CN107213538B - Medicine storage and atomizing device for aerosol inhalation administration - Google Patents
Medicine storage and atomizing device for aerosol inhalation administration Download PDFInfo
- Publication number
- CN107213538B CN107213538B CN201710564506.9A CN201710564506A CN107213538B CN 107213538 B CN107213538 B CN 107213538B CN 201710564506 A CN201710564506 A CN 201710564506A CN 107213538 B CN107213538 B CN 107213538B
- Authority
- CN
- China
- Prior art keywords
- atomization
- medicine
- atomizing
- module
- cup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0063—Storages for pre-packed dosages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a medicine storage and atomization device for aerosol inhalation administration, which comprises: the medicine cup module comprises a medicine cup with a cavity for containing medicine liquid, and the medicine cup is provided with an atomizing opening communicated with the cavity; the atomization module comprises an atomization piece for atomizing the liquid medicine; a separation component positioned between the atomization port and the atomization module and used for allowing the liquid medicine to contact the atomization component only during atomization administration; when the medicine storage and atomization device is in an atomization administration state, the isolation component is pulled away, removed or damaged, liquid medicine in the medicine cup is contacted with the atomization component, and the medicine cup module further comprises a first connection component used for connecting an atomization device host; the atomization module further comprises a second connecting part used for connecting an atomization mask or a suction nozzle. The cleaning step after the atomization of the medicine is finished is omitted, the cross contamination of the medicine caused by the unclean cleaning is avoided, the loss of the atomization device host is reduced, and the service life of the atomization device host can be prolonged.
Description
Technical Field
The invention belongs to the field of aerosol inhalation administration, and particularly relates to a drug storage and atomization device for aerosol inhalation administration.
Background
Inhalation therapy plays an important role in alleviating respiratory diseases such as asthma, chronic obstructive pulmonary disease, respiratory infection and the like, and for the treatment of specific diseases, inhalation administration is more advantageous than other administration modes, and particularly, some macromolecular drugs which are easily degraded in intestinal tracts and are influenced by the first pass effect of livers are more suitable for reaching the respiratory region of the lung through inhalation administration. Inhalation administration currently there are three methods of inhalation administration: metered Dose Inhalers (MDIs), dry Powder Inhalers (DPIs) and nebulizers (nebulizers). Wherein, the atomization inhalation administration has the advantages of good atomization effect, simple operation, low noise, small volume, portability and the like, so that the clinical application of the atomization inhalation administration is more and more extensive.
Nebulized spray administration is attracting attention because of its unique advantages in nebulizing effect, operability, portability, etc., and is widely used in clinical treatment of various respiratory diseases and even other systemic diseases. Nebulizers are devices that deliver droplets of a drug to the lungs in the form of a liquid spray, break the equilibrium at the interface of the drug solution or suspension by means of oxygen, compressed air or ultrasound, and, in combination with specific nebulizing assemblies and structural designs, facilitate the nebulization of the drug solution into small liquid particles (so-called "mist") that are inhaled through the mouth piece into the respiratory tract and lungs.
Compared with other administration modes, the aerosol inhalation mainly has the following advantages: (1) The inhaled medicine can directly reach respiratory tract and lung and directly enter blood through pulmonary capillaries, so the medicine has faster effect and is more effective than oral medicine; (2) Because the medicine is directly sucked into the respiratory tract and directly enters the blood through the pulmonary capillary, the first pass effect of the liver is avoided, the dosage of the medicine only needs one tenth of other administration modes at most, the toxic and side effect of the medicine is obviously reduced, which is particularly important for children and old people; (3) Humidifying the air passage and diluting the sputum, and can be widely used for various respiratory diseases; (4) For some diseases (such as cold) which mainly take virus infection and can be self-healed, the aerosol inhalation treatment can obviously relieve symptoms and shorten the course of disease; (5) The medicine has direct action and quick response, has obvious and quick effect on relieving the bronchial asthma, is superior to other treatment modes, and can save the life of a patient even in critical time.
The goal of aerosol inhalation therapy is to introduce a therapeutic dose of a drug into the respiratory tract or lungs in the form of aerosolized particles in a relatively short period of time, typically 5-15 minutes. In the atomizing process, the medicine cup with a specific volume is used as a container for containing medicine solution, and after a specific part of the container is opened, the medicine solution is contacted with the atomizing sheet, so that the efficient atomization of the medicine solution is realized. Administration by aerosol inhalation has several advantages over enteral or other parenteral administration: the traditional Chinese medicine composition has the advantages of quick response, reduction of treatment dosage, reduction of toxic and side effects and the like, so that the traditional Chinese medicine composition is widely used for clinical or family care at present and is used as a treatment administration mode for specific diseases.
Nebulized inhalers include various solution or suspension formulations to which specific excipients are added to achieve the therapeutic goal of the drug. All currently nebulized solutions or suspensions are sterile and are mostly dispensed in unit dosage form to avoid contamination by antibiotics or microorganisms. A typical inhalation nebulizer product comprises a liquid medicine holding device (nebulizing cup), a baffle, a host machine (or compression device) containing a nebulizing patch, a mouthpiece or face mask, etc.
At present, in clinical or domestic atomizing system, the atomizing piece all is as atomizing host computer non-detachable partly, puts into atomizing cup with the liquid medicine during the use, and the atomizing piece contacts with liquid medicine, realizes atomizing through compression or ultrasonic technology. After once dosing, just will rinse the atomizing piece like this, too much washing step not only brings the inconvenience for the user, still can increase atomizing device's loss, in case atomizing device or atomizing piece break down, will face abandoning of whole atomizer. Meanwhile, the atomizing sheet is used as a component of the atomizer, is exposed in the environment for a long time, is easily polluted by various harmful substances such as bacteria, fungi, antibiotics and the like, and cannot thoroughly remove the pollutants even after being sterilized, which is very unfavorable for the atomization of the medicine solution requiring sterility. In addition, the traditional atomizer is adopted to atomize the medicine, so that cross contamination is easily generated during treatment of different medicines, and the treatment effect of diseases is greatly influenced.
Disclosure of Invention
On the premise of comprehensively considering all factors, the invention provides a medicine storage and atomization device for atomization inhalation administration, which does not need to clean an atomization piece and can be integrally replaced without influencing a main machine of atomization equipment.
The technical scheme adopted by the invention is as follows:
a drug storage and aerosolization device for aerosolization inhalation delivery, comprising:
the medicine cup module comprises a medicine cup with a cavity for containing medicine liquid, and the medicine cup is provided with an atomizing opening communicated with the cavity;
the atomization module comprises an atomization piece for atomizing the liquid medicine;
a separation component positioned between the atomizing port and the atomizing module for allowing the liquid medicine to contact the atomizing member only during the administration of the atomized medicine;
wherein, the medicine storage and atomization device has an atomization administration state, when in the atomization administration state, the isolation component is drawn away, removed or destroyed, the medicine liquid in the medicine cup contacts with the atomization component,
the medicine cup module further comprises a first connecting part for connecting the atomizing equipment main machine; the atomization module further comprises a second connecting part used for connecting an atomization mask or a suction nozzle.
Preferably, the isolation component is selected from one or more of a packaging cover, a packaging film and a diaphragm layer; wherein:
the packaging cover is connected to the cup wall of the medicine cup to seal the atomizing opening, and the packaging cover is provided with a weak part which is broken after external force is applied;
the packaging film can be arranged between the medicine cup and the atomizing module or on the medicine cup or on the atomizing module in a drawing-away, extrusion deformation or puncture manner;
the membrane layer covers and is formed on the atomizing part and can be damaged or removed.
Preferably, the atomization piece is a piezoelectric ceramic atomization piece, and a large number of micropores are distributed on the piezoelectric ceramic atomization piece.
More preferably, the first connecting means comprises at least one pair of access probes for connecting with the nebulizing device host to obtain electrical signals.
Further, be equipped with on the medicine cup with access probe corresponds at least a pair of first conductive probe of electricity connection, the atomizing module includes to the piezoceramics atomization piece provides at least a pair of second conductive probe of signal of telecommunication, works as when the atomizing device of dosing is in the atomizing state of dosing, first conductive probe with second conductive probe meets.
Further, the atomizing module includes to the piezoceramics atomizing piece provides the at least a pair of second conductive probe of signal of telecommunication, when the atomizing device of dosing is in the atomizing state of dosing, access electric probe pass through the wire with the second conductive probe meets.
Preferably, the outer wall of the cup has at least one outwardly extending flange disposed around the atomizing orifice, and the spacer member is disposed on the flange.
More preferably, the flange includes an inner flange and an outer flange, the inner flange is disposed around the atomizing port, the outer flange is disposed around the inner flange, the isolation member includes a sealing cap and a sealing film, the sealing cap is disposed on the inner flange and has a weak portion that is broken when an external force is applied thereto, and the sealing film is disposed on the outer flange and can be punctured or pressed to deform.
Preferably, the second attachment means comprises an atomising mask seat.
Preferably, the medicine cup is further provided with an air hole, and a medicine cup packaging cover which is used for sealing the air hole and can be removed to expose the air hole is arranged on the medicine cup.
The medicine cup module and the atomization module are combined with each other to form a device for atomizing medicine solution. The atomizing opening of the medicine cup is removed with the packaging film and the packaging cover, and the atomizing module is butted with the atomizing module after the atomizing module is removed with the bottom cover, so that the liquid medicine in the medicine cup is fully contacted with the atomizing sheet. When the atomization device host machine without the atomization sheet is switched on, atomization can be driven by various methods, including but not limited to spraying, mesh or ultrasonic and the like, so that atomization of the liquid medicine is realized. Preferably, the medicine cup module and the atomization module are independent components, and the medicine liquid is atomized after seamless butt joint before use. Further preferably, the atomization driving force of the atomization module is mesh atomization.
The main body of the medicine cup module can be cylindrical, conical, cubic or a closed structure consisting of specific faces and edges, and preferably is a cylindrical structure. The position of the atomizing opening of the medicine cup is the side surface or the bottom of the surface of the medicine cup. Preferably, the atomizing opening is positioned on the side wall of the medicine cup and is in a circular protruding structure. The middle part of the medicine cup atomizing opening is provided with an atomizing opening packaging cover, and the outer side part of the atomizing opening is provided with a medicine cup atomizing opening packaging film. The medicine cup atomizing mouth also can be located medicine cup bottom, and medicine cup encapsulation lid is sunk structure this moment, makes the medicine cup can normally steadily place.
The atomization module is provided with the atomization sheet on one side, and the atomization module bottom cover is arranged on the outer side of the atomization sheet and used for being isolated from the outside, so that the pollution of bacteria or toxic substances is avoided. Preferably, the atomization sheet is a piezoelectric ceramic sheet. Further preferably, the piezoelectric ceramic atomizing sheet has a microporous structure with a specific size and uniformly distributed in a net shape. Further preferably, the size of the micropores is 5 μm or less.
The atomization module can be combined with the medicine cup into an integral structure, and then the liquid medicine in the medicine cup is atomized by utilizing the atomization equipment host which is externally independent of the atomization equipment host. At this time, the medicine cup module does not contain the atomizing opening encapsulation cover and the conductive probe, and only an encapsulation film is arranged. And the conductive probe on the atomization module is directly connected with the access probe on the medicine cup module through a lead. Before atomization, the packaging film of the atomizing opening of the medicine cup is removed or destroyed in a specific mode. When the atomization device host machine without the atomization sheet is connected, the atomization of the liquid medicine is directly realized.
Above-mentioned overall structure also can not contain the encapsulation membrane, has the diaphragm layer this moment between atomizing piece and the medicine cup subassembly of atomizing subassembly for keep apart atomizing piece and liquid medicine.
The atomization piece module and the medicine cup module are combined into an integral inseparable integral structure, and no matter the atomization piece module and the medicine cup module are of an encapsulation film or a diaphragm layer, the atomization piece module and the medicine cup module are required to be destroyed or removed in a specific mode before atomization, and the destruction or removal mode comprises but is not limited to puncture, extrusion, drawing and the like, so that the liquid medicine is directly contacted with the atomization piece, and the atomization of the medicine is realized.
The inseparable integral structure can be used as a container device for holding medicinal solution in the process of medicament production. In this unitary construction, the atomizing assembly can be located above, to the side of, or at the bottom of the cup assembly.
Compared with the prior art, the invention has the following advantages by adopting the scheme:
the atomizing module is independent from the atomizing equipment main machine and forms a matching device with the medicine cup for containing the liquid medicine, so that the cleaning step after the medicine is atomized is omitted, the medicine cross contamination caused by unclean cleaning is avoided, the loss of the atomizing equipment main machine is reduced, and the service life of the atomizing equipment main machine can be prolonged. In addition, regard as one set of independent device with the medicine cup of atomizing module and splendid attire atomizing liquid medicine, when facilitating the use, also can be accurate carry out the ration to the medicine dose, reduce the error, improve the drug effect.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings required to be used in the description of the embodiments will be briefly introduced below, and it is apparent that the drawings in the description below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained based on these drawings without creative efforts.
FIG. 1 is a sectional view of a drug storage and atomizing device for aerosol inhalation administration in accordance with embodiment 1 of the present invention;
FIG. 2 is an exploded view of a drug storage and atomizing device for aerosol inhalation administration in accordance with embodiment 1 of the present invention;
FIG. 3 is a sectional view of a drug storage and atomizing device for aerosol inhalation administration in accordance with embodiment 2 of the present invention;
FIG. 4 is a sectional view of a drug storage and atomizing device for aerosol inhalation administration in accordance with embodiment 3 of the present invention.
In the above-described drawings, it is shown,
1. a medicine cup; 11. an upper cover; 110. air holes are formed; 111. a vent cover; 111a, a weak portion; 12. a cup body; 120. an atomizing port; 121. an inner flange; 122. an outer flange; 123. a first conductive probe; 13. a bottom cover; 130. accessing a probe;
2. an isolation member; 21. a package cover; 21a, a weak portion; 22. packaging the film; 23. diaphragm layer
3. An atomization module; 30. an atomizing sheet; 31. an atomizing mask base; 32. atomizing sheet silica gel cover; 33. an atomization module bottom cover; 34. a screw; 35. a second conductive probe.
Detailed Description
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the invention may be more readily understood by those skilled in the art. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
The embodiment provides a medicine storage and atomization device for aerosol inhalation administration, which comprises a medicine cup module, an atomization module and an isolation component. This atomizing inhales storage medicine and atomizing device of using of dosing can regard as independent device, after connecting the atomizing equipment host computer, can directly atomize the medicine in the medicine cup module, then administrate to the patient through connecting the atomizing face guard or the suction nozzle on the device. The isolation component is positioned between the medicine cup module and the atomization module and is used for allowing the liquid medicine to contact the atomization piece of the atomization module only during atomization administration; the medicine storage and atomization device for aerosol inhalation administration has an aerosol administration state, and when the aerosol administration state is in, the isolation component is drawn away, removed or destroyed, and the liquid medicine in the medicine cup is contacted with the atomization component.
In this embodiment, the medicine cup module and the atomizing module are integrated, and the packaging part is directly disposed on the medicine cup module. Referring to fig. 1-2, the medicine cup module includes a medicine cup 1, the medicine cup 1 is composed of a cup body 12, an upper cover 11 and a bottom cover 13, the upper cover 11 and the bottom cover 13 are respectively fixedly connected to the upper end and the lower end of the cup body 12 for sealing the cup body, so that a cavity for containing medicine liquid is formed therein. Wherein, the side wall of the cup body 12 is provided with an atomizing opening 120 communicated with the cavity, the upper cover 11 is provided with an air hole 110 communicated with the cavity, and the upper cover 11 and a vent cover 111 for sealing the air hole 110 are integrally formed or fixedly connected, in particular made of medical grade plastic. The vent cover 111 has a weak portion 111a (specifically, at a connection portion with the upper cover 11), and when an external force is applied, the weak portion 111a is broken to break the vent cover 111 and expose the vent holes 110. When in use, the vent cover 111 can be separated from the upper cover 11 by a certain force (such as breaking, pulling, tearing and the like), so that the medicinal solution in the vent cover can be poured out or sucked conveniently. A pair of access probes 130 is embedded in the middle of the bottom cover 13 and is a part of the first connecting component for connecting the atomizing device main unit. The main body of the atomizing device is a main body of the atomizing device which does not include an atomizing module, and one of functions of the main body is to provide an electric signal to the medicine storage and atomizing device for atomizing, inhaling and administering the medicine. After the medicine storage and atomizing device for the atomized inhalation administration is connected with the atomizing equipment host, the access probe 130 acquires an electric signal from the atomizing equipment host and transmits the electric signal to the atomizing module 3.
The isolation component 2 is selected from one or more of a packaging cover, a packaging film and a diaphragm layer; the specific setting mode is as follows:
the packaging cover is connected on the cup wall of the medicine cup 1 to seal the atomizing opening 120, and the packaging cover is provided with a weak part which is broken after being subjected to external force;
the packaging film can be arranged between the medicine cup 1 and the atomizing module 3 or on the medicine cup 1 or the atomizing module 3 in a drawing, extruding, deforming or puncturing way;
the membrane layer is formed on the atomizing member and can be damaged or removed.
Specifically, in the device for storing and atomizing a medicinal aerosol for inhalation and administration shown in fig. 1, the outer wall of the cup 1 has at least one outwardly extending flange, the flange is disposed around the atomizing port 120, and the partition member 2 is disposed on the flange. More specifically, the atomization port 120 is opened in the side wall of the cup body 12, the flange is formed in the side wall of the cup body 12, and the partition member 2 includes the encapsulation cover 21 and the encapsulation film 22. The flange includes an inner flange 121 and an outer flange 122, the inner flange 121 is disposed around the atomizing opening 120, the outer flange 122 is disposed around the inner flange 121, the isolation component 2 includes a sealing cover 21 and a sealing film 22, the sealing cover 21 is disposed on the inner flange 121, the sealing cover 21 has a weak portion 21a which is broken when an external force is applied to the sealing cover 21, the sealing film 22 is disposed on the outer flange 122 and can be punctured or squeezed to deform, and the sealing cover 21 and the sealing film 22 both sequentially cover the atomizing opening 120. When in use, the packaging film 22 and the packaging cover 21 of the atomizing opening 120 of the medicine cup 1 can be separated from the medicine cup 1 by certain force.
The atomizing module 3 is an assembly including an atomizing plate 30. The atomizing plate 30 in the atomizing module 3 is preferably a piezoelectric ceramic atomizing plate. The atomizing sheet 30 has a plurality of micro-holes with uniform size and micron-sized diameter, the size of the micro-holes is less than 5 microns, and the micro-holes are closely arranged and distributed in a net shape. The atomization piece 30 is arranged in an atomization piece silica gel sleeve 32, and the atomization piece silica gel sleeve 32 is arranged in an atomization module bottom cover 33. The atomizing plate 30 is fixed in the atomizing plate silica gel sleeve 32 through a small fixing screw 34.
A pair of first conductive probes 123 which are correspondingly and electrically connected with the access probe 130 are arranged in the atomizing opening 120 of the medicine cup 1, and the first conductive probes 123 are telescopic. The atomizing module 3 includes a pair of second conductive probe 35 to the power supply of piezoceramics atomizing piece 30, works as when the atomizing medicine feeding device is in the atomizing state of dosing, encapsulation lid 21 and encapsulation membrane 22 are got rid of, and first conductive probe 123 and second conductive probe 35 directly meet, transmit the signal of telecommunication of atomizing equipment host computer to atomizing piece 30. The first conductive probe 123 is specifically a telescopic conductive probe, and is preferably located in the middle of the atomizing opening 120, and can be changed in position by sliding, so as to be conveniently connected to the second conductive probe 35 of the atomizing module 3. It is further preferred that the first conductive probe 123 and the second conductive probe 35 are parallel and arranged in a horizontal direction. The second conductive probe 35 is in contact with the atomizing plate 30 through the space in the middle of the atomizing plate silicone sleeve 32. The second connecting part comprises an atomizing mask seat 31, and the other side of the atomizing plate 30 is communicated with the atomizing mask seat 31. The access probe 130 may also be electrically connected to the second conductive probe 35 directly by a wire without the first conductive probe 123.
This embodiment provides a form of the cup module and the aerosolization module 3 that can be used separately and in combination, i.e., as two separate components prior to administration of a clinical aerosol. During the use, the medicine cup module can constitute a whole with atomizing module 3, and behind the atomizing equipment host computer that the switch-on does not contain atomizing piece 30, can directly realize atomizing to the liquid medicine in the medicine cup module.
Example 2
Referring to fig. 3, this embodiment is basically the same as embodiment 1, and differs from embodiment 1 only in that:
adopt the medicine cup module of separable each other and the 3 forms of atomizing module and use after the combination, do not set up the encapsulation membrane on the medicine cup module, mainly keep apart liquid medicine and outside through encapsulation lid 21 this moment, break behind the encapsulation lid 21, dock integratively with atomizing module 3, connect the atomization plant host computer, realize the atomizing to the liquid medicine.
Example 3
Referring to fig. 4, this embodiment is basically the same as embodiment 1, and differs from embodiment 1 only in that:
the medicine cup 1 and the atomizing module 3 are assembled into a whole in manufacturing, and cannot be separated in the process of medicine storage and transportation, the medicine cup module does not contain the packaging cover 21, the packaging film 22 and the inner flange 121, but a diaphragm layer 23 is arranged on the surface of the atomizing sheet 30 of the atomizing module 3, the atomizing module 3 is inserted in the outer flange 122, and the first conductive probe 123 and the second conductive probe 35 are directly connected. When the atomizing cup is used, the diaphragm layer 23 is removed or damaged, so that the medicinal solution is in direct contact with the atomizing sheet 30, and after the atomizing equipment host which does not contain the atomizing sheet 30 is connected, atomization of the liquid medicament in the medicinal cup module can be directly realized.
In addition, there are the following embodiments:
The medicine cup module and the atomization module 3 are combined with each other to form a device for atomizing medicine solution. The packaging film 22 and the packaging cover 21 of the atomizing opening 120 are removed from the atomizing opening 120 of the medicine cup 1, and the atomizing module 3 is butted with each other after the atomizing module bottom cover 33 is removed, so that the medicine liquid in the medicine cup 1 is fully contacted with the atomizing sheet 30. When the atomizer main body without the atomizing plate 30 is switched on, atomization can be driven by various methods, including but not limited to spraying, mesh or ultrasonic, so as to realize atomization of the liquid medicine. Preferably, the medicine cup module and the atomization module 3 are independent components, and the medicine liquid is atomized after being seamlessly butted before use. Further preferably, the atomization driving force of the atomization module 3 is mesh atomization.
The invention provides a novel liquid medicine packaging form for medicine production, namely, the medicine is contained in the medicine cup 1 in the medicine sterile production process and is isolated from the outside through the packaging film 22, so that the medicine is aseptically stored and transported. The invention provides a novel medicine solution storage and atomization device which is formed by independently taking an atomization sheet 30 of a medicine storage and atomization device for atomization inhalation administration out of atomization equipment and combining the atomization sheet with a medicine cup module.
The medicine cup module and the atomization module 3 are separable components, the isolation part 2 is removed before use, the medicine cup module and the atomization module are combined into a whole, and after the liquid medicine is contacted with the atomization sheet 30, atomization of the medicine is realized. In the process of packaging the medicament, preferably, each cup module is provided with an atomizing module 3. In addition, the number of the medicine cup modules and the atomizing modules 3 can be set according to the treatment course of the medicine.
The medicine cup module and the atomizing module 3 can also be an inseparable whole and are used for containing medicine solution in the medicine production process. An encapsulation film 22 or a diaphragm layer is arranged between the medicine solution in the medicine cup module and the atomizing plate 30 of the atomizing module 3 to prevent the medicine solution from directly contacting the atomizing plate 30. When the device is used, the drug solution is directly contacted with the atomizing sheet 30 through a specific mode including but not limited to puncturing, stripping, extracting, extruding and the like, and then is atomized through an electric signal provided by the atomizing device host.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and are preferred embodiments, which are intended to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the scope of the present invention. All equivalent changes or modifications made according to the principles of the present invention should be covered within the protection scope of the present invention.
Claims (5)
1. A medicine storage and atomizing device for aerosol inhalation administration, comprising:
the medicine cup module comprises a medicine cup with a cavity for containing medicine liquid, wherein an atomization opening communicated with the cavity is formed in the medicine cup, an air hole is further formed in the medicine cup, a vent hole cover for sealing the air hole is arranged on the medicine cup, the vent hole cover is provided with a weak part, and the weak part breaks when external force is applied to the weak part, so that the vent hole cover is broken off to expose the air hole;
the atomizing module comprises an atomizing piece for atomizing liquid medicine, the medicine cup module and the atomizing module form a whole, and when an atomizing equipment host machine without an atomizing sheet is switched on during atomizing medicine feeding, liquid medicine in the medicine cup module can be directly atomized;
a separation component positioned between the atomization port and the atomization module and used for allowing the liquid medicine to contact the atomization component only during atomization administration;
wherein, the medicine storage and atomization device has an atomization administration state, when in the atomization administration state, the isolation component is drawn away, removed or destroyed, the medicine liquid in the medicine cup contacts with the atomization component,
the medicine cup module further comprises a first connecting part used for being connected with an atomization device host, the first connecting part comprises at least one pair of access probes used for being connected with the atomization device host to obtain electric signals, the medicine cup is provided with at least one pair of first conductive probes electrically connected with the access probes correspondingly, the atomization piece is a piezoelectric ceramic atomization piece, the atomization module comprises at least one pair of second conductive probes providing the electric signals for the piezoelectric ceramic atomization piece, and when the atomization administration device is in an atomization administration state, the first conductive probes are connected with the second conductive probes; the outer wall of the medicine cup is provided with at least one circle of flange extending outwards, the flange comprises an inner flange and an outer flange, the inner flange is arranged around the atomizing opening, the outer flange is arranged around the inner flange, the isolation component comprises an encapsulation cover and an encapsulation film, the encapsulation cover is arranged on the inner flange and is provided with a weak part which is broken after external force is applied, the encapsulation film is arranged on the outer flange and can be punctured or extruded to deform, the atomizing module further comprises a second connecting component used for connecting an atomizing mask or a suction nozzle, and the atomizing module is independent from the atomizing equipment host.
2. The device of claim 1, wherein the separator is selected from one or more of a sealing cap, a sealing membrane, and a membrane layer; wherein:
the packaging cover is connected to the cup wall of the medicine cup to seal the atomizing opening, and the packaging cover is provided with a weak part which is broken after external force is applied;
the packaging film can be arranged between the medicine cup and the atomizing module or on the medicine cup or on the atomizing module in a drawing-away, extrusion deformation or puncture manner;
the membrane layer is formed on the atomizing member in a covering manner and can be destroyed or removed.
3. The aerosol inhalation delivery drug storage and aerosolization apparatus of claim 1, wherein a plurality of micropores are distributed through the piezoceramic aerosolization plate.
4. The device of claim 1, wherein the flange is disposed around the aerosolization opening and the separator member is disposed on the flange.
5. The aerosol inhalation delivery drug storage and aerosolization apparatus according to claim 1, wherein the second coupling component comprises an aerosolization mask holder.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710564506.9A CN107213538B (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomizing device for aerosol inhalation administration |
| CN202310336013.5A CN116271361A (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomization device for atomization inhalation administration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710564506.9A CN107213538B (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomizing device for aerosol inhalation administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310336013.5A Division CN116271361A (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomization device for atomization inhalation administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107213538A CN107213538A (en) | 2017-09-29 |
| CN107213538B true CN107213538B (en) | 2023-03-21 |
Family
ID=59952395
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310336013.5A Pending CN116271361A (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomization device for atomization inhalation administration |
| CN201710564506.9A Active CN107213538B (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomizing device for aerosol inhalation administration |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310336013.5A Pending CN116271361A (en) | 2017-07-12 | 2017-07-12 | Medicine storage and atomization device for atomization inhalation administration |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN116271361A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602983B (en) * | 2019-01-22 | 2021-02-12 | 张磊 | Be applied to newborn paediatrics clinical disposable oxygen nebulizer |
| TWI734450B (en) * | 2019-04-23 | 2021-07-21 | 微邦科技股份有限公司 | Atomization device |
| CN112891060B (en) * | 2021-01-19 | 2021-10-08 | 浙江靓章生物科技有限公司 | Visual atomization eye patch and control method thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5819730A (en) * | 1993-06-09 | 1998-10-13 | Glaxo Wellcome Australia Ltd. | Device for administering pharmaceutical substances |
| CN101648041A (en) * | 2009-09-02 | 2010-02-17 | 王成 | Medical micropore atomization medicine absorber |
| CN102160906B (en) * | 2010-11-01 | 2012-08-08 | 常州市富艾发进出口有限公司 | Oral-suction type portable atomizer |
| TWM437821U (en) * | 2011-11-11 | 2012-09-21 | Microbase Technology Corp | Atomizer with liquid replenishment container |
| CN103432660B (en) * | 2013-08-01 | 2015-12-09 | 张学军 | Portable medical atomizer |
| CN204428565U (en) * | 2015-01-27 | 2015-07-01 | 南方医科大学南方医院 | Child's aerosol apparatus |
| CN105286091B (en) * | 2015-11-25 | 2018-10-30 | 卓尔悦欧洲控股有限公司 | Atomizer and its electronic cigarette |
| CN106377821A (en) * | 2016-10-12 | 2017-02-08 | 盐城工学院 | Piezoelectric ceramic atomization device |
| CN106620970A (en) * | 2016-10-30 | 2017-05-10 | 田中枢 | Portable atomization and administration device |
-
2017
- 2017-07-12 CN CN202310336013.5A patent/CN116271361A/en active Pending
- 2017-07-12 CN CN201710564506.9A patent/CN107213538B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN116271361A (en) | 2023-06-23 |
| CN107213538A (en) | 2017-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7261102B2 (en) | Breath-enhanced ultrasonic nebulizer and dedicated unit dose ampoule | |
| US11975164B2 (en) | Nasal drug delivery device and method of making same | |
| US8925544B2 (en) | Portable nebulizer device | |
| CN107213538B (en) | Medicine storage and atomizing device for aerosol inhalation administration | |
| US9402947B2 (en) | Portable fluid delivery system for the nasal and paranasal sinus cavities | |
| WO2022017187A1 (en) | Medical atomizing device | |
| CN107106790A (en) | Aerosol generator and the aerosol delivery-device including aerosol generator | |
| US20140283820A1 (en) | Method for Esophageal Drug Delivery | |
| US20160339188A1 (en) | Portable Fluid Delivery System for the Nasal and Paranasal Sinus Cavities | |
| CN111840715A (en) | Combined portable inhalation device containing disposable special bottle for atomized medicament | |
| WO2023071818A1 (en) | Atomizer integrating screen and mouthpiece | |
| CN212416581U (en) | Combined portable inhalation device containing disposable special bottle for atomized medicament | |
| CN218458425U (en) | A simple and easy portable atomizer for traditional chinese medicine aerosol inhalation | |
| EP2822623B1 (en) | Portable nebulizer device | |
| CN208405629U (en) | The drug storage of nebulizer administration and atomising device | |
| WO2018072665A1 (en) | Multi-cavity atomizing apparatus | |
| CN213048754U (en) | Active delivery type inhalation drug delivery device | |
| CN213667328U (en) | Portable electronic atomizer | |
| CN210044627U (en) | Special drainage suction nozzle for handheld micro-screen atomizer | |
| CN207640760U (en) | Gas compression formula children's nebulizer | |
| CN205994825U (en) | A kind of aerosol apparatus | |
| EP3237038B1 (en) | Portable fluid delivery system for the nasal and paranasal sinus cavities | |
| CA3133664C (en) | Precise insulin aerosolization and respiratory system aerosolization device | |
| CN219090629U (en) | Atomizing medicine feeder | |
| CN215351311U (en) | Tubular atomizing face guard that sustainability humidification was used |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Unit 304, 305, 306-2, 307, 3rd floor, No. 12, helix 3 Road, International Biological Island, Guangzhou, Guangdong 510320 Applicant after: Suno biomedical technology (Guangzhou) Co.,Ltd. Applicant after: CHANGZHOU ZHENGYUAN MEDICAL TECHNOLOGY Co.,Ltd. Address before: Unit 304, 305, 306-2, 307, 3rd floor, No. 12, helix 3 Road, International Biological Island, Guangzhou, Guangdong 510320 Applicant before: GUANGZHOU NANOTIDES PHARMACEUTICALS Co.,Ltd. Applicant before: CHANGZHOU ZHENGYUAN MEDICAL TECHNOLOGY Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |