,随访半年无复发。
Claims (8)
1.一种治疗痔疮的中药制剂,其特征在于:它由以下重量份含量的原料制成:桃仁45-55份、芒硝45-55份、莪术45-55份、白芨45-55份、蝉衣25-35份、冰片10-20份、金银花25-35份、木鳖子25-35份、酒精45-55份、麻油适量。
2.根据权利要求1所述的一种治疗痔疮的中药制剂,其特征在于:它由以下重量份含量的原料制成:桃仁50份、芒硝50份、莪术50份、白芨50份、蝉衣30份、冰片15份、金银花30份、木鳖子30份、酒精50份、麻油适量。
3.根据权利要求1或2所述的一种治疗痔疮的中药制剂,其特征在于:所述酒精的浓度为95%。
4.一种治疗痔疮的中药制剂,其特征在于:它由以下重量份含量的原料制成:桃仁45-55份、芒硝45-55份、莪术45-55份、白芨45-55份、蝉衣25-35份、冰片10-20份、金银花25-35份、木鳖子25-35份、基质适量。
5.根据权利要求4所述的一种治疗痔疮的中药制剂,其特征在于:它由以下重量份含量的原料制成:桃仁50份、芒硝50份、莪术50份、白芨50份、蝉衣30份、冰片15份、金银花30份、木鳖子30份、基质适量。
6.根据权利要求4或5所述的一种治疗痔疮的中药制剂,其特征在于:所述基质为可可豆脂和芝麻油。
7.一种根据权利要求6所述治疗痔疮的中药制剂的制备方法,其特征在于该方法包括以下步骤:
A、按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除金银花和木鳖子之外的其他中药原料混合粉碎过千目筛,制得药粉;
B、将栓模洗净、擦干,用润滑剂少许涂布于栓模内部,取可可豆脂入熔器,再在熔器中加入适量芝麻油将其熔融后加入药粉并充分混匀;
C、注入栓模,待其冷却凝固后用刀修理边缘,成鱼雷状,取出既得。
8.一种根据权利要求3所述治疗痔疮的中药制剂的制备方法,其特征在于该方法包括以下步骤:
A、按组方的用量称取组方中各中药原料,将各中药原料用清水洗净并晒干,晒干后将除冰片、金银花和木鳖子外的其他中药原料混合粉碎过千目筛,制得药粉;
B、取冰片并粉碎过千目筛,将冰片粉末加入药钵中并在药钵中加入酒精,水飞取其细末与药粉混匀,装瓶备用,用时取适量以麻油调和制成膏剂。
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