CN107320528A - A kind of Chinese medical extract and medicine for treating alpastic anemia - Google Patents
A kind of Chinese medical extract and medicine for treating alpastic anemia Download PDFInfo
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- CN107320528A CN107320528A CN201710405516.8A CN201710405516A CN107320528A CN 107320528 A CN107320528 A CN 107320528A CN 201710405516 A CN201710405516 A CN 201710405516A CN 107320528 A CN107320528 A CN 107320528A
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- extract
- medicine
- chinese medical
- alpastic anemia
- hilllock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Chinese medical extract and medicine for treating alpastic anemia, extract is that fruit extract is harvested on hilllock, and is used as using the single extract active ingredient of medicine.The extract of the present invention has the effect for the treatment of alpastic anemia, and using south of the Five Ridges genunie medicinal materials, raw material is easy to get, and medicine extraction process is easy, is conducive to putting into big production, product quality is easy to control.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese herbal medicine that there is treatment alpastic anemia to act on.
Background technology
Alpastic anemia (aplastic anemia, AA) referred to as hinders again, is one group of marrow hemopoiesis group reduction, hematopoiesis
MSOF, causes the syndrome of Peripheral blood whole blood trace elements.Clinically often show as more serious anaemia, bleeding and sense
Dye.Male is more than women during primary hinders again, and youth is more than old age.According to disease pace of change and state of an illness weight, with reference to blood picture
It can be divided into acute and chronic type by hindering again with bone marrow smear.If it is secondary to have pathogenesis such as medicine, chemicals, radiation, infection
Property.The domestic diagnostic criteria hindered again is whole blood trace elements, and acute aplastic anemia diagnostic criteria is that hemoglobin declines comparatively fast, leucocyte
Significantly reduce, blood platelet<20×10<SUP>9</SUP>/ L etc..Drug therapy the more commonly used at present is androgen and cyclosporine
A combination treatments, clinical data shows preferable curative effect.Kidney-nourishing tcm drug is used in traditional Chinese medicine, generates heat and adds further according to bleeding
Subtract.Traditional Chinese medicine can be reduced and instead of hormone and blood transfusion, and final cure hinders again.
South of the Five Ridges Chinese herbal medicine, many platymiscium herbal medicine, and mostly annual herbaceous plant, many bitter colds of its nature and flavor, its effect
The effect with clearing heat and promoting diuresis or clearing damp, is used for egoistic, enteritis mostly, catches a cold, hyperpyrexia polydipsia, tonsillitis, sphagitis, gas
Guan Yan, pertussis, catarrhal jaundice, wild gill fungus, arsenic intoxication etc..
Therefore, using Chinese Traditional Medicine resource, using modern biotechnology, with reference to the characteristics of the Chinese herbal medicine of the south of the Five Ridges, research is opened
Hair is a kind of to have the obvious south of the Five Ridges Chinese herbal medicine of anti-CaM antibody effect, has great importance, while also there is huge market to open
Send out potentiality.
The content of the invention
It is an object of the invention to provide a kind of Chinese medical extract for treating alpastic anemia.
It is a still further object of the present invention to provide the medicine for the treatment of alpastic anemia.
The object of the present invention is achieved like this：A kind of Chinese medical extract for treating alpastic anemia, its feature exists
In：Extract is that fruit extract is harvested on hilllock.
Extract is that dry fruit extract is harvested on hilllock.
Described extract is the water extract that dry fruit is harvested on hilllock.
Described water extract is decocted by water heating and extracts gained
Described water extract concentration is about 1g active compounds/ml.
A kind of medicine for treating regeneration sexual dysfunction anaemia, including active ingredient and conventional auxiliary, according to Chinese medicine conventional formulation work
The oral formulations material that skill is prepared into, it is characterised in that：Described active ingredient is above-mentioned Chinese medical extract.
Described oral formulations are tablet, capsule, granule, oral liquid or pill.
The extract of the present invention has the effect that treatment hinders again, and blood tonification effect, and using south of the Five Ridges genunie medicinal materials, raw material is easy
, medicine extraction process is easy, is conducive to putting into big production, product quality is easy to control.
Embodiment
Hilllock is harvested, and Rhodomyrtustomentosa ripe dry fruit is harvested on Myrtaceae Myrtus hilllock.It is sweet, puckery,
Mild-natured, nourishing blood and hemoslasis, puckery intestines controlling nocturnal emission with astringent drugs is generally used for dysentery, traumatism and bleeding, the deficiency of blood is weak.
The present invention is a kind of single medicinal material extract treated and hindered again, and extract is harvested fruit (preferably dry fruit) for hilllock and carried
Thing is taken, is water extract.Using traditional decocting method, heat and decoct by solvent of water, final water extract concentration is about 1g/
Ml, most preferably 1g active compound/ml.
A kind of medicine for treating regeneration sexual dysfunction anaemia of the present invention, including active ingredient and conventional auxiliary, it is normal according to Chinese medicine
The oral formulations material that rule preparation process is prepared into, described active ingredient is the Chinese medical extract of above-mentioned single.In order to which patient takes
Convenience and the characteristic according to extract, the present invention can prepare the extract addition various routines required during different dosage forms
Auxiliary material, any oral formulations are prepared into according to Chinese medicine conventional formulation technique, such as tablet, capsule, granule, oral liquid,
Pill etc..
The preparation method of the present invention, all skills realized based on the above of the present invention will be further illustrated in the following example
Art belongs to the scope of the present invention.
Embodiment 1
Take dry hilllock to harvest fruit, smash to certain particle size (crossing 12 mesh sieves), weigh 1000g, add about 2 liters of distilled water immersions
20 minutes, add 3 liters of water and start decoction, seethe with excitement 1.5 hours, filtering, filter residue adds 3 liters of decoctings to boil to rise 1.5 hours again, filter
Cross, merging filtrate, be concentrated into about 600ml, add water and be settled to 1 liter, fruit water extract is harvested on the hilllock for obtaining about 1g/ml.
Embodiment 2
Example 1 is extract obtained, measures the 120ml extracts and is placed in 200ml volumetric flasks, plus distilled water constant volume,
Harvest fruit water extract in the hilllock for producing 0.6g/ml.
Embodiment 3
Example 1 is extract obtained, measures the 60ml extracts and is placed in 200ml volumetric flasks, plus distilled water constant volume, i.e.,
Harvest fruit water extract in the hilllock for obtaining 0.3g/ml.
Experimental example
Positive control drug is：Testosterone undecanoate soft capsule (specification is 40mg) and ciclosporin soft capsules (specification is 25mg),
Two kinds of medicines respectively take one, are dissolved in 154ml water, are stirred continuously until dissolving, produces testosterone undecanoate 0.00026g/ml and ring
Spore element 0.00016mg/ml, is used as positive drug comparison medicine.
Take above-described embodiment 1-3 extract obtained, zoopery is carried out as test medicine, to prove the present invention to regeneration
The therapeutic action of sexual dysfunction anaemia.
Take kunming mice 80, body weight 18-22g, male and female half and half, warp60Co elements set dosage to be 7.5Gy/min, irradiation
4min, causes to regenerate the pathological model of sexual dysfunction anaemia.It is randomly divided into model group, positive drug group, high group of fruit (extract by embodiment 1
Thing), group (extract of embodiment 2) in fruit, low group (extract of embodiment 3) of fruit, male and female half and half, every group 16, then separately take 16
The normal mouse of male and female half and half is as blank control group, six groups of mouse altogether.Give experimental mice gavage correspondence medicine, model pair
Poured water according to group and blank control group, continuous gavage 14 days (two weeks) once a day, during which normally raises mouse.In last time
Water is can't help in fasting after administration, is taken a blood sample by eyeball of mouse within second day, is done blood routine examination, and leucocyte meter is chosen in obtained project
The indexs such as number (WBC), red blood cell count(RBC) (RBC), hemoglobin number (HGB), platelet count (PLT) carry out data analysis.It is real
Test after end, all experimental datas are handled with SPSS20.0 statistical softwares.Counting index is usedRepresent, wherein tying
Fruit P ＜ 0.05 have statistical significance.Analysis result is as follows：
Extract is harvested to hindering the influence of mouse again in the hilllock of table 1
Experiment analysis results show：Model group is compared with normal group, and all indexs are respectively less than normal group, and statistical analysis
Display shows difference substantially (P ＜ 0.01), shows modeling success.Positive drug group is compared with model group, and all indexs rise substantially,
Positive drug can increasing leukocyte number, red blood cell number, hemoglobin number, hence it is evident that increased platelets counts number, and with significant difference,
Illustrate positive drug determined curative effect.
Experimental group is compared with model group, and there were significant differences, and all indexs rise obvious；Compared with positive drug, the high group of fruit is without aobvious
Write sex differernce, and fruit neutralize fruit it is low on a declining curve, and fruit low group there was no significant difference with model group.Show that fruit water extract is harvested on hilllock
High concentration and positive drug are in similar therapeutic effects, and hilllock can be harvested to fruit high concentration water extract can be as medicinal application to treating aregeneratory
In property anaemia.It can raise mouse red blood cell number, hemoglobin number simultaneously, it is taken as that fruit is harvested on hilllock certain work of enriching blood
With.
Claims (7)
1. a kind of Chinese medical extract for treating alpastic anemia, it is characterised in that：Extract is that fruit extract is harvested on hilllock.
2. the Chinese medical extract for the treatment of alpastic anemia according to claim 1, it is characterised in that：Extract is hilllock
Harvest dry fruit extract.
3. the Chinese medical extract for the treatment of alpastic anemia according to claim 1, it is characterised in that：Described extraction
Wu Wei harvests on hilllock the water extract of dry fruit.
4. the Chinese medical extract for the treatment of alpastic anemia according to claim 3, it is characterised in that：Described water extraction
Take thing to be decocted by water heating and extract gained.
5. the Chinese medical extract for the treatment of alpastic anemia according to claim 3, it is characterised in that：Described water extraction
It is about 1g active compounds/ml to take thing concentration.
6. a kind of medicine for treating regeneration sexual dysfunction anaemia, including active ingredient and conventional auxiliary, according to Chinese medicine conventional formulation technique
The oral formulations material being prepared into, it is characterised in that：Described active ingredient is Chinese medical extract described in claim 1-5.
7. medicine according to claim 6, it is characterised in that：Described oral formulations be tablet, capsule, granule,
Oral liquid or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710405516.8A CN107320528A (en) | 2017-06-01 | 2017-06-01 | A kind of Chinese medical extract and medicine for treating alpastic anemia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710405516.8A CN107320528A (en) | 2017-06-01 | 2017-06-01 | A kind of Chinese medical extract and medicine for treating alpastic anemia |
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| Publication Number | Publication Date |
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| CN107320528A true CN107320528A (en) | 2017-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710405516.8A Pending CN107320528A (en) | 2017-06-01 | 2017-06-01 | A kind of Chinese medical extract and medicine for treating alpastic anemia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358836A (en) * | 2018-12-25 | 2020-07-03 | 南方医科大学中西医结合医院 | Traditional Chinese medicine extract for enhancing immunity and application thereof |
-
2017
- 2017-06-01 CN CN201710405516.8A patent/CN107320528A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358836A (en) * | 2018-12-25 | 2020-07-03 | 南方医科大学中西医结合医院 | Traditional Chinese medicine extract for enhancing immunity and application thereof |
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Application publication date: 20171107 |