CN107223133A - 一种可溶的异质二聚t细胞受体及其制法和应用 - Google Patents

一种可溶的异质二聚t细胞受体及其制法和应用 Download PDF

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CN107223133A
CN107223133A CN201580060677.7A CN201580060677A CN107223133A CN 107223133 A CN107223133 A CN 107223133A CN 201580060677 A CN201580060677 A CN 201580060677A CN 107223133 A CN107223133 A CN 107223133A
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tcr
chain
exon
cell receptor
chains
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CN107223133B (zh
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李懿
樊辉
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Xiangxue Life Science Technology Guangdong Co ltd
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GUANGZHOU XIANGXUE PHARMACEUTICAL CO Ltd
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

本发明提供了一种高稳定性的T细胞受体(TCR)，所述TCR包含(ⅰ)除其跨膜结构域以外的全部或部分TCRα链，和(ⅱ)除其跨膜结构域以外的全部或部分TCRβ链，其中(ⅰ)和(ⅱ)均包含TCR链的功能性可变结构域和至少一部分恒定结构域。人工链间二硫键连接所述TCRα与β链的恒定区，并且所述T细胞受体的Tm值大于或等于45℃。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201580060677.7A 2014-11-07 2015-11-04 一种可溶的异质二聚t细胞受体及其制法和应用 Active CN107223133B (zh)

Applications Claiming Priority (3)

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CN2014106293218 2014-11-07
CN201410629321 2014-11-07
PCT/CN2015/093806 WO2016070814A1 (zh) 2014-11-07 2015-11-04 一种可溶的异质二聚t细胞受体及其制法和应用

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CN107223133A true CN107223133A (zh) 2017-09-29
CN107223133B CN107223133B (zh) 2021-01-29

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US (1) US11851469B2 (zh)
EP (1) EP3216801B1 (zh)
JP (1) JP6415716B2 (zh)
CN (1) CN107223133B (zh)
CA (1) CA2967073A1 (zh)
WO (1) WO2016070814A1 (zh)

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CN110016074B (zh) * 2018-01-08 2021-03-30 中国科学院广州生物医药与健康研究院 Mage-a3人源化t细胞受体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048410A2 (en) * 2002-11-22 2004-06-10 Isis Innovation Limited T-cell receptors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519143A (ja) * 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖ｔ細胞レセプタータンパク質
CN1464790A (zh) * 2000-06-05 2003-12-31 苏诺尔分子公司 T细胞受体融合物及共轭物以及其使用方法
DE60203125T2 (de) * 2001-08-31 2006-04-06 Avidex Ltd., Abingdon Löslicher t zell rezeptor
GB0226227D0 (en) * 2002-11-09 2002-12-18 Avidex Ltd Receptors
ATE432290T1 (de) * 2002-11-09 2009-06-15 Immunocore Ltd T ZELL REZEPTOR ßDISPLAYß
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
ATE475669T1 (de) * 2004-06-29 2010-08-15 Immunocore Ltd Einen modifizierten t-zellen-rezeptor exprimierende zellen
JP2008514685A (ja) * 2004-10-01 2008-05-08 メディジーン リミテッド 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター
GB0908613D0 (en) 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048410A2 (en) * 2002-11-22 2004-06-10 Isis Innovation Limited T-cell receptors

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JP2017534288A (ja) 2017-11-24
JP6415716B2 (ja) 2018-10-31
US20180355012A1 (en) 2018-12-13
WO2016070814A1 (zh) 2016-05-12
EP3216801A4 (en) 2018-04-11
EP3216801A1 (en) 2017-09-13
US11851469B2 (en) 2023-12-26
CA2967073A1 (en) 2016-05-12
CN107223133B (zh) 2021-01-29
EP3216801B1 (en) 2020-01-01

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