CN107253795B - Prepare the device and preparation method thereof of sterilized water for injection - Google Patents
Prepare the device and preparation method thereof of sterilized water for injection Download PDFInfo
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- CN107253795B CN107253795B CN201710676347.1A CN201710676347A CN107253795B CN 107253795 B CN107253795 B CN 107253795B CN 201710676347 A CN201710676347 A CN 201710676347A CN 107253795 B CN107253795 B CN 107253795B
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F9/00—Multistage treatment of water, waste water or sewage
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/001—Processes for the treatment of water whereby the filtration technique is of importance
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/02—Treatment of water, waste water, or sewage by heating
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/02—Treatment of water, waste water, or sewage by heating
- C02F1/04—Treatment of water, waste water, or sewage by heating by distillation or evaporation
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
- C02F1/441—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis by reverse osmosis
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2301/00—General aspects of water treatment
- C02F2301/08—Multistage treatments, e.g. repetition of the same process step under different conditions
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/04—Disinfection
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- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention discloses a kind of devices and preparation method thereof for preparing sterilized water for injection, including upper tank body, first filter device, lower tank, secondary steam tank, second filter device and finished product collection device, raw water, which enters after upper tank body, filters out partial impurities through the first filter device, steam is formed in lower tank, using the double evaporation-cooling of double evaporation-cooling tank after condensation, through refined filtration twice after condensing again, finally water quality is detected in finished product collection device, after water quality meets indices, detection tank is connected to finished pot, water is put into finished pot, water in finished pot after encapsulating sterilization treatment up to sterilized water for injection, and water quality it is unqualified when, then make water back flow back into upper tank body to be processed again until water quality is qualified.It is low to water quality requirement, and apparatus structure is simply convenient for safeguarding, while to water quality real-time detection, improving the quality and safety in utilization of sterilized water for injection.Preparation process is simply easy to grasp simultaneously, effectively reduces preparation cost.
Description
Technical field
The present invention relates to medical processing technique field, in particular to a kind of device for preparing sterilized water for injection and its preparation
Method.
Background technique
With the development of modern science and technology, pharmaceutical factory, hospital and R&D institution etc. want the production of used water for injection
Continuous improvement is asked, this requires production equipment enterprises to be capable of providing efficient, high-quality equipment, to guarantee the matter of water for injection
Amount, while equipment produced can reach the targets such as energy conservation, long service life.However most commonly used currently on the market is multiple-effect
Distillation machine, such equipment is use process water yield is small, energy consumption is high, service life of equipment is short, takes up a large area, water quality is unstable
It is fixed, height is required to raw water quality, affects production efficiency, and device structure is complicated, maintenance maintenance cost is excessively high, so at this stage
How more efficiently high-quality production sterilized water for injection is particularly important.
Summary of the invention
It is an object of the invention to solve at least the above problems, and provide the advantages of at least will be described later.
It is low to water quality requirement it is a still further object of the present invention to provide a kind of device for preparing sterilized water for injection, and fill
It is simply convenient for safeguarding to set structure, while to water quality real-time detection, improving the quality and safety in utilization of sterilized water for injection.
It is a still further object of the present invention to provide a kind of preparation method of sterilized water for injection, preparation process is simply easy to slap
It holds, effectively reduces preparation cost.
In order to realize these purposes and other advantages according to the present invention, a kind of dress for preparing sterilized water for injection is provided
It sets, comprising:
Upper tank body, top center are provided with the pipeline for protruding from the upper tank body upper surface, and the pipeline is in protrusion institute
The one end for stating upper tank body surface is connected with Y tube, and the long end interface of the Y tube is connected with the pipeline, the Y tube
Another both ends are respectively the raw water input port for being used for raw water input and the annex solution input port for adding annex solution；The upper tank body
It is inside provided with agitating device, the agitating device includes rotary shaft and stirring blade, and the rotary shaft is vertically installed on described
Tank interior, and the both ends of the upper tank body are fixed on, the rotary shaft is hollow setting, and is communicated with the pipeline, described
Hollow setting of the stirring blade for another end opening closed at one end, open end and the rotation axis connection of the stirring blade, and with
The inside of the rotary shaft is connected to, and is provided with aperture on the side and top surface of the stirring blade；
First filter device comprising the first filter cartridge and the first filter membrane, the top of first filter cartridge and it is described on
The lower removable of tank body connects, and with the upper tank body fluid communication, first filter membrane is set to first filter cartridge
Inside, and the edge of first filter membrane and the inner wall of first filter cartridge fit；
Lower tank, upper part are provided with the first liquid storage box, are provided with first on the side wall of first liquid storage box and bottom surface
Heating plate, first liquid storage box are internally provided with the first temperature sensor being connected with first heating plate；Described
The upper end of one liquid storage box is connect with the lower removable of first filter cartridge, the first atomization of lower end connection of first liquid storage box
Pipeline, the first atomization pipeline is waveform setting, and the first atomization pipeline is in the side towards the lower tank bottom surface
The first atomization mouth is set up；The first quartz plate is provided on the bottom surface of the lower tank, centered on first quartz plate
The lower part of downwardly projecting concave structure, first quartz plate is provided with primary heater；Above the side wall of the lower tank
It is provided with the first steam (vapor) outlet；
Secondary steam tank, side wall are equipped with steam inlet, and first steam (vapor) outlet passes through the first spiral cold-finger and institute
It states steam inlet to be connected, the second liquid storage box, second storage is connected at the steam inlet in the secondary steam tank
The second heating plate is provided on the side wall of liquid box and bottom surface, second liquid storage box is internally provided with and second heating plate
Connected second temperature sensor；Lower end connection the second atomization pipeline of second liquid storage box, the second atomization pipeline are
Waveform setting, and the second atomization pipeline is provided with the second atomization on the direction towards secondary steam tank bottom face
Mouthful；It is provided with the second quartz plate on the bottom surface of the lower tank, downwardly projecting concave structure centered on second quartz plate,
The lower part of second quartz plate is provided with secondary heater；The second steam (vapor) outlet is provided with above the side wall of the lower tank；
Second filter device comprising the second filter cartridge, the second filter membrane and third filter membrane, the inner wall of second filter cartridge
On be arranged in parallel with 2 card slots, second filter membrane and third filter membrane be respectively engaged with 2 described in card slot, second mistake
Filter device is set to the bottom of the secondary steam tank, and is connected by the second spiral cold-finger with second steam (vapor) outlet
It connects；
Finished product collection device comprising detect tank, finished pot and three-way valve, be provided with water quality detection in the detection tank
Device, the Water quality detector are connected with the three-way valve, to control each of the three-way valve according to water quality detection result
The opening and closing of a liquid outlet, and the detection tank is connected with the liquid outlet of second filter device, the two of the three-way valve
A liquid outlet is separately connected finished pot and detection tank, another liquid outlet of the three-way valve is connected to described by catheter
Pipeline.
Preferably, in the device for preparing sterilized water for injection, further includes:
Drive control mechanism, with the rotary shaft, the first temperature sensor, second temperature sensor, primary heater
It is separately connected with secondary heater.
Preferably, in the device for preparing sterilized water for injection, air inlet is offered on the side wall of the upper tank body
Valve.
Preferably, in the device for preparing sterilized water for injection, setting in the lower tank and secondary steam tank
There is a pressure sensor, is provided with urgent exhaust valve, and the urgent exhaust valve on the side wall of the lower tank and secondary steam tank
It is controlled by the pressure sensor.
Preferably, in the device for preparing sterilized water for injection, check valve is provided in the pipeline.
Preferably, in the device for preparing sterilized water for injection, first filter membrane, the second filter membrane and third filter
Film is reverse osmosis filter membrane, and the aperture of first filter membrane is the aperture of 0.4-0.5 μm, second filter membrane and third filter membrane
It is 0.2-0.25 μm.
Preferably, in the device for preparing sterilized water for injection, the top of first filter device is respectively provided with
There is baffle, the baffle is embedded in the groove of the upper tank body lower part, so as to the baffle is pulled, the upper tank body and the first mistake
Filter device fluid communication.
Preferably, in the device for preparing sterilized water for injection, first spiral cold-finger and the second spiral
Condenser pipe is integrally inclined S-shaped setting, and one end of first helix tube and the second helix tube connection steam (vapor) outlet is high
In the other end, meanwhile, the radian of the S-shaped of one end of first helix tube and the second helix tube connection steam (vapor) outlet is less than described
The radian of the other end of first helix tube and the second helix tube；In addition, first spiral cold-finger and the second spiral cold-finger
It is tool double-layer structure with dissection, and first spiral cold-finger and the second spiral cold-finger connect one end of steam (vapor) outlet
It is respectively arranged with cooling water intake, the other end of first spiral cold-finger and the second spiral cold-finger is provided with cooling water
Water outlet, and the cooling water intake and cooling water outlet are connected to raw water input terminal, so as to be formed in the interlayer
Cooling water circulation.
Preferably, in the device for preparing sterilized water for injection, raw water by the raw water input port before being entered
It also needs to filter by quartz sand and active carbon.
A method of sterilized water for injection, including following step are prepared with the device for preparing sterilized water for injection
It is rapid:
Step 1 is each led at the both ends of the Y tube by the weight ratio of raw water and annex solution for 1:0.003-0.005
Raw water and annex solution, mixing obtain the first mixed liquor；
Wherein, the annex solution is the mixed liquor of alkalinity potassium permanganate and phosphoric acid；
First mixed liquor is removed sediment through first membrane filtration by step 2, and to the first liquid storage box of lower tank
In be heated to 80 DEG C, and through the first atomization pipeline atomization；
The atomized liquid that step 3, step 2 generate obtains just steaming vapor after quartz plate heats；
Step 4 just steams vapor after the first spiral cold-finger into secondary steam tank, and by two in secondary steam tank
Secondary heating obtains the second vapor；
Step 5, the second vapor obtain primary injection water after condensing, and dual through the second filter membrane and third filter membrane
Filtering, obtains secondary injection water；
Step 6, secondary injection water are after Water quality detector detection is qualified, through 100 DEG C of flowing steam sterilization 25-
To get the sterilized water for injection after 40min.
The present invention is include at least the following beneficial effects:
The present invention is by setting upper tank body, lower tank, secondary steam tank and filter device at different levels, so that raw water is being added
One of the various micro substances are eliminated under the processing of liquid, and then primary filtration obtains more pure water, then pass through lower tank
Body is thermally formed vapor, the purified water after obtaining level-one distillation, then using the second distillation of secondary steam tank, so that
Water quality is further purified, and finally passes through double-filtration, obtains pure water for injection, and apparatus structure is simple and the degree of automation
Height effectively reduces the maintenance and maintenance cost of device, thereby reduces the production cost of sterile water for injection, convenient for extensive
It promotes the use of.
By the way that the stirring blade of hollow rotary shaft and special construction is arranged in upper tank body, enable to raw water through pipe
When road enters upper tank body, passed through by rotary shaft and stirring blade, and is provided with through-hole on the side of stirring blade and top surface, so that
When raw water is flowed out by through-hole, the forward motive force of stirring blade is given, so that rotary shaft drives stirring blade rotation more to save
Power saves the energy, and the through-hole of top surface flows upwards out raw water, promotes the rolling of raw water in upper tank body, so that adding
Liquid feeding and raw water mixing are more complete, convenient for the various substances in annex solution removal raw water.
It, can be convenient for the heating to water by the way that heating plate and temperature sensor is respectively set in the first and second liquid storage boxes
With the control of water temperature, to make moisture be easier to be formed by evaporation to vapor.And the quartz plate of spill is wherein used, it enables to
Moisture is largely gathered in the center of quartz plate, without spreading around, convenient for the aggregation and evaporation of moisture, and quartz plate matter
Ground is more pure, can be further reduced the generation of impurities in water.In addition, being atomized by the waveform for being provided with atomizer
Pipeline enables to water to fall on quartz plate in the form of atomization before the evaporation, so that vapor generation is more quick, into
And the efficiency of device is improved, while wavy atomization pipeline can store a large amount of water, and the aqueous vapor of atomization can be made in tank
Intracorporal distribution is more uniform.
It is fitted by the side wall of limitation filter membrane and filter cartridge, so that liquid passes fully through membrane filtration, that is, be ensure that into
The quality of product.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the device of the present invention for preparing sterilized water for injection；
Fig. 2 is the bottom view of the first atomization pipeline of the present invention and the second atomization pipeline.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art referring to specification text
Word can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of a other elements or combinations thereof.
As shown in Figure 1, the present invention provides a kind of device for preparing sterilized water for injection, comprising: upper tank body 1, top in
The heart is provided with the pipeline 2 for protruding from 1 upper surface of upper tank body, and the pipeline 2 connects in the one end for protruding 1 surface of upper tank body
It is connected to Y tube 3, the long end interface of the Y tube 3 is connected with the pipeline 2, and the another both ends of the Y tube 3 are respectively to be used for
The raw water input port that raw water inputs and the annex solution input port for adding annex solution；Stirring dress is provided in the upper tank body 1
It sets, the agitating device includes rotary shaft 4 and stirring blade 5, and the rotary shaft 4 is vertically installed in inside the upper tank body 1, and
The both ends of the upper tank body 1 are fixed on, the rotary shaft 4 is hollow setting, and is communicated with the pipeline 2, the stirring blade 5
Open end for the hollow setting of another end opening closed at one end, the stirring blade 5 is connect with rotary shaft 4, and with the rotation
The inside of shaft 4 is connected to, and is provided with aperture 6 on the side and top surface of the stirring blade 5.
First filter device comprising the first filter cartridge 7 and the first filter membrane, the top of first filter cartridge 7 with it is described
The lower removable of upper tank body 1 connects, and with 1 fluid communication of upper tank body, first filter membrane is set to first filtering
The inside of box 7, and the edge of first filter membrane and the inner wall of first filter cartridge 7 fit.
Lower tank 8, upper part are provided with the first liquid storage box 9, and is provided on the side wall of first liquid storage box 9 and bottom surface
One heating plate, first liquid storage box 9 are internally provided with the first temperature sensor being connected with first heating plate；It is described
The upper end of first liquid storage box 9 is connect with the lower removable of first filter cartridge 7, the lower end of first liquid storage box 9 connection the
One atomization pipeline 10, the first atomization pipeline 10 are that waveform is arranged, and described first is atomized pipeline 10 towards under described
The first atomization mouth 11 is provided on the direction of 8 bottom surface of tank body；The first quartz plate 12, institute are provided on the bottom surface of the lower tank 8
Downwardly projecting concave structure centered on the first quartz plate 12 is stated, the lower part of first quartz plate 12 is provided with the first heating
Device；The first steam (vapor) outlet 13 is provided with above the side wall of the lower tank 8.
Secondary steam tank 14, side wall are equipped with steam inlet 15, and first steam (vapor) outlet 13 is condensed by the first spiral
Pipe 16 is connected with the steam inlet 15, is connected with the second liquid storage at the steam inlet 15 in the secondary steam tank 14
Box 17 is provided with the second heating plate on the side wall of second liquid storage box 17 and bottom surface, and the inside of second liquid storage box 17 is set
It is equipped with the second temperature sensor being connected with second heating plate；The lower end of second liquid storage box 17 connects the second mist pipe
Road 19, the second atomization pipeline 19 is waveform setting, and the second atomization pipeline 19 is towards the secondary steam tank
The second atomization mouth 20 is provided on the direction of 14 bottom surfaces；It is provided with the second quartz plate 21 on the bottom surface of the lower tank 8, described
Downwardly projecting concave structure centered on two quartz plates 21, the lower part of second quartz plate 21 are provided with secondary heater；Institute
It states and is provided with the second steam (vapor) outlet 22 above the side wall of lower tank 8.
Second filter device comprising the second filter cartridge 23, the second filter membrane 24 and third filter membrane 25, second filter cartridge
Be arranged in parallel with 2 card slots on 23 inner wall, second filter membrane 24 and third filter membrane 25 be respectively engaged with 2 described in card slot
Interior, second filter device is set to the bottom of the secondary steam tank 14, and by the second spiral cold-finger 26 with it is described
Second steam (vapor) outlet 22 is connected.
Finished product collection device comprising detect tank 27, finished pot 28 and three-way valve 29, be provided in the detection tank 27
Water quality detector 30, the Water quality detector 30 are connected with the three-way valve 29, to control institute according to water quality detection result
The opening and closing of each liquid outlet of three-way valve 29 is stated, and the detection tank 27 is connected with the liquid outlet of second filter device
Connect, two liquid outlets of the three-way valve 29 be separately connected finished pot 28 and detection tank 27, the three-way valve 29 it is another
A liquid outlet is connected to the pipeline 2 by catheter 18.
In the above scheme, raw water, which enters after upper tank body to react with annex solution, gets rid of the impurity such as chlorine and ammonia therein, so
Impurity is filtered out by the first filter device afterwards, forms steam in lower tank, and condenses to obtain through the first spiral cold-finger
Purified water after flush distillation further removes impurities in water then using the double evaporation-cooling of double evaporation-cooling tank, is purified
Purified water is passed through the filtering twice of the second filter device by water, so that the more pure free from admixture of purified water, is finally collected in finished product
In device, because being mounted with Water quality detector, water quality detection can be carried out to the water for injection that production obtains, meet pH in water quality
After the items water for injection index such as value, conductivity, Water quality detector controls three-way valve and the tank connected liquid outlet of the finished product,
Finished product water for injection is put into finished pot, the sterilization treatment after encapsulating of the water for injection in finished pot is infused to get sterilizing has been arrived
It penetrates with water, and when Water quality detector detection finished product water for injection is unqualified, then controls going out for three-way valve and catheter connection
Liquid mouth is opened, so that finished product water for injection back flows back into upper tank body, is processed again, until water quality is qualified.By second
Two layers of filter membrane is set in filter device, and can carry out secondary fine filtering to water for injection ensure that medicine so that water quality is more pure
Product use safe.It is detected by the way that finished product water for injection is first passed through detection tank, further ensures drug quality, while energy
It enough monitors water for injection quality in real time, avoids underproof water for injection from being mixed into qualified water, while water energy enough loops back again
Secondary processing, has saved water resource, reduces production cost.Wherein, the setting of the first spiral cold-finger and the second spiral cold-finger,
So that circulation distance of the vapor in pipe rises appreciably, so that vapor has time enough to be condensed into liquid water, just
In subsequent processing and collection.
In one preferred embodiment, further includes: drive control mechanism, with the rotary shaft 4, the first temperature sensor,
Two temperature sensors, primary heater and secondary heater are separately connected.
In the above scheme, although the through-hole on stirring blade can be pushed away when being passed through raw water to stirring blade is certain
Power, but because motive force is limited, and flow rate of water flow is unstable, so that the rotation of agitating shaft is not necessarily smooth, thus passes through setting
Drive control mechanism is able to drive rotary shaft and is rotated, and under the auxiliary of stirring blade, can save a large amount of energy
Source reduces preparation cost, while by the way that the first temperature sensor of drive control mechanism controls and second temperature sensor is arranged,
So that temperature can be monitored at any time and is arranged in drive control mechanism, and then guarantee that vapor smoothly generates.
In one preferred embodiment, intake valve 30 is offered on the side wall of the upper tank body 1.
It in the above scheme, can be in the mixed liquor of raw water and annex solution by opening up intake valve on the side wall of upper tank body
When filtering, nitrogen is passed through by intake valve, enables the pressure accelerated filtration of gas, improves the working efficiency of device, and nitrogen
Gas is practically insoluble in water, will not impact to water quality.
In one preferred embodiment, pressure sensor, the lower tank are provided in the lower tank 8 and secondary steam tank 14
8 and secondary steam tank 14 side wall on be provided with urgent exhaust valve 31, and the urgent exhaust valve 31 is controlled by the pressure and passes
Sensor.
In the above scheme, by the way that pressure sensor is arranged on lower tank and secondary steam tank and is controlled by the pressure
The urgent exhaust valve of sensor, can be when pressure be excessive in tank body, outside vent water vapor, and then improves described device and make
Safety.
In one preferred embodiment, check valve is provided in the pipeline 2.
In the above scheme, by the way that check valve is arranged in pipeline, so that pipeline can only convey liquid into tank body, without
Can be to outward leakage, and then ensure that going on smoothly for preparation process, it also ensures the health of tank vivo environment, improves and be prepared into
Water for injection quality.
In one preferred embodiment, first filter membrane, the second filter membrane and third filter membrane are reverse osmosis filter membrane, and described
The aperture of one filter membrane is 0.4-0.5 μm, the aperture of second filter membrane and third filter membrane is 0.2-0.25 μm.
It in the above scheme, is reverse osmosis membrane by setting first to third filter membrane, so that water will not be reverse osmosis, in turn
It ensure that the safety of the water quality of filtering, meanwhile, by a large amount of repetitious experiment discovery, the aperture of each filter membrane is limited to be upper
When stating numerical value, the sterile water for injection of preparation is best in quality, wherein and with the aperture of the first filter membrane for 0.45 μm, the second filter membrane
When aperture with third filter membrane is 0.22 μm, the efficiency highest of sterile water for injection is prepared, it is best in quality.
In one preferred embodiment, the top of first filter device is provided with baffle 32, and the baffle 32 is embedded in institute
In the groove for stating 1 lower part of upper tank body, so as to the baffle 32 is pulled, the upper tank body 1 and the first filter device fluid communication.
In the above scheme, by the way that baffle is arranged between filter device and tank body, so that mixed liquor ability when needing to filter
Baffle is opened, can be realized filtering, to avoid mixed liquor is unmixed from uniformly flowing into subsequent processing by filter device.
In one preferred embodiment, first spiral cold-finger 16 and 26 entirety of the second spiral cold-finger are inclined S
Shape setting, and one end of first helix tube 16 and the second helix tube 26 connection steam (vapor) outlet is higher than the other end, meanwhile, it is described
The radian of the S-shaped of one end of the first helix tube 16 and the second helix tube 26 connection steam (vapor) outlet is less than 16 He of the first helix tube
The radian of the other end of second helix tube 26；In addition, first spiral cold-finger 16 and the second spiral cold-finger 26 are tool
Double-layer structure with dissection, and one end point of first spiral cold-finger 16 and the second spiral cold-finger 26 connection steam (vapor) outlet
It is not provided with cooling water intake, the other end of first spiral cold-finger 16 and the second spiral cold-finger 26 is provided with cooling
Water water outlet, and the cooling water intake and cooling water outlet are connected to raw water input terminal, so that shape in the interlayer
It is recycled at cooling water.
It in the above scheme, is S-shaped setting by setting condenser pipe, so that being passed through by the vapor that steam (vapor) outlet comes out
There is a small amount of stop when first radian, convenient for the condensation of vapor, but integral inclined setting is so that condensed water will not accumulate in
It is excessive at camber, and second radian is larger, and condensed water is enabled quickly to flow into subsequent processing, so that the system of whole device
Standby efficiency significantly improves.It is double-layer structure by setting spiral cold-finger, and vapor is carried out as cooling water by raw water
Condensation, so that preparation cost further decreases.
In one preferred embodiment, raw water is entering preceding also need by quartz sand and active carbon mistake by the raw water input port
Filter.
In the above scheme, quartz sand and active carbon is first passed through by limiting raw water to filter, it can first will be in raw water
Large granular impurity is removed, so that the preparation process of subsequent sterile water for injection more succinctly facilitates, improves filter membrane
Service life.
A method of sterilized water for injection, including following step are prepared with the device for preparing sterilized water for injection
It is rapid:
Step 1 is each led at the both ends of the Y tube by the weight ratio of raw water and annex solution for 1:0.003-0.005
Raw water and annex solution, mixing obtain the first mixed liquor；
Wherein, the annex solution is the mixed liquor of alkalinity potassium permanganate and phosphoric acid；
First mixed liquor is removed sediment through first membrane filtration by step 2, and to the first liquid storage box of lower tank
In be heated to 80 DEG C, and through the first atomization pipeline atomization；
The atomized liquid that step 3, step 2 generate obtains just steaming vapor after quartz plate heats；
Step 4 just steams vapor after the first spiral cold-finger into secondary steam tank, and by two in secondary steam tank
Secondary heating obtains the second vapor；
Step 5, the second vapor obtain primary injection water after condensing, and dual through the second filter membrane and third filter membrane
Filtering, obtains secondary injection water；
Step 6, secondary injection water are after Water quality detector detection is qualified, through 100 DEG C of flowing steam sterilization 25-
To get the sterilized water for injection after 40min.
In the above scheme, by the chemical treatment to raw water, then filtering carries out secondary steam condensation, finally again into
Row secondary fine filtering, filling sterilizing, entire preparation method is simply easily operated, and can be straight after the device for preparing sterilized water for injection
It connects and encapsulating and sterilizing installation is added, the Fully-automatic production line type production of sterilized water for injection can be realized, water yield is big, and is made
Sterilized water for injection quality is high.Wherein, by the way that annex solution is added in raw water, the alkalinity potassium permanganate in annex solution can be removed
Organic matter and carbon dioxide in raw water, and phosphoric acid can make the ammonia in raw water become nonvolatile ammonium salt, and then through first
It is removed after membrane filtration.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (10)
1. a kind of device for preparing sterilized water for injection, wherein include:
Upper tank body, top center are provided with the pipeline for protruding from the upper tank body upper surface, and the pipeline is protruding on described
One end of tank surface is connected with Y tube, and the long end interface of the Y tube is connected with the pipeline, and another the two of the Y tube
End is respectively the annex solution input port for the raw water input port of raw water input and for adding annex solution；It is set in the upper tank body
It is equipped with agitating device, the agitating device includes rotary shaft and stirring blade, and the rotary shaft is vertically installed in the upper tank body
Inside, and the both ends of the upper tank body are fixed on, the rotary shaft is hollow setting, and is communicated with the pipeline, the stirring
Blade is the hollow setting of another end opening closed at one end, the open end of the stirring blade and rotation axis connection, and with it is described
The inside of rotary shaft is connected to, and is provided with aperture on the side and top surface of the stirring blade；
First filter device comprising the first filter cartridge and the first filter membrane, the top of first filter cartridge and the upper tank body
Lower removable connection, and with the upper tank body fluid communication, first filter membrane is set to the inside of first filter cartridge,
And the edge of first filter membrane and the inner wall of first filter cartridge fit；
Lower tank, upper part are provided with the first liquid storage box, are provided with the first heating on the side wall of first liquid storage box and bottom surface
Plate, first liquid storage box are internally provided with the first temperature sensor being connected with first heating plate；First storage
The upper end of liquid box is connect with the lower removable of first filter cartridge, and the lower end of first liquid storage box connects the first mist pipe
Road, the first atomization pipeline is waveform setting, and the first atomization pipeline is in the direction towards the lower tank bottom surface
On be provided with the first atomization mouth；Be provided with the first quartz plate on the bottom surface of the lower tank, centered on first quartz plate to
The lower part of the concave structure of lower protrusion, first quartz plate is provided with primary heater；It is set above the side wall of the lower tank
It is equipped with the first steam (vapor) outlet；
Secondary steam tank, side wall are equipped with steam inlet, and first steam (vapor) outlet passes through the first spiral cold-finger and the steaming
Vapour entrance is connected, and the second liquid storage box, second liquid storage box are connected at the steam inlet in the secondary steam tank
Side wall and bottom surface on be provided with the second heating plate, being internally provided with for second liquid storage box is connected with second heating plate
Second temperature sensor；Lower end connection the second atomization pipeline of second liquid storage box, the second atomization pipeline is wave
Shape setting, and the second atomization pipeline is provided with the second atomization mouth on the direction towards secondary steam tank bottom face；Institute
It states and is provided with the second quartz plate on the bottom surface of lower tank, downwardly projecting concave structure, described centered on second quartz plate
The lower part of second quartz plate is provided with secondary heater；The second steam (vapor) outlet is provided with above the side wall of the lower tank；
Second filter device comprising the second filter cartridge, the second filter membrane and third filter membrane are put down on the inner wall of second filter cartridge
Row is provided with 2 card slots, second filter membrane and third filter membrane be respectively engaged with 2 described in card slot, the second filtering dress
The bottom for being placed in the secondary steam tank is installed, and is connected by the second spiral cold-finger with second steam (vapor) outlet；
Finished product collection device comprising tank, finished pot and three-way valve are detected, is provided with Water quality detector in the detection tank,
The Water quality detector is connected with the three-way valve, with according to water quality detection result control the three-way valve it is each go out
The opening and closing of liquid mouth, and the detection tank is connected with the liquid outlet of second filter device, two of the three-way valve go out
Liquid mouth is separately connected finished pot and detection tank, another liquid outlet of the three-way valve is connected to the pipe by catheter
Road.
2. preparing the device of sterilized water for injection as described in claim 1, wherein further include:
Drive control mechanism, with the rotary shaft, the first temperature sensor, second temperature sensor, primary heater and
Two heaters are separately connected.
3. preparing the device of sterilized water for injection as described in claim 1, wherein offered on the side wall of the upper tank body into
Air valve.
4. preparing the device of sterilized water for injection as described in claim 1, wherein set in the lower tank and secondary steam tank
It is equipped with pressure sensor, is provided with urgent exhaust valve, and the urgent exhaust on the side wall of the lower tank and secondary steam tank
Valve is controlled by the pressure sensor.
5. preparing the device of sterilized water for injection as described in claim 1, wherein be provided with check valve in the pipeline.
6. preparing the device of sterilized water for injection as described in claim 1, wherein first filter membrane, the second filter membrane and the
Three filter membranes are reverse osmosis filter membrane, and the aperture of first filter membrane is 0.4-0.5 μm, second filter membrane and third filter membrane
Aperture is 0.2-0.25 μm.
7. preparing the device of sterilized water for injection as described in claim 1, wherein the top of first filter device is all provided with
It is equipped with baffle, the baffle is embedded in the groove of the upper tank body lower part, so as to the baffle is pulled, the upper tank body and first
Filter device fluid communication.
8. preparing the device of sterilized water for injection as described in claim 1, wherein first spiral cold-finger and the second spiral shell
Rotation condenser pipe is integrally inclined S-shaped setting, and first helix tube and the second helix tube connect one end of steam (vapor) outlet
Higher than the other end, meanwhile, the radian of the S-shaped of one end of first helix tube and the second helix tube connection steam (vapor) outlet is less than institute
State the radian of the other end of the first helix tube and the second helix tube；In addition, first spiral cold-finger and the condensation of the second spiral
Pipe is tool double-layer structure with dissection, and first spiral cold-finger and the second spiral cold-finger connect the one of steam (vapor) outlet
It holds and is respectively arranged with cooling water intake, the other end of first spiral cold-finger and the second spiral cold-finger is provided with cooling
Water water outlet, and the cooling water intake and cooling water outlet are connected to raw water input terminal, so that shape in the interlayer
It is recycled at cooling water.
9. preparing the device of sterilized water for injection as described in claim 1, wherein raw water enters by the raw water input port
It is preceding also to need to filter by quartz sand and active carbon.
10. a kind of method for preparing sterilized water for injection with the device for preparing sterilized water for injection as described in claim 1,
In, comprising the following steps:
Step 1 each leads into raw water by raw water and the weight ratio of annex solution at the both ends of the Y tube for 1:0.003-0.005
And annex solution, mixing obtain the first mixed liquor；
Wherein, the annex solution is the mixed liquor of alkalinity potassium permanganate and phosphoric acid；
First mixed liquor is removed sediment through first membrane filtration, and added into the first liquid storage box of lower tank by step 2
Heat is atomized to 80 DEG C, and through the first atomization pipeline；
The atomized liquid that step 3, step 2 generate obtains just steaming vapor after quartz plate heats；
Step 4 is just steamed vapor after the first spiral cold-finger into secondary steam tank, and is added in secondary steam tank by secondary
Heat obtains the second vapor；
Step 5, the second vapor obtain primary injection water after condensing, and the dual mistake through the second filter membrane and third filter membrane
Filter, obtains secondary injection water；
Step 6, secondary injection water are after Water quality detector detection is qualified, after 100 DEG C of flowing steam sterilization 25-40min,
Up to the sterilized water for injection.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710676347.1A CN107253795B (en) | 2017-08-09 | 2017-08-09 | Prepare the device and preparation method thereof of sterilized water for injection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710676347.1A CN107253795B (en) | 2017-08-09 | 2017-08-09 | Prepare the device and preparation method thereof of sterilized water for injection |
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| CN107253795B true CN107253795B (en) | 2019-03-29 |
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| CN109293105A (en) * | 2018-08-28 | 2019-02-01 | 芜湖鸣人热能设备有限公司 | Heatable environmental protection purifier |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2782664Y (en) * | 2004-11-30 | 2006-05-24 | 浙江省医疗器械研究所 | Aseptic medical used injection water treatment equipment |
| CN202829637U (en) * | 2012-07-31 | 2013-03-27 | 湖北科伦药业有限公司 | Water for injection automatic preparation system |
| CN205635224U (en) * | 2016-05-19 | 2016-10-12 | 江西新天地药业有限公司 | Injection water water preparation system |
-
2017
- 2017-08-09 CN CN201710676347.1A patent/CN107253795B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2782664Y (en) * | 2004-11-30 | 2006-05-24 | 浙江省医疗器械研究所 | Aseptic medical used injection water treatment equipment |
| CN202829637U (en) * | 2012-07-31 | 2013-03-27 | 湖北科伦药业有限公司 | Water for injection automatic preparation system |
| CN205635224U (en) * | 2016-05-19 | 2016-10-12 | 江西新天地药业有限公司 | Injection water water preparation system |
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