CN107684530A - Acne-removing composition and preparation method thereof - Google Patents
Acne-removing composition and preparation method thereof Download PDFInfo
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- CN107684530A CN107684530A CN201710747307.1A CN201710747307A CN107684530A CN 107684530 A CN107684530 A CN 107684530A CN 201710747307 A CN201710747307 A CN 201710747307A CN 107684530 A CN107684530 A CN 107684530A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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Abstract
A kind of acne-removing composition and preparation method thereof, it contains anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers and emollient and appropriate solvent.Wherein, the mass ratio of anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers and emollient is 2.5~6.4:2.5~7.5:1.75~5.25:1.25~3.75:0.5~1.5:6.5~19.5.The acne-removing composition of the present invention, can effectively remove acarus and bacteria, and suppress acarid regeneration.Commonly using skin smooth can be made fine and smooth, and effectively play the effect except acarus and bacteria and anti-acne.
Description
Technical field
The present invention relates to a kind of acne-removing composition and preparation method thereof.
Background technology
The generation of acne and/or small pox mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection and inflammation
The factors such as disease reaction are closely related.And acarid is infected on skin, the more easy generation for inducing acne and/or small pox.Once skin
Skin infects acarid, gently then blocks pore, allows skin to be difficult to absorb the nutritional ingredient in skin care item, heavy then make the dark and gloomy nothing of skin
Light, cause the skin problems such as thick pore, pachylosis heavy wool, acne, acne, small red pimple.Therefore, eliminated to reach face cleaning
The purpose of acne and/or small pox, people generally select the skin care item removal acarid for being capable of mite killing.However, present except mite cleaning
Effect of the product due to pursuing disinfecting mite-removing simply, its excitant to skin than more serious, can cause a skin inflammation on the contrary or
The symptoms such as person's macula.
The content of the invention
In view of this, it is necessary to a kind of more gentle not excitory acne-removing composition is provided, and sterilization can be played and removed
The effect of mite and anti-acne.
A kind of preparation method of above-mentioned acne-removing composition is provided in addition, there is a need to.
A kind of acne-removing composition, it contains anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers and profit
Skin agent, wherein, the anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, the mass ratio of permeation enhancers and emollient are
2.5~6.4:2.5~7.5:1.75~5.25:1.25~3.75:0.5~1.5:6.5~19.5.
A kind of preparation method of acne-removing composition, the acne-removing composition contain anti-acne agent, skin conditioning agent, pH regulations
Agent, astringent, permeation enhancers and emollient, wherein, the anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, rush are oozed
The mass ratio of saturating agent and emollient is 2.5~7.5:2.5~7.5:1.75~5.25:1.25~3.75:0.5~1.5:6.5~
19.5；
The preparation method of the acne-removing composition includes step：The emollient is heated；Institute is added after emulsion tank preheating
State emollient；Pass through cooling water temperature；Grind the anti-acne agent and the skin conditioning agent；Dissolve the pH adjusting agent；Treat
After emollient forms lotion, the skin conditioning agent and the anti-acne agent, the pH adjusting agent are sequentially added, and is stirred equal
It is even.
The acne-removing composition of the present invention, can effectively remove acarus and bacteria, and suppress acarid regeneration.Meanwhile the anti-acne combination
PH adjusting agent is with the addition of in thing, the pH adjusting agent can make the pH value of the acne-removing composition relatively more close to human body skin
The pH value of skin, it is more gentle to skin, it is not easy to stimulate skin.Commonly using skin smooth can be made fine and smooth, and effectively play except mite
Sterilization and the effect of anti-acne.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that
Described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based on the implementation in the present invention
Example, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, is belonged to
The scope of protection of the invention.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein " and/or " include one or more phases
The arbitrary and all combination of the Listed Items of pass.
In the case where not conflicting, the feature in following embodiment and embodiment can be mutually combined.
Acne-removing composition involved in the present invention, it has the effect of disinfecting mite-removing, cleaning anti-acne.The acne-removing composition
Contain anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers and emollient and appropriate solvent (such as water).
Wherein, the mass ratio of anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers and emollient is 2.5~6.4:
2.5~7.5:1.75~5.25:1.25~3.75:0.5~1.5:6.5~19.5.
Preferably, the quality of the anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers and emollient
Than for 4.0~6.4：4~6：2.5~4.5：2~3：0.8~1.2：2.5~4.5.
A major reason is skin infection acarid caused by acne and/or small pox, causes clogging of pores, skin infection red
It is swollen.The anti-acne agent of the present invention is advantageous to kill acarid and can play a part of sterilizing.
The anti-acne agent may be selected from least one of sulphur, Sublimated Sulphur.
After skin suffers damage, self healing needs the long period, and within a period of time before healing, skin is relative
It is more fragile, it is more vulnerable to the infection such as bacterium, acarid.The skin conditioning agent of the present invention can be skin extra-nutrition element, soon
Speed repairs the skin of damage, is advantageous to skin histology healing.
The skin conditioning agent can be zinc oxide.
The skin surface of people covers one layer of natural emulsifying film, and healthy emulsifying film be in faintly acid, its pH value for 4.5~
6.5, average value 5.7.When the pH value of the emulsifying film is unbalance, chafing or macula are easily induced.The pH of the present invention
Conditioning agent approaches the pH value of the acne-removing composition and the pH value of skin, is advantageous to skin and keeps faintly acid, to the thorn of skin
Sharp property is smaller.
The pH adjusting agent may be selected from least one of citric acid, triethanolamine and sodium citrate.Preferably, the pH
Conditioning agent makes the pH value of the acne-removing composition between 5.5 and 6.5.
After skin infection acarid, pore can increase, and influence attractive in appearance, and also easy dust stratification is not easy to clean.The astringent of the present invention
Be advantageous to restrain skin pore, compact skin, prevents extraneous dirty intrusion, and make skin-tightening smooth.
The astringent can be selected from least one of borax, alum.
For the more serious pore of stopping state or the skin of oiliness, its more difficult nutriment for absorbing skin care item.This
The permeation enhancers of invention may advantageously facilitate skin and absorb nutriment.
The permeation enhancers can be Laurocapram.
Moisture content of skin is most suitable 10%~20%, if less than 10%, skin is in drying regime, it appears coarse relaxation,
Time is grown, and wrinkle just occurs.The emollient of the present invention can moisten cuticula, control skin water and oil balance.
The emollient can be selected from cetanol, stearyl alcohol, dimethyl silicone polymer, isopropyl myristate, the octanoic acid/last of the ten Heavenly stems
At least one of acid glycerol three ester, hexadecanol, octadecyl alcolol.
Further, in order to improve the effect of skin moisture-keeping, NMF can also be added in the acne-removing composition.It is described
NMF can be selected from glycerine, propane diols, collagen, marine algae extract, tartaric acid, mushroom extract, honey, Sucus Luffae, breast
Sour sodium, urea, polyethylene glycol, D-sorbite, hyaluronic acid, chondroitin sulfate, elastin, amino acid, pyrrolidines copper carboxylic acid,
At least one of citrate, ossein, allantoin, jojoba oil and lanolin.
It is appreciated that for unclogging, reach the turbid purpose of the row of removing contamination, finally realize thorough cleaning skin, it is described to dispel
Cutin exfoliant can also be added in acne composition.The cutin exfoliant can be salicylic acid.
It is appreciated that to play a part of hydrophily and hydrophobic combination in emulsification and stable acne-removing composition, make combination
The form of thing is relatively stable, and emulsifying agent can also be added in the acne-removing composition.The emulsifying agent can gather selected from stearyl alcohol
At least one of ether -2, stereth -21.
It is appreciated that in order that the acne-removing composition performance and Consumer's Experience is improved, in the acne-removing composition
Thickener and aromatic can be added.The thickener can be selected from polysorbate -20, acrylamide/ammonium acrylate copolymerization
At least one of thing, polyisobutene.The aromatic can be essence.
It should be understood that to avoid breed bacteria in the acne-removing composition, so that the acne-removing composition can be stablized
Preserve, bactericide can be also added in the acne-removing composition.The bactericide is selected from eucalyptus oil, tea tree ethereal oil, honeysuckle extraction
Thing, ginkgo biloba p.e, chitosan, allicin, Chinese ilex, menthol, Malan Straw, bamboo charcoal, rose wate extract, lophatherum gracile extraction
Thing jute root extract, poly (hexamethylene) hydrochloride, hexamethylene, iodine propilolic alcohol butyl mephenesin Carbamate,
2- benzimidazole carbamates, methylchloroisothiazandnone, methylisothiazolinone, chitin, isopropanol, 2- phenoxy group second
Alcohol, phenoxy group isopropanol, Phenoxyethanol, thiadiazole maninich alkali, 1- o-hydroxyphenyl butanones, chitosan and dimethyl two
At least one of methylol beta-lactam.
It is appreciated that in order that the acne-removing composition is unlikely to deteriorate damage, wherein preservative can also be added.It is described anti-
Rotten agent can be selected from triclosan (DP-300), methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, propane diols, iodine third
In alkynol butyl mephenesin Carbamate, hydroxy methyl, hydroxy propyl ester, diazonium imidazolidinyl urea, iodopropynyl butyl carbamate extremely
Few one kind.
The acne-removing composition of the present invention, can effectively remove acarus and bacteria, and suppress acarid regeneration.Meanwhile the anti-acne combination
PH adjusting agent is with the addition of in thing, the pH adjusting agent can make the acne-removing composition be in integrally faintly acid, and its pH value is relatively
It is more gentle to skin more close to the pH value of human body skin, it is not easy to stimulate skin.Commonly using skin smooth can be made fine and smooth,
And effectively play the effect except acarus and bacteria and anti-acne.
Below by specific embodiment, the present invention is described further.
Embodiment 1
The acne-removing composition specific formula ginseng table one of embodiment 1.
Table one
The preparation of the acne-removing composition of embodiment 1：
In embodiment 1, the composition is the form of creams, and its raw material point ginseng following table two is prepared：
Table two
The preparation process of the acne-removing composition of the creams form is as follows：
A phases are heated up to 85 DEG C by step 1.；
Step 2. is B heat phases to 85 DEG C；
In step 1 and step 2, vacuum preheating is carried out to A phases and B phases in closed container, to avoid in A phases and B phases
It is mixed into bubble.
Step 3. emulsion tank first preheats, and is first pumped into B phases, then is pumped into A phases, exhausts homogeneous 3 minutes after A phases；
In step 3, emulsion tank is preheated to about 80 DEG C, can be at high temperature after being subsequently added to A phases and B with guarantee
Emulsification, while beneficial to homogeneous, elimination bubble.
Step 4. stirring insulation 30 minutes, after bubble is wholly absent, lead to cooling water temperature, mixing speed is 20 revs/min
Clock；
Step 5. dissolves by heating C phases and F phases respectively, and D phases are ground with colloid mill in advance, and dissolving is complete in advance for G phases；
In steps of 5, in order to prevent salicylic acid from volatilizing, the heating-up temperature of F phases should be less than or equal to 60 DEG C.Utilize colloid mill
When grinding D phases, qs glycerin is added, makes sulphur or Sublimated Sulphur more scattered, is advantageous to that each phase component subsequently is mixed in into one
Rise；Further, after colloid mill grinding D phases, by the sulphur after grinding or Sublimated Sulphur by the screen filtration of 200 mesh numbers, make
Sulphur or Sublimated Sulphur particle after grinding is more tiny, and then makes quality exquisiteness, the sense of touch of the acne-removing composition good.
Step 6. sequentially adds C, D, E, F, G phase after A phases and B phases and after being cooled to 40 DEG C~45 DEG C, 25-30 revs/min
Clock, stir；
Step 7. examines qualified discharging.
Ratio between composition in embodiment, voluntarily ensures in the range of above.
Embodiment 2
The acne-removing composition specific formula ginseng table three of embodiment 2.
Table three
The preparation of the composition of embodiment 2：
In example 2, the composition is the form of creams, and its raw material point ginseng following table four is prepared：
Table four
The preparation process of the acne-removing composition of the creams form is as follows：
Step 1. carries out stock operation by the health system of preparation；
A, B phase are heated up and are heated to 80 DEG C -85 DEG C by step 2. respectively；
In step 2, vacuum preheating is carried out to A phases and B phases in closed container, to avoid being mixed into gas in A phases and B phases
Bubble.
Step 3. emulsion tank first preheats, and is first pumped into B phases, then is pumped into A phases, exhausts homogeneous 2 minutes after A phases；
In step 3, emulsion tank is preheated to about 85 DEG C, can be at high temperature after being subsequently added to A phases and B with guarantee
Emulsification, while beneficial to homogeneous, elimination bubble.
Step 4. is incubated 30 minutes, after bubble is wholly absent, opens cooling water temperature, mixing speed is 20 revs/min；
Step 5. is ground after mixing C, D with colloid mill, and F, G phase dissolve by heating respectively, and E phases suitably dissolve by heating；
In steps of 5, in order to prevent salicylic acid from volatilizing, the heating-up temperature of F phases should be less than or equal to 60 DEG C.Utilize colloid mill
When grinding D phases, qs glycerin is added, makes sulphur or Sublimated Sulphur more scattered, is advantageous to that each phase component subsequently is mixed in into one
Rise；Further, after colloid mill grinding D phases, by the sulphur after grinding or Sublimated Sulphur by the screen filtration of 200 mesh numbers, make
Sulphur or Sublimated Sulphur particle after grinding is more tiny, and then makes quality exquisiteness, the sense of touch of the acne-removing composition good.For
Prevent each component in E phases from volatilizing, the heating-up temperature of E phases should be less than or equal to 60 DEG C.
Step 6. sequentially adds C, D, E, F, G phase after A phases and B phases tie cream and are cooled to 40 DEG C~45 DEG C, and 25-30 turns/
Minute, homogeneous 3 minutes, stir, add H phases, homogeneous 5 minutes.
Step 7.35 DEG C~40 DEG C sampling detection, examines qualified discharging.
Ratio between composition in embodiment, voluntarily ensures in the range of above.
Using effect is tested：To there are acne and/or small pox and an acne production and/or small pox life degree is suitable 20 divides for each person
For two groups, every group of each 10 people.First group of composition for using embodiment 1, second group of composition for using embodiment 2.Wipe daily
Skin is wiped, dynamics and frequency is wiped and is accustomed to according to each one, to be comfortably advisable, is used continuously one month.Experimental result shows, institute
The skin gloss lubrication of 20 people is stated, and acne on skin and/or small pox have been reduced.
In above-described embodiment, the carrier of the acne-removing composition is specifically described in the form of creams, however, it is possible to manage
Solution, the carrier of the acne-removing composition are not limited to face cream form, and it can also be solution, suspension, spray, wash
The forms such as agent, gel, paste, medicine rod, balm, cleaning agent (containing shampoo and perfumed soap), ointment, facial mask.When the anti-acne combines
When the carrier of thing is any form of above-mentioned carrier, the content of its solvent included, thickener, emulsifying agent and emollient etc.
Depending on the appearance form of the carrier.For example, when the carrier of the acne-removing composition is solution, its solvent and emollient can fit
Amount increases, and the content of thickener can be reduced in right amount.The rest may be inferred, and to save space, this specification does not repeat one by one.
In addition, those skilled in the art can also the claims in the present invention scope of disclosure and spirit in do other forms and
Various modifications, addition and replacement in details.Certainly, these various modifications, addition and replacements for being made according to present invention spirit
Deng change, should all be included within scope of the present invention.
Claims (11)
- A kind of 1. acne-removing composition, it is characterised in that：The acne-removing composition contains anti-acne agent, skin conditioning agent, pH regulations Agent, astringent, permeation enhancers and emollient, wherein, the anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, rush are oozed The mass ratio of saturating agent and emollient is 2.5~6.4:2.5~7.5:1.75~5.25:1.25~3.75:0.5~1.5:6.5~ 19.5。
- 2. acne-removing composition as claimed in claim 1, it is characterised in that：The anti-acne agent, skin conditioning agent, pH regulations Agent, astringent, the mass ratio of permeation enhancers and emollient are 4.0~6.4:4~6:2.5~4.5:2~3:0.8~1.2:2.5 ~4.5.
- 3. acne-removing composition as claimed in claim 1, it is characterised in that：The anti-acne agent is in sulphur, Sublimated Sulphur At least one；And/or the skin conditioning agent is zinc oxide；And/or the emollient is selected from cetanol, stearyl alcohol, dimethyl silicone polymer, isopropyl myristate, caprylic/capric At least one of triglycerides, hexadecanol, octadecyl alcolol；And/or the pH adjusting agent makes the pH value of the acne-removing composition pH adjusting agent is selected between 5.5 and 6.5 At least one of citric acid, triethanolamine and sodium citrate；And/or the astringent is selected from least one of borax, alum；And/or the permeation enhancers are Laurocapram.
- 4. acne-removing composition as claimed in claim 1, it is characterised in that：Also contain NMF, institute in the acne-removing composition State NMF and be selected from glycerine, propane diols, collagen, marine algae extract, tartaric acid, mushroom extract, honey, Sucus Luffae, lactic acid Sodium, urea, polyethylene glycol, D-sorbite, hyaluronic acid, chondroitin sulfate, elastin, amino acid, pyrrolidines copper carboxylic acid, lemon At least one of lemon hydrochlorate, ossein, allantoin, jojoba oil and lanolin；And/or also containing cutin exfoliant in the acne-removing composition, the cutin exfoliant is salicylic acid；And/or also containing aromatic in the acne-removing composition, the aromatic is essence；And/or also contain emulsifying agent in the acne-removing composition, the emulsifying agent be selected from stereth -2, stereth - At least one of 21；And/or also contain thickener in the acne-removing composition, the thickener be selected from polysorbate -20, acrylamide/ At least one of ammonium acrylate copolymer, polyisobutene；And/or also containing bactericide in the acne-removing composition, the bactericide is selected from eucalyptus oil, tea tree ethereal oil, honeysuckle and carried Thing, ginkgo biloba p.e, chitosan, allicin, Chinese ilex, menthol, Malan Straw, bamboo charcoal, rose wate extract, lophatherum gracile is taken to carry Take thing jute root extract, poly (hexamethylene) hydrochloride, hexamethylene, iodine propilolic alcohol butyl ammonia formic acid Ester, 2- benzimidazole carbamates, methylchloroisothiazandnone, methylisothiazolinone, chitin, isopropanol, 2- benzene oxygen Base ethanol, phenoxy group isopropanol, Phenoxyethanol, thiadiazole maninich alkali, 1- o-hydroxyphenyl butanones, chitosan and diformazan At least one of base dihydroxymethyl beta-lactam；And/or also contain preservative in the acne-removing composition, the preservative be selected from triclosan (DP-300), methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, propane diols, iodine propilolic alcohol butyl mephenesin Carbamate, hydroxy methyl, hydroxy propyl ester, At least one of diazonium imidazolidinyl urea, iodopropynyl butyl carbamate.
- 5. a kind of preparation method of acne-removing composition, the acne-removing composition contain anti-acne agent, skin conditioning agent, pH adjusting agent, Astringent, permeation enhancers and emollient, wherein, the anti-acne agent, skin conditioning agent, pH adjusting agent, astringent, permeation enhancers And the mass ratio of emollient is 2.5~7.5:2.5~7.5:1.75~5.25:1.25~3.75:0.5~1.5:6.5~19.5； The preparation method of the acne-removing composition includes step：The emollient is heated；The emollient is added after emulsion tank preheating；Pass through cooling water temperature；Grind the anti-acne agent and the skin conditioning agent；Dissolve the pH adjusting agent；After emollient forms lotion, the skin conditioning agent and the anti-acne agent, the pH adjusting agent are sequentially added, and stir Mix uniformly.
- 6. the preparation method of acne-removing composition as claimed in claim 5, it is characterised in that：Also contain in the acne-removing composition Emulsifying agent, while the emollient is heated, the emulsifying agent and the emollient are heated to 85 DEG C jointly.
- 7. the preparation method of acne-removing composition as claimed in claim 6, it is characterised in that：To also it contain in the acne-removing composition There are astringent and solvent, after the emulsifying agent and emollient heating, the astringent and the solvent are heated to 85 ℃。
- 8. the preparation method of acne-removing composition as claimed in claim 7, it is characterised in that：The emulsion tank is preheated to 85 DEG C Afterwards, the astringent and the solvent are first added, adds the emulsifying agent and the emollient.
- 9. the preparation method of acne-removing composition as claimed in claim 8, it is characterised in that：Also contain in the acne-removing composition Cutin exfoliant, after dissolving the pH adjusting agent, the cutin exfoliant is dissolved by heating.
- 10. the preparation method of acne-removing composition as claimed in claim 9, it is characterised in that：Treat the emulsifying agent, the moisturizing After agent, the astringent and the solvent knot cream, the skin conditioning agent and the anti-acne agent, cutin stripping are sequentially added Fall agent, the pH adjusting agent, and stir.
- 11. the preparation method of acne-removing composition as claimed in claim 5, it is characterised in that：Grind the anti-acne agent and institute When stating skin conditioning agent, glycerine is added；And/or after grinding the anti-acne agent and the skin conditioning agent, pass through anti-acne described in the screen filtration of 200 mesh numbers Agent and the skin conditioning agent.
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| CN112535653A (en) * | 2020-12-25 | 2021-03-23 | 西南林业大学 | Dendrobium officinale moisturizing and repairing essence milk and preparation method thereof |
| CN113318146A (en) * | 2021-06-08 | 2021-08-31 | 高家伟 | Sulfur paste and using method thereof |
| CN114917268A (en) * | 2022-05-30 | 2022-08-19 | 厦门医肤康生物有限公司 | External medicine for treating acne rosacea, acne and seborrheic dermatitis and preparation method thereof |
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