A kind of production method of medical artificial skin
Technical field
The invention belongs to medical macromolecular materials preparation field, and in particular to a kind of production method of medical artificial skin.
Background technology
Skin is an outmost Rotating fields for human body, is a maximum organ of human body.He is both the sense of nervous system
Feel device, be effector again, hot and cold, pain, emotional change etc. mechanically and chemically cause skin vasoconstriction to sexual stimulus all reflectivity
With diastole, arrectores pilorum contraction, the change of sweat gland secretion, capillary of skin permeability.Skin covers whole body, and it makes various in vivo
Tissue and organ are from physical, mechanicalness, the chemically invasion and attack with pathogenic microorganism.
Skin is the natural cover for defense for protecting body, for the patient of skin serious defect, a large amount of losses of body fluid and wound
Infection is to threaten the principal element of patient vitals.Therefore, now preparing a kind of has a certain degree of intensity, toughness, waterproof, thoroughly
The medical artificial skin of gas performance close to real skin is particularly important, and this makes it possible to mitigate patient's pain, saves patient
Life.
Artificial skin refers to the principle and method of utilizing works and cell biology, the skin generation manually developed in vitro
Articles for use, are a kind of dressing for being used to treat skin trauma face, membrane-like are formed into because it is general, so being visually referred to as more
Artificial skin.
Because medical grade silicon rubber has higher temperature tolerance, resistance to oxidation, hydrophobicity, flexibility, permeability, ageing-resistant transparent
Spend height, physiological inertia, good, nontoxic, tasteless, not carcinogenic etc. a series of excellent with tissue and blood adhesion, biocompatibility
Good characteristic, therefore be widely used medical in preparing artificial peritonaeum, artificial knuckle, soft tissue expander, artificial skin etc.
Product.
For in the silicon rubber of productive manpower skin because injection add-on type liquid silicon rubber have excellent transparency,
Intensity and tearing toughness, excellent resilience, excellent heat endurance and weatherability, yellowing-resistant, heat-resisting old are stretched in excellent drawing
The characteristics such as change, so injection add-on type liquid silicon rubber is one of most suitable raw material, injection add-on type liquid silicon rubber is to contain
There is the poly- of vinyl to there is siloxanes to make base polymer, poly- containing Si -- H bond has siloxanes to make crosslinking agent, exists in platinum catalyst
Under, one kind of cross-linking vulcanization has silicon materials under room temperature or heating.It is that one kind is suitable for noting to inject add-on type liquid silicon rubber
The high anti-tear liquid silicon rubber material of two-component platinum catalysis high transparency of moulding process is penetrated, injection add-on type liquid silicon rubber is general
It is divided into component A and B component, wherein, the composition of component A is vinyl silicone oil, methyl-silicone oil, white carbon and platinum catalyst etc., B
The composition of component is vinyl silicone oil, methyl-silicone oil, containing hydrogen silicone oil and silica etc., meanwhile, it is formulated and by adjusting with adding
The methods of controlling curingprocess rate into reaction suppressor, the product for adapting to multiple use can be made.
At present, in the related data in existing medical artificial skin production technology, only disclosing a kind of preparation method,
That is (patent of invention number is ZL201210490496.6) a kind of porous silicone rubber method for manufacturing thin film for artificial skin, it is
Added in agitator and be well mixed by a certain percentage by silicon rubber predecessor, non-solvent or pore-foaming agent, effumability solvent, obtained
Film liquid, film liquid form silicon rubber film after solvent volatilizees and solidifies again, and thereafter, film is by solvent soaking or extracting 3-4
It removes non-solvent or pore-foaming agent, needs to change solvent daily in immersion or extractive process, porous silicon rubber is finally prepared
Glue film.Being drawn through overtesting, porous silicone rubber membrane pore size is smaller made from this method, though the external world can be being resisted to a certain degree
The intrusion of bacterium, but gas permeability is not strong;And the preparation technology complexity of this porous silicone rubber film is cumbersome, long preparation period,
Low production efficiency;Meanwhile need to use a series of organic solvent, the volatilization of one side organic solvent and waste liquid in preparation process
High risks can be caused to environment, on the other hand, has in final products porous silicone rubber film and residual organic solvent be present
May, it is impossible to its security is completely secured.
The content of the invention
(1) technical problems to be solved
In view of the shortcomings of the prior art, the technical problem to be solved in the present invention is to provide a kind of production of medical artificial skin
Method, this method is simple and practical, short preparation period, efficiency high, in process of production without using organic solvent, safety and environmental protection, together
When, the environment that a moistening can be provided to wound promotes its healing, adhesion wound in use, reduces patient when changing
Pain, reduces the pain of patient when changing, and the medical artificial skin resistance bacterium property and gas permeability produced are all good.
(2) technical scheme
In order to solve the above-mentioned technical problem, the invention provides the production method of such a medical artificial skin, specifically
Comprise the following steps:
A. according to mass percent meter, 65-75% injection add-on type liquid silicon rubber component A and 25-35% are taken
Purified water, it is mixed evenly at normal temperatures, mixing speed 1500-3000r/min, obtains mixture one;
B. according to mass percent meter, 65-75% injection add-on type liquid silicon rubber B component and 25-35% are taken
Purified water, it is mixed evenly at normal temperatures, mixing speed 1500-3000r/min, obtains mixture two;
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three;
D. mixture three is inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification temperature 70-90
DEG C, hardening time is 25-35 minutes, is evaporated again after solidification, and evaporating temperature is 120-150 DEG C, and evaporation time is 60-90 points
Clock, obtain silicon rubber film;
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
Preferably, in step, according to mass percent meter, 70% injection add-on type liquid silicon rubber component A is taken
Purified water with 30%, is mixed evenly at normal temperatures, mixing speed 2300r/min, obtains mixture one;In step B
In, according to mass percent meter, 70% injection add-on type liquid silicon rubber B component and 30% purified water are taken, in normal temperature
Under be mixed evenly, mixing speed 2300r/min, obtain mixture two;In step C, according to mass percent meter, take
With the mixture two of 50% mixture one and 50%, it is mixed evenly, mixing speed 500r/min, obtains at normal temperatures
Mixture three.
Preferably, in step D, solidification is carried out using staged, solidifies the first stage, and solidification temperature is 75 DEG C, solidification
Time is 7 minutes;Solidify second stage, solidification temperature is 80 DEG C, and hardening time is 10 minutes;Solidify phase III, solidification temperature
Spend for 85 DEG C, hardening time is 13 minutes;It is evaporated again after solidification, evaporation is carried out using staged, evaporates the first stage, is steamed
It is 125 DEG C to send out temperature, and evaporation time is 20 minutes;Second stage is evaporated, evaporating temperature is 135 DEG C, and evaporation time is 25 minutes;
Evaporate the phase III, evaporating temperature is 145 DEG C, and evaporation time is 30 minutes.
(3) beneficial effect
The present invention compared with prior art, overcomes the deficiencies in the prior art, first, passes through certain matter under certain condition
The injection add-on type liquid silicon rubber component A and B component for measuring ratio are first each well mixed with purified water, and mutual under certain condition
Mix uniformly and input slobbering machine and carry out salivation film forming, and solidify and evaporate under the temperature and time of specific selection, then
Medical artificial skin finished product is obtained by the step such as puncturing, cutting and wind, without the solvent soaking Jing Guo prior art
Or extracting removes non-solvent or pore-foaming agent for 3-4 days, and need the steps such as replacing solvent daily in immersion or extractive process, significantly
The production technology of medical artificial skin finished product has been simplified, has made its simple processing practical, meanwhile, manufacturing cycle is shortened, is improved
Production efficiency;Secondly, in process of production without using organic solvent, but using purified water as pore-foaming agent, purified water is passed through
It is organic to eliminate medical artificial skin finished product residual so as to produce many fine fine and close air-vents on silicon rubber film for evaporation
The possibility of solvent, solve organic solvent and volatilize in process of production and endangered with waste liquid to caused by environment, so as to safer
Environmental protection, to human body and environment non-hazardous, also, the nontoxic no sensitization of artificial skin so produced, with the skin of human body in itself
Skin good biocompatibility;Again, dressing of the invention can promote its healing to the environment of wound one moistening of offer, meanwhile, this
The dressing of invention can realize with wound adhesion, significantly reduce pain during changing medicine for patient;Finally, just because of purified water is made
For pore-foaming agent, pass through evaporating so as to produce many fine fine and close air-vents on silicon rubber film, in conjunction with profit for purified water
Silicon rubber film is punctured with porcupine roller, so that not only gas permeability is extremely strong for the medical artificial skin finished product so produced, and
And resistance bacterium performance is also especially excellent, the performance of each side and the real skin of human body are close.In general, the present invention is easy to be real
With, short preparation period, efficiency high, in process of production without using organic solvent, safety and environmental protection, meanwhile, it is capable to give wound to provide
The environment of one moistening promotes its healing, adhesion wound in use, reduces the pain of patient when changing, reduces and suffer from when changing
The pain of person, and the medical artificial skin resistance bacterium property and gas permeability produced are all good.
Further, in step A, B and C, it is specific selection injection add-on type liquid silicon rubber component A and B groups and
The combined amount of purified water, and select to be mixed under optimum temperature and stirring condition uniformly, it can so improve medical people
The uniformity of work skin finished product, so as to ensure that intensity, tearing toughness and resilience are stretched in the drawing for producing medical artificial skin finished product
Property, meanwhile, improve final product quality, it is ensured that the heat endurance and weatherability of finished product.
Further, in step D, using stepwise being solidified and evaporated, in combination with optimum temperature and
Time parameter, these parameters are all the optimized parameters by largely testing and attempting just to draw, have high practicality, are led to
Cross the temperature and time condition optimized to be solidified, significantly improve medical artificial skin finished product molding effect, make it more
It is frivolous, it is closer with real skin, also it is relatively beneficial to the progress of subsequent evaporative step;Pass through the temperature and time condition of optimization
It is evaporated, on the one hand, the evaporation for greatly optimizing purified water produces the permeability of air-vent on silicon rubber film, improves
The permeability of medical artificial skin finished product, on the other hand, it in turn ensure that silicon rubber thin when purifying water evaporation produces air-vent
The compactness of film in itself, hinder bacterium property so as to strengthen the medical artificial skin produced.
Embodiment
, below will be right to be easy to understand the technical means, the inventive features, the objects and the advantages of the present invention
Technical scheme in the embodiment of the present invention carries out clear, complete description, so that the present invention is expanded on further, it is clear that described
Embodiment is only the part of the embodiment of the present invention, rather than whole embodiments.
Embodiment 1
A kind of production method of medical artificial skin, specifically comprises the following steps:
A. according to mass percent meter, 65% injection add-on type liquid silicon rubber component A and 35% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 1500r/min, obtains mixture one.
B. according to mass percent meter, 65% injection add-on type liquid silicon rubber B component and 35% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 1500r/min, obtains mixture two.
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three.
D. mixture three being inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification temperature is 70 DEG C,
Hardening time is 35 minutes, is evaporated again after solidification, and evaporating temperature is 120 DEG C, and evaporation time is 90 minutes, obtains silicon rubber
Film.
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
By said process, the sample 1 of medical artificial skin finished product is obtained.
Embodiment 2
A kind of production method of medical artificial skin, specifically comprises the following steps:
A. according to mass percent meter, 70% injection add-on type liquid silicon rubber component A and 30% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 2300r/min, obtains mixture one.
B. according to mass percent meter, 70% injection add-on type liquid silicon rubber B component and 30% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 2300r/min, obtains mixture two.
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three.
D. mixture three being inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification temperature is 80 DEG C,
Hardening time is 30 minutes, is evaporated again after solidification, and evaporating temperature is 135 DEG C, and evaporation time is 75 minutes, obtains silicon rubber
Film.
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
By said process, the sample 2 of medical artificial skin finished product is obtained.
Embodiment 3
A kind of production method of medical artificial skin, specifically comprises the following steps:
A. according to mass percent meter, 75% injection add-on type liquid silicon rubber component A and 25% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 3000r/min, obtains mixture one.
B. according to mass percent meter, 75% injection add-on type liquid silicon rubber B component and 25% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 3000r/min, obtains mixture two.
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three.
D. mixture three being inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification temperature is 90 DEG C,
Hardening time is 25 minutes, is evaporated again after solidification, and evaporating temperature is 150 DEG C, and evaporation time is 60 minutes, obtains silicon rubber
Film.
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
By said process, the sample 3 of medical artificial skin finished product is obtained.
Embodiment 4
A kind of production method of medical artificial skin, specifically comprises the following steps:
A. according to mass percent meter, 65% injection add-on type liquid silicon rubber component A and 35% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 1500r/min, obtains mixture one.
B. according to mass percent meter, 65% injection add-on type liquid silicon rubber B component and 35% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 1500r/min, obtains mixture two.
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three
D. mixture three is inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification uses staged
Carry out, solidify the first stage, solidification temperature is 75 DEG C, and hardening time is 7 minutes;Solidifying second stage, solidification temperature is 80 DEG C,
Hardening time is 10 minutes;Solidify the phase III, solidification temperature is 85 DEG C, and hardening time is 13 minutes;Steamed again after solidification
Hair, evaporation are carried out using staged, are evaporated the first stage, and evaporating temperature is 125 DEG C, and evaporation time is 20 minutes;Evaporation second
Stage, evaporating temperature are 135 DEG C, and evaporation time is 25 minutes;Evaporate the phase III, evaporating temperature is 145 DEG C, and evaporation time is
30 minutes, obtain silicon rubber film.
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
By said process, the sample 4 of medical artificial skin finished product is obtained.
Embodiment 5
A kind of production method of medical artificial skin, specifically comprises the following steps:
A. according to mass percent meter, 70% injection add-on type liquid silicon rubber component A and 30% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 2300r/min, obtains mixture one.
B. according to mass percent meter, 70% injection add-on type liquid silicon rubber B component and 70% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 2300r/min, obtains mixture two.
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three.
D. mixture three is inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification uses staged
Carry out, solidify the first stage, solidification temperature is 75 DEG C, and hardening time is 7 minutes;Solidifying second stage, solidification temperature is 80 DEG C,
Hardening time is 10 minutes;Solidify the phase III, solidification temperature is 85 DEG C, and hardening time is 13 minutes;Steamed again after solidification
Hair, evaporation are carried out using staged, are evaporated the first stage, and evaporating temperature is 125 DEG C, and evaporation time is 20 minutes;Evaporation second
Stage, evaporating temperature are 135 DEG C, and evaporation time is 25 minutes;Evaporate the phase III, evaporating temperature is 145 DEG C, and evaporation time is
30 minutes, obtain silicon rubber film.
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
By said process, the sample 5 of medical artificial skin finished product is obtained.
Embodiment 6
A kind of production method of medical artificial skin, specifically comprises the following steps:
A. according to mass percent meter, 75% injection add-on type liquid silicon rubber component A and 25% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 3000r/min, obtains mixture one.
B. according to mass percent meter, 75% injection add-on type liquid silicon rubber B component and 25% purified water are taken,
It is mixed evenly at normal temperatures, mixing speed 3000r/min, obtains mixture two.
C. according to mass percent meter, the mixture two of 50% mixture one and 50% is taken, mixes stir at normal temperatures
Mix uniformly, mixing speed 500r/min, obtain mixture three.
D. mixture three is inputted into slobbering machine and carries out salivation film forming, solidified after salivating film forming, solidification uses staged
Carry out, solidify the first stage, solidification temperature is 75 DEG C, and hardening time is 7 minutes;Solidifying second stage, solidification temperature is 80 DEG C,
Hardening time is 10 minutes;Solidify the phase III, solidification temperature is 85 DEG C, and hardening time is 13 minutes;Steamed again after solidification
Hair, evaporation are carried out using staged, are evaporated the first stage, and evaporating temperature is 125 DEG C, and evaporation time is 20 minutes;Evaporation second
Stage, evaporating temperature are 135 DEG C, and evaporation time is 25 minutes;Evaporate the phase III, evaporating temperature is 145 DEG C, and evaporation time is
30 minutes, obtain silicon rubber film.
E. silicon rubber film is punctured using porcupine roller, is carried out by blower fan air-cooled after puncture, cut after air-cooled,
Wound again after cutting, obtain medical artificial skin finished product.
By said process, the sample 6 of medical artificial skin finished product is obtained.
Sample 1, sample 2, sample 3, sample 4, sample 5 and the sample 6 that above-described embodiment obtains are taken respectively, and another enchashment has skill
Produced under art, and the sample 7 of commercially conventional medical artificial skin, and it is in use to test above-mentioned seven kinds of samples respectively
Resistance bacterium property and gas permeability, while test respectively again the drawing of above-mentioned seven kinds of sample materials in itself stretch intensity, tearing toughness, return
Elasticity, heat endurance and weatherability, following result is drawn by corresponding Experimental Comparison:
First, by the technique of production process in the present invention and using material, this method simplicity can intuitively be found out very much
Practicality, short preparation period, efficiency high, moreover, in process of production without using organic solvent, safety and environmental protection;Secondly, sample 1, sample
Product 2, sample 3, sample 4, the resistance bacterium performance of sample 5 and sample 6 are slightly above sample 7, sample 1, sample 2, sample 3, sample 4, sample
The permeability of product 5 and sample 6 is far above sample 7;Finally, the drawing of sample 1, sample 2, sample 3, sample 4, sample 5 and sample 6
It is all suitable with sample 7 to stretch intensity, tearing toughness and resilience, it is preferably horizontal, and sample 1, sample 2, sample 3, sample
Product 4, the heat endurance of sample 5 and sample 6 and weatherability are all slightly above sample 7.For synthesis, sample 1, sample 2, sample 3, sample
The combination property of product 4, sample 5 and each side of sample 6 is all higher than sample 7, it can thus be seen that the method for the present invention and existing skill
Production under art is compared, and superiority is fairly obvious, and the product of production has marked improvement.
The present invention compared with prior art, first, under certain condition by certain mass than injection add-on type liquid
Silicon rubber component A and B component are first each well mixed with purified water, and are well mixed mutually under certain condition and are inputted salivation
Machine carries out salivation film forming, and solidifies and evaporate under the temperature and time of specific selection, then by puncture, cutting and winding etc.
Step obtains medical artificial skin finished product, and non-solvent is removed within 3-4 days without the solvent soaking Jing Guo prior art or extracting
Or pore-foaming agent, and need in immersion or extractive process to change the step such as solvent daily, simplified significantly medical artificial skin into
The production technology of product, make its simple processing practical, meanwhile, manufacturing cycle is shortened, improves production efficiency;Secondly, producing
During without using organic solvent, but using purified water as pore-foaming agent, by the evaporation of purified water so as in silicon rubber film
It is upper to produce many fine fine and close air-vents, the possibility of medical artificial skin finished product residual organic solvent is eliminated, has been solved
Solvent is volatilized in process of production to endanger with waste liquid to caused by environment, so as to more safety and environmental protection, to human body and environment without
Harm, also, the nontoxic no sensitization of artificial skin so produced, with the skin good biocompatibility of human body in itself;Again,
The environment that the dressing of the present invention can provide a moistening to wound promotes its healing, meanwhile, dressing of the invention can be realized and hindered
Mouth adhesion, significantly reduces pain during changing medicine for patient;Finally, just because of using purified water as pore-foaming agent, purified water is passed through
Evaporation so as to produce many fine fine and close air-vents on silicon rubber film, silicon rubber film is entered in conjunction with using porcupine roller
Row punctures, so that not only gas permeability is extremely strong for the medical artificial skin finished product so produced, and resistance bacterium performance is also especially excellent,
The performance of each side and the real skin of human body are close.In general, simple and practical, short preparation period of the invention, efficiency high,
In process of production without using organic solvent, safety and environmental protection, meanwhile, it is capable to which the environment that a moistening is provided to wound promotes it to be cured
Close, adhesion wound in use, reduce the pain of patient when changing, reduce the pain of patient when changing, and produce
Medical artificial skin resistance bacterium property and gas permeability are all good.
Further, in step A, B and C, it is specific selection injection add-on type liquid silicon rubber component A and B groups and
The combined amount of purified water, and select to be mixed under optimum temperature and stirring condition uniformly, it can so improve medical people
The uniformity of work skin finished product, so as to ensure that intensity, tearing toughness and resilience are stretched in the drawing for producing medical artificial skin finished product
Property, meanwhile, improve final product quality, it is ensured that the heat endurance and weatherability of finished product.
Further, in step D, using stepwise being solidified and evaporated, in combination with optimum temperature and
Time parameter, these parameters are all the optimized parameters by largely testing and attempting just to draw, have high practicality, are led to
Cross the temperature and time condition optimized to be solidified, significantly improve medical artificial skin finished product molding effect, make it more
It is frivolous, it is closer with real skin, also it is relatively beneficial to the progress of subsequent evaporative step;Pass through the temperature and time condition of optimization
It is evaporated, on the one hand, the evaporation for greatly optimizing purified water produces the permeability of air-vent on silicon rubber film, improves
The permeability of medical artificial skin finished product, on the other hand, it in turn ensure that silicon rubber thin when purifying water evaporation produces air-vent
The compactness of film in itself, hinder bacterium property so as to strengthen the medical artificial skin produced.
The technical characteristics and general principle and associated advantages of the present invention are the foregoing described, for those skilled in the art
For, it is clear that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and it is in the design without departing substantially from the present invention or substantially special
In the case of sign, the present invention can be realized in other specific forms.Therefore, all should be by embodiment no matter from the point of view of which point
To regard exemplary as, and be nonrestrictive, the scope of the present invention is limited by appended claims rather than described above,
It is intended that all changes fallen in the implication and scope of the equivalency of claim are included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.