CN107469063A - A kind of nano traditional Chinese medicine colloid decoction for treating vertigo and preparation method thereof - Google Patents

A kind of nano traditional Chinese medicine colloid decoction for treating vertigo and preparation method thereof Download PDF

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CN107469063A
CN107469063A CN201710724952.1A CN201710724952A CN107469063A CN 107469063 A CN107469063 A CN 107469063A CN 201710724952 A CN201710724952 A CN 201710724952A CN 107469063 A CN107469063 A CN 107469063A
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chinese medicine
traditional chinese
nano
treating vertigo
decoction
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张涛
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Abstract

The invention discloses a kind of nano traditional Chinese medicine colloid decoction for treating vertigo and preparation method thereof, it is made up of following components and its parts by weight：Ligusticum wallichii 15 17, the bletilla striata 15 17, Radix Angelicae Sinensis 12 13, the dried rhizome of rehmannia 12 13, cassia twig 12 13, PORIA ALBA 15 17, the bighead atractylodes rhizome 10 12, radix glycyrrhizae 10 12, keel 60 65, oyster 60 65, longan core 56, the tuber of multiflower knotweed 15 17, saline cistanche 15 17, rice vinegar 100 120, fish bone collagen albumen 80 90, edible gelatin 20 23, schizonepeta 13 15, wrinkled giant hyssop 15 17, propolis 10 12, Semen sesami nigrum 13 15.A kind of nano traditional Chinese medicine colloid decoction for treating vertigo of the present invention, color and luster is gentle, delicate mouthfeel, is in semisolid under normal temperature, efficacy stability, drug effect is slowly discharged after intake, has the function that lasting, sustained release.

Description

A kind of nano traditional Chinese medicine colloid decoction for treating vertigo and preparation method thereof
Technical field
The present invention relates to traditional Chinese herbal decoction technical field, more particularly to a kind of nano traditional Chinese medicine colloid decoction for treating vertigo and Its preparation method.
Background technology
It is stronger that majority extracts isolated active ingredient activity from Chinese medicine, have in corresponding disease is treated compared with The effect of good, as oleanolic acid has good bioactivity to liver；SN38 (SN-38) has very Strong active anticancer；Ginkgolides has the effect of notable to cardiovascular and cerebrovascular disease；Legalon is to acute, chronic hepatitis, hepatic sclerosis There is the effect of preferable with toxic liver injury；Taxol has the effect of prominent etc. for breast cancer, non-small cell lung cancer.But These effective component of chinese medicine often have that solubility is small, and the problems such as bioavilability is low, it is new that this limits its to a certain extent The exploitation and its clinical practice of medicine.Therefore, suitable method is found out to improve the solubility of Chinese medicine hardly soluble active ingredient, is improved Its bioavilability is one of significant challenge that current Chinese medicine preparation worker faces.In recent years, nano suspension is as a kind of The novel Drug Delivery Systems of insoluble drug, constantly attract people's attention.Nano suspension (nanosuspensions) system uses A small amount of surfactant is stablized a kind of sub-micrometer colloidal dispersion research that pure drug particle is formed and shown, the dissolving of medicine Different degrees of change can occur with change of size for degree, and when particle diameter is reduced to Nano grade, the solubility behavior of medicine can occur Significantly improve.And medicine is exactly to exist with nm regime in nano suspension, high degree of dispersion, beneficial to the dissolution and absorption of medicine, The bioavilability of medicine can be significantly improved.Therefore, nanometer suspension technology be presently believed to be solve insoluble drug dissolving and The best method of absorption problem.Whether it is insoluble in the medicine of water or is not only insoluble in water but also is insoluble in the medicine of oil, can By crushing or controlling crystallization technology that corresponding nano suspension is prepared.With traditional matrix scaffold type nanometer System is different, and nano suspension without carrier material, divide medicine by the toxic side effect and cyclodextrin that effectively prevent cosolvent Requirement of sub- size etc..Due to characteristic possessed by nano suspension, it has all embodied uniqueness in various methods of administration Advantage, hank this as prescription is simple, prepares hoof that is quick, advantageously reducing reactive compound, improve drug dissolution and biology Excitant and toxic side effect and relatively low administered volume etc. caused by availability, supplementary element of forgoing.Wherein high pressure homogenization method It is to utilize cavitation and cavitation effect caused by high pressure homogenizer, the drug particles of micronizing is further crushed as nano-scale Particle, while reduce the polydispersity of diameter of aspirin particle.The method is applied widely and preparation process is simple, without using organic examination Agent, suitable for being both insoluble in water or being insoluble in the medicine of oil, and the reappearance of technique is preferable, is easy to large-scale industry metaplasia Production, so as to be considered as the optimal preparation method of nano suspension.For the nano suspension stablized, nanoparticle is avoided Son condenses, and needs to add some surfactants in preparation process.Surfactant is made using SDS, PVPK30 combination, Obtained nano suspension particle diameter is small, and the system energy long period keeps stable.
Guo Jingjing exists《The research of Chinese medicine hardly soluble active ingredient delivery system based on nanometer suspension technology》It is middle by nanometer Suspension technology is applied to grinding for Chinese medicine hardly soluble active ingredient delivery system and made internal disorder or usurp, intend choosing the slightly solubility of medicine Semen Herpetospermi effectively into It is divided into model drug, using advanced nanometer suspension technology, nano suspension is prepared by the choosing of technique hoof, formulation optimization etc., and it is right It carries out external physicochemical property and internal Pharmacokinetic Evaluation, is made internal disorder or usurp for other grinding for Chinese medicine hardly soluble active ingredient delivery system Foundation is provided, to improve the dissolution in vitro of Chinese medicine hardly soluble active ingredient and vivo biodistribution availability.
Chinese medicine is processed using nanometer technology, drug particles is reached the level of superfines, specific surface area and adhesion show Increase is write, solubility of the medicine in intestines and stomach substantially increases, and extends with intestinal wall time of contact, so as to increase the biology profit of medicine Expenditure.He Jun etc. compares research using rat to the silymarin solid lipid nanoparticles oral absorption of different-grain diameter, It was found that the bioavilability of 150 nm solid lipid nano granules apparently higher than particle diameter be two kinds of preparations of 500 nm and 1 000 nm, grain Footpath size has a significant impact to the oral absorption of silymarin.Chinese medicine is processed using nanometer technology, can break the cell membrane of plant It is broken, it is easy to oozing out for active ingredient.Ganoderma lucidum embrace son have it is tough and tensile it is double-deck embrace wall, general crushing technology difficulty is by its broken wall, it is impossible to carries Lipid active material therein is taken, thus its effect is had a greatly reduced quality.Traditional Chinese medicine formulation is with respect to aging, single.It is existing in recent years Occur in succession for Chinese medicine such as dripping pill, injection, cutaneous permeable agent etc., but compared with chemical drugs etc., modern Chinese herbal medicine formulation quantity is still It is relatively fewer, kind is more single.Nano traditional Chinese medicine particle diameter is small, Selective adsorption is strong, there is stronger penetration power.Utilize nanometer technology It is undoubtedly abundant form of Chinese drug with nano material, promotes the effective way of modernization of Chinese medicine development.
The content of the invention
A kind of the defects of the object of the invention is exactly to make up prior art, there is provided nano traditional Chinese medicine colloid for treating vertigo Decoction.
The present invention is achieved by the following technical solutions：
A kind of nano traditional Chinese medicine colloid decoction for treating vertigo, it is made up of following components and its parts by weight：
Ligusticum wallichii 15-17, bletilla striata 15-17, Radix Angelicae Sinensis 12-13, dried rhizome of rehmannia 12-13, cassia twig 12-13, PORIA ALBA 15-17, bighead atractylodes rhizome 10-12, Radix glycyrrhizae 10-12, keel 60-65, oyster 60-65, longan core 5-6, tuber of multiflower knotweed 15-17, saline cistanche 15-17, rice vinegar 100-120, fish Bone collagen 80-90, edible gelatin 20-23, schizonepeta 13-15, wrinkled giant hyssop 15-17, propolis 10-12, Semen sesami nigrum 13-15.
A kind of described nano traditional Chinese medicine colloid decoction for treating vertigo, is made of the following steps：
1）, respectively Ligusticum wallichii, Radix Angelicae Sinensis, the dried rhizome of rehmannia, cassia twig, PORIA ALBA, the bighead atractylodes rhizome, radix glycyrrhizae, keel, oyster, longan core, the tuber of multiflower knotweed are cleaned it is dry After net, preliminary cutting makes uniform in size, natural-wind dry, then adds pulverizer and is crushed, crosses 60-80 mesh sieves；
2）, will add rice vinegar after the bletilla striata, saline cistanche, schizonepeta, wrinkled giant hyssop, Semen sesami nigrum rinse and soaked, then measure steaming with 10-12 times Distilled water mixing adds mixer uniform stirring, filter-cloth filtering slagging-off, filtrate is added to 13-15% bamboo charcoal, stands 2-2.5 hours；
3）, by SDS and PVPK30 with 2:3-4 ratio mixing, 1000-1500 times of addition are measured distilled water and fully dissolved, and take quality Fraction is that the 1-1.2% solution mixes with step 1 gained medicinal powder, and adds step 2 gained filtrate, in 7000-8000r/min height Fast Probe Ultrasonic Searching 6-8 times, the even 8-10 circles of high pressure breast under the conditions of pressure is 1000-1200bar；
4）, step 3 gains and fish bone collagen albumen, edible gelatin, propolis are sufficiently mixed, be heated to 85-90 while stirring DEG C, 50-60 DEG C is cooled to after homogeneous, is distributed into bag, it is stored refrigerated.
It is an advantage of the invention that：
1st, a kind of nano traditional Chinese medicine colloid decoction for treating vertigo of the invention, color and luster is gentle, delicate mouthfeel, solid in half under normal temperature State, efficacy stability, drug effect is slowly discharged after intake, have the function that lasting, sustained release.
2nd, a kind of nano traditional Chinese medicine colloid decoction for treating vertigo of the invention, to avoid nano-particle from condensing, Surfactant, obtained nano-colloid decoction good dispersion, and system energy are made using SDS, PVPK30 combination in preparation process Long period keeps stable；The characteristics of nano traditional Chinese medicine is due to its particle diameter and form, is easily caught and gulped down by the Kupffer Cell of liver Bite, medicine then progressively degraded, be discharged into blood, so as to strengthen drug effect in aggregation in liver.
3rd, a kind of nano traditional Chinese medicine colloid decoction for treating vertigo of the invention, Chinese medicine is processed using nanometer technology, makes medicine Composition granule reaches the level of superfines, and specific surface area and adhesion significantly increase, and solubility of the medicine in intestines and stomach is obvious Increase, extend with intestinal wall time of contact, so as to increase the bioavilability of medicine.
4th, a kind of nano traditional Chinese medicine colloid decoction for treating vertigo of the invention, the contained tuber of multiflower knotweed is bitter in taste, sweet, puckery, tepor, Enter liver and kidney channel, there is the effect of filling liver kidney, benefiting essence-blood, the deficiency of blood is weak, feels dizzy for treating, and is equipped with oyster, bighead atractylodes rhizome tonifying spleen QI invigorating, it is equipped with Ligusticum wallichii and calms the nerves；Saline cistanche nature and flavor are sweet, warm, enter kidney, large intestine channel, have the function that nourishing kidney and replenishing pneuma, establishing-Yang laxation, match somebody with somebody With Radix Angelicae Sinensis, dried rhizome of rehmannia tonifying Qi, radix glycyrrhizae, bletilla striata anti-inflammatory, analgesic are equipped with；Schizonepeta property and flavor of peppery and warm, enter lung, Liver Channel, there is inducing sweat and dispelling exogenous evils, disappear The effect of scorching, it is equipped with wrinkled giant hyssop wind-dispelling heat-dissipating.
Embodiment
A kind of nano traditional Chinese medicine colloid decoction for treating vertigo, it is made up of following components and its parts by weight：
Ligusticum wallichii 15, the bletilla striata 15, Radix Angelicae Sinensis 12, the dried rhizome of rehmannia 12, cassia twig 12, PORIA ALBA 15, the bighead atractylodes rhizome 10, radix glycyrrhizae 10, keel 60, oyster 60, Longan core 5, the tuber of multiflower knotweed 15, saline cistanche 15, rice vinegar 100, fish bone collagen albumen 80, edible gelatin 20, schizonepeta 13, wrinkled giant hyssop 15, propolis 10th, Semen sesami nigrum 13.
A kind of described nano traditional Chinese medicine colloid decoction for treating vertigo, is made of the following steps：
1）, respectively Ligusticum wallichii, Radix Angelicae Sinensis, the dried rhizome of rehmannia, cassia twig, PORIA ALBA, the bighead atractylodes rhizome, radix glycyrrhizae, keel, oyster, longan core, the tuber of multiflower knotweed are cleaned it is dry After net, preliminary cutting makes uniform in size, natural-wind dry, then adds pulverizer and is crushed, crosses 60 mesh sieves；
2）, will after the bletilla striata, saline cistanche, schizonepeta, wrinkled giant hyssop, Semen sesami nigrum rinse, add rice vinegar soaked, then with 10 times amount distilled water Mixing adds mixer uniform stirring, filter-cloth filtering slagging-off, by the bamboo charcoal of filtrate addition 13%, stands 2 hours；
3）, by SDS and PVPK30 with 2:3 ratio mixing, add 1000 times of amount distilled water and fully dissolve, it is 1% to take mass fraction The solution mixes with step 1 gained medicinal powder, and adds step 2 gained filtrate, in 7000r/min high speeds Probe Ultrasonic Searching 6 times, is pressing Even 8 circle of high pressure breast under the conditions of power is 1000bar；
4）, step 3 gains and fish bone collagen albumen, edible gelatin, propolis are sufficiently mixed, be heated to 85 DEG C while stirring, 50 DEG C are cooled to after homogeneous, is distributed into bag, it is stored refrigerated.

Claims (2)

1. a kind of nano traditional Chinese medicine colloid decoction for treating vertigo, it is characterised in that it is by following components and its parts by weight system Into：
Ligusticum wallichii 15-17, bletilla striata 15-17, Radix Angelicae Sinensis 12-13, dried rhizome of rehmannia 12-13, cassia twig 12-13, PORIA ALBA 15-17, bighead atractylodes rhizome 10-12, Radix glycyrrhizae 10-12, keel 60-65, oyster 60-65, longan core 5-6, tuber of multiflower knotweed 15-17, saline cistanche 15-17, rice vinegar 100-120, fish Bone collagen 80-90, edible gelatin 20-23, schizonepeta 13-15, wrinkled giant hyssop 15-17, propolis 10-12, Semen sesami nigrum 13-15.
2. a kind of nano traditional Chinese medicine colloid decoction for treating vertigo according to claim 1, it is characterised in that be by following Made of step：
1）, respectively Ligusticum wallichii, Radix Angelicae Sinensis, the dried rhizome of rehmannia, cassia twig, PORIA ALBA, the bighead atractylodes rhizome, radix glycyrrhizae, keel, oyster, longan core, the tuber of multiflower knotweed are cleaned it is dry After net, preliminary cutting makes uniform in size, natural-wind dry, then adds pulverizer and is crushed, crosses 60-80 mesh sieves；
2）, will add rice vinegar after the bletilla striata, saline cistanche, schizonepeta, wrinkled giant hyssop, Semen sesami nigrum rinse and soaked, then measure steaming with 10-12 times Distilled water mixing adds mixer uniform stirring, filter-cloth filtering slagging-off, filtrate is added to 13-15% bamboo charcoal, stands 2-2.5 hours；
3）, by SDS and PVPK30 with 2:3-4 ratio mixing, 1000-1500 times of addition are measured distilled water and fully dissolved, and take quality Fraction is that the 1-1.2% solution mixes with step 1 gained medicinal powder, and adds step 2 gained filtrate, in 7000-8000r/min height Fast Probe Ultrasonic Searching 6-8 times, the even 8-10 circles of high pressure breast under the conditions of pressure is 1000-1200bar；
4）, step 3 gains and fish bone collagen albumen, edible gelatin, propolis are sufficiently mixed, be heated to 85-90 while stirring DEG C, 50-60 DEG C is cooled to after homogeneous, is distributed into bag, it is stored refrigerated.
CN201710724952.1A 2017-08-22 2017-08-22 A kind of nano traditional Chinese medicine colloid decoction for treating vertigo and preparation method thereof Pending CN107469063A (en)

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Application publication date: 20171215