CN107412049A - A kind of preparation for cleaning and nursing for skin and preparation method thereof - Google Patents

A kind of preparation for cleaning and nursing for skin and preparation method thereof Download PDF

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Publication number
CN107412049A
CN107412049A CN201710567082.1A CN201710567082A CN107412049A CN 107412049 A CN107412049 A CN 107412049A CN 201710567082 A CN201710567082 A CN 201710567082A CN 107412049 A CN107412049 A CN 107412049A
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parts
product
preparation
skin
sodium hyaluronate
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程雷
袁伟
刘笃寿
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Nine Guizhou Lide Biological Pharmaceutical Co Ltd
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Nine Guizhou Lide Biological Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

The invention discloses a kind of preparation for cleaning and nursing for skin and preparation method thereof, mainly it is made up of poly hexamethylene biguanide, vitamin B12, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urea Bursin, glycerine, poloxamer, EDTA 2Na and menthol.Invention formulation is nonirritant, is not in husking and rejection, has no side effect, no bad smell, after repair the phase also will not on skin chromogenesis precipitate.Bacterium can effectively be suppressed and diminished inflammation, repair injured nerve tip, reduce the liquid that postoperative complications are repaired in beauty.

Description

A kind of preparation for cleaning and nursing for skin and preparation method thereof
Technical field
It is particularly a kind of to reduce itch the present invention relates to a kind of preparation for cleaning and nursing for skin and preparation method thereof Skin cleaning and nursing preparation and preparation method thereof.
Technical background
The such as common mildy wash of general cleaning supplies on the market, using saponification or by adding surfactant breast Change and type into milky face cleaning emulsion.This product disclosure satisfy that requirement during everyday home use, but without deep The effect of layer is antibacterial and repairs, especially before skin repair and medical cosmetology is carried out, it is desirable to which skin surface fully and completely cleans, and disappears Except harmful bacteria, stabilization damaged cell, the factor that diminishes inflammation and medium.In terms of this, in general face cleaning product can not be complete Meet to require.
So beauty doctor is often carried out disinfection processing, but alcohol, Iodophor using products such as alcohol, Iodophors to skin surface Deng there is certain excitant to skin and having bad smell, after repair the phase chromogenesis can be precipitated on skin.Meanwhile pierce Sharp performance section causes skin serious husking and rejection occur, can cause three days patient's discomforts of Post operation, influence patient Compliance.
Therefore, the preparation of skin cleaning and nursing is currently used for, there is excitant to skin, causes skin to occur seriously Husking and rejection, side effect is big, and has bad smell, after repair the phase can also on skin chromogenesis precipitate.
The content of the invention：
The purpose of the present invention, it is to provide a kind of preparation for cleaning and nursing for skin and preparation method thereof.Present invention system Agent is nonirritant, is not in husking and rejection, has no side effect, no bad smell, and the phase also will not be in skin after repair Upper chromogenesis precipitation.Bacterium can effectively be suppressed and diminished inflammation, repair injured nerve tip, reduced beauty and repair complicated by postoperative The liquid of disease.
In order to solve the above technical problems, the present invention is realized using following technical scheme：One kind is used for skin and cleans and nurse Preparation, calculate in parts by weight, mainly by poly hexamethylene biguanide 160-240 parts, vitamin B12 470-530 parts, chamomile Extract 260-340 parts, hamamelis extract 260-340 parts, small molecule sodium hyaluronate 1600-2400 parts, urea Bursin 8800- 9200 parts, glycerine 18000-22000 parts, poloxamer 8800-9200 parts, EDTA-2Na 180-220 parts and menthol 80-120 Part is made.
The preparation of skin cleaning and nursing is previously described for, is calculated in parts by weight, mainly by poly hexamethylene biguanide 180-220 parts, vitamin B12 490-510 parts, camomile extract 290-310 parts, hamamelis extract 280-320 parts, small point Sub- sodium hyaluronate 1900-2100 parts, urea Bursin 8900-9100 parts, glycerine 19000-21000 parts, poloxamer 8900-9100 Part, EDTA-2Na 190-210 parts and menthol 90-110 parts are made.
The preparation of skin cleaning and nursing is previously described for, is calculated in parts by weight, mainly by poly hexamethylene biguanide 200 Part, 500 parts of vitamin B12,300 parts of camomile extract, 300 parts of hamamelis extract, 2000 parts of small molecule sodium hyaluronate, urea 100 parts of 9000 parts of Bursin, 20000 parts of glycerine, 9000 parts of poloxamer, 200 parts of EDTA-2Na and menthol are made.
It is previously described in the preparation of skin cleaning and nursing, the small molecule sodium hyaluronate is urinated for the glass of 100,000 molecular weight Acid.
A kind of preparation method for the preparation for being previously described for skin cleaning and nursing, comprises the following steps：
(1) vitamin B12 is weighed in proportion, 5-6 times is dissolved in and measures in purified water, after stirring 110-130min, utilizes 0.22 Micron sterilizing filter is filtered into sterile chamber, obtains A product；
(2) poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urine are weighed in proportion Plain Bursin, glycerine, poloxamer, EDTA-2Na and menthol, add 3-5 times to measure purified water, stir evenly, obtain B product；
(3) B product are filtered with 0.22 micron of sterilizing filter, collects filtrate, obtain C product；
(4) A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
The preparation method of the preparation of skin cleaning and nursing is previously described for, is comprised the following steps：
(1) vitamin B12 is weighed in proportion, is dissolved in 5 times of amount purified waters, after stirring 120min, is removed using 0.22 micron Bacterium filter is filtered into sterile chamber, obtains A product；
(2) poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urine are weighed in proportion Plain Bursin, glycerine, poloxamer, EDTA-2Na and menthol, add 4 times of amount purified waters, stir evenly, obtain B product；
(3) B product are filtered with 0.22 micron of sterilizing filter, collects filtrate, obtain C product；
(4) A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
The preparation of the present invention for cleaning and nursing for skin is mainly by poly hexamethylene biguanide, vitamin B12, ocean Flos Chrysanthemi extract, hamamelis extract, small molecule sodium hyaluronate, urea Bursin, glycerine, poloxamer, EDTA-2Na and menthol It is made.Wherein, poly hexamethylene biguanide, environment-friendly type macromolecule polymer disinfection sanitizer --- polyhexamethylene guanide, have and kill Bacterium wide spectrum；Valid density is low；Work fast；Property is stable；Premium properties soluble in water；It can use at normal temperatures；For a long time It is antibacterial, have no side effect；Non-corrosiveness；It is colourless, odorless；It is nontoxic.Camomile extract, camomile extract, effect：Calmness peace God, it is aid digestion, improve skin, it is anti-oxidant.Hamamelis extract, the natural essence of witch hazel take thing, effect：Anti-inflammatory, anti-acne.Effectively Composition：Tannic acid and stearopten.Sodium hyaluronate, sodium hyaluronate small molecule establish rapidly " water " environment of subcutaneous cell, it is suppressed that from Trigger the occurrence probability of melanin by base, desalinate pigment, make the increase of cell transparency, form significant whitening effect and light spot effect Fruit；HA-800 not only have increase skin sodium hyaluronate content function, and can stimulating endothelial cell identification injury, So as to carry out initial protection and reparation to injury, for promoting wound healing effect notable.HA-800, which has, promotes hair Thin vascularization, this turns to be yellow, for eliminating red blood silk significant effect for improving skin colour.Glycerine, i.e. glycerine, it is colourless Sweet clear and bright thick liquid.It is odorless.There is warm sweet taste.In papermaking, cosmetics, process hides, photograph, printing, intermetallic composite coating, electrical material Extensive purposes is suffered from in the industry such as rubber.Poloxamer (Poloxamer) is that polyoxyethylene poly-oxygen propylene aether block is total to Polymers, pharmaceutic adjuvant.In theory, the compound of such basic structure can have countless, NF standards provide its molecular weight from More than 1000 to 7000, it is different from the polyoxyethylene of appropriate amount to be copolymerized into oleophylic water balance value by the polyoxypropylene of appropriate amount Compound.Disodium ethylene diamine tetraacetate, which is called, is EDTA-2Na, is a kind of good compounding ingredient in chemistry, and it has six coordinations Atom, the complex of formation are called chelant thing, and EDTA is often used in complexometric titration, usually determine containing for metal ion Amount.EDTA industrially has important use in dyestuff, food, medicine etc..Menthol, organic compound, colorless needle crystals or grain Shape.For the main component in peppermint and lavender essential oil, exist with free and ester state.Menthol has 8 kinds of isomers, they It is different in fragrance matter, levorotatory menthol has the function that peppermint fragrance and has refrigerant, and racemization menthol also has refrigerant work With other isomers are without refrigerant effect.It can be used as the odorant of toothpaste, perfume, beverage and candy etc..It is used as thorn in medicine Swash medicine, act on skin or mucous membrane, there is refrigerant itching-relieving action；It is for oral administration to can be used for headache and nose, pharynx, laryngitis etc..
The preparation for cleaning and nursing for skin is made of above-mentioned raw materials by the present invention, and manufactured preparation is nonirritant, no Occur husking and rejection, have no side effect, no bad smell, after repair the phase chromogenesis will not also be sunk on skin Form sediment.Bacterium can effectively be suppressed and diminished inflammation, repair injured nerve tip, reduce the liquid that postoperative complications are repaired in beauty.No Effectively cleaning face is only capable of, can also replace commonly using the sterilized articles therefroms such as alcohol, Iodophor on the market, while there is reparation nerve endings, Reduce itch, a kind of Multi-functional skin cleaning-nursing liquid of stable cell.
Experimental example.
The effect detection of invention formulation is proved by Guizhou medical university and part Out-patient Clinic of Department of Gynecology：
1. antibacterial effective percentage：
Bacterial strain Efficient (%)
White chain pearl bacterium 94.6%
Staphylococcus aureus 89.8%
Pseudomonas aeruginosa 92.3%
Escherichia coli 99.8%
2. treat example
Skin cleaning is carried out to patient using invention formulation (being prepared by embodiment 1) by beauty doctor, can be bright Aobvious to observe the red and swollen disappearance of face, patient's reaction pruritis mitigates.Bacteria Culture is carried out to extracting cortex at, finds this Product can maintain to control the growth of bacterium in 24 hours, prevent from repairing site infection.
Therefore, invention formulation is nonirritant can effectively suppress bacterium and diminish inflammation, and repair injured nerve tip, reduce The liquid of postoperative complications is repaired in beauty.Face can not only be effectively cleaned, can also replace commonly using the sterilization such as alcohol, Iodophor on the market Product, while there is reparation nerve endings, reduce itch, a kind of Multi-functional skin cleaning-nursing liquid of stable cell.
Compared with prior art, invention formulation is nonirritant, is not in husking and rejection, has no side effect, nothing Bad smell, after repair the phase also will not on skin chromogenesis precipitate.Bacterium can effectively be suppressed and diminished inflammation, repair by Nerve endings is damaged, reduces the liquid that postoperative complications are repaired in beauty.Face can not only be effectively cleaned, can also replace commonly using on the market The sterilized articles therefroms such as alcohol, Iodophor, while there is reparation nerve endings, itch is reduced, a kind of Multi-functional skin of stable cell is clear Cleaning and nursing liquid.
Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.
Embodiment：
Embodiment 1
Formula：Poly hexamethylene biguanide 200g, vitamin B12500g, camomile extract 300g, hamamelis extract 300g, small molecule sodium hyaluronate 2000g, urea Bursin 9000g, glycerine 20000g, poloxamer 9000g, EDTA 2Na 200g, Menthol 100g.
The small molecule sodium hyaluronate is the sodium hyaluronate of 100,000 molecular weight.
Technique：Comprise the following steps：
(1) vitamin B12 is weighed in proportion, is dissolved in 5 times of amount purified waters, after stirring 120min, is removed using 0.22 micron Bacterium filter is filtered into sterile chamber, obtains A product；
(2) poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urine are weighed in proportion Plain Bursin, glycerine, poloxamer, EDTA-2Na and menthol, add 4 times of amount purified waters, stir evenly, obtain B product；
(3) B product are filtered with 0.22 micron of sterilizing filter, collects filtrate, obtain C product；
(4) A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
Usage and dosage：First with warm water skin, spontaneously dry.Spray bottle outer packing is opened, cleaning-nursing liquid is sprayed on skin Skin surface simultaneously wipes uniform, natural drying with clean cotton piece.
Embodiment 2.
Formula：Poly hexamethylene biguanide 220g, vitamin B12 510g, camomile extract 310g, hamamelis extract 320g, small molecule sodium hyaluronate 2100g, urea Bursin 9100g, glycerine 21000g, poloxamer 9100g, EDTA-2Na 210g and Menthol 110g.
The small molecule sodium hyaluronate is the sodium hyaluronate of 100,000 molecular weight.
Technique：Comprise the following steps：
(1) vitamin B12 is weighed in proportion, is dissolved in 6 times of amount purified waters, after stirring 130min, is removed using 0.22 micron Bacterium filter is filtered into sterile chamber, obtains A product；
(2) poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urine are weighed in proportion Plain Bursin, glycerine, poloxamer, EDTA-2Na and menthol, add 5 times of amount purified waters, stir evenly, obtain B product；
(3) B product are filtered with 0.22 micron of sterilizing filter, collects filtrate, obtain C product；
(4) A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
Usage and dosage：First with warm water skin, spontaneously dry.Spray bottle outer packing is opened, cleaning-nursing liquid is sprayed on skin Skin surface simultaneously wipes uniform, natural drying with clean cotton piece.
Embodiment 3.
Formula：Poly hexamethylene biguanide 180g, vitamin B12 490g, camomile extract 290g, hamamelis extract 280g, small molecule sodium hyaluronate 1900g, urea Bursin 8900g, glycerine 19000g, poloxamer 8900g, EDTA-2Na 190g and Menthol 90g.
The small molecule sodium hyaluronate is the sodium hyaluronate of 100,000 molecular weight.
Technique：Comprise the following steps：
(1) vitamin B12 is weighed in proportion, is dissolved in 5 times of amount purified waters, after stirring 110min, is removed using 0.22 micron Bacterium filter is filtered into sterile chamber, obtains A product；
(2) poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urine are weighed in proportion Plain Bursin, glycerine, poloxamer, EDTA-2Na and menthol, add 3 times of amount purified waters, stir evenly, obtain B product；
(3) B product are filtered with 0.22 micron of sterilizing filter, collects filtrate, obtain C product；
(4) A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
Usage and dosage：First with warm water skin, spontaneously dry.Spray bottle outer packing is opened, cleaning-nursing liquid is sprayed on skin Skin surface simultaneously wipes uniform, natural drying with clean cotton piece.

Claims (6)

  1. A kind of 1. preparation for cleaning and nursing for skin, it is characterised in that：Calculate in parts by weight, mainly by poly- six methylene Base biguanides 160-240 parts, vitamin B12 470-530 parts, camomile extract 260-340 parts, hamamelis extract 260-340 Part, small molecule sodium hyaluronate 1600-2400 parts, urea Bursin 8800-9200 parts, glycerine 18000-22000 parts, poloxamer 8800-9200 parts, EDTA-2Na 180-220 parts and menthol 80-120 parts are made.
  2. 2. the preparation for cleaning and nursing for skin as claimed in claim 1, it is characterised in that：Calculate in parts by weight, it is main Will be by
    Poly hexamethylene biguanide 180-220 parts, vitamin B12 490-510 parts, camomile extract 290-310 parts, witch hazel Extract 280-320 parts, small molecule sodium hyaluronate 1900-2100 parts, urea Bursin 8900-9100 parts, glycerine 19000-21000 Part, poloxamer 8900-9100 parts, EDTA-2Na 190-210 parts and menthol 90-110 parts are made.
  3. 3. the preparation for cleaning and nursing for skin as claimed in claim 2, it is characterised in that：Calculate in parts by weight, it is main Will by 200 parts of poly hexamethylene biguanide, 500 parts of vitamin B12,300 parts of camomile extract, 300 parts of hamamelis extract, 2000 parts of small molecule sodium hyaluronate, 9000 parts of urea Bursin, 20000 parts of glycerine, 9000 parts of poloxamer, 200 parts of EDTA-2Na and 100 parts of menthol is made.
  4. 4. the preparation for being used for skin and cleaning and nursing as any one of claim 1-3, it is characterised in that：Described small point Sub- sodium hyaluronate is the sodium hyaluronate of 100,000 molecular weight.
  5. 5. a kind of preparation method for being used for the preparation that skin is cleaned and nursed as any one of claim 1-3, it is special Sign is：
    Comprise the following steps：
    （1）Vitamin B12 is weighed in proportion, 5-6 times is dissolved in and measures in purified water, after stirring 110-130min, utilizes 0.22 micron Sterilizing filter is filtered into sterile chamber, obtains A product；
    （2）Poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urea capsule are weighed in proportion Element, glycerine, poloxamer, EDTA-2Na and menthol, add 3-5 times to measure purified water, stir evenly, obtain B product；
    （3）B product are filtered with 0.22 micron of sterilizing filter, filtrate is collected, obtains C product；
    （4）A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
  6. 6. the preparation method for the preparation for cleaning and nursing for skin as claimed in claim 5, it is characterised in that：Including following Step：
    （1）Vitamin B12 is weighed in proportion, is dissolved in 5 times of amount purified waters, after stirring 120min, is utilized 0.22 micron of degerming mistake Filter is filtered into sterile chamber, obtains A product；
    （2）Poly hexamethylene biguanide, camomile extract, hamamelis extract, small molecule sodium hyaluronate, urea capsule are weighed in proportion Element, glycerine, poloxamer, EDTA-2Na and menthol, add 4 times of amount purified waters, stir evenly, obtain B product；
    （3）B product are filtered with 0.22 micron of sterilizing filter, filtrate is collected, obtains C product；
    （4）A product are added in C product, are mixed, are obtained D product, and D product are filling, outer packing labeling, are put in storage and are produced.
CN201710567082.1A 2017-07-12 2017-07-12 A kind of preparation for cleaning and nursing for skin and preparation method thereof Pending CN107412049A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846779A (en) * 2019-03-06 2019-06-07 上海乐宝日化股份有限公司 A kind of maintenance makeup remover and preparation method thereof containing vitamin B12
CN111467249A (en) * 2020-04-24 2020-07-31 嘉兴力山明朗生物医药科技有限公司 Washing-free antibacterial gel and preparation method thereof
IT202000029288A1 (en) * 2020-12-01 2022-06-01 Altergon Sa BIGUANIDINE MICROBIOCIDE SALTS WITH GLYCOSAMINOGLYCANS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105596222A (en) * 2016-01-25 2016-05-25 广东工业大学 Preparation method of mask for accurate repair and care
CN105726404A (en) * 2016-03-25 2016-07-06 广东嘉丹婷日用品有限公司 Fresh skin care composition
CN106377455A (en) * 2016-09-28 2017-02-08 贵州特力达纳米碳素科技有限公司 Ice silkworm silk nanocarbon mask
CN106389134A (en) * 2016-11-17 2017-02-15 维尼健康（深圳）股份有限公司 All-cotton wet tissue for infant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105596222A (en) * 2016-01-25 2016-05-25 广东工业大学 Preparation method of mask for accurate repair and care
CN105726404A (en) * 2016-03-25 2016-07-06 广东嘉丹婷日用品有限公司 Fresh skin care composition
CN106377455A (en) * 2016-09-28 2017-02-08 贵州特力达纳米碳素科技有限公司 Ice silkworm silk nanocarbon mask
CN106389134A (en) * 2016-11-17 2017-02-15 维尼健康（深圳）股份有限公司 All-cotton wet tissue for infant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张贵荣 等: ""维生素B12外用治疗放射性皮肤损伤临床观察"", 《实用肿瘤学杂志》 *
王昌涛 等编著: "《化妆品植物添加剂的开发与应用》", 30 April 2013, 中国轻工业出版社 *
贵州九立德生物制药有限公司: ""皮肤平衡调理液"", 《国产非特殊用途化妆品备案服务平台（HTTP://125.35.6.80:8181/FTBAN/FW.JSP）》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846779A (en) * 2019-03-06 2019-06-07 上海乐宝日化股份有限公司 A kind of maintenance makeup remover and preparation method thereof containing vitamin B12
CN111467249A (en) * 2020-04-24 2020-07-31 嘉兴力山明朗生物医药科技有限公司 Washing-free antibacterial gel and preparation method thereof
IT202000029288A1 (en) * 2020-12-01 2022-06-01 Altergon Sa BIGUANIDINE MICROBIOCIDE SALTS WITH GLYCOSAMINOGLYCANS
WO2022118163A1 (en) * 2020-12-01 2022-06-09 Altergon S.A. Soluble polyelectrolytic complexes of polymeric biguanidine microbiocides with glycosaminoglicans

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