CN107668726A - 一种含氨基酸鳌合钙的b族维生素片的薄膜包衣工艺 - Google Patents
一种含氨基酸鳌合钙的b族维生素片的薄膜包衣工艺 Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
本发明提供了一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,其特征在于,包括氨基酸鳌合钙的制备:先将河蚌壳粉碎成河蚌壳粉,再用酸提取得到钙源,将豆粕酶解得到氨基酸,钙源与氨基酸鳌合反应得到氨基酸鳌合钙;将原料混合、过筛制得颗粒,将颗粒与硬脂酸镁混合、压片,得到B族维生素片;将所得B族维生素片放入包衣机内,用薄膜包衣液进行喷雾包衣,得到所述维生素片。
Description
技术领域
本发明涉及保健品领域,具体涉及一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺。
背景技术
河蚌贝壳类动物在我国来源广泛,价格低廉。然而,多数蚌类副产物作为废弃物直接被丢弃,造成环境污染和资源浪费。蚌壳中含有钙源,对其进行加工处理、提取应用。豆粕是大豆提取豆油后得到的一种副产品,对其进行酶解处理可得到氨基酸,实现资源的再利用,具有很重要的意义。
维生素是维持人体正常生理功能的微量有机物质,在物质代谢中起到重要的调节作用,缺少维生素会出现各种症状,可以通过维生素片对人体进行定时定量的补充。
发明内容
本发明提供了一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,依照该工艺制备的维生素片稳定性好,在补充维生素的同时可以补充钙。
本发明采用如下技术方案:
一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,其特征在于,由以下步骤制成:
(1)氨基酸鳌合钙的制备:
将10-20重量份河蚌壳用自来水洗净,在NaOH溶液中浸泡30-40min,水洗3-5次,粉碎、过80-100目筛,得到河蚌壳粉;1:5-10加入盐酸溶液,升温到110-115℃反应1-2h,得到钙源;
将10-20重量份脱脂豆粕用自来水洗涤后,再1:5-10加入自来水,搅拌均匀得到浆料,加入木瓜蛋白酶,在pH为7-8、温度为40-50℃条件下酶解1-2h,然后在沸水水浴中灭酶15-20min,冷却至室温,离心,取上清液,得到氨基酸;
将所得钙源与氨基酸混合,调pH为7.5-8.5,在55-65℃下鳌合反应40-50min,得到氨基酸螯合钙溶液,离心、用乙醇洗涤、再离心,将所得沉淀物在120-140℃下干燥3-4h,研磨粉碎,得到氨基酸鳌合钙;
(2)B族维生素片的制备:
将2-4重量份维生素B1、2-4重量份维生素B2、2-4重量份维生素B6、0.001-0.002重量份维生素B12、140-150重量份微晶纤维素、300-320重量份淀粉、280-300重量份糊精、190-200重量份D-甘露糖醇与(1)中所得氨基酸鳌合钙混合,研磨粉碎,过60-80目筛后,1:5-10加入纯化水,搅拌均匀,过10-30目筛,将所得湿颗粒在50-60℃下干燥完全,过18-20目筛,得到干颗粒;将所得干颗粒与7-10重量份硬脂酸镁混合5-10min,压片,得到B族维生素片;
(3)B族维生素片薄膜包衣工艺:
薄膜包衣液的制备:将90-100重量份纯化水放入不锈钢桶中,缓慢加入4-6重量份薄膜包衣粉,搅拌均匀,得到包衣液;
包衣片的制备:将所得B族维生素片放入包衣机内,药片在片床上预热15-20min,然后进行喷雾包衣50-90min,在55-65℃干燥完全,按规格进行包装。
其中,步骤(1)中所述NaOH溶液浓度为4-5%,盐酸溶液浓度为5-5.2mol/L,木瓜蛋白酶的用量为18000-20000U/g,离心为4000-5000r/min处理10-15min,乙醇浓度为90-95%。步骤(3)中所述包衣机转速为10-20r/min,进风温度为75-85℃,出风温度为40-50℃,蠕动泵流量为170-190g/min。
本发明的有益效果:
以大豆粕、河蚌壳为原料,将河蚌壳粉碎、酸提取的到钙源,将大豆粕酶解得到氨基酸,两者螯合反应制得可食性氨基酸螯合钙,将其添加到维生素片中,制得一种含氨基酸鳌合钙的B族维生素片;所得B族维生素片中含有多种维生素,容易发生化学变化,通过薄膜包衣,可降低了药物的吸湿率,保证其品质稳定;所得维生素片含有多种维生素,满足人体所需,在补充维生素的同时可实现补钙的目的。
具体实施方式
下面通过具体的实施例对本发明做进一步的详细描述,不是对本发明的限制。
实施例
一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,包括以下步骤:
(1)氨基酸鳌合钙的制备:
将20kg河蚌壳用自来水洗净,在NaOH溶液中浸泡35min,水洗5次,粉碎、过100目筛,得到河蚌壳粉;1:10加入盐酸溶液,升温到110-115℃反应2h,得到钙源;
将15kg脱脂豆粕用自来水洗涤后,再1:10加入自来水,搅拌均匀得到浆料,加入木瓜蛋白酶,在pH为7-8、温度为40-50℃条件下酶解2h,然后在沸水水浴中灭酶20min,冷却至室温,离心,取上清液,得到氨基酸;
将所得钙源与氨基酸混合,调pH为7.5-8.5,在55-65℃下鳌合反应45min,得到氨基酸螯合钙溶液,离心、用乙醇洗涤、再离心,将所得沉淀物在120-140℃下干燥3h,研磨粉碎,得到氨基酸鳌合钙;
(2)B族维生素片的制备:
将4kg维生素B1、3kg维生素B2、2kg维生素B6、0.001kg维生素B12、140kg微晶纤维素、300kg淀粉、280kg糊精、190kg D-甘露糖醇与(1)中所得氨基酸鳌合钙混合,研磨粉碎,过80目筛后,1:10加入纯化水,搅拌均匀,过30目筛,将所得湿颗粒在50-60℃下干燥完全,过20目筛,得到干颗粒;将所得干颗粒与10kg硬脂酸镁混合10min,压片,得到B族维生素片;
(3)B族维生素片薄膜包衣工艺:
薄膜包衣液的制备:将95kg纯化水放入不锈钢桶中,缓慢加入5kg薄膜包衣粉,搅拌均匀,得到包衣液;
包衣片的制备:将所得B族维生素片放入包衣机内,药片在片床上预热20min,然后进行喷雾包衣80min,在55-65℃干燥完全,按规格进行包装。
其中,步骤(1)中所述NaOH溶液浓度为4%,盐酸溶液浓度为5mol/L,木瓜蛋白酶的用量为20000U/g,离心为4500r/min处理15min,乙醇浓度为90%。步骤(3)中所述包衣机转速为15r/min,进风温度为75-85℃,出风温度为40-50℃,蠕动泵流量为190g/min。
Claims (4)
1.一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,其特征在于,包括氨基酸鳌合钙的制备:先将河蚌壳粉碎成河蚌壳粉,再用酸提取得到钙源,将豆粕酶解得到氨基酸,钙源与氨基酸鳌合反应得到氨基酸鳌合钙;将原料混合、过筛制得颗粒,将颗粒与硬脂酸镁混合、压片,得到B族维生素片;将所得B族维生素片放入包衣机内,用薄膜包衣液进行喷雾包衣,得到所述维生素片。
2.权利要求1所述的一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,其特征在于:
(1)氨基酸鳌合钙的制备:
将10-20重量份河蚌壳用自来水洗净,在NaOH溶液中浸泡30-40min,水洗3-5次,粉碎、过80-100目筛,得到河蚌壳粉;1:5-10加入盐酸溶液,升温到110-115℃反应1-2h,得到钙源;
将10-20重量份脱脂豆粕用自来水洗涤后,再1:5-10加入自来水,搅拌均匀得到浆料,加入木瓜蛋白酶,在pH为7-8、温度为40-50℃条件下酶解1-2h,然后在沸水水浴中灭酶15-20min,冷却至室温,离心,取上清液,得到氨基酸;
将所得钙源与氨基酸混合,调pH为7.5-8.5,在55-65℃下鳌合反应40-50min,得到氨基酸螯合钙溶液,离心、用乙醇洗涤、再离心,将所得沉淀物在120-140℃下干燥3-4h,研磨粉碎,得到氨基酸鳌合钙;
(2)B族维生素片的制备:
将2-4重量份维生素B1、2-4重量份维生素B2、2-4重量份维生素B6、0.001-0.002重量份维生素B12、140-150重量份微晶纤维素、300-320重量份淀粉、280-300重量份糊精、190-200重量份D-甘露糖醇与(1)中所得氨基酸鳌合钙混合,研磨粉碎,过60-80目筛后,1:5-10加入纯化水,搅拌均匀,过10-30目筛,将所得湿颗粒在50-60℃下干燥完全,过18-20目筛,得到干颗粒;将所得干颗粒与7-10重量份硬脂酸镁混合5-10min,压片,得到B族维生素片;
(3)B族维生素片薄膜包衣工艺:
薄膜包衣液的制备:将90-100重量份纯化水放入不锈钢桶中,缓慢加入4-6重量份薄膜包衣粉,搅拌均匀,得到包衣液;
包衣片的制备:将所得B族维生素片放入包衣机内,药片在片床上预热15-20min,然后进行喷雾包衣50-90min,在55-65℃干燥完全,按规格进行包装。
3.权利要求2所述的一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,其特征在于,步骤(1)中所述NaOH溶液浓度为4-5%,盐酸溶液浓度为5-5.2mol/L,木瓜蛋白酶的用量为18000-20000U/g,离心为4000-5000r/min处理10-15min,乙醇浓度为90-95%。
4.权利要求2所述的一种含氨基酸鳌合钙的B族维生素片的薄膜包衣工艺,其特征在于,步骤(3)中所述包衣机转速为10-20r/min,进风温度为75-85℃,出风温度为40-50℃,蠕动泵流量为170-190g/min。
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