CN107184947A - It is a kind of to treat pharmaceutical composition of arthrosis disease and its production and use - Google Patents

It is a kind of to treat pharmaceutical composition of arthrosis disease and its production and use Download PDF

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Publication number
CN107184947A
CN107184947A CN201710613521.8A CN201710613521A CN107184947A CN 107184947 A CN107184947 A CN 107184947A CN 201710613521 A CN201710613521 A CN 201710613521A CN 107184947 A CN107184947 A CN 107184947A
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parts
pharmaceutical composition
root
bulk drug
chinese
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CN107184947B (en
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罗才贵
罗建
徐侥
陈文英
许学良
魏礼红
杨丽新
蒙霞
程晓娇
王璐
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Teaching Hospital of Chengdu University of TCM
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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Abstract

The invention discloses a kind of pharmaceutical composition, it is made up of the bulk drug of following weight proportion：5 25 parts of notopterygium root, 5 25 parts of levisticum, 5 25 parts of turmeric, 5 25 parts of frankincense, 5 25 parts of peach kernel, 5 25 parts of myrrh, 15 parts of asarum, 5 25 parts of Radix Angelicae Sinensis, 5 25 parts of Ligusticum wallichii, 5 25 parts of safflower, 5 25 parts of rhizoma cibotii, 5 25 parts of reticulate millettia, 5 25 parts of radix cyathulae, 5 25 parts of lycopodium calvatum, 5 25 parts of the bark of eucommia, 5 25 parts of the root of Dahurain angelica, 5 25 parts of rhizoma zingiberis, 5 25 parts of Chinese ephedra, 5 25 parts of Chinese cassia tree, 5 25 parts of cassia twig, 5 25 parts of monkshood.Present invention also offers the preparation method of described pharmaceutical composition and purposes.Arthrosis disease caused by medicine composite for curing Cold-dampness of the present invention, it is evident in efficacy, have no side effect, the present invention is overcome the problem of patient's medication is difficult, a kind of new selection is provided for clinical application by the way of external fumigation and washing.

Description

It is a kind of to treat pharmaceutical composition of arthrosis disease and its production and use
Technical field
The present invention relates to a kind of pharmaceutical composition for treating arthrosis disease and its production and use, specifically, It is related to a kind of pharmaceutical composition for treating arthrosis disease caused by Cold-dampness.
Background technology
Bone and joint diseases, including degenerative arthritis, bursal synovitis, synovitis, cervical spondylopathy, lumbar vertebra disease, scapulohumeral periarthritis, hyperostosis Life, rheumatic arthritis, rheumatoid arthritis, caput femoris necrosis etc., ill basic reason are not that bone there occurs disease Become, modern medicine study is found, old complaint is that forfeiture of the cartilage etc. " joint protection system " to joint protective capability.
It is in particular in：The generation of all kinds of bone and joint diseases often starts from the lesions of synovium contributed, cartilage and is damaged or is denatured；Take Cartilage damage caused by some anti-inflammatory classes, hormone medicine is also one of main reason of many bone and joint diseases.Due to closing The missing of synovial membrane, the damage of cartilage and knuckle synovia is saved, causes joint bone to lack necessary protection, so that human body one is lived Dynamic, due to a lack of necessary " cartilage protection " violent rigid friction directly occurs for the bone of joint, and trigger patient articular's pain, A variety of symptoms such as swelling, deformation, spur hyperplasia.Even more important, if human synovial organ immune disorder, joint is inevitable because lacking Weary necessary " immunoprotection " and the intrusion for causing extraneous inflammatory factor, ultimately result in the generation of all kinds of bone and joint diseases.
Syndrome of cold-dampness blocking collaterals refers to the heresy retardance channels and collaterals of cold-dampness, with the heavy crymodynia of limbs or affected part, numbness, or swelling, fears cold Limb is cool, and white,slippery and moist fur etc. is the syndrome of common disease, is common in rheumatism.Syndrome of cold-dampness blocking collaterals is formed in the case of the damp evil that is affected by the cold, such as： The ground of humidity, severe cold frostbite are occupied long, greedy cool slept in the open, are dossed when wind, heavy rain pour pouring, underwater work or sweat Water Exit etc., cold-dampness heresy Gas is noted in flesh natural fibre line of meat channels and collaterals, is stranded in joint muscles and bones, causes qi and blood numbness to hinder.Limbs joint pain is shown as, pain gesture is more acute, and position is solid It is fixed, meet cold then pain very, it is slow to obtain hot then pain, joint joint stuffiness, local skin or have creeping chill.Tongue nature is light, thin white fur of tongue, veins string Tightly.Syndrome of cold-dampness blocking collaterals can also cause the backbones such as cervical spondylopathy, the protrasion of the lumbar intervertebral disci, the periarthritis of shoulderjoint, knee osteoarthritis to close Save disease.
Prior art is to using advanced instrument treatment, costly, treatment time is long, uncomfortable more than the treatment of arthrosis disease Close Clinical practice.
The content of the invention
To solve the above problems, the present invention provides a kind of pharmaceutical composition for treating arthrosis disease.
Present invention also offers the preparation method of described pharmaceutical composition and purposes.
The invention provides a kind of pharmaceutical composition, it is prepared from by the bulk drug of following weight proportion：Notopterygium root 5- 25 parts, 5-25 parts of levisticum, 5-25 parts of turmeric, 5-25 parts of frankincense, 5-25 parts of peach kernel, 5-25 parts of myrrh, 1-5 parts of asarum, Radix Angelicae Sinensis 5- 25 parts, 5-25 parts of Ligusticum wallichii, 5-25 parts of safflower, 5-25 parts of rhizoma cibotii, 5-25 parts of reticulate millettia, 5-25 parts of radix cyathulae, 5-25 parts of lycopodium calvatum, 5-25 parts of the bark of eucommia, 5-25 parts of the root of Dahurain angelica, 5-25 parts of rhizoma zingiberis, 5-25 parts of Chinese ephedra, 5-25 parts of Chinese cassia tree, 5-25 parts of cassia twig, 5-25 parts of monkshood.
Preferably, it is prepared from by the bulk drug of following weight proportion：15 parts of notopterygium root, 15 parts of levisticum, 15 parts of turmeric, 15 parts of frankincense, 15 parts of peach kernel, 15 parts of myrrh, 3 parts of asarum, 15 parts of Radix Angelicae Sinensis, 15 parts of Ligusticum wallichii, 15 parts of safflower, 15 parts of rhizoma cibotii, reticulate millettia 15 parts, 15 parts of radix cyathulae, 15 parts of lycopodium calvatum, 15 parts of the bark of eucommia, 15 parts of the root of Dahurain angelica, 15 parts of rhizoma zingiberis, 15 parts of Chinese ephedra, 15 parts of Chinese cassia tree, cassia twig 15 parts, 15 parts of monkshood.
Wherein, described pharmaceutical composition is the primary medicinal powder by the bulk drug, or water or extractive with organic solvent are Active component, adds pharmaceutically acceptable auxiliary material or complementary composition is prepared from preparation.
Wherein, the preparation is external preparation.
Wherein, the external preparation is decoction, liniment, ointment, paste, patch or powder.
The invention provides the preparation method of described pharmaceutical composition, comprise the following steps：
A) bulk drug of each weight proportion is weighed；
B) coarse powder is dry, pulverize into, sieves, produces.
The invention provides purposes of the described pharmaceutical composition in the medicine for preparing treatment arthrosis disease.
Wherein, the arthrosis disease is arthrosis disease caused by Cold-dampness.
Specifically, expelling wind and clearing away cold is being prepared the invention provides described pharmaceutical composition, in the medicine of effect of removing obstruction in channels to relieve pain Purposes.
Pharmaceutical composition of the present invention is by notopterygium root, levisticum, turmeric, frankincense, peach kernel, myrrh, asarum, Radix Angelicae Sinensis, Ligusticum wallichii, red Flower, rhizoma cibotii, reticulate millettia, radix cyathulae, lycopodium calvatum, the bark of eucommia, the root of Dahurain angelica, rhizoma zingiberis, Chinese ephedra, Chinese cassia tree, cassia twig, the medicine group of monkshood 21 Into.We are longer than expelling wind and eliminating dampness, numbness relieving and pain relieving using notopterygium root, levisticum as monarch drug in a prescription；The root of Dahurain angelica, lycopodium calvatum are ministerial drug, and work(is removed in wind-dispelling It is wet, stimulate the circulation of the blood and cause the muscles and joints to relax；Peach kernel, safflower, frankincense, myrrh are promoting blood circulation and removing blood stasis；Ligusticum wallichii, Chinese Angelica blood replonishing and battalion；Turmeric, reticulate millettia promoting blood circulation row Gas；The bark of eucommia, rhizoma cibotii, radix cyathulae filling liver kidney, strong waist and knee；Monkshood, Chinese cassia tree, rhizoma zingiberis Wen Jing activate yang, dispelling cold and removing dampness；It is Chinese ephedra, cassia twig, thin It is pungent to dissipate exterior cold, open space between skin and muscles.All medicines share, plays dispelling wind and eliminating dampness, work(that is warming channel and expelling cold, promoting blood circulation and removing obstruction in channels, exempting from numbness analgesic altogether.
According to the above of the present invention, according to the ordinary technical knowledge and customary means of relevant art, not Depart under the premise of above-mentioned basic fundamental thought of the invention, the modification of other diversified forms can also be made, replace or change.
Embodiment
The preparation of the pharmaceutical composition of the present invention of embodiment 1
1. raw material：Notopterygium root 15g, levisticum 15g, turmeric 15g, frankincense 15g, peach kernel 15g, myrrh 15g, asarum 3g, Radix Angelicae Sinensis It is 15g, Ligusticum wallichii 15g, safflower 15g, rhizoma cibotii 15g, reticulate millettia 15g, radix cyathulae 15g, lycopodium calvatum 15g, bark of eucommia 15g, root of Dahurain angelica 15g, dry Ginger 15g, Chinese ephedra 15g, Chinese cassia tree 15g, cassia twig 15g, monkshood 15g.
2. preparation method：Weigh the bulk drug of each weight proportion；Medicine is dried, coarse powder is ground into, No. 1 sieve is crossed, produces.
3. application method：External application, weighs 100 grams of medicines, adds in 3 kilograms of water, boils external application fumigation washing.
The preparation of the pharmaceutical composition of the present invention of embodiment 2
1. raw material：Notopterygium root 10g, levisticum 5g, turmeric 5g, frankincense 10g, peach kernel 12g, myrrh 12g, asarum 1g, Radix Angelicae Sinensis 10g, Ligusticum wallichii 10g, safflower 5g, rhizoma cibotii 10g, reticulate millettia 15g, radix cyathulae 15g, lycopodium calvatum 15g, bark of eucommia 10g, root of Dahurain angelica 12g, rhizoma zingiberis 12g, Chinese ephedra 13g, Chinese cassia tree 10g, cassia twig 12g, monkshood 13g.
2. preparation method：Weigh the bulk drug of each weight proportion；Medicine is dried, coarse powder is ground into, No. 1 sieve is crossed, produces.
3. application method：External application, weighs 100 grams of medicines, adds in 3 kilograms of water, boils external application fumigation washing.
The preparation of the pharmaceutical composition of the present invention of embodiment 3
1. raw material：Notopterygium root 20g, levisticum 22g, turmeric 22g, frankincense 20g, peach kernel 10g, myrrh 15g, asarum 5g, Radix Angelicae Sinensis It is 18g, Ligusticum wallichii 23g, safflower 20g, rhizoma cibotii 18g, reticulate millettia 23g, radix cyathulae 15g, lycopodium calvatum 25g, bark of eucommia 18g, root of Dahurain angelica 15g, dry Ginger 18g, Chinese ephedra 22g, Chinese cassia tree 22g, cassia twig 23g, monkshood 18g.
2. preparation method：Weigh the bulk drug of each weight proportion；Medicine is dried, coarse powder is ground into, No. 1 sieve is crossed, produces.
3. application method：External application, weighs 100 grams of medicines, adds in 3 kilograms of water, boils external application fumigation washing.Below by way of specific Clinical test proves beneficial effects of the present invention：
Test example 1：The clinical efficacy of the present composition
1st, clinical data
1.1 diagnostic criteria：
Arthrosis disease caused by Cold-dampness：Heumatism is due to worn with age, bone mistake nourishing, and qi and blood, which loses, to wither, caused office Portion or Whole Body Bone Scanning degenerative joint change.Clinical manifestation is with large joint pain, and limitation of activity is primary symptom.It is more common in degeneration Bones and joints Disease, hypertrophy is sexually revised.
Diagnosis basis
1. being had a dull ache from the beginning of common waist-leg, spinal column, knee joint etc., bend and stretch, pitching, change one's position it is unfavorable, light activity slightly delay Solution, climate change is aggravated, repeatedly touching not to be cured.
2. insidious onset, morbidity is slow, person in middle and old age are more common in.
3. local joint can mild swelling, often there are noise made in coughing or vomiting thorn sound or grating in joint when movable.The visible muscular atrophy of severe patient. Joint deformity, the curved back of the body camel of waist.
4.X lines take the photograph piece inspection：Show osteoporosis, articular surface is irregular, and joint space is narrow, subchondral bony sclerosis, with And edge lip sample changes, spur is formed.
5. have a blood test heavy, anti-" O ", mucoprotein, rheumatoid factor etc. mutually differentiate with rheumatism numbness, Wang numbness.
The deficiency of yang is cold solidifying：Limbs joint pain, heavily write, joint stuffiness, Changes in weather is aggravated, and daytime light night weight, pain increase in intensity under coldness is obtained Heat slightly subtracts.Pale tongue, tongue is white, and deep thready pulse delays.
1.2 inclusive criteria
The case for meeting 1.1 section diagnostic criteria is included.
2nd, treatment method
Experimental group：Give the medicine of the embodiment of the present invention 1.
Specifically medication is：
Give the application method in embodiment 1.
3rd, observation of curative effect
3.1 criterion of therapeutical effect：
Cure：Disappear, movable function recovers normal, and laboratory examination is normal.
Take a turn for the better：Arthralgia, swelling mitigate, and movable function takes a turn for the better.
It is not cured：Arthralgia and swelling are unchanged.
3.2 treatment results
As shown in table 1：
Group Cure Take a turn for the better It is not cured It is efficient
Experimental group (100 people) 37 56 7 93%
Experiment conclusion：The present invention is directed to arthrosis disease determined curative effect caused by Cold-dampness, has no side effect, is worth facing Bed popularization and application.
In summary, arthrosis disease caused by medicine composite for curing Cold-dampness of the present invention, evident in efficacy, no pair Effect, the present invention overcomes the problem of patient's medication is difficult by the way of external fumigation and washing, is provided for clinical application a kind of new Selection.

Claims (9)

1. a kind of pharmaceutical composition, it is characterised in that：It is prepared from by the bulk drug of following weight proportion：Notopterygium root 5-25 Part, 5-25 parts of levisticum, 5-25 parts of turmeric, 5-25 parts of frankincense, 5-25 parts of peach kernel, 5-25 parts of myrrh, 1-5 parts of asarum, Radix Angelicae Sinensis 5-25 Part, 5-25 parts of Ligusticum wallichii, 5-25 parts of safflower, 5-25 parts of rhizoma cibotii, 5-25 parts of reticulate millettia, 5-25 parts of radix cyathulae, 5-25 parts of lycopodium calvatum, Du Secondary 5-25 parts, 5-25 parts of the root of Dahurain angelica, 5-25 parts of rhizoma zingiberis, 5-25 parts of Chinese ephedra, 5-25 parts of Chinese cassia tree, 5-25 parts of cassia twig, 5-25 parts of monkshood.
2. pharmaceutical composition according to claim 1, it is characterised in that：It is the bulk drug preparation by following weight proportion Form：15 parts of notopterygium root, 15 parts of levisticum, 15 parts of turmeric, 15 parts of frankincense, 15 parts of peach kernel, 15 parts of myrrh, 3 parts of asarum, 15 parts of Radix Angelicae Sinensis, 15 parts of Ligusticum wallichii, 15 parts of safflower, 15 parts of rhizoma cibotii, 15 parts of reticulate millettia, 15 parts of radix cyathulae, 15 parts of lycopodium calvatum, 15 parts of the bark of eucommia, the root of Dahurain angelica 15 Part, 15 parts of rhizoma zingiberis, 15 parts of Chinese ephedra, 15 parts of Chinese cassia tree, 15 parts of cassia twig, 15 parts of monkshood.
3. pharmaceutical composition according to claim 1 or 2, it is characterised in that：It is the primary medicinal powder by the bulk drug, Or water or extractive with organic solvent are active component, add pharmaceutically acceptable auxiliary material or complementary composition is prepared from Agent.
4. pharmaceutical composition according to claim 3, it is characterised in that：The preparation is external preparation.
5. pharmaceutical composition according to claim 4, it is characterised in that：The external preparation be decoction, powder, liniment, Ointment, paste or patch.
6. a kind of method for preparing claim 1-5 any one described pharmaceutical compositions, it is characterised in that：Including following step Suddenly：
A) bulk drug of each weight proportion is weighed；
B) coarse powder is dry, pulverize into, sieves, produces.
7. purposes of the claim 1-5 any one described pharmaceutical composition in the medicine for preparing treatment arthrosis disease.
8. purposes according to claim 7, it is characterised in that：The arthrosis disease is Bones and joints caused by Cold-dampness Class disease.
9. claim 1-5 any one described pharmaceutical composition is preparing expelling wind and clearing away cold, in the medicine of effect of removing obstruction in channels to relieve pain Purposes.
CN201710613521.8A 2017-07-25 2017-07-25 Pharmaceutical composition for treating osteoarticular diseases and preparation method and application thereof Active CN107184947B (en)

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