CN107158131B

CN107158131B - Traditional Chinese medicine composition for treating dermatitis and preparation method thereof

Info

Publication number: CN107158131B
Application number: CN201710271343.5A
Authority: CN
Inventors: 李佳祎
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-04-24
Filing date: 2017-04-24
Publication date: 2020-10-02
Anticipated expiration: 2037-04-24
Also published as: CN107158131A

Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating dermatitis, which is prepared from the following raw materials in parts by weight: 20-40 parts of rheum officinale, 20-40 parts of coptis chinensis, 20-40 parts of golden cypress, 5-15 parts of frankincense, 5-15 parts of myrrh, 10-30 parts of talc, 50-70 parts of indigo naturalis, 3-8 parts of borneol, 5-10 parts of herba lycopi, 2-6 parts of chaulmoogratree seed, 8-15 parts of herba artemisiae rugosae and 2-6 parts of parasitic loranthus. The invention also discloses a preparation method of the traditional Chinese medicine composition. The invention adopts the medicines for use together, and has the effects of clearing heat and cooling blood, removing blood stasis and detoxifying, relieving pain and promoting granulation. The traditional Chinese medicine composition is used for treating herpes zoster, eczema, insect dermatitis and the like, and has a remarkable effect.

Description

Traditional Chinese medicine composition for treating dermatitis and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating dermatitis and a preparation method thereof.

Background

Dermatitis is a common skin disease, and in recent years, the onset of dermatitis is on an increasing trend, which may be related to environmental pollution, climate change, irregular life, mental stress, dietary structure change and the like. The incidence of dermatitis tends to increase year by year in some areas. Dermatitis causes great pain to patients and is difficult to treat.

At present, the dermatitis is treated by a plurality of western medicines, but the western medicines have poor treatment effect and often cause the recurrence of the disease, the oral antihistamine medicines are mostly taken, the corticoid medicines are temporarily inhibited, the damage to the skin is increased rapidly, the adverse reaction is obvious, and the medicines only relieve the symptom of the dermatitis, can not radically treat the dermatitis and have great side effect.

Therefore, the dermatitis should be treated mainly by traditional Chinese medicines in terms of traditional Chinese medicine, eczema is an allergic disease, and the eczema can be radically cured only by improving allergic constitution, so that the recurrence of the eczema is prevented.

With the development of traditional Chinese medicines in recent years, a plurality of methods for treating dermatitis appear, and the treatment effect is better compared with that of western medicines. However, dermatitis is of various types and should be treated by combining different traditional Chinese medicine formulas according to different symptoms, causes, severity and the like.

Chinese patent application 201610748134.0 discloses a medicament for treating eczema dermatitis, and particularly relates to a Chinese medicinal composition for treating eczema dermatitis, a medicinal preparation and an application thereof, wherein the Chinese medicinal composition mainly comprises the following raw materials in parts by weight: 20-30 parts of mulberry twig, 15-25 parts of tree peony bark, 20-30 parts of dendrobium, 20-30 parts of cortex dictamni, 15-25 parts of lithospermum, 20-30 parts of cortex lycii radicis, 15-25 parts of garden balsam stem, 15-25 parts of suberect spatholobus stem and 15-25 parts of common cnidium fruit. The invention has the functions of clearing heat, eliminating dampness, promoting blood circulation, relieving itching and detoxifying, has good curative effect on dermatitis and eczema, high cure rate, difficult repeated attack, convenient administration and no toxic or side effect. The formula of the medicine comprises traditional Chinese medicine dendrobe which is expensive and difficult to take, but the medicine is an oral preparation and has slow effect.

Chinese patent application 201410164717.X discloses a pharmaceutical composition for treating dermatitis, which is characterized by being prepared from the following raw materials in parts by weight: 20-40 parts of cactus, 10-20 parts of bamboo shavings, 15-30 parts of corn stigma, 10-30 parts of holy basil, 20-40 parts of gentian, 30-50 parts of garlic, 2-5 parts of wormwood and 2-10 parts of fructus forsythiae. The pharmaceutical composition for treating dermatitis can treat dermatitis by the complementary action of the traditional Chinese medicines, but the pharmaceutical composition has large dosage and long treatment period.

Chinese patent application 201410640259.2 discloses an application of a composition in preparing a medicament for preventing children dermatitis, wherein the composition comprises, by weight, 30-70 parts of lithospermum erythrorhizon, 30-70 parts of coptis chinensis, 30-70 parts of rheum officinale and 5-20 parts of borneol. Pulverizing radix Arnebiae into powder, grinding Borneolum Syntheticum into powder, mixing the extracts with oil phase, and collecting water phase; stirring the oil phase, adding the 1/3 water phase, stirring for 3-4 minutes, adding the rest water phase, maintaining the temperature at 80 ℃, stirring for 15 minutes, naturally cooling, adding the lithospermum and borneol powder when the temperature is reduced to about 40 ℃, and stirring and mixing uniformly until uniform cream is formed to obtain the ointment; the medicine prepared from the composition is specially used for treating children dermatitis, has the effects of clearing heat, removing toxicity, promoting diuresis, relieving itching and the like, and is easily accepted by children patients and parents. The medicine is mainly used for children patients, so that the medicine has no obvious effect on adult patients and patients with recurrent dermatitis.

201110257644.5 discloses a capsule for clearing away heat and toxic materials, which is prepared from the following raw materials in parts by weight: 110-130 parts of wild chrysanthemum flower, 110-130 parts of Chinese violet, 110-130 parts of dandelion, 110-130 parts of paris polyphylla, 150-170 parts of honeysuckle, 70-90 parts of scutellaria baicalensis, 70-90 parts of coptis chinensis, 70-90 parts of gardenia and 3-5 parts of talcum powder; the preparation method comprises the following steps: 1) weighing the coptis chinensis and the rhizoma paridis according to the formula, crushing into fine powder, and uniformly mixing for later use. 2) Taking wild chrysanthemum flower, Chinese violet, dandelion, honeysuckle flower, scutellaria baicalensis and gardenia according to the formula amount, respectively adding 4-6 times of water for decoction for the first extraction, then adding 1-3 times of water for decoction for the second extraction, combining decoction liquids, filtering, and concentrating the filtrate into thick paste with the relative density of 1.10-1.20 for later use; 3) mixing the thick paste and the fine powder, drying at 70-80 ℃, crushing, adding talcum powder, mixing uniformly, and filling into capsules. 2. The heat-toxin clearing capsule according to claim 1, characterized in that: the weight ratio of the raw materials is as follows: 120 parts of wild chrysanthemum flower, 120 parts of Chinese violet, 120 parts of dandelion, 120 parts of rhizoma paridis, 160 parts of honeysuckle flower, 80 parts of scutellaria baicalensis, 80 parts of coptis chinensis, 80 parts of gardenia and 5 parts of talcum powder. The Chinese medicinal composition has the effects of clearing heat and removing toxicity, can be used for treating psoriasis, insect bite dermatitis and other symptoms belonging to toxic heat, and provides a more convenient and rapid Chinese medicinal treatment mode for clinical treatment of skin diseases. But the medicine has poor curative effect and certain toxic and side effects.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides a traditional Chinese medicine composition for treating dermatitis and a preparation method thereof. The traditional Chinese medicine composition is used for treating herpes zoster, eczema, insect dermatitis and the like, and has a remarkable effect.

The technical scheme of the invention is as follows: the traditional Chinese medicine composition for treating dermatitis is prepared from the following raw materials in parts by weight:

the traditional Chinese medicine composition for treating dermatitis is prepared from the following raw materials in parts by weight:

the preparation method of the traditional Chinese medicine composition for treating dermatitis comprises the following steps:

step 1: pulverizing radix et rhizoma Rhei, Coptidis rhizoma, cortex Phellodendri, Olibanum, Myrrha, indigo naturalis, herba Lycopi, semen Hydnocarpi, herba Artemisiae Anomalae and herba Taxilli, decocting with 10-12 times of water for 1-1.5 hr for 2-3 times, filtering to obtain decoction and residue, mixing decoctions, and concentrating to obtain fluid extract with relative density of 1.3-1.35 at 50 deg.C;

step 2: and (2) drying and crushing the medicine residues in the step (1), adding the medicine residues into vaseline, stirring for 24-48 hours, adding talcum and borneol and the clear paste obtained in the step (1), continuously stirring uniformly, and cooling to normal temperature to obtain the ointment.

Further, the dregs in step 2 are crushed and then sieved by a sieve with 120-150 meshes.

Further, the mass ratio of the vaseline to the dregs in the step 2 is 3-4: 2. the vaseline has good shielding effect on the affected part and prevents external bacteria from entering the wound surface. Meanwhile, the vaseline has the effects of moisturizing and repairing the skin, and the moist environment is more favorable for healing the affected part.

Further, the temperature of the vaseline in the step 2 is 55-60 ℃, the temperature is maintained until the talcum, the borneol and the clear paste obtained in the step 1 are added, and the mixture is stirred uniformly. After the vaseline is melted at the temperature, the traditional Chinese medicine components can be well mixed uniformly to generate a synergistic effect, and the temperature does not cause adverse effects on the traditional Chinese medicine components.

Further, the talcum and the borneol are obtained by sieving through a sieve of 120-150 meshes after being crushed.

The using method comprises the following steps: the prepared medicine composition is dipped by a sterile cotton swab and is applied to an affected part, the application area is slightly larger than the affected part area, the medicine is applied for 2-3 times every day, and the local cleanness and the dryness are kept after the medicine is applied. 7 days is a course of treatment until the wound surface is healed.

The rhubarb: the rheum officinale has the effects of purging heat, dredging intestines, cooling blood, removing toxicity, removing blood stasis and stimulating the menstrual flow, the catechu compound contained in the rheum officinale can reduce capillary permeability and reduce wound surface liquid extravasation, and the effective monomer rheum officinale can inhibit bacteria, resist inflammation, improve microcirculation and promote granulation tissue growth and epidermis generation.

Coptis chinensis: has effects in clearing away heat, eliminating dampness, nourishing yin, purging pathogenic fire, removing toxic materials, astringing dampness, promoting blood circulation, dispelling blood stasis, dispelling pathogenic wind, and relieving itching.

Phellodendron bark: bitter taste and cold nature, kidney and bladder meridians, clearing heat and drying dampness, purging fire and removing toxicity, and relieving deficiency heat.

Frankincense: pungent, bitter and warm, and has effects of promoting blood circulation, activating qi-flowing, relieving pain, removing necrotic tissue and promoting granulation.

Myrrh: bitter and neutral. It enters liver, spleen, heart and kidney meridians. Promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. Can be used for treating blood stasis and pain in chest and abdomen, dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, carbuncle, swelling, sore, ulcer, intestinal abscess, and conjunctival congestion with swelling and pain.

Talc: pungent, sweet and cold with smooth property, cold can detoxify summer-heat, dispel dampness and heal wound, smooth property can induce resuscitation, and has the effects of inducing diuresis and excreting dampness, and magnesium silicate contained in the magnesium silicate has the functions of adsorption and convergence.

Indigo naturalis: has effects in clearing away heat, purging pathogenic fire, cooling blood, and removing toxic materials.

Borneol: the flavor is cool, pungent, bitter and cool, and the meridian entered heart, liver and lung meridians, it has the actions of clearing heat, alleviating pain and relieving swelling. It is indicated for sores and ulcers with swelling pain and unhealing after ulceration.

Ze lan, with bitter and pungent taste and mild nature. Promoting blood circulation, removing blood stasis, promoting diuresis, relieving swelling, removing toxic substance, and treating carbuncle. Can be used for treating dysmenorrhea, edema, traumatic injury, carbuncle, swelling, and sore.

Da Feng Zi is warm and pungent in flavor. Expelling wind, counteracting toxic substances and killing parasites. Can be used for treating leprosy and scab.

Big head is old, pungent, bitter and flat. Dispel wind, relieve exterior syndrome, resolve dampness and remove food stagnation. Can be used for treating dermatitis, common cold, headache, fever, abdominal pain, diarrhea, dyspepsia, etc.

Loranthus mulberry mistletoe, bitter and sweet, neutral, has the effects of nourishing liver and kidney, strengthening bones and muscles, expelling wind-damp and calming fetus.

According to the traditional Chinese medicine composition, the medicine components are subjected to dialectical compatibility, the heat-clearing medicines are adopted, the pyretic hydnocarpus is selected, the adverse effect of excessive heat-clearing medicines on a body is avoided, and meanwhile, various traditional Chinese medicine components assist each other in action, so that the traditional Chinese medicine composition has the effects of soothing the liver, regulating the flow of qi, tonifying the lung, tonifying the spleen, purging intense heat, detoxifying, dispelling wind, promoting diuresis, nourishing blood, moistening dryness, cooling blood and removing stasis. Can be used for treating dermatitis such as herpes zoster, with good analgesic effect and heat and toxic materials clearing away effects. The preparation method of the composition can effectively extract the active ingredients in the medicinal materials, has good activity of the active ingredients and good skin permeability of the medicament, and promotes the absorption of the medicament.

The invention is a pure Chinese medicinal component, adopts the medicaments for use together, and has the effects of clearing heat and cooling blood, removing blood stasis and detoxifying, relieving pain and promoting granulation; meanwhile, the immunity of the patient is improved by adjusting the body of the patient, so that the effect of treating both principal and secondary aspects of disease is achieved. The traditional Chinese medicine composition is simple and convenient to prepare, wide in medicine source and low in cost. Clinical application proves that the traditional Chinese medicine composition has obvious and reliable curative effect, mild medicine property and no toxic or side effect, and the traditional Chinese medicine composition has obvious effect when being used for treating herpes zoster, eczema, insect dermatitis and the like.

Detailed Description

Example 1

step 1: pulverizing radix et rhizoma Rhei, Coptidis rhizoma, cortex Phellodendri, Olibanum, Myrrha, indigo naturalis, herba Lycopi, semen Hydnocarpi, herba Artemisiae Anomalae and herba Taxilli, decocting with 12 times of water for 1 hr for 3 times, filtering to obtain decoction and residue, mixing decoctions, and concentrating to obtain fluid extract with relative density of 1.32 at 50 deg.C;

step 2: and (2) taking the medicine residues obtained in the step (1), drying, crushing, sieving by a 120-mesh sieve, adding into vaseline at 55 ℃, keeping the temperature at 55 ℃, stirring for 24 hours, adding the talc and the borneol which are crushed and sieved by the 120-mesh sieve and the clear paste obtained in the step (1), continuously stirring uniformly, and cooling to normal temperature to obtain the medicine.

Wherein the mass ratio of the vaseline to the dregs is 3: 2.

example 2

step 1: pulverizing radix et rhizoma Rhei, Coptidis rhizoma, cortex Phellodendri, Olibanum, Myrrha, indigo naturalis, herba Lycopi, semen Hydnocarpi, herba Artemisiae Anomalae and herba Taxilli, decocting with 10 times of water for 1.25 hr for 2 times, filtering to obtain decoction and residue, mixing decoctions, and concentrating to obtain fluid extract with relative density of 1.33 at 50 deg.C;

step 2: and (2) taking the medicine residues obtained in the step (1), drying, crushing, sieving with a 125-mesh sieve, adding into vaseline at 56 ℃, keeping the temperature at 56 ℃ and stirring for 36 hours, adding the talc and the borneol which are crushed and sieved with the 125-mesh sieve and the clear paste obtained in the step (1), continuously stirring uniformly, and cooling to normal temperature to obtain the traditional Chinese medicine.

Wherein the mass ratio of the vaseline to the dregs is 2: 1.

example 3

step 1: pulverizing radix et rhizoma Rhei, Coptidis rhizoma, cortex Phellodendri, Olibanum, Myrrha, indigo naturalis, herba Lycopi, semen Hydnocarpi, herba Artemisiae Anomalae and herba Taxilli, decocting with 11 times of water for 1.2 hr for 3 times, filtering to obtain decoction and residue, mixing decoctions, and concentrating to obtain fluid extract with relative density of 1.33 at 50 deg.C;

step 2: and (2) taking the medicine residues obtained in the step (1), drying, crushing, sieving by a 130-mesh sieve, adding into vaseline at the temperature of 58 ℃, keeping the temperature at 58 ℃ and stirring for 30 hours, adding the talc and the borneol which are crushed and sieved by the 130-mesh sieve and the clear paste obtained in the step (1), continuously stirring uniformly, and cooling to normal temperature to obtain the traditional Chinese medicine composition.

Wherein the mass ratio of the vaseline to the dregs is 3: 2.

example 4

step 1: pulverizing radix et rhizoma Rhei, Coptidis rhizoma, cortex Phellodendri, Olibanum, Myrrha, indigo naturalis, herba Lycopi, semen Hydnocarpi, herba Artemisiae Anomalae and herba Taxilli, decocting with 10 times of water for 2 times, each time for 1 hr, filtering to obtain decoction and residue, mixing decoctions, and concentrating to obtain fluid extract with relative density of 1.3 at 50 deg.C;

step 2: and (2) taking the medicine residues obtained in the step (1), drying, crushing, sieving by a 140-mesh sieve, adding into vaseline at 55 ℃, keeping the temperature at 55 ℃, stirring for 24 hours, adding the talc and the borneol which are crushed and sieved by the 140-mesh sieve and the clear paste obtained in the step (1), continuously stirring uniformly, and cooling to normal temperature to obtain the medicine.

Wherein the mass ratio of the vaseline to the dregs is 3: 2.

example 5

step 1: pulverizing radix et rhizoma Rhei, Coptidis rhizoma, cortex Phellodendri, Olibanum, Myrrha, indigo naturalis, herba Lycopi, semen Hydnocarpi, herba Artemisiae Anomalae and herba Taxilli, decocting with 12 times of water for 1.5 hr for 3 times, filtering to obtain decoction and residue, mixing decoctions, and concentrating to obtain fluid extract with relative density of 1.35 at 50 deg.C;

step 2: and (2) taking the medicine residues obtained in the step (1), drying, crushing, sieving with a 150-mesh sieve, adding into vaseline at the temperature of 60 ℃, keeping the temperature at 60 ℃, stirring for 48 hours, adding the talc and the borneol which are crushed and sieved with the 150-mesh sieve and the clear paste obtained in the step (1), continuously stirring uniformly, and cooling to normal temperature to obtain the traditional Chinese medicine composition.

Wherein the mass ratio of the vaseline to the dregs is 2: 1.

example 6

Wherein the mass ratio of the vaseline to the dregs is 3: 2.

clinical results

First, observation of clinical efficacy of eczema dermatitis

1. General data

100 patients were out-patient and were randomly divided into two groups.

Experimental groups: 50 of the above-mentioned three groups of the Chinese medicinal composition are 27 male and 23 female, wherein the age is 15-61 years, and the average age is 36.9 years.

Control group: 50 of the above-mentioned three-dimensional male sex disease patients are 26 male sex diseases and 24 female sex diseases, the age is 15-59 years, and the average age is 35.3 years.

The patients with acute and subacute dermatitis and eczema are diagnosed in an outpatient clinic.

Acute dermatitis and eczema: erythema, papules, blisters, crusting.

Subacute dermatitis and eczema: infiltrative erythema, small pimples or papules, crusting.

2. The treatment method comprises the following steps: dipping the prepared medicinal composition with sterile cotton bud, applying onto the affected part with the application area slightly larger than the affected part area for 3 times per day, and keeping local clean and dry after application; 7 days is a treatment course, and 2 treatment courses are total.

Experimental groups: the composition prepared in example 1 was used.

Control group: the composition prepared in example 6 was used.

3. And (3) judging the curative effect: and (3) healing: the skin lesions subside and the symptoms disappear; the effect is shown: the skin lesion is faded by 60-90%, and the symptoms are obviously improved; improvement: the skin lesion is faded by 20-59%, and the symptoms are improved; and (4) invalidation: the skin damage is reduced by less than or equal to 20 percent, and the symptom is not improved.

4. As a result: the treated group and the control group have common conditions, have no significant difference and are in line with comparability. The treatment results of the two groups are shown in table 1, the curative effect is effective rate, the total effective rate of the two groups is 96% and 78% respectively, and the statistical treatment shows that the treatment effect of the treatment group is obviously higher than that of the control group.

TABLE 1

Group of

Number of examples

Recovery method

Show effect

Improvement of life

Invalidation

Total effective rate

Treatment group

50

36(72％)

9(18％)

3(6％)

2(4％)

96％

Control group

50

26(52％)

6(12％)

7(14％)

11(22％)

78％

Second, observation of clinical efficacy of dermatitis due to insect bite

1. General data

120 patients were out-patient (standard of diagnosis of insect dermatitis) and were divided into two groups at random.

Experimental groups: 60 men and 25 women, the ages of 16-58 years, and the average age of 35.1 years.

Control group: 60 men and 24 women aged 14-62 years, with an average age of 36.6 years.

Experimental groups: the composition prepared in example 1 was used.

Control group: the composition prepared in example 6 was used.

4. As a result: the treated group and the control group have common conditions, have no significant difference and are in line with comparability. The treatment results of the two groups are shown in table 2, the cure and obvious effect is effective rate, the total effective rate of the two groups is respectively 95% and 76.7%, and the statistical treatment shows that the treatment effect of the treatment group is obviously higher than that of the control group.

TABLE 2

Group of

Number of examples

Recovery method

Show effect

Improvement of life

Invalidation

Total effective rate

Treatment group

60

44(73.3％)

9(15％)

4(6.7％)

3(5％)

95％

Control group

60

31(51.7％)

7(11.7％)

8(13.3％)

14(23.3％)

76.7％

From the above data, it can be seen that the Chinese medicinal composition for treating dermatitis of the present invention has the effects of treating eczema dermatitis and insect bite dermatitis, and has high total effective rate and no side effects.

The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating dermatitis is prepared from the following raw materials in parts by weight:

2. the traditional Chinese medicine composition for treating dermatitis is prepared from the following raw materials in parts by weight:

3. the method for preparing the traditional Chinese medicine composition for treating dermatitis as claimed in claim 1 or 2, comprises the following steps:

step 2: and (2) drying and crushing the medicine residues in the step (1), adding the medicine residues into vaseline, stirring for 24-48 hours, adding talcum, borneol and the clear paste obtained in the step (1), stirring uniformly, and cooling to normal temperature to obtain the ointment.

4. The method according to claim 3, wherein the dregs obtained in step 2 are ground and then sieved through a 120-mesh and 150-mesh sieve.

5. The preparation method according to claim 3, wherein the mass ratio of the vaseline to the dregs in step 2 is 3-4: 2.

6. The preparation method according to claim 3, wherein the temperature of vaseline in step 2 is 55-60 deg.C, and the temperature is maintained until talc and borneol, and the fluid extract obtained in step 1 are added, and stirred uniformly.

7. The process according to any one of claims 3 to 6, wherein the talc and the borneol are obtained by pulverizing and sieving with a sieve of 120-150 mesh.