CN107279812A - 一种提高免疫力的保健食品及其制作方法 - Google Patents
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Abstract
本发明公开了一种提高免疫力的保健食品及其制备方法，所述保健食品主要由活胎毛蛋、蜂王浆、薄荷、乳清蛋白和左旋肉碱制作而成。所述保健品具有显著而明确的提高免疫力的作用，效果明显。
Description
技术领域
本发明涉及一种提高免疫力的保健食品及其制作方法，属于药品技术的领域。
技术背景
免疫力是人体自身的防御机制，是人体识别和消灭外来侵入的任何异物(病毒、细菌等)，处理衰老、损伤、死亡、变性的自身细胞，以及识别和处理体内突变细胞和病毒感染细胞的能力。免疫力可分为非特异性免疫和特异性免疫：1、先天性免疫，是人一生下来就有的；2、获得性免疫，是人生下来以后在生活过程中自然获得的，或者用人工辅助的方法被动得到。
机体免疫***的一些特殊细胞能将入侵体内的细菌、病毒和体内已衰老死亡的细胞、已突变的细胞以及引起***反应的物质，统统地加以吞噬和消灭，从而维持体内环境的稳定，保持机体健康。但机体免疫功能在30岁左右就开始减迟，这种变化是悄然、缓慢、持续地进行。当人体免疫功能失调，或者免疫***不健全时，免疫***不能正常发挥保护作用。在此情况下，极易招致细菌、病毒、真菌等感染，因此免疫力低下最直接的表现就是容易生病。经常患病，加重了机体的消耗，所以一般有体质虚弱、营养不良、精神萎靡、疲乏无力、食欲降低、睡眠障碍等表现；此外，需要很长时间才能病愈，而且常常反复发作。长此以往会导致身体和智力发育不良，还易诱发重大疾病。导致上述现象发生的深层原因是免疫力低下或免疫力不健全。
现代社会，环境问题越来越突出，人们工作压力大、缺乏锻炼，进而导致人的免疫力越来越差，提高免疫力称为现代人关心的热门话题，大量的具有提高免疫力功能的保健品应运而生。目前，常见的保健品种类主要有：以维生素和矿物质为主要成分的营养性保健品、以天然或珍贵植物为原料提取出有效营养成分的保健品、以名贵中药过有药用价值的动植物为主要原料的补养型保健品、从海洋生物中提取有效成分制成的保健品或以动物初乳为原料制成的保健品。但是，现有的提高免疫的保健品中，大多不能具有明确的提高免疫力的作用，大部分人群认为服用提高免疫力的保健品后效果不明显。
发明内容：
本发明的目的在于，提供一种提高免疫力的保健食品及其制作方法。所述保健品具有显著而明确的提高免疫力的作用，效果明显。
为解决上述技术问题，本发明采用以下技术方案实现：一种提高免疫力的保健食品，按重量份计算，主要由活胎毛蛋20-30份、蜂王浆13-19份、薄荷3-9份、乳清蛋白1-3份和左旋肉碱0.1-1.0份制作而成。
前述的提高免疫力的保健食品中，按重量份计算，主要由活胎毛蛋22-28份、蜂王浆15-17份、薄荷5-7份、乳清蛋白1.5-2.5份和左旋肉碱0.3-0.7份制作而成。
前述的提高免疫力的保健食品中，按重量份计算，主要由活胎毛蛋25份、蜂王浆16份、薄荷6份、乳清蛋白2份和左旋肉碱0.5份制作而成。
前述的提高免疫力的保健食品中，所述活胎毛蛋为未出壳的小鸡提取物。
一种前述的提高免疫力的保健食品的制作方法，取上述原料，可以加辅料，也可以不加辅料，按照常规工艺，制成口服制剂。
前述的提高免疫力的保健食品的制作方法，所述口服制剂为颗粒剂、含片或胶囊剂。
前述的提高免疫力的保健食品的制作方法，所述颗粒剂这样制作：取上述原料，加8-10倍量的水浸泡10-15分钟，先大火煎煮10-15min，再继续用小火煎煮15-25min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.15-1.20的浸膏，浸膏与浸膏量20％的淀粉和20％的糊精粉混合制粒，干燥，即得。
前述的提高免疫力的保健食品的制作方法，所述胶囊剂这样制作：取上述原料，加8-10倍量的水浸泡10-15分钟，先大火煎煮10-15min，再继续用小火煎煮15-25min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.20-1.25的浸膏，另取浸膏量30％的淀粉和0.7％的硬脂酸镁与浸膏混匀，用60％的乙醇制粒，干燥，粉碎，填充胶囊，即得。
本发明所述保健品主要由活胎毛蛋、蜂王浆、薄荷、乳清蛋白和左旋肉碱制成，其中，活胎毛蛋，即活胎毛蛋为未出壳的小鸡提取物，即在鸡孵化时有意中止孵化，形成活胎毛蛋，在很多地方(至少辽宁的很多城市)作为滋补品食用(常是烧烤)。蜂王浆(royaljelly)，是蜜蜂巢中培育幼虫的青年工蜂咽头腺的分泌物，是供给将要变成蜂王的幼虫的食物，也是蜂王终身的食物。主要作用：1、辅助降低血糖。此作用主要因其含有的胰岛素样肽类推理得来，胰岛素样肽类是治疗糖尿病的特效药物。2、抗氧化功效。此作用是蜂王浆被大众普遍肯定的作用，它对细胞的修复以及再生具有很强的作用。3、降低血脂。蜂王浆含有人体必须的维生素达10种以上，能平衡脂肪代谢和糖代谢，可降低肥胖者的高血脂和高血糖，非常适合肥胖型糖尿病患者。4、控制血管扩张、降低血压。这个结论来自于其所含的10－羟基－癸烯酸(王浆酸)以及王浆主要蛋白-1。5、保护肝脏。蜂王浆不仅能够杀灭肝炎病毒，并且能抑制病毒在肝脏细胞内复制。6、抗菌、消炎。蜂王浆有抗菌和对伤口感染具有促进愈合的作用。7、抗衰老作用，和强化性功能作用，同时还有抗辐射，增强记忆力的作用。薄荷，是中华常用中药之一。它是辛凉性发汗解热药，治流行性感冒、头疼、目赤、身热、咽喉、牙床肿痛等症。外用可治神经痛、皮肤瘙痒、皮疹和湿疹等。平常以薄荷代茶，清心明目。乳清蛋白(whey protein)被称为蛋白之王，是从牛奶中提取的一种蛋白质，具有营养价值高、易消化吸收、含有多种活性成分等特点，是公认的人体优质蛋白质补充剂之一。左旋肉碱(L-carnitine)，又称L-肉碱或音译卡尼丁，是一种促使脂肪转化为能量的类氨基酸，补充左旋肉碱可以促进细胞内丙酮酸脱氢酶的活性，从而促进葡萄糖的氧化利用，有利于延缓运动时的疲劳发生。运动时乳酸产生过多会增加血液和组织液的酸性，降低ATP的生成，导致疲劳发生，补充左旋肉碱可以清除过多乳酸，提高运动能力，促进运动性疲劳的恢复。
与现有技术相比，本发明采用上述原料制成保健品，制成的保健品具有显著而明确的提高免疫力的作用，效果明显。
实验例：
1、资料与方法
1.1健康Wistar大鼠20只，体重(200±10)g，试验前，为使大鼠适应环境将大鼠放在实验室饲养一周，随后按照随机法将健康Wistar大鼠分为实验组和对照组，每组10只。
1.2饲料配制
对照组大鼠使用普通大鼠饲料，实验组在对照组的基础上每100g饲料中混合20g本发明保健品(按实施例1进行制备)。
1.3试验方法
1.3.1试验仪器
24、96孔培养板(上海卧宏生物科技有限公司)，高速离心机(张家港市中沃机械有限公司)，全自动生化仪(普朗医疗器械有限公司)。
1.3.2试验方法
2组大鼠连续饲养10周，饲养结束后，将大鼠禁食12h，无菌取出脾脏分离获得脾淋巴细胞。
白介素-2、4(interleukin，IL-2，IL-4)测定。将淋巴细胞悬液分别加入24孔平底培养板，每孔1mL，随后再向每孔加入100μL浓度为50mg/L的ConA，放入CO2培养箱中培养，温度37℃，培养时间48h。培养结束后，将培养板中的淋巴细胞上清液在无菌条件下吸取后，载分别装入0.5mL EP管中，置入-20℃的冰箱中保存，用于IL-2和IL-4含量的检测。采用ELISA检测试剂盒检测检测IL-2和IL-4的含量。
1.4数据记录与统计分析
饲养期间观察2组大鼠的活动情况及死亡情况并记录；并对2组大鼠淋巴细胞的白介素-2、4(interleukin，IL-2，IL-4)结果进行记录。
本次研究所获得数据均采用SPSS20.0进行处理，组件比较采用t检验，以(x±s)表示，以P＜0.05为统计学存在差异。
2结果
2.1观察结果
在饲养期间，2组大鼠均未出现死亡，且通过观察发现实验组大鼠活力及精力强于对照组大鼠。
2.2小鼠脾淋巴细胞白介素含量对比
结果见表1.
表1小鼠脾淋巴细胞白介素含量对比表
注：与对照组相比，*P<0.05.
由表可知，本发明保健品具有显著而明确的提高免疫力的作用，效果明显。
有益效果：本发明所述保健品具有显著而明确的提高免疫力的作用，效果明显。
具体实施方式：
下面结合实施例对发明作进一步的说明，但并不作为对本发明限制的依据。
实施例1.
配方：活胎毛蛋25kg、蜂王浆16kg、薄荷6kg、乳清蛋白2kg和左旋肉碱0.5kg。
工艺：取上述原料，加9倍量的水浸泡12分钟，先大火煎煮13min，再继续用小火煎煮20min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.15-1.20的浸膏，浸膏与浸膏量20％的淀粉和20％的糊精粉混合制粒，干燥，即得颗粒剂。
规格：5g/袋。
用法用量:每次5-10g，每日2-3次。
实施例2.
配方：活胎毛蛋28kg、蜂王浆17kg、薄荷7kg、乳清蛋白2.5kg和左旋肉碱0.7kg。
工艺：取上述原料，加9倍量的水浸泡12分钟，先大火煎煮13min，再继续用小火煎煮20min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.15-1.20的浸膏，浸膏与浸膏量20％的淀粉和20％的糊精粉混合制粒，干燥，即得颗粒剂。
规格：5g/袋。
用法用量:每次5-10g，每日2-3次。
实施例3。
配方：活胎毛蛋22kg、蜂王浆15kg、薄荷5kg、乳清蛋白1.5kg和左旋肉碱0.3kg。
工艺：取上述原料，加10倍量的水浸泡15分钟，先大火煎煮15min，再继续用小火煎煮25min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.20-1.25的浸膏，另取浸膏量30％的淀粉和0.7％的硬脂酸镁与浸膏混匀，用60％的乙醇制粒，干燥，粉碎，填充胶囊，即得胶囊剂。
规格：0.5g/粒。
用法用量:每次2-3粒，每日2-3次。
Claims (8)
1.一种提高免疫力的保健食品，其特征在于：按重量份计算，主要由活胎毛蛋20-30份、蜂王浆13-19份、薄荷3-9份、乳清蛋白1-3份和左旋肉碱0.1-1.0份制作而成。
2.如权利要求1所述的提高免疫力的保健食品，其特征在于：按重量份计算，主要由活胎毛蛋22-28份、蜂王浆15-17份、薄荷5-7份、乳清蛋白1.5-2.5份和左旋肉碱0.3-0.7份制作而成。
3.如权利要求2所述的提高免疫力的保健食品，其特征在于：按重量份计算，主要由活胎毛蛋25份、蜂王浆16份、薄荷6份、乳清蛋白2份和左旋肉碱0.5份制作而成。
4.如权利要求1-3中任一项所述的提高免疫力的保健食品，其特征在于：所述活胎毛蛋为未出壳的小鸡提取物。
5.一种如权利要求1-3中任一项所述的提高免疫力的保健食品的制作方法，其特征在于：取上述原料，可以加辅料，也可以不加辅料，按照常规工艺，制成口服制剂。
6.如权利要求5所述的提高免疫力的保健食品的制作方法，其特征在于：所述口服制剂为
颗粒剂、胶囊剂或含片。
7.如权利要求5所述的提高免疫力的保健食品的制作方法，其特征在于：所述颗粒剂这样制作：取上述原料，加8-10倍量的水浸泡10-15分钟，先大火煎煮10-15min，再继续用小火煎煮15-25min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.15-1.20的浸膏，浸膏与浸膏量20%的淀粉和20%的糊精粉混合制粒，干燥，即得。
8.如权利要求5所述的提高免疫力的保健食品的制作方法，其特征在于：所述胶囊剂这样制作：取上述原料，加8-10倍量的水浸泡10-15分钟，先大火煎煮10-15min，再继续用小火煎煮15-25min，煎煮3次，过滤，合并滤液，滤液浓缩成50-60℃时相对密度为1.20-1.25的浸膏，另取浸膏量30%的淀粉和0.7%的硬脂酸镁与浸膏混匀，用60%的乙醇制粒，干燥，粉碎，填充胶囊，即得。
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