CN107569781B - Neutron capture therapy system - Google Patents
Neutron capture therapy system Download PDFInfo
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- CN107569781B CN107569781B CN201710545372.6A CN201710545372A CN107569781B CN 107569781 B CN107569781 B CN 107569781B CN 201710545372 A CN201710545372 A CN 201710545372A CN 107569781 B CN107569781 B CN 107569781B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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Abstract
The utility model provides a neutron capture treatment system, including beam shaping body, it includes the beam entry, locate neutron production portion in the beam shaping body, border on the retardation body of neutron production portion, surround reflector and beam outlet outside the retardation body, neutron production portion takes place nuclear reaction with the proton beam incident from the beam entry in order to produce the neutron, the retardation body retards the neutron that produces from neutron production portion, the reflector leads off neutron back to the retardation body in order to improve epithermal neutron beam intensity, beam shaping body includes at least one can be to keeping away from or being close to the moving part of neutron production portion direction motion, the moving part has first position and second position, the moving part moves between this first position and second position, when being located the first position, neutron production portion can be changed; when the movable member is located at the second position, the neutron generating portion cannot be replaced. This application neutron production portion changes conveniently, simple structure, and the application is nimble.
Description
Technical Field
The present invention relates to a neutron capture therapy system, and more particularly, to a neutron capture therapy system in which a neutron generating unit can be replaced.
Background
With the development of atomic science, radiation therapy such as cobalt sixty, linacs, electron beams, etc. has become one of the main means of cancer treatment. However, the traditional photon or electron therapy is limited by the physical conditions of the radiation, and can kill tumor cells and damage a large amount of normal tissues in the beam path; in addition, due to the difference in the sensitivity of tumor cells to radiation, conventional radiotherapy is often ineffective in treating malignant tumors with relatively high radiation resistance, such as multiple glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma).
In order to reduce the radiation damage of normal tissues around tumor, the target therapy concept in chemotherapy (chemotherapy) is applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high Relative Biological Effect (RBE) are also actively developed, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. Wherein, the neutron capture treatment combines the two concepts, such as boron neutron capture treatment, and provides better cancer treatment selection than the traditional radioactive rays by the specific accumulation of boron-containing drugs in tumor cells and the precise neutron beam regulation.
In the boron neutron capture treatment of an accelerator, a neutron generating unit for generating a neutron beam by nuclear reaction with a proton beam is required to be subjected to irradiation and irradiation of accelerated protons, and the neutron generating unit is damaged to some extent, and has a very important influence on the quality of the generated neutron beam.
However, most of accelerator boron neutron capture therapy retarders in the prior art are cylindrical, the neutron generating part is usually disposed in the retarder at a certain depth, and when the neutron generating part is damaged and needs to be replaced, a large number of steps must be taken to detach the neutron generating part, which may result in that the replacement work of the neutron generating part is not easy to be performed.
Therefore, there is a need to provide a new technical solution to solve the above problems.
Disclosure of Invention
To address the above-mentioned problems, one aspect of the present invention provides a neutron capture therapy system, comprising a beam shaper, the beam shaping body comprises a beam inlet, a neutron generating part arranged in the beam shaping body, a retarder adjacent to the neutron generating part, a reflector surrounding the neutron generating part and the retarder and a beam outlet, the neutron generating section nuclear-reacts with a proton beam incident from the beam inlet to generate neutrons, the retarder retards neutrons generated from the neutron generation part, the reflector guides off neutrons back to the retarder to improve the intensity of epithermal neutron beams, the beam shaping body comprises at least one movable piece capable of moving far away from or close to the neutron generating part, the movable piece moves between a first position and a second position, and when the movable piece is located at the first position, the neutron generating part can be replaced; when the movable member is located at the second position, the neutron generating portion cannot be replaced when the movable member is located at the second position.
Further, in order to facilitate replacement of the neutron generating section, it is preferable that the movable member is a partial reflector or a combination of a partial reflector and a partial retarder.
further, in order to facilitate taking out of the neutron generating portion, the movable member has a symmetry plane, the movable member is symmetrical along the symmetry plane, the neutron generating portion has an axis, the symmetry plane of the movable member passes through the axis of the neutron generating portion, the reflector has a first linear height, the movable member has a second linear height, the neutron generating portion has a third linear height, and the second linear height is smaller than or equal to the first linear height and larger than the third linear height.
further, when the second linear height of the movable member is equal to the first linear height of the reflector, if the joint surface between the movable member and the reflector is a plane-to-plane joint, radiation generated during neutron capture treatment may leak through the joint surface, as a preferable example, the reflector has a first connection portion having a first connection surface and a first joint surface, the movable member has a second connection portion having a second connection surface and a second joint surface, when the second linear height of the movable member is smaller than the first linear height of the reflector and larger than the third linear height of the neutron generating portion, the first connection surface of the reflector coincides with the first joint surface, the second connection surface of the movable member coincides with the second joint surface, the second joint surface of the movable member is connected with the first joint surface of the reflector and coincides with any one of the planes in which the axes of the neutron generating portion are located And (6) mixing.
Further, the reflector has a first connection portion, the first connection portion has a first connection surface and a first combination surface, the movable member has a second connection portion, the second connection portion has a second connection surface and a second combination surface, when a second straight line height of the movable member is equal to the first straight line height of the reflector, the first connection surface and the first combination surface are connected but located on different planes, the second connection surface and the second combination surface are connected but located on different planes, the first connection surface and the second connection surface are connected, and the first combination surface and the second combination surface are connected.
The neutron capture treatment system further comprises a driving assembly, wherein the driving assembly comprises a gate carrying a movable piece and a guide rail allowing the gate to move far away from or close to the neutron generating part, the gate moves far away from or close to the beam shaper along the guide rail, and when the gate moves far away from the beam shaper, the movable piece moves far away from the neutron generating part; when the gate moves towards the direction close to the beam shaping body, the movable piece moves towards the direction close to the neutron generating part.
Furthermore, the guide rail is arranged outside the beam shaping body, the driving assembly further comprises a support frame, one end of the support frame supports the gate, the other end of the support frame moves in the guide rail, and the gate moves in the direction far away from or close to the beam shaping body along with the movement of the support frame along the guide rail.
Further, the neutron capture treatment system further comprises a driving assembly, wherein the driving assembly comprises a gate and a rotating piece which supports the gate and allows the gate to rotate, the gate supports a moving piece, and when the gate rotates upwards around the rotating piece, the moving piece moves towards the direction close to the neutron generating part; when the gate rotates downwards around the rotating piece, the moving piece moves towards the direction far away from the neutron generating part.
Further, the neutron capture treatment system further comprises a driving assembly, wherein the driving assembly comprises a first connecting rod, a second connecting rod and a third connecting rod connected with the first connecting rod and the second connecting rod, the first connecting rod is fixed outside the beam shaping body, one end of the second connecting rod is fixed to the moving part, the other end of the second connecting rod is connected to the first connecting rod, the first connecting rod drives the third connecting rod to move, and the third connecting rod drives the second connecting rod to move so that the moving part moves in a direction far away from or close to the neutron generating part.
Further, when the second linear height of the movable member is smaller than the first linear height of the reflector and larger than the third linear height of the neutron generation part, a guide rail is arranged in the reflector, and the movable member is mounted in the beam shaper and can move along the guide rail in a direction away from or close to the neutron generation part.
Compared with the prior art, the method has the following beneficial effects: this application can be to keeping away from or being close to the moving part of neutron production portion direction motion through the setting, the change of the neutron production portion of being convenient for, simple structure, the application is nimble.
Drawings
FIG. 1 is a schematic view of a neutron capture therapy system of the present application;
FIG. 2a is a schematic view of the movable member of the present application in a second position;
FIG. 2b is a schematic view of the moveable member of the present application in a first position;
FIG. 3a is a schematic view of a second bonding surface of the movable member of the present application connected to the first bonding surface of the reflector and coinciding with a plane on which an axis of the neutron-generating portion is located;
FIG. 3b is a cross-sectional view of the movable member of the present application taken along plane of symmetry A;
FIG. 4a is a schematic view of the first connecting surface and the first bonding surface of the reflector being disposed at an oblique angle;
FIG. 4b is a schematic view of the groove surface of the mover and the protrusion surface of the reflector engaging with each other;
FIG. 5a is a schematic view of a portion of the movable member embedded in the gate;
FIG. 5b is a schematic view of the drive assembly with the support bracket;
FIG. 6 is a schematic diagram of a second embodiment of the present application;
FIG. 7 is a schematic diagram of a third embodiment of the present application;
Fig. 8 is a schematic view of embodiment four of the present application.
Detailed Description
Neutron capture therapy has been increasingly used in recent years as an effective means of treating cancer, with boron neutron capture therapy being the most common, the neutrons that supply boron neutron capture therapy being supplied by nuclear reactors or accelerators. The embodiments of the present application take an accelerator boron neutron capture therapy as an example, and the basic components of an accelerator boron neutron capture therapy generally include an accelerator for accelerating charged particles (such as protons, deuterons, etc.), a neutron generating section and heat removal system, and a beam shaper, wherein the accelerated charged particles react with the metal neutron generating section to generate neutrons, depending on the requirementsThe neutron yield and energy, the available energy and current of the accelerated charged particles, the physical and chemical properties of the metal neutron generating part, etc. to select the appropriate nuclear reaction, the nuclear reaction in question is7Li(p,n)7Be and9Be(p,n)9B, both reactions are endothermic. The energy thresholds of the two nuclear reactions are 1.881MeV and 2.055MeV respectively, because the ideal neutron source for boron neutron capture treatment is epithermal neutrons with keV energy level, theoretically if a metallic lithium neutron generating part is bombarded by protons with energy only slightly higher than the threshold, neutrons with relatively low energy can Be generated, and can Be used clinically without too much slowing treatment, however, the proton interaction cross section of the two neutron generating parts of lithium metal (Li) and beryllium metal (Be) and the threshold energy is not high, and in order to generate enough neutron flux, protons with higher energy are usually selected to initiate the nuclear reaction.
The ideal neutron generator should have the characteristics of high neutron yield, neutron energy distribution close to the super-thermal neutron energy region, no generation of too much intense penetrating radiation, safety, cheapness, easy operation, high temperature resistance and the like, but actually, the nuclear reaction meeting all the requirements cannot be found. In the boron neutron capture treatment process, the neutron generating part is inevitably damaged due to the impact and radiation of the accelerated protons, and the neutron generating part has a great influence on the quality of the neutron beam generated by the beam shaper, so that it is necessary to replace the neutron generating part periodically or according to the damage condition of the neutron generating part, and a neutron capture treatment system capable of replacing the neutron generating part is introduced below.
fig. 1 is a schematic diagram of a neutron capture therapy system 100 of the present application. The neutron capture therapy system 100 includes a beam shaper 10 and a drive assembly 20.
the beam shaper 10 includes a beam entrance 11, a neutron generating unit 12, a retarder 13 adjacent to the neutron generating unit 12, a reflector 14 surrounding the neutron generating unit 12 and the retarder 13, and a beam exit 15. The neutron generation unit 12 performs a nuclear reaction with a proton beam incident from the beam inlet 11 to generate neutrons, the retarder 13 retards the neutrons generated from the neutron generation unit 12, and the reflector 14 guides off neutrons back to the retarder 13 to improve the epithermal neutron beam intensity.
The reflector 14 includes at least one movable member 16 that is movable away from or toward the neutron-generating portion 12. The movable member 16 has a first position L1 and a second position L2 (fig. 2a and 2b are combined), the movable member 16 moves between the first position L1 and the second position L2, and the neutron generating portion 12 can be replaced when the movable member 16 is located at the first position L1; when the movable piece 16 is located at the second position L2, the neutron generating section 12 cannot be replaced. Specifically, when the movable element 16 moves to the first position L1 in a direction away from the neutron generating unit 12, the neutron generating unit 12 is exposed from the beam shaper 10, the neutron generating unit 12 is taken out, and the neutron generating unit 12 is replaced; after the replaced neutron generating part 12 is installed in the beam shaper 10, the movable member 16 moves to a second position L2 in a direction close to the neutron generating part 12 (the movable member 16 covers the periphery of the neutron generating part 12, and the neutron generating part 12 cannot be replaced), and the movable member 16 and the reflector 14 together guide back the deviated neutrons in the subsequent neutron capture treatment process.
the moving member 16 may be a partial reflector or a combination of a partial reflector and a partial retarder. The case where the movable element 16 is a partial reflector means that the neutron generating section 12 is disposed in front of the retarder 13 and covered with the reflector 14, and the retarder 13 is adjacent to the rear of the neutron generating section 12, and at this time, the neutron generating section is replaced by merely disposing the partial reflector in a movable structure (i.e., a movable element) and moving the movable element away from the neutron generating section. The case where the movable element 16 is a combination of a partial reflector and a partial retarder means that the neutron generating unit 12 is partially covered with the reflector 14 in front of the retarder 13 and partially embedded in the retarder 13 and covered with the retarder 13, and at this time, in order to enable replacement of the neutron generating unit 12, the partial reflector and the partial retarder covering the neutron generating unit 12 are provided in a movable structure (i.e., movable element), thereby enabling replacement of the neutron generating unit 12.
With reference to fig. 3a and 3b, in order to facilitate replacement of the neutron generating section 12, it is preferable that the movable member 16 is a symmetrical member having a symmetry plane a along which the movable member 16 is symmetrical, the symmetry plane a passes through an axis I of the neutron generating section 12, the reflector 14 has a first straight height H1, the movable member 16 has a second straight height H2, the neutron generating section 12 has a third straight height H3, and the second straight height H2 of the movable member 16 is smaller than or equal to the first straight height H1 of the reflector 14 and is greater than the third straight height H3 of the neutron generating section 12.
With reference to fig. 4a and 4b, the reflector 14 further has a first connecting portion 140, and the movable member 16 has a second connecting portion 160. The first connection portion 140 has a first connection surface 141 and a first combining surface 142 connected to the first connection surface 141, and the second connection portion 160 has a second connection surface 161 and a second combining surface 162 connected to the second connection surface 161.
When the second linear height H2 of the movable element 16 is smaller than the first linear height H1 of the reflector 14 and larger than the third linear height H3 of the neutron generating portion 12, the first connection surface 141 of the reflector 14 coincides with the first connection surface 142, the second connection surface 161 of the movable element 16 coincides with the second connection surface 162, and the second connection surface 162 of the movable element 16 is connected with the first connection surface 142 of the reflector 14 and coincides with any plane where the axis of the neutron generating portion 12 is located (see fig. 3 a). In this case, the movable element 16 is a part of the reflector 14, and in this case, when the movable element 16 moves to the first position L1 in a direction away from the neutron generating portion 12, the movable element 16 forms a notch in the reflector 14, from which the neutron generating portion 12 is exposed, and the neutron generating portion 12 is replaced at the notch; when the movable member 16 moves to the second position L2 in a direction approaching the neutron generating portion 12, the movable member 16 surrounds the periphery of the neutron generating portion 12, and the movable member 16 and the reflector 14 together guide back the deviated neutrons during the subsequent neutron capture treatment.
When the second linear height H2 of the movable element 16 is equal to the first linear height H1 of the reflector 14, the movable element 16 is half of the reflector 14 surrounding the neutron generating section 12. In order to reduce particles or radiation leaking from the joint of the movable member 16 and the reflector 14 during the subsequent neutron capture treatment, it is preferable that the first connecting surface 141 and the first connecting surface 142 of the reflector 14 are located on different planes, the second connecting surface 161 and the second combining surface 162 of the movable member 16 are located on different planes, the first connecting surface 141 and the second connecting surface 161 are attached, and the first combining surface 142 and the second combining surface 162 are attached. The first connecting portion 140 and the second connecting portion 160 can be specifically configured as follows (refer to fig. 4a), the second connecting surface 161 and the second connecting surface 162 are disposed at an inclined angle, the first connecting surface 142 and the first connecting surface 141 are disposed at an inclined angle, and the sum of the two inclined angles is 180 degrees. When the movable element 16 surrounds the outer periphery of the neutron generating section 12, the second coupling surface 162 is attached to the first coupling surface 142, and the second connection surface 161 is attached to the first connection surface 141. The first connection portion 140 and the second connection portion 160 may be provided such that the second coupling surface 162 is a recessed surface recessed from the second connection surface 161, the first coupling surface 142 is a protruding surface protruding from the first connection surface 141, and the recessed surface and the protruding surface are fitted to each other when the movable element 16 surrounds the outer periphery of the neutron generating portion 12 (see fig. 4 b).
The structure of the driving assembly 20 is described in detail below, and since the structure of the movable member 16 has been described in detail above, the description will not be repeated below, and in practical applications, the structure of the movable member 16 can be combined with the driving assembly 20 described below according to specific requirements, and although the following embodiment is described by taking a reflector having two movable members as an example, if the movable member 16 is provided in practical applications, the neutron generating portion 12 can be replaced easily, then only one movable member may be provided.
fig. 2a and 2b also illustrate a first embodiment of the present application, which is described by way of example in which the reflector 14 has two interconnected moving members 16 (i.e., a first moving member 163 and a second moving member 164) located on opposite sides of the neutron generating portion 12. The driving assembly 20 includes a guide rail 21 disposed outside the beam shaper 10 and a gate 22 supporting the movable member 16, wherein the gate 22 moves in the guide rail 21 to move the movable member 16 away from or close to the neutron generating portion 12. The movable member 16 includes a first movable member 163 and a second movable member 164, the gate 22 includes a first gate 221 and a second gate 222 moving along the guide rail 21, the first gate 221 supports the first movable member 163, and the second gate 222 supports the second movable member 164. The first gate 221 and the second gate 222 move in the guide rail 21 to respectively drive the first movable member 163 and the second movable member 164 to move away from or close to the neutron generating portion 12. When the first gate 221 and the second gate 222 move to the first position L1 in the direction away from the beam shaper 10, respectively, the first movable element 163 and the second movable element 164 also move in the direction away from the neutron generating unit 12, respectively, and at this time, the neutron generating unit 12 is exposed from the beam shaper 10, and the neutron generating unit 12 is replaced; when the first gate 221 and the second gate 222 respectively move to the second position L2 in the direction close to the neutron generating portion 12, the first movable member 163 and the second movable member 164 also move in the direction close to the neutron generating portion 12 until the first movable member 163 and the second movable member 164 cover the periphery of the neutron generating portion 12, and the first movable member 163 and the second movable member 164 are used for guiding back the deviated neutrons in the subsequent neutron capture treatment process.
For convenience of structural design, it is preferable that the first movable member 163 and the second movable member 164 have the same structure, and the first gate 221 and the second gate 222 have the same structure, and for convenience of description, the movable member 16 and the gate 22 are collectively referred to hereinafter.
The structure of the gate 22 can be various, in this embodiment, when the second linear height H2 of the movable element 16 is equal to the first linear height H1 of the reflector 14, the gate 22 covers the outer circumference of the movable element 16, it can be understood that the movable element 16 is embedded in the gate 22, the movement of the gate 22 in the guide rail 21 is equivalent to the opening and closing movement of the gate 22, and the movable element 16 moves away from or close to the neutron generating part 12 with the opening and closing of the gate 22. Preferably, the gate 22 is made of concrete. Of course, in order to save space or cost, half or even less of the movable element 16 may be embedded in the gate 22 (see fig. 5a), as long as the gate 22 is designed to support the movable element 16 and drive the movable element 16 to move away from or close to the neutron generating portion 12. A support bracket 23 (see fig. 5b) can also be provided between the gate 22 and the guide rail 21 when the second linear height H2 of the movable element 16 is less than the first linear height of the reflector 14. One end of the support 23 is fixed to the gate 22 and the other end moves in the guide 21 in a direction away from or towards the beam shaper 10. The movable member 16 moves along the guide rail 21 in a direction away from or close to the neutron generating section 12 in accordance with the movement of the gate 22. That is, the gate 22 is moved by the movement of the support bracket 23 in the guide rail 21 to move the gate 22, so as to avoid the need to set the gate 22 to a size large enough to move directly in the guide rail 21, thereby reducing the size of the gate 22.
Fig. 6 is a schematic diagram of a second embodiment of the present application. The drive assembly 20 includes a rotor 24 (e.g., a shaft) and a gate 22' retained on the rotor 24. The rotor 24 is located directly below the beam shaper 10 and the axis of the rotor 24 is parallel to the axis of the neutron generating section 12. The gate 22 ' rotates up and down around the rotating part 24, when the gate 22 ' moves down, the gate 22 ' drives the moving part 16 to move away from the neutron generating part 12, the neutron generating part 12 is exposed, and the neutron generating part 12 is replaced; when the gate 22' rotates upward, the movable member 16 is driven to rotate in a direction close to the neutron generating portion 12, and the movable member 16 surrounds the periphery of the neutron generating portion 12 and is used for guiding back the deviated neutrons in the subsequent neutron capture treatment process.
fig. 7 is a schematic diagram of the third embodiment of the present application. The driving assembly 20 in this embodiment includes a first connecting rod 25 fixed outside the beam shaper 10, a second connecting rod 26 connected to the movable member 16, and a third connecting rod 27 connecting the first connecting rod 25 and the second connecting rod 26, wherein the third connecting rod 27 moves to drive the second connecting rod 26 to move, and the movable member 16 moves away from or close to the neutron generating portion 12 along with the movement of the second connecting rod 26.
Fig. 8 is a schematic view of a fourth embodiment of the present application. When the second linear height H2 of the movable member 16 is smaller than the first linear height H1 of the reflector 14 (especially when the second linear height H2 of the movable member 16 is greater than the third linear height H3 of the neutron generating portion 12), a guide rail 28 may be disposed in the reflector 14, and a handle 165 may be disposed on an outer wall surface of the movable member 16, so that the movable member 16 is driven by the push-pull handle 165 to move along the guide rail 28 in a direction away from or close to the neutron generating portion 12. Of course, the driving assembly of the first to third embodiments can be applied to the present embodiment instead of the handle, and will not be described in detail here.
the neutron capture treatment system disclosed in the present application is not limited to the structures described in the above embodiments and shown in the drawings. Obvious changes, substitutions or alterations in the materials, shapes and positions of the components in the present application are all within the scope of the claims of the present application.
Claims (6)
1. A neutron capture therapy system comprising a beam shaper, characterized in that: the beam shaping body comprises a beam inlet, a neutron generating part arranged in the beam shaping body, a retarder adjacent to the neutron generating part, a reflector surrounding the neutron generating part and the retarder and a beam outlet, the neutron generating section nuclear-reacts with a proton beam incident from the beam inlet to generate neutrons, the neutron generating unit has an axis, the retarder retards neutrons generated from the neutron generating unit, the reflector directs deviated neutrons back to the retarder to increase epithermal neutron beam intensity, the beam shaping body comprises at least one movable piece capable of moving far away from or close to the neutron generating part, the movable piece is provided with a first position and a second position, the movable piece moves between the first position and the second position, and when the movable piece is located at the first position, the neutron generating part can be replaced; when the movable member is located at the second position, the neutron generating portion cannot be replaced, the movable member is a partial reflector or a combination of the partial reflector and a partial retarder, the reflector is provided with a first connecting portion, the first connecting portion is provided with a first connecting surface and a first combining surface, the movable member is provided with a second connecting portion, the second connecting portion is provided with a second connecting surface and a second combining surface, the reflector is provided with a first straight line height perpendicular to the axis direction and the moving direction of the movable member, the movable member is provided with a second straight line height perpendicular to the axis direction and the moving direction of the movable member, the neutron generating portion is provided with a third straight line height perpendicular to the axis direction and the moving direction of the movable member, and when the second straight line height of the movable member is smaller than the first straight line height of the reflector and larger than the third straight line height of the neutron generating portion, the first connecting surface of the reflector coincides with the first combining, and the second connecting surface of the movable piece is superposed with the second combining surface, and the second combining surface of the movable piece is connected with the first combining surface of the reflector and superposed with any plane where the axis of the neutron generating part is located.
2. The neutron capture therapy system of claim 1, wherein: the moving part is provided with a symmetry plane, the moving part is symmetrical along the symmetry plane, the neutron generation part is provided with an axis, the symmetry plane of the moving part passes through the axis of the neutron generation part, the reflector is provided with a first straight line height, the moving part is provided with a second straight line height, the neutron generation part is provided with a third straight line height, and the second straight line height is smaller than or equal to the first straight line height and larger than the third straight line height.
3. The neutron capture therapy system of claim 1, wherein: the neutron capture treatment system further comprises a driving assembly, the driving assembly comprises a gate carrying a movable piece and a guide rail allowing the gate to move far away from or close to the neutron generation part, the gate moves far away from or close to the beam shaping body along the guide rail, and when the gate moves far away from the beam shaping body, the movable piece moves far away from the neutron generation part; when the gate moves towards the direction close to the beam shaping body, the movable piece moves towards the direction close to the neutron generating part.
4. The neutron capture therapy system of claim 1, wherein: the neutron capture treatment system further comprises a driving assembly, wherein the driving assembly comprises a gate and a rotating part which supports the gate and allows the gate to rotate, the gate supports a moving part, and when the gate rotates upwards around the rotating part, the moving part moves towards the direction close to the neutron generating part; when the gate rotates downwards around the rotating piece, the moving piece moves towards the direction far away from the neutron generating part.
5. The neutron capture therapy system of claim 1, wherein: the neutron capture treatment system further comprises a driving assembly, the driving assembly comprises a first connecting rod, a second connecting rod and a third connecting rod, the third connecting rod is connected with the first connecting rod and the second connecting rod, the first connecting rod is fixed outside the beam shaping body, one end of the second connecting rod is fixed to the moving part, the other end of the second connecting rod is connected to the third connecting rod, the first connecting rod drives the third connecting rod to move, and the third connecting rod drives the second connecting rod to move so that the moving part moves in the direction far away from or close to the neutron generating part.
6. The neutron capture therapy system of claim 2, wherein: when the second linear height of the moving member is smaller than the first linear height of the reflector and larger than the third linear height of the neutron generating part, a guide rail is arranged in the reflector, and the moving member is arranged in the beam shaping body and can move along the guide rail in the direction far away from or close to the neutron generating part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710545372.6A CN107569781B (en) | 2015-11-12 | 2015-11-12 | Neutron capture therapy system |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| RU2739171C1 (en) | 2017-12-15 | 2020-12-21 | Нойборон Медтех Лтд. | Neutron capture therapy system |
| CN109925610B (en) * | 2017-12-15 | 2024-03-22 | 南京中硼联康医疗科技有限公司 | Neutron capture therapy system |
| CN109925607B (en) * | 2017-12-15 | 2024-03-22 | 南京中硼联康医疗科技有限公司 | Neutron capture therapy system |
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| JP2007240330A (en) * | 2006-03-08 | 2007-09-20 | Mitsubishi Heavy Ind Ltd | Neutron generator and neutron irradiation system |
| CN104548388A (en) * | 2014-12-08 | 2015-04-29 | 南京中硼联康医疗科技有限公司 | Beam shaping body for neutron capture therapy |
| CN205235192U (en) * | 2015-11-12 | 2016-05-18 | 南京中硼联康医疗科技有限公司 | Neutron capture treatment system |
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| JP5178238B2 (en) * | 2008-02-27 | 2013-04-10 | 住友重機械工業株式会社 | Target recovery device |
| BR112012026233B8 (en) * | 2010-04-13 | 2021-04-13 | Varian Med Sys Inc | radiation treatment system |
| JP5490651B2 (en) * | 2010-09-01 | 2014-05-14 | 住友重機械工業株式会社 | Neutron beam irradiation system |
| JP5996470B2 (en) * | 2013-03-29 | 2016-09-21 | 住友重機械工業株式会社 | Neutron capture therapy device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007240330A (en) * | 2006-03-08 | 2007-09-20 | Mitsubishi Heavy Ind Ltd | Neutron generator and neutron irradiation system |
| CN104548388A (en) * | 2014-12-08 | 2015-04-29 | 南京中硼联康医疗科技有限公司 | Beam shaping body for neutron capture therapy |
| CN205235192U (en) * | 2015-11-12 | 2016-05-18 | 南京中硼联康医疗科技有限公司 | Neutron capture treatment system |
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| CN107412962B (en) | 2019-08-20 |
| CN107412961A (en) | 2017-12-01 |
| CN107412961B (en) | 2019-08-06 |
| CN107412960A (en) | 2017-12-01 |
| CN107412960B (en) | 2019-08-06 |
| CN107412962A (en) | 2017-12-01 |
| CN106474633B (en) | 2017-11-10 |
| CN107569781A (en) | 2018-01-12 |
| CN106474633A (en) | 2017-03-08 |
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